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May 21
Protein-Rich Breakfast Successfully Wards Off Hunger Pangs
Researchers from University of Missouri suggest that the best way to avoid hunger pangs throughout the day is to eat a protein rich breakfast.

The study, which has been published in the journal Obesity, followed teenagers over a period of three weeks. The teenagers skipped the breakfast completely, ate a 500-calorie normal breakfast meals or ate protein rich breakfast such as syrup and yogurt.

The researchers asked the students to fill out a questionnaire at the end of each week as well as took out MRI brain scans before the lunch and found that those who ate protein rich breakfast had lower appetite throughout the day while the MRI scans showed activity in the brain regions that controlled food motivation to be low when the individual ate breakfast in the morning.

"These findings suggest that a protein-rich breakfast might be an effective strategy to improve appetite control and prevent overeating in young people", the researchers said.

May 21
Dairy does not increase heart-attack risk!
In what would be great news for lovers of dairy products, a new study has found that consumption of dairy foods has no link whatsoever to an increase in a person's risk of heart disease!

On the basis of a comprehensive analysis, researchers from the Department of Community Heath at Brown University in Providence, R. I., have come to the conclusion that there was no statistical difference between the number of heart attacks cases in people who consumed dairy products and those who did not.

The data that the researchers - Stella Aslibekyan, Ana Baylin, and Hannia Campos - analyzed comprised statistics from a Harvard School of Public Health survey of 3,630 Costa Rican men and women, aged less than 75 years.

The new analysis, which divided into five groups based on dairy consumption, found that dairy intake was not linked with the risk of heart attack.

In fact, noting that dairy - which, for the study, included butter, buttermilk, cheese, cottage cheese, cream cheese, cream, ice cream, lactocrema, 1 percent milk, 2 percent milk, whole milk and yogurt - is a rich source of calcium, magnesium, potassium and vitamin D, the researchers said that the effect of dairy products is "likely to involve a balance of factors."

Commenting on the findings, Aslibekyan confirmed: "The overall message of dairy consumption, at least in the levels we studied, is that it is not likely to increase your risk of heart attack"!

May 20
Cooked tomatoes 'as good as statins' for battling cholesterol
They are common ingredients found in millions of kitchen cupboards.

But pasta sauces and pizza toppings could add much more than a tasty tomato flavour to a family's favourite meals.

Scientists said that cooked tomatoes can have the same benefits as statins for patients battling against high cholesterol levels or high blood pressure

They could be an 'effective alternative' to statins, the class of drugs commonly prescribed for these conditions which can lead to heart problems, according to a study.

And just two ounces of tomato paste or a pint of juice a day could be enough to help many patients.

The secret lies in high levels of the compound lycopene which gives ripe tomatoes their bright red colour. This powerful anti-oxidant is essential for good health as it helps lower the risk of heart attacks and strokes.

Cooked tomatoes are best as tests showed the body can absorb more lycopene from these than raw fruit.

Experts in Australia analysed the results of 14 international studies into the benefits of lycopene over the past 55 years.

They concluded that it could provide a natural defence to raised levels of so-called 'bad cholesterol' - or low-density lipoprotein - in the blood.

The effect was comparable to small doses of statins which are used to treat many of the 2.5million-plus Britons with high cholesterol or blood pressure

These conditions can be a factor in cardiovascular disease, the country's biggest killer.

One of the study's authors, Dr Karin Ried, of the University of Adelaide, said tomatoes have particularly high levels of lycopene.

In the journal Maturitas, she added half a litre of tomato juice or 50 grams of tomato paste daily 'would provide protection against heart disease'.

Eating just one tomato a day would not be enough. Dr Ried said: 'I would really recommend looking at tomato paste. It is very rich in lycopene and it is not difficult to get 50 grams a day in pasta or on a pizza or as a drink. Our study suggests that if more than 25 milligrams of lycopene is taken daily, it can reduce "bad" cholesterol by up to 10 per cent.

'That's comparable to the effect of low doses of medication commonly prescribed but without side-effects, which can include muscle pain and weakness and nerve damage.'

Lycopene is also found in watermelon, guava, papaya, pink grapefruit, apricots and rosehip but in lower concentrations.

