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Jan 20
Kidney Cancer Linked to Mutated Genes- PBRM1, VHL
A mutated gene has been found in 1/3 patients with the most common form of renal cancer. This finding will help researchers understand how kidney cancer develops and in future it might lead to new treatments and earlier diagnosis.

Every individual is born with a gene called PBRM1. However in some people this gene might get damaged leading to the development of cancer. 40% cases of renal cancer presented with a mutated PBRM1 gene. 20 years ago it was known that the main gene involved, the tumor suppressor VHL, is mutated in 8 out of 10 patients. Scientists now believe that these two genes together are implicated in majority of kidney cancers.

Renal cancer is the 7th most common cancer in men and the 9th in women. Therefore this new discovery will provide a new insight for future therapeutic measures.

Jan 19
Coffee and aspirin best remedy for hangover
Besides providing the much required boost of morning energy, a cup of coffee along with an aspirin has been found to be extremely effective at overcoming a hangover, reveals a recent study led by Philadelphia researcher Michael Oshinsky.

The caffeine content present in coffee adds to the anti-inflammatory ingredients of aspirin found to combat the chemical compounds of alcohol.

Consumption of alcohol results in headaches due to the production of chemical acetates, causing more severe headaches in some people as compared to others.

"One of the major causes of hangovers is a chemical called acetate, a by-product of how the body processes alcohol. Caffeine and certain types of painkiller block its effects. And the best time to take them would be about four hours after drinking," Prof Oshinsky said.

The study details:

The study looked at a group of laboratory rats who were administered small amounts of ethanol or pure alcohol in order to induce headaches in them.

Further, additional doses of caffeine and anti-inflammatories were given to the rats after a four hour gap.

The doses were found to produce a soothing effect on the rats by blocking the acetate produced by alcohol.

Oshinsky told the journal 'New Scientist' that "none of the commonly cited causes of hangovers could have caused this response."

Drinking water instead of coffee is believed to be a better option by some experts due to the rehydrating properties of water.

Also, some others are against the use of painkillers like aspirin and ibuprofen as they over burden the liver which is already struggling for relief, resulting in stomach disorders.

The study has been published in the recent issue of peer-reviewed online science journal 'PLoS One.'

Relief from hangover
Coke, coffee, ginseng, Vegemite on toast, cold pizza, bananas, peanut butter, honey and banana sandwich, and chocolate milk can help against nausea generated during a hangover.

Sugar and mineral levels of the body get raised on consuming alcohol which can be balanced out by taking ginseng, orange juice, tomato, sauerkraut, pickle juice, eggs, or fruit juice.

Aspirin, bananas, and coffee can help relieve headache, according to experts. Also, a hot bath too is extremely helpful in sweating out the toxins.

However, the best advice would be to drink not more than one alcoholic beverage hydrated with water per hour at a party or outing.

Jan 18
Women could be paid for donating their eggs to infertile couples
The Human Fertility and Embryology Authority (HFEA) believes that the current level of remuneration - 250 pounds per donation for "reasonable expenses" and loss of earnings - could be deterring donors.

Meanwhile, demand from infertile couples for donated eggs and sperm is steadily rising. Up to a seventh of British couples have problems conceiving.

Prof Lisa Jardine, the chairman of the HFEA, said: "We know that many people are facing long waiting lists at clinics because of a shortage of donors. We want to ensure that we have the best policies in place so that there are no unnecessary barriers in the way of those wishing to donate while protecting those who are born as a result of donation."

In Spain, which has much higher donation levels, women are given a payment of 900 euros (about 760 pounds).

In Britain, women can opt to "egg-share", donating their eggs in return for IVF or other fertility treatment worth thousands of pounds.

This type of donation makes up 40 per cent of contributions. The revised level of cash compensation could be raised to be in line with this - although some experts fear that raising the level too high could attract donors purely for financial reasons rather than for the public good.

The HFEA is starting the public consultation process, which is being carried out online, today.

