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Oct 25
Antibiotics 'not effective' in relieving cough
A new research has suggested that antibiotics are not effective in treating cough due to the common cold in children.

The study found that when children with acute cough were treated with either antitussive medication or antibiotics, antibiotics alone showed a lower percentage of cough resolution.

"In our experience, antibiotics are often prescribed by the general practitioner to treat cough in children, many times to pacify parents," said lead study author Francesco de Blasio, MD, FCCP, Clinic Center Private Hospital, Naples, Italy.

"However, antibiotics show very little effectiveness at treating cough due to your average head cold," he revealed.

To understand how antibiotics were being used in a clinical pediatric setting, Dr. de Blasio and colleagues from the University of Bologna and Dompe SPA in Italy observed the treatment and outcomes of 305 children who required pediatric consultation due to acute cough from the common cold.

Of the children, 89 received antibiotics only, while 38 received a combination of antibiotics and antitussives; central (codeine and cloperastine) in 16 cases, and peripheral (levodropropizine) in 22 children. Forty-four and 79 children received only central or peripheral antitussives, respectively, without antibiotics; 55 children did not receive medication.

Observational results showed no difference in percentage of cough resolution between children treated with antitussive alone vs children receiving a combination of antibiotics and antitussives.

On the contrary, children treated with antibiotics only had a lower percentage of cough resolution than children treated with antitussive only. Furthermore, the use of the peripheral antitussive levodropropizine demonstrated a significant beneficial effect in terms of cough resolution compared with centrally acting antitussive drugs.

"Few drugs are effective as cough suppressants, and antibiotics are no more effective in relieving cough than the use of no medication. However, peripheral antitussives, such as levodropropizine, appear to be the best option at relieving cough," he said.

Although antibiotics may not be an effective therapy for cough, they can be useful in treating underlying infections that may produce cough, noted Dr. de Blasio.

But he warned that antibiotics should not be overuse indicating that repeated use of it, especially when they are ineffective, can lead to adverse allergic reactions or a resistance to the medications.

The study was presented at CHEST 2012, the annual meeting of the American College of Chest Physicians.

Oct 25
Grieving husbands are 30% more likely to have an early death - but women carry on as before
Male widows are more likely to die shortly after losing their wife than vice versa, new research suggests

Researchers from the Rochester Institute of Technology in America found that grieving husbands were 30 per cent more likely to die after being recently widowed, compared with their normal risk of mortality.

Women, however, did not have any increased risk of dying perhaps due to them being more independent and prepared, the researchers suggested.

Professor Javier Espinosa, who led the study said: 'When a wife dies, men are often unprepared.

'They have often lost their caregiver, someone who cares for them physically and emotionally, and the loss directly impacts the husband's health.

'This same mechanism is likely weaker for most women when a husband dies.

'Therefore, the connection in mortalities for wives may be a reflection of how similar mates' lives become over time.'

Professor Espinosa used data records from married people born between 1910 and 1930 to examine when partners died in relation to one another.

He also uncovered a strong connection between the death of a child and the mortality of the mother, regardless of the cause of death, gender of the child, marital status, family size, income or education level of the mother.

If a woman lost a child, her chances of dying increased by as much as 133 per cent, he found.

Looking at results from more than 69,000 mothers aged between 20 and 50 over nine years, Professor Espinosa found those who had lost a child were three times more likely to die in the two years afterwards.

Prof Espinosa, an expert in health and labour economics, said: 'To my knowledge, this is the first study to empirically analyse this issue with a large, nationally represented US data set.

'The evidence of a heightened mortality rate for the mother, particularly in the first two years of the child's passing, is especially relevant to public health policy and the timing of interventions that aim to improve the adverse health outcomes mothers experience after the death of a child.'

Prof Espinosa's study, co-written by William Evans from the University of Notre Dame, was published in the Economics and Human Biology journal.

The research adds to the theory that it may really be possible for some of us to die of a broken heart. Just last week researchers from the University Clinic of Rostock, in northern Germany claimed to have discovered exactly how a sudden discovery or traumatic experience can be fatal.