May 18
WHO report: Diseases once linked to rich nations increasingly affect poor
The world is experiencing a change in the geographic distribution of diseases. Traditionally, infectious diseases, which claim the lives of so many children, have affected poor countries and non-communicable diseases, such as diabetes, cardiac ailments and cancer, have plagued rich countries.

But the latest statistics released by the World Health Organisation (WHO) on Friday show that the income level of nations is no longer so important, and that all countries now face the burden of both kinds of diseases.

Up to now, non-communicable diseases tended to be identified as the ills of opulence, limited to high-income countries, WHO's director of health statistics and informatics, Ties Boerma, told IPS.

However, due to changes caused by the ageing population, improvements brought about by the global effort to meet the millennium development goals (MDGs), changes in birthrates and other factors, developing countries are now also fighting non-infectious diseases, he said.

Boerma noted that the phenomenon began in urban areas of developing nations, among the most highly educated population groups, but it is now expanding rapidly. That was one of the central conclusions reached by WHO experts on the basis of the World Health Statistics 2011 report published on Friday.

The study confirms that important progress has been made in improving the main health indicators, fighting poverty, bolstering gender equality and education, and moving towards the other goals outlined in the eight MDGs, which were agreed by the international community in the 2000 UN general assembly and have a 2015 deadline, Boerma said.

Over the past 10 years, the rate of improvement of infant and maternal mortality rates - key MDG targets - has been twice as fast as progress made in the 1990s.

Many countries are still lagging, some of them considerably, which means a huge effort is needed over the next five years to meet the MDGs, Boerma said. Nevertheless, the rate of progress is speeding up overall, he added.

In the case of child mortality, the world is only halfway to the MDG target, while in the case of maternal mortality, the world is only one-third of the way there, the WHO expert said.

The question of infant mortality will be evaluated again in September, when WHO and Unicef, the UN children's fund, release new statistics. For now, "we are still standing at 8.1 million" children under five who died in 2009, Boerma said, compared with 12.4 million in 1990.

With respect to the situation in the Americas, he said the statistics show that "very good progress" has been made in many countries.

In Brazil, Argentina and Chile, for example, "there have been steady but relatively fast declines in child mortality, and coverage intervention is high. And they also reduced the inequity between the poorest and the richest. Brazil has been a very good case study of where the poorest have benefited," he said, adding that Mexico has also progressed.

At the other extreme, of course, is Haiti, he said, adding that the health indicators are still worrying in countries like Bolivia and Peru, which have made some advances but "still have a much longer way to go".

Boerma cited the case of Cuba, pointing out that although it is not a rich country, it "spends quite a lot on health" and does so "in a very equitable way.

"Everybody has (free) access to health services," he said. "So in terms of life expectancy it ranks quite high and it has low child mortality and high coverage of intervention. So it is very successful in reaching the whole population and getting good value" for its investment, he added.

The expert noted that the US "is not at the top" in terms of health statistics in the Americas. He said: "They are at the top when it comes to the amount of money they spend on health. But they are not at the top in terms of getting good results for their investments in health services.

"One reason," he said, "may be that coverage of the whole population is not so good. So much of the expenditure goes to relatively expensive curative interventions or interventions that benefit a smaller proportion of the population."

The WHO study reported that average global life expectancy rose from 64 years in 1990 to 68 in 2009. In poor countries, the average is 56 years, while it has climbed to 80 years in wealthy countries.

Life expectancy for women is five years longer on average than for men. That difference has held fairly steady, between four and five years, over the past two decades.

The WHO figures show there is still a huge gap in health spending between low and high-income countries, averaging an annual $32 per capita in the former and $400 per capita in the latter.

The study reports that high-income countries have, per capita, 10 times more doctors, 12 times more nurses and midwives and 30 times more dentists, on average, than low-income countries.

May 18
Now, lung cancer detection through patient's nose
Researchers at the Boston University Medical Centre say they have developed a "minimally-invasive" technique to detect lung cancer early by using cells from a patient's nose.

Epithelial cells sampled from the inside of a person's nose share the same genetic markers that show up in people with lung cancer, the researchers said.

The "simple technique using cells from the interior of the nose could help clinicians detect lung cancer in its earliest and most treatable stages".

For their study, the researchers collected nasal epithelial cells from 33 smokers who were undergoing tests for suspicion of lung cancer.

Of these patients, 11 were found to have benign disease and 22 had lung cancer.

Brushings were taken from the right or left nostril and profiled on microarrays, a process that allows researchers to study gene expression changes.