The findings will be presented to the HFEA board, which will draw up new regulations, in July,

Tony Rutherford, the chairman of the British Fertility Society, warned against setting the level of compensation for women too high.

Paying them the cash equivalent of the value of fertility treatment given to "egg-sharers" would be too much, he said. "That clearly becomes a financial incentive. If that happens, I think there's a real danger that we would lose the altruistic reasons for donation."

However, Mr Rutherford thought the current level of remuneration was too low for women, who had to undergo "at least six hospital visits, injections, a series of appointments and counselling" when donating.

The HFEA consultation will also look at whether the limit on how many families can use the sperm from any one donor, should be changed.

At the moment, up to 10 families can use one donor's sperm, with each able to have as many offspring as they like with it.

The limit is to minimise the chance of any resultant children unknowingly having incestuous relationships and conceiving offspring.

However, Prof Jardine said that the way the clinics worked meant the 10-family limit often resulted in only two or three families using the sperm.

"That's tremendously wasteful," she said. The limit could be raised to 25.

Jan 18
Low-fat food won't make you lose weight
Trying to lose weight by adopting a low fat diet? Well, you may be committing the biggest mistake of your 'weight loss regime', says an Oz fitness expert.

Celebrity trainer James Duigan, whose clients include model Elle Macpherson, said, "I see so many people trying their best and it''s just
not working because they don't understand that it's not fat that makes you fat, it's sugar and it's carbohydrates."

"You need a healthy balanced diet with fish and chicken and meat and vegetables and berries and nuts and things like that. [Low-fat diets] just don't work - it's not sustainable. You need to look at how you can keep yourself happy and healthy throughout your life," Stuff.co.nz quoted him as saying.

Weight lossDuigan, whose second book Clean & Lean: Flat Tummy Fast! is out, has suggested some small steps one can follow for a flattened stomach.

Don't overcook your food as you'll kill off or reduce the nutrient content. Try to make sure around 50 percent of the food on your plate is raw. If you can stomach it, eat all your vegetables raw.

Don't buy cheap meat - organic meat is more expensive, but it also contains less toxic junk such as antibiotics. If you can afford only one organic thing make sure it's meat.

Don't eat foods that weaken your abdominal wall, as this will make it slack and lead to a protruding stomach. Foods that can weaken your abdominal wall often contain gluten.

Avoid sugar, in all its forms, as it fattens your mid-section.

Make sure you eat enough fibre. A lack of fibre will lead to inflammation in the bowel. Eat plenty of vegetables (ideally raw) and drink at least two litres of still, room temperature water every day.

Duigan has suggested having the occasional 'cheat' meal, so you can eat a piece of cake or a brownie and actually help your weight loss.

"Feed your soul because you can't live your whole life in denial. And it helps the fat-burning process, it can boost your metabolism and get you leaner the next day. The key is to keep it to one meal," he said.

Another factor for a healthy lifestyle is reducing stress, he added.

Jan 17
Blueberries help curb high blood pressure
Eating two handfuls of blueberries a week can slash the risk of developing high blood pressure, which leads to strokes and heart disease, a new research has found.

High blood pressure or hypertension affects at least 10 million people in Britain, reports express.co.uk.

The latest findings show that bio - active compounds in blueberries - called anthocyanins - offer protection against hypertension.

Compared with people who did not eat blueberries, those eating at least one serving a week - the equivalent of a couple of handfuls - reduced their risk of developing the condition by 10 percent.

The superfood has already been found to fight hardening of the arteries, which can cause a heart attack or stroke, as well as helping to guard against diseases such as cancer and Alzheimer's.

Anthocyanins belong to the family of compounds called flavonoids and are also found in blackcurrants, raspberries, aubergines and blood orange juice.

The research, carried out by the University of East Anglia and Harvard University, is the first large study to investigate the effect of different flavonoids on hypertension.

The scientists studied 134,000 women and 47,000 men over a period of 14 years. None of the participants had hypertension at the start of the study.