They say the news or event causes the body to produce large amounts of stress hormones including adrenaline, which narrows the main arteries which supply blood to the heart.

This paralyses the heart's main pumping chamber, causing a sudden change in rhythm similar to a heart attack.

It is estimated that 2 per cent of the 300,000 Britons recorded as having a heart attack every year have suffered from broken heart syndrome amounting to some 6,000 patients.

Dr Christoph Nienaber, director of cardiology at the university, said: 'These patients suffer under a heavy emotional load, either positive or negative. Their hearts literally break. It usually happens within minutes to an hour of hearing the news.'

Oct 24
Just a few minutes of exposure to second-hand smoke is enough to stop you breathing properly
Second-hand smoke, such as that found in smoke-filled rooms or cars, can impair breathing within 20 minutes, new research suggests.

Even after just a few minutes of exposure, people exposed to the smoke showed near immediate physiological changes that caused their airways to narrow, making it more difficult for the body to take in the oxygen it needs.

Lead reseacher Panagiotis Behrakis, of the University of Athens, said: 'Bars and cars are places where high concentrations of fine particles usually occur because of smoking.

'Non-smokers are then forced to inhale extreme amounts directly into their lungs.

'These results tell us that even a short exposure is indeed harmful for normal airways.'

Although exposure to second-hand smoke appears to be slightly less harmful than direct smoking, Dr. Behrakis believes second-hand smoking should be recognised as a global health issue.

He said: 'Second-hand smoking is the most widespread form of violence exerted on children and workers on a global level. The whole issue needs to be recognised as a global problem of human rights violation.'

The British Lung Foundation says around 300,000 GP visits a year result from the exposure of children to second-hand smoke.

In order to test the effects of short-term second-hand smoke exposure, Dr Behrakis and his colleagues from the Harvard School of Public Health, exposed 15 healthy participants to air heavily concentrated with smoke particles within an exposure chamber - simulating a bar or moving car - for 20 minutes.

Results showed that short-term exposure to concentrated second-hand smoke significantly and immediately impacted participants' airways, making them narrow and reducing the body's oxygen intake.

The Greek study was presented at the annual meeting of the American College of Chest Physicians.

Commenting on the research, Dr Penny Woods, chief executive of the British Lung Foundation said: 'This research suggests that just a short exposure to concentrated second-hand smoke, of the kind you might experience when travelling in a car in which someone has smoked, can be enough to cause your airways to narrow, making it more difficult for your body to take in the oxygen it needs.

'Findings such as these are of particular significance to children travelling in cars in which an adult has smoked, as their breathing is faster, their lungs and immune systems less developed, and the effects of narrowing likely to be greater on their smaller airways.'

This research is the latest in a series of studies into the short and long- term effects of passive smoke in confined spaces, which have united the medical community and charities such as the British Lung Foundation in calling for legislation to ban smoking in cars with children on board.

Dr Woods added: 'Legislation is scheduled to be discussed in the House of Commons next week, and we hope MPs take this opportunity to protect the health of our children - just as they helped protect the health of adults in the workplace with the smoking ban in 2007.'

Last month scientists at Northumbria University reported that non-smokers regularly exposed to second-hand smoke were at risk of damaging their memory. The study was the first of its kind first to explore the relationship between second-hand smoke and memory problems.

They compared a group of current smokers with two groups of non-smokers - those regularly exposed to second-hand smoke and those who were not.

Non-smokers exposed to second-hand smoke forgot almost 20 per cent more than the non-smokers who were not exposed.

Oct 24
In vitro fertilization may increase risk of birth defects
Infants conceived through in vitro fertilization a method of fertilizing an egg with a sperm outside the body have an increased risk of being born with a birth defect, HealthDay News reported.

Researchers from the Mattel Children's Hospital at UCLA analyzed hospital admission records of 51,000 babies born in California between 2006 and 2007. Also examining other vital statistics such as prenatal information and following the child's medical history through the first year of life, the scientists found that 3,500 babies suffered from significant congenital malformations. About 4,800 of the 51,000 had been conceived through IVF treatments.