"Our data suggests that evaluating gene expression changes in nasal cells found in the interior surface of the nose may serve as a non-invasive approach for the early detection of lung cancer in smokers," said study author Christina Anderlind, Instructor of medicine at Boston University Medical Centre.

After analyzing the cells, the researchers found there were 170 different genes whose level of activity was different, depending on whether or not a patient had lung cancer.

Lung cancer is the most common cause of cancer mortality, with an average five-year survival rate of only 15 percent.

However, survival rates are highly dependent upon how advanced the cancer is when detected.

"At an early stage, the five-year survival rate is 60 percent compared to only two per cent at a late stage," Anderlind said.

"Despite this fact, early diagnosis is hard to achieve since the diagnostic tests currently available are highly invasive, such as open lung biopsy.

"We wanted to determine if a minimally invasive site like the nose could be used to diagnose cancer in its early stages, when there is a much greater chance of long-term survival".

Anderlind said the results of the current study are an initial indication that simple nasal brushings could offer an alternative to lung biopsy and other invasive techniques aimed at identifying lung cancer in its early stages.

"The development of a nasal biomarker for diagnosis of lung cancer would make early diagnosis of lung cancer more feasible," Anderlind said.

May 17
Surgical Anesthesia Not All That Effective, Say Researchers
Experts in Australia have suggested that anesthesia during surgery is not that effective since a large number of patients regain consciousness at some part during the surgery, leading to long-term post-traumatic stress disorder in some patients.


Researchers led by Professors Andrew Davidson and Kate Leslie, from Melbourne's Royal Children's Hospital, found that at least one in 1,000 patients had some sort of awareness during surgery while they number doubled among children with one in 500 saying that they were awake during surgery.

Professor Davidson said that the awareness differed from being vaguely aware among some patients while others were fully aware of what exactly was happening during the surgery. He went on to add that at least a quarter of the patients from the latter category suffered from some form of post-traumatic stress disorder including nightmares and depression.

"It seems to be the people that are most traumatized are the ones that are paralyzed and in pain and wide awake and unable to move and terrified about doing anything", Professor Davidson added.

May 16
Digestive Problems Early in Life 'may Up Depression Risk'
Depression and anxiety may result from short-term digestive irritation early in life, a study of laboratory rats by researchers at the Stanford University School of Medicine has indicated.

The findings suggested that some human psychological conditions might be the result, rather than the cause, of gastrointestinal disorders such as irritable bowel syndrome.

"A lot of research has focused on understanding how the mind can influence the body," said Pankaj Pasricha, professor and chief of gastroenterology and hepatology.

"But this study suggests that it can be the other way around. Gastric irritation during the first few days of life may reset the brain into a permanently depressed state," added Pasricha.

To test their hypothesis, the researchers used a laboratory model of functional dyspepsia they had developed years earlier. They subjected 10-day-old laboratory rats to mild stomach irritation daily for six days.

"We hypothesized that this treatment might also be affecting the development of central nervous system, and driving the animals to anxiety and depression," said Pasricha.

"We hypothesized that this treatment might also be affecting the development of central nervous system, and driving the animals to anxiety and depression," said Pasricha.


Indeed, as the researchers assessed the behaviour of the treated rats when the animals were 8 to 10 weeks old, they found that those rats with early gastric irritation were significantly more likely than their peers to display depressed and anxious behaviours including a decreased consumption of sugar water, less-active swimming in a pool of warm water and a preference for dark rather than light areas in a maze.

"It seems that when the rats are exposed to gastric irritation at the appropriate point in time," said Pasricha, "there is signaling across the gut to the brain that permanently alters its function."

May 16
Parsley, celery fight against breast cancer
Parsley and celery, usually used as a decorative accent to a scrumptious meal, can stop certain breast cancer tumor cells from multiplying and growing, suggests a new study.

In his study, Salman Hyder, a University of Missouri researcher, exposed rats with a certain type of breast cancer to apigenin, a common compound found in parsley, celery, apples, oranges, nuts and other plant products.

The rats that were exposed to the apigenin developed fewer tumors and experienced significant delays in tumor formation compared to those rats that were not exposed to apigenin. Hyder believes this finding could impact women who are taking certain hormone replacement therapies.

"Six to 10 million women in the United States receive hormone replacement therapy (HRT)," Hyder said.