Subjects were asked to complete health questionnaires every two years and their dietary intake was assessed every four years. Incidence of newly diagnosed hypertension during the 14 - year period was then related to consumption of various flavonoids.

During the study, 35,000 participants developed hypertension.

The dietary information identified tea as the main contributor of flavonoids, with apples, orange juice, blueberries, red wine and strawberries also providing important amounts.

Aedin Cassidy of the University of East Anglia said: "Our findings are exciting and suggest that an achievable dietary intake of anthocyanins may contribute to the prevention of hypertension."

Jan 17
Govt plans health cover for all Indians
A health insurance scheme that will cover every Indian is on the cards. A committee of experts appointed by Prime Minister Manmohan Singh and headed by K Srinath Reddy, chief of the Public Health Foundation of India, is working on a public-funded scheme, likely to be introduced in the 12th Five
related stories

* Coming soon: health insurance portability

Year Plan, starting in 2012-13.

"We are looking at a scheme where people will pay premium depending on their income," said Planning Commission member secretary Sudha Pillai.

For instance, the government may pay the entire premium for those below the poverty line. For the better off, the government's contribution will diminish the higher the individual's income.

This scheme is likely to cover not only hospitalisation expenses, but also treatment undergone at listed hospitals. Most private health insurance schemes cover only hospitalisation. It will also provide cover for conditions private schemes frequently do not - like heart ailments and pregnancy.

The scheme also intends the Centre to pay a higher premium for women - across all sections.

There is already a health insurance scheme under the Rashtriya Swasth Bima Yojana for BPL families. Close to half of 6 crore BPL families are covered under this scheme. In the next step, all those enrolled in the Mahatma Gandhi National Rural Employment Guarantee Scheme will be covered, followed by women enrolled in over 10 lakh angwanwadi centers around the country.

According to the National Sample Survey Office, an Indian spends 80 % of his health expenses on buying medicine. The high cost of treatment makes health services unaffordable to many.

Presently, over 90 % Indians are not covered by any public or private health insurance.

Jan 14
India's health is a cause for worry
It is no secret that the two areas where India has failed its people most are education and health. But a recent report in Lancet, the prestigious British medical journal, brings home starkly just how bad that failure is - most Indians pay up to 78% of their medical bills themselves.

The only country worse off as far as private spending on health is concerned is Pakistan, where the figure is 82.5%.

One of the primary authors of the analysis, Dr AK Shiva Kumar, is part of the prime minister's expert group on universal health coverage. He points out that 39 million people are pushed into poverty because of ill-health every year. Almost 30% of rural India cannot afford any kind of treatment at all, up from 15% in 1995. This is a terrible demonstration of how the situation has deteriorated over the years.

Of course, none of this should be a surprise. Even though we boast about our hi-tech speciality hospitals and newspapers are full of cutting age medical procedures carried out in our hospitals, the fact is that we do not even have primary health centres in most villages. People travel for miles to get treatment and can be treated so shoddily at government hospitals -that they prefer private treatment. Public spending is 0.94% of our GDP - among the lowest in the world. How bad the situation is can be measured by the fact that India leads in infant and maternal mortality rates - with figures much worse than the poorest region of the world - sub-Saharan Africa.

As we aim to become a major global player, we have to realise how urgently we need to set our own house in order. While our public health system flounders, our private hospitals rake in crores. Most will have some reason why they cannot treat lower income patients and thus cannot be relied upon. The onus has to be on public health. Unfortunately, the landscape between dismal public health and exorbitant private care is usually populated by quacks who provide some sort of affordable treatment.

While we share in the reflected glory of the India story, we need to work hard to make sure that the story is not a nightmare for most of our population.

Jan 13
Stress on need to raise chronic disease prevention rate
India must substantially increase the rate of effective prevention and control of chronic diseases, according to the third article of the Lancet series on 'India: Towards Universal Health Coverage.'

This is imperative for India which has passed the early stage of the chronic disease burden, the article noted. The authors have also called for the integration of national programmes for various chronic diseases and injuries with one another.