"Naturally conceived infants in the control arm of our study had a 6.6 percent baseline rate of major birth defects, while infants born after IVF had a 9 percent rate," study researcher Dr. Lorraine Kelley-Quon, a general surgery resident at Ronald Reagan UCLA Medical Center, told HealthDay News.

According to Kelley-Quon, there is only a 3 percent rate of birth defects for the general population. Researchers tracked three kinds of abnormalities in the study. Eye problems occurred 0.3 percent in IVF infants as opposed to 0.2 percent in children naturally conceived; heart defects were found in 5 percent of IVF babies vs. 3 percent of those naturally conceived; and genital/urinary systems problems occurred in 1.5 percent of the IVF group, compared to 1 percent of the control.

"This translated to an odds ratio of 1.25, meaning there was a 25 percent increased risk of birth defects for infants born after IVF, compared to naturally conceived infants with similar baseline maternal and infant characteristics," Kelley-Quon told HealthDay news.

While numerous studies have looked at this relationship, the researchers said that more work needs to be done to better understand why IVF may increase this risk if it does at all. Kelley-Quon noted that parents should be informed, but the research isn't meant to discourage them from seeking IVF treatment in order to conceive.

"They should be reassured that there are tens of thousands of infants born each year after IVF who are perfectly healthy," Kelley-Quon told HealthDay news. "The purpose of our research was to highlight an interesting association between IVF and birth defects. Our results do not prove that IVF causes birth defects."

Oct 23
Delhi fears dengue, 600 cases and counting
With more than 600 dengue cases reported in Delhi so far, the residents in this Congress-ruled state are in a state of panic and seeking urgent medical advice to save themselves from the fast spreading vector-borne infection.

The death of legendary filmmaker Yash Chopra due to dengue combined with the report of the Deputy Director of All India Institute of Medical Sciences (AIIMS) falling victim to it has further left many Delhiites panicky.

AIIMS Deputy Director Vineet Choudhary is currently undergoing treatment. However, with a large number of fresh dengue case being reported every day, a typical blame-game between the state and local bodies has also begun with the two refusing to take responsibility for the situation.

When asked to comment on measures being taken, Delhi Chief Minister Sheila Dikshit shifted the question to the Municipal Corporation of Delhi. "Please ask the MCD," she replied.

Resident doctors in many government and private hospitals have reported a sharp rise in calls from patients suffering from suspected or confirmed dengue infection, seeking admission to the hospital.

Reacting to the situation, Delhi Health Minister AK Walia said, "I would request the residents of Delhi to take care and precaution. Don't let water stagnate and sprinkle diesel or kerosene on it if there is any. We have to get together and take these precautions."

As per reports, the number of dengue patients has doubled in the year 2012. On Monday, 33 new cases of the vector-borne infection were reported, taking the total number of those afflicted to 682.

Oct 23
Antibiotics not effective in relieving cough
A new research has suggested that antibiotics are not effective in treating cough due to the common cold in children.

The study found that when children with acute cough were treated with either antitussive medication or antibiotics, antibiotics alone showed a lower percentage of cough resolution.

"In our experience, antibiotics are often prescribed by the general practitioner to treat cough in children, many times to pacify parents," said lead study author Francesco de Blasio, MD, FCCP, Clinic Center Private Hospital, Naples, Italy.

"However, antibiotics show very little effectiveness at treating cough due to your average head cold," he revealed.

To understand how antibiotics were being used in a clinical pediatric setting, Dr. de Blasio and colleagues from the University of Bologna and Dompe SPA in Italy observed the treatment and outcomes of 305 children who required pediatric consultation due to acute cough from the common cold.

Of the children, 89 received antibiotics only, while 38 received a combination of antibiotics and antitussives; central (codeine and cloperastine) in 16 cases, and peripheral (levodropropizine) in 22 children. Forty-four and 79 children received only central or peripheral antitussives, respectively, without antibiotics; 55 children did not receive medication.