"We know that certain synthetic hormones used in HRT accelerate breast tumor development. In our study, we exposed the rats to one of the chemicals used in the most common HRTs received in the United States - a progestin called medroxyprogesterone acetate (MPA) - which also happens to be the same synthetic hormone that accelerates breast tumor development."

Hyder also found that the compound reduced the overall number of tumors. However, while apigenin did delay tumor growth, it did not stop the initial formation of cancer cells within the breast.

Hyder said, "Researchers have not identified a apigenin dosage for humans yet."

"However, it appears that keeping a minimal level of apigenin in the bloodstream is important to delay the onset of breast cancer that progresses in response to progestins such as MPA," Hyder said.

It's probably a good idea to eat a little parsley and some fruit every day to ensure the minimal amount," he added.

The study was published recently in Cancer Prevention Research.

May 13
Being mildly obese benefits ALS patients: Study
Massachusetts General Hospital (MGH) researchers have found that the amyotrophic lateral sclerosis (ALS) patients who were mildly obese survived longer than who were normal weight, underweight or even overweight.

"We have long known that being underweight shortens survival for ALS patients, and several studies in an animal model have shown that weight gain is associated with increased survival," said Anne-Marie Wills, of the MGH Neurology Clinical Trials Unit, senior author of the report.

"Our study was designed to investigate how cholesterol levels affect survival. We were surprised to find that body mass index or BMI - a measure of weight adjusted for height - made a large difference in survival. Patients with a BMI of 30 to 35, who would be considered mildly clinically obese, lived the longest; and patients who were overweight, with a BMI of 25 to 30, lived the second longest," she added.

ALS is a progressive neurodegenerative disease affecting motor neurons in the brain and spinal cord. Death of these nerve cells stops the transmission of neural impulses to muscle fibers, leading to weakness, paralysis and usually death from respiratory failure. During the course of their disease ALS patients usually lose even more weight than can be attributed to the loss of muscle mass caused by nerve destruction and the related muscle inactivity. Studies have shown that ALS patients burn more calories than would be expected from their limited physical activity, but the mechanism for this metabolic change is currently unknown.

The study will appear in the journal Muscle and Nerve and has been detailed online.

May 13
Sugar makes the medicine work better
Researchers found that taking antibiotics with sugar could dramatically improve their effectiveness against stubborn infections such as tuberculosis.

Laboratory tests showed that glucose and fructose - a type of sugar found in plants - stimulated bugs and made them more vulnerable to drug treatments.

Professor James Collins, from Boston University, said: "You know the old saying: 'a spoonful of sugar makes the medicine go down? This is more like 'a spoonful of sugar makes the medicine work'."

Chronic and recurrent infections often occur when bacteria shut down and become metabolically dormant.

This allows the bugs, known as "persisters", to dodge the effects of antibiotics.

Over the course of weeks or months, the bacteria return to life, often stronger and more aggressive than they were before, and the patient relapses.

Persistent bugs are different from those that develop antibiotic resistance through genetic mutations, but may be just as much of a problem.

Bacterial resistance can stretch illnesses out over months and cause infections to spread to kidneys and other organs.

The scientists looked at a new way of tackling persistent bacteria by rousing them from hibernation using a simple weapon, sugar.

They found that sugar acts as a stimulant that switches on normal bacterial responses, rendering the bugs vulnerable to antibiotic attack.

Testing the strategy on Eschericia coli (E. coli) bacteria, a common cause of urinary infections, the researchers were able to eliminate 99.9 per cent of persisters within just two hours.

Without sugar, the drugs they used had no effect.

The approach, reported in the journal Nature, was similarly effective against persistent Staphylococcus aureus bacteria, which can produce serious infections.

Prof Collins now plans to investigate whether sugar additives can improve the effectiveness of drugs against tuberculosis (TB).

TB is a chronic lung infection responsible for more deaths worldwide than any other infectious disease.

Each day around 4,700 people die from the effects of TB, according to the World Health Organisation.

"Our goal was to improve the effectiveness of existing antibiotics, rather than invent new ones, which can be a long and costly process," said Prof Collins' Boston University colleague, Kyle Allison, who was the first author on the study.

The findings have the potential to improve the lives of untold numbers of people who struggle with nagging infections, while also reducing healthcare costs substantially, he added.

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