With direct relevance to control and prevention, the team recommended implementation of interventions for tobacco control, reduction of dietary salt intake, promotion of healthy diets and physical activity, the use of a combination of aspirin and low-dose drugs to lower blood pressure and cholesterol in individuals at high risk for cardiovascular disease. Specific interventions to change individual behaviour are also important especially for those who already have chronic diseases.

The article, authored by Vikram Patel of the London School of Hygiene and Tropical Medicine, et al, begins with the fact that chronic diseases - cardiovascular diseases, mental health disorders, diabetes, and cancer - and injuries are the leading causes for death and disability in India. The projected increases in their contribution to the burden of diseases during the next 25 years are pronounced.

Although a range of cost-effective primary and secondary prevention strategies are available, the article calls to question their coverage, especially in rural and poor populations. The authors, including S.Chatterji of Health Statistics and Informatics, D.Chisholm of WHO, S.Ebrahim, D.Prabhakaran and K.S.Reddy of Public Health Foundation of India, G.Gururaj of NIMHANS, V.Mohan of Dr.Mohan's Diabetes Specialities Centre, and R.D.Ravindran of Aravind Eye Care System, have suggested setting up social and policy frameworks. These would enable the implementation of interventions such as taxation on bidis, smokeless tobacco, and locally-brewed alcohol.

The article also highlights a couple of interventions in the field level, both incidentally from Tamil Nadu. Aravind Eye Hospital's work on elimination of avoidable blindness in rural India and DMVDSC's Chunampet Rural Diabetes Prevention Project are highlighted in separate panels within the paper. Both interventions have been recognised for their involvement of the community in the programme, one of the key recommendations the authors make in their article. The Madurai-based Aravind Eye Hospital recently established 30 permanent village-based vision centres for primary eye care, with access to telemedicine. The Chunampet project aims at preventing diabetes in 50,000 people in 42 villages around Chunampet in Kancheepuram district of Tamil Nadu. Started about four years ago, within a year of implementation, over 90 per cent of the entire adult population of the villages had been screened. Screening is free, and treatment is free for those who cannot pay. About 60 per cent of patients pay subsidised rates for their treatment. The project has been touted as a "good model for delivering preventive and therapeutic diabetes health care to rural areas."

Jan 13
Despite Supreme Court breather, HIV patients will have to wait for treatment
Despite the Supreme Court's directive last month to make second- line HIV/AIDS treatment available free of cost to all those who need it, patients in non-metros will have to wait till March.

The National AIDS Control Organisation (NACO), under the Union Ministry of Health and Family Welfare, which has to implement the order, will need time before making second line universally available in all the anti-retroviral therapy (ART) centres in India.
Second-line treatment is needed by patients when resistance is developed towards first-line medication. It currently costs about Rs4,000-8,000 per month in the private market, making it unaffordable to several patients.

The government started giving second-line treatment free from 2008 in 10 ART centres, but laid out a set of criteria, because of which just 1,516 patients have availed of it till now.

Though exact numbers of the patients requiring second-line treatment is unavailable, experts say about 3-4% of HIV patients develop resistance to first line every year, thereby needing second line. India has about 2.27 million HIV-positive patients, as per data by the government, and various international bodies.

With the court order, NACO will start making second line universally available first in centres in New Delhi, Mumbai, Chennai, and Kolkata. March onwards it willroll it out in ART centres in Imphal, Ahmedabad, Varanasi, Bangalore, Hyderabad, Chandigarh.

Gradually, second line would also be rolled out in centres in Pune, Aurangabad, Nagpur, Hubli, Vijayawada, which were till now providing only first-line treatment.

"The process of procuring the medicines, which is done through international competitive bidding, will take six to eight months. Also, time is needed to increase manpower to execute the programme. Thus, it would be rolled out in a phased manner," said a government official.

This phased roll-out would give NACO time to study and get an accurate number of people needing second line. "In March, NACO will prepare a status report and present it to the Honorable Court, along with a plan for phase II, where the treatment would be made available at all centres," said the official.