Observational results showed no difference in percentage of cough resolution between children treated with antitussive alone vs children receiving a combination of antibiotics and antitussives.

On the contrary, children treated with antibiotics only had a lower percentage of cough resolution than children treated with antitussive only. Furthermore, the use of the peripheral antitussive levodropropizine demonstrated a significant beneficial effect in terms of cough resolution compared with centrally acting antitussive drugs.

"Few drugs are effective as cough suppressants, and antibiotics are no more effective in relieving cough than the use of no medication. However, peripheral antitussives, such as levodropropizine, appear to be the best option at relieving cough," he said.

Although antibiotics may not be an effective therapy for cough, they can be useful in treating underlying infections that may produce cough, noted Dr. de Blasio.

But he warned that antibiotics should not be overuse indicating that repeated use of it, especially when they are ineffective, can lead to adverse allergic reactions or a resistance to the medications.

The study was presented at CHEST 2012, the annual meeting of the American College of Chest Physicians.

Oct 22
High-carb diets may increase Alzheimer's risk
Older people, who eat a carbohydrate rich diet are four times more likely to develop mild cognitive impairment, which is a precursor to Alzheimer's disease, a new research has claimed.

The research from the Mayo Clinic in America has found that the risk is also higher with a diet high in sugar, while on the other hand, proteins and fats appeared to offer some protection as people who consumed plenty of them were less likely to suffer cognitive decline, the Daily Mail reported.

Not everyone suffering from mild cognitive impairment (MCI) develops Alzheimer's disease, but many do, lead author Rosebud Roberts, a professor in the department of epidemiology at the Mayo Clinic, said.

The research tracked 1,230 people of ages between 70- 89 and asked them to provide data on what they ate last year.

Among that group, only 940 people who showed no traces of cognitive impairment were asked to return for follow-ups every 15 months.

By the study's fourth year, 200 of the 940 began to show mild cognitive impairment - trouble with memory, language, thinking and judgment.

"If we can stop people from developing MCI, we hope we can stop people from developing dementia. Once you hit the dementia stage, it's irreversible," Professor Roberts told USA Today.

"A high-carbohydrate intake could be bad for you because carbohydrates impact your glucose and insulin metabolism.

"Sugar fuels the brain, so moderate intake is good. However, high levels of sugar may actually prevent the brain from using the sugar - similar to what we see with type 2 diabetes," she added.

Oct 22
Hip disorder cured using stem cells
A multi-specialty hospital here has successfully used stem cells to cure a hip joint disorder, relieving affected patients from expensive surgery and conservative treatment.

"We have so far treated seven patients, including two non-resident Indians (NRIs) suffering from hip joint disorder using their stem cells and helped them to resume normal life within months," Live 100 Hospital chairman HN Nagaraj said.

Known medically as avascular necrosis, the uncommon disease leads to temporary or permanent loss of blood supply to hip joint bone and causes disorder. If not treated early, the dislocation of the hip bone with joint surface can result in disability. Any serious injury, medications such as steroids, blood coagulation or excessive alcohol can cause blood loss.

"Stem cell therapy has been used for the first time in the world to treat the hip bone disorder by rejuvenating its tissues with the bone marrow of the patient. Stem cells in the marrow of the affected bone are separated from red blood cells and blood plasma through a clinical process and injected into the hip joint of the patient," Nagaraj said, demonstrating a case study.The private hospital on the city`s outskirts has tied up with a Pune-based laboratory to harvest the stem cells and transplant them through four injections over four weeks to restore the hip joint function lost due to damage to its cartilage. The stem cells also repair bone cells as they can differentiate between bone and cartilage cells.

"The novel treatment has no bleeding or scar formation as the process does not involve surgery. The patient has to visit our hospital for a day in a week for each of the four injections," Nagaraj said.

Though the treatment costs a patient Rs.350,000 currently, the hospital hopes to bring it down over time when awareness of the stem cell therapy spreads and more patients opt for the treatment.

