World's first medical networking and resource portal

Articles
Category : All
Medical Articles
Jul22
STUDY OF SERUM LIPOPROTEIN (A) AS A ARISK FACTOR IN
AIMS AND OBJECTIVES:

Lp (a) a cholesterol ester rich LDL like particle that contains apo B 100 linked by disulphide bridge to a highly polymorphic glycoprotein  apolipoprotein. Lp(a) has both atherogenic and thrombogenic properties. In this study serum Lp(a) of Coroanry artery disease patients were correlated with of controls to find out any correlation between Lp(a) and Coronary Artery Disease.

MATERIALS AND METHODS:

In the present study 50 percent of cases of newly detected Coronary artery disease with various presentations of acute coronary syndrome (ACS) like unstable angina, NSTEMI & STEMI were taken. Cases were confirmed by clinical criteria, ECG and increased cardiac markers. Lp(a) level was estimated by Nephelometric method. Sample taken either within 6 hours of onset of symptoms or after 28 days of onset of symptoms. 30 suitably age and sex matched controls were taken having no evidence of coronary artery disease and their Lp(a) level estimated. Serum lipid profile (TG, Cholesterol, VLDL, LDL, HDL) were also estimated.

OBSERVATION:

The mean age of the patients in the study was 55.4 years (45-70 years). Anteroseptal MI was predominate (42%) followed by inferior wall MI (28%), anterolateral MI (26%), inferior & RV MI in 4%. Distribution of different risk factors were smoking in 52%, DM in 12%, hypertension in 24%, family history of CAD in 13%, hypercholesterolemia in 24% and hypertriglyceridemia in 17%. In the present study the mean serum Lp(a) in cases was (28.86.0 mg/dl) and the control group was (18.34.0mg/dl) with P value < 0.01).

CONCLUSION:

Patients of coronary artery disease group had significantly higher level of Lp(a) in comparison to controls without coronary artery disease establishing the role of serum Lp(a) as an independent risk factor for coronary artery disease.


Category (General Medicine)  |   Views (3677)  |  User Rating
Rate It


Browse Archive