The court order comes as a major relief to HIV/AIDS patients in India who needed second line.

The government considered only those patients eligible for second-line treatment, who were on the government programme for first line for minimum two years.

"This was unfair, as the government started giving first line free of cost only from 2004, while AIDS has been in India since the 1980s. Secondly, only those who were in the below poverty line (BPL) category could get second line. Those economically higher than what the government considered BPL, could not get it," said HIV patient Deepak Leimapokpam, from the Manipur Network of Positive People.

Eldred Tellis, founder director of Sankalp Rehabilitation Trust, which works with HIV/AIDS patients, and one of the petitioners in this matter in the SC, said the Supreme Court order is in the right direction, as now treatment can be unconditionally available for everyone.

Jan 11
Dentists routinely failing children with serious tooth decay
Serious tooth decay in children as young as two is being either ignored or badly treated as a result of a system of "poor care" and "supervised neglect", a leading dental expert has warned.

Young children are suffering pain, facial infections and blood poisoning because their baby teeth are being left untreated, with some undergoing the trauma of having teeth extracted because many dentists wrongly think primary or "milk" teeth are not worth repairing, said Monty Duggal, a professor of children's dentistry.

The mistaken belief that baby teeth should not be filled is leading to NHS dental hospitals having to perform emergency removals of children's teeth - which can sometimes involve extracting every tooth in what is called a "full clearance" - he adds.

Writing in the Faculty Dental Journal, Duggal criticises dentists and parents who believe that problematic milk teeth can be left to drop out naturally.

He condemns non-intervention in such children as "wrong and unjustifiable", and asks: "How can we condone the non-treatment of a disease that carries such a high morbidity and knowingly put the child at risk of pain and suffering?"

Duggal, the head of paediatric dentistry at the NHS's Leeds Dental Institute, writes: "We must ensure that those children who still get caries [dental decay] do not suffer further from the provision of poor care and its consequences.

"Specialists in hospitals treat children on a daily basis with severe oro-facial infections caused by poor restorations, placed with a disregard for good restorative principles or a non-interventionist 'keep under observation' approach.

"Hospital paediatric dental services across the UK are replete with children referred by general dental practitioners for pain due to untreated or inadequately treated caries in the primary dentition," said Duggal.

That workload shows that the current neglect of children's teeth "has serious cost implications" for the NHS, he adds.

Most of the children suffering in this way are from the country's poorest families, Duggal stresses.

Those from deprived backgrounds are worst affected because of poor diet, lack of dental education and never being taken to see a dentist by their parents. As a result, about 80% of all dental disease in children occurs among those in social classes IV and V.

Children in poorer areas can have eight times as many dental problems as those in better-off families, research shows.

Duggal disputes the belief among dentists that treating decay in children's first teeth would unsettle them, adding: "I have been unable to find any convincing evidence in the literature that leaving primary teeth untreated in children is not likely to cause at least discomfort and in many cases pain and suffering.

"Sometimes dentists don't think it's important to fill baby teeth to a high standard because they will fall out by the age of 12 at the latest."

As few as 10-12% of decayed primary teeth are repaired, and it can be as few as 5% in some areas, which is "a matter of national shame", says the article in the journal, which is produced by the Royal College of Surgeons of England.

Duggal sees 10-15 children a week, aged between three and eight, with severe toothache from several decayed teeth. Most are from the most deprived estates in Leeds.

He blames the NHS's way of funding dentists for producing "supervised neglect" of children's teeth. Dentists serving poorer communities find that the money they need to undertake sometimes extensive work is unavailable because payment, by Units of Dental Activity (UDAs), is capped. The system "fails to recognise the increased treatment needs of such children" and "includes economic disincentives to the provision of such intervention", Duggal writes.

The British Dental Association, which represents the UK's 23,000 dentists, said that there was "a clear and unacceptable chasm between those with the best and worst oral health. The gap is depressingly correlated with social deprivation."

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