The hospital will soon submit the therapy treatment protocol for publication in the Journal of Mass & Heat Transfer in the United States and Britain and file for international patent and intellectual property rights.

Among the patients cured at the hospital are two NRIs from the United States - Jayadeep Panduranga, 37, and Aishwariya, 18, who could not get relief from shooting pain due to hip disorder despite years of conventional treatment like core decompression.

"Though I underwent core decompression for nine years in California, there was no relief. Stem cell therapy has reduced pain and hip movements are almost normal," Panduranga said.

Similarly, Aishwariya, an under-graduate in Detroit, suffered pain in the right hip and faced difficulty in moving around.

"I`m able to walk again with a walker," Aishwariya said.

Oct 20
Low calcium hormone disease risk
Having too little calcium in the diet increases women's risk of a hormone condition that can cause bone fractures and kidney stones, scientists suggest.

Primary hyperparathyroidism (PHPT) affects around one in 800 people during their lifetime and is most common in post-menopausal women.

Writing in the British Medical Journal, the team suggest increasing calcium intake cuts the risk of the disease.

Adults need around 700mg of calcium a day.

Milk and other dairy foods, nuts and fish such as sardines and pilchards (where the bones are eaten) are some dietary sources of calcium.

Taking too much could cause stomach pains and diarrhoea.

PHPT is caused by overactive parathyroid glands secreting too much parathyroid hormone.

As well as bone and kidney problems, there have also been suggestions it is linked to an increased risk of high blood pressure, heart attack and stroke.
Benefits v risks

The US team from Brigham and Women's Hospital looked at 58,300 women who were taking part in a much broader ongoing piece of research called the Nurses' Health Study.

All were aged between 39 and 66 in 1986, when the study began, and had no history of PHPT.

The women have completed food questionnaires to record how frequently they ate particular foods or supplements - including calcium - every four years, with the latest being completed in 2008.

Over that 22 year period, 277 cases of PHPT were confirmed.

The researchers divided all the women into five groups , depending on the calcium intake.

They accounted for factors such as age, body mass and ethnicity.

It was found those with the highest intake of dietary calcium had a 44% reduced risk of developing PHPT compared with the group with the lowest.

Writing in the journal, the team led by Dr Julie Paik, said: "Increased calcium intake, including both dietary and supplemental calcium, is independently associated with a reduced risk of developing primary hyperparathyroidism in women."

Oct 20
Painkiller abuse next big epidemic in US: Study
Adolescents' abuse of prescription painkillers (analgesics) like vicodin, valium and oxycontin at a rate 40% higher than previous generations, is turning into an epidemic in the US, says a study.

"Prescription drug use is the next big epidemic," said Richard Miech, professor of sociology at the University of Colorado Denver, who led the study.

"Everyone in this field has recognised that there is a big increase in the abuse of non-medical analgesics but our study shows that it is accelerating among today's generation of adolescents," said Miech, the Journal of Adolescent Health reports.

That makes it the second most common form of illegal drug use in the US after marijuana, according to Miech.

The study drew on data from the National Survey on Drug Use and Health, a series of annual, nationally representative, cross-sectional surveys of US drug use. The analysis used data from 1985 through 2009, according to a Colorado statement.

Miech said that the prevalence of prescription pain medication abuse among the current generation of youth was "higher than any generation ever measured".

"The increasing availability of analgesics in the general population is well documented, as the total number of hydrocodone and oxycodone products prescribed legally in the US increased more than fourfold from about 40 million in 1991 to nearly 180 million in 2007," the study said.

"Youth who observe their parents taking analgesics as prescribed may come to the conclusion that any use of these drugs is OK and safe," Meich said. Yet, the consequences are often severe.

Miech said there were now more deaths due to accidental overdoses of these drugs than deaths due to overdoses of cocaine and heroin combined. Most people who abuse prescription pain relievers report that they obtained them from family or friends.

"While most people recognise the dangers of leaving a loaded gun lying around the house," said Miech, "what few people realise is that far more people die as a result of unsecured prescription medications."

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