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Jul 23
More than 30 mn girls at risk of Female Genital Mutilation over next decade: Unicef
The Unicef has reportedly found that there are more than 30 million girls who are `at risk` of being subject to Female Genital Mutilation (FGM) over the next decade.

FGM, a ritual cutting of girls` genitals is practised by some African, Middle Eastern and Asian communities in the belief it protects a woman`s virginity and more than 125 million girls and women alive today underwent this procedure which is now opposed by a majority of countries where it was practiced.

According to the report, Unicef survey found that support for FGM from both men and women has seen a decline and the organization wants action to end the practice completely.

Unicef deputy executive director Geeta Rao Gupta said that FGM `is a violation of a girl`s rights to health, well-being and self-determination and added that legislation is not enough to end the practice.

The study found that FGM remains almost universal in Somalia, Guinea, Djibouti and Egypt and there was little discernible decline in Chad, Gambia, Mali, Senegal, Sudan or Yemen.

However, it was seen that most girls and women and a significant number of boys and men, opposed the practice.

Rao Gupta said that the challenge now is to let girls and women, boys and men speak out loudly and clearly and announce they want this harmful practice abandoned.

The report added that the consequences of FGM include severe bleeding, problems in urinating, infections, infertility and increased risk of newborn deaths in childbirth.

Jul 23
Skipping breakfast can give you heart attack
Men who regularly skip breakfast are at a 27 percent higher risk of heart attack or death from coronary heart disease than those who don`t.

Researchers analyzed food frequency questionnaire data and tracked health outcomes for 16 years (1992-2008) on 26,902 male health professionals ages 45-82.

The study suggested that men who reported not eating breakfast were younger than those who did, and were more likely to be smokers, employed full time, unmarried, less physically active and drank more alcohol.

It was also found that men who reported eating late at night- eating after going to bed- had a 55 percent higher coronary heart disease risk than those who didn`t. But researchers were less convinced this was a major public health concern because few men in the study reported this behaviour.

During the study, 1,572 of the men had first-time cardiac events.

"Skipping breakfast may lead to one or more risk factors, including obesity, high blood pressure, high cholesterol and diabetes, which may in turn lead to a heart attack over time," Leah E. Cahill, Ph.D., study lead author and Postdoctoral Research Fellow in the Department of Nutrition at Harvard School of Public Health in Boston, Mass said.

Men who reported eating breakfast ate on average one more time per day than those who skipped breakfast, implying that those who abstained from breakfast were not eating additional make-up meals later in the day.

Although there was some overlap between those who skipped breakfast and those who ate late at night, 76 percent of late-night eaters also ate breakfast, researchers said.

According to researchers, while the current study group was composed of men who were of 97 percent white European descent, the results should also apply to women and other ethnic groups, but this should be tested in additional studies.

The study was published in the American Heart Association journal Circulation.

Jul 22
33% of throat cancer cases linked to Human Papillomavirus
One third of people suffering from throat cancer are infected with a form of the Human Papillomavirus (HPV), a study has suggested.

More than 100 types of HPV are there and there are two HPV strains that are likelier to cause cancer - HPV-16 and HPV-18.

HPV-16 is believed to be responsible for about 60 percent of cervical cancers, 80 percent of cancers in the anus and 60 percent of oral cancers.

The new study observed HPV`s link with cancer of the back of the throat - oropharyngeal cancer .


In the study, the researchers looked at blood test results collected from people who took part in a huge prospective study into lifestyle and cancer, who were healthy at the beginning.

They compared blood test results of 135 people, who went on to develop throat cancer, and for 1,599 people free of cancer.

The University of Oxford team found 35 percent of those with throat cancer had the antibodies, compared with fewer than 1 percent of those who were cancer-free, the BBC reported.

The study has been published in the Journal of Clinical Oncology.

Jul 22
Soon, drugs to starve cancer to death
Scientists believe that cancer could be cured by starving tumours to death.

The key may be a newly identified protein, eEF2K, which helps cancer cells to thrive but can be shut off without causing ill effects.

A team of researchers at the University of Southampton is now experimenting with various drugs to block the work of this protein.

Professor Chris Proud, from the university, said that cancer cells grow and divide much more rapidly than normal cells, meaning they have a much higher demand for and are often starved of, nutrients and oxygen.

A cellular component, eEF2K, plays a critical role in allowing cancer cells to survive nutrient starvation, while normal, healthy cells do not usually require eEF2K in order to survive.

Therefore, by blocking the function of eEF2K, we should be able to kill cancer cells, without harming normal, healthy cells in the process.

Hopes are that the treatment will be available within five years.

Jul 19
Fish oil compound could help relieve chronic pain
A new study revealed that a derivative of DHA (docosahexaenoic acid), a main ingredient of over-the-counter fish oil supplements, can soothe and prevent neuropathic pain caused by injuries to the sensory system.

The research, by Duke University, focused on a compound called neuroprotectin D1=protectin D1 (NPD1=PD1), a bioactive lipid produced by cells in response to external stimuli.

NPD1=PD1 is present in human white blood cells, and was first identified based on its ability to resolve abdominal and brain inflammation.

"These compounds are derived from omega-3 fatty acids found in fish oil, but are 1,000 times more potent than their precursors in reducing inflammation," Ru-Rong Ji, professor of anesthesiology and neurobiology at Duke University Medical Center and principal investigator of the study, said.

The team used laboratory mouse models of nerve injuries to simulate pain symptoms commonly associated with post-surgical nerve trauma.

They treated these animals with chemically-synthesized NPD1=PD1, either through local administration or injection, to investigate whether the lipid compound could relieve these symptoms.

Their findings revealed that NPD1=PD1 not only alleviated the pain, but also reduced nerve swelling following the injuries.

Its analgesic effect stems from the compound`s ability to inhibit the production of cytokines and chemokines, which are small signaling molecules that attract inflammatory macrophages to the nerve cells.

By preventing cytokine and chemokine production, the compound protected nerve cells from further damage. NPD1=PD1 also reduced neuron firing so the injured animals felt less pain.

Ji believes that the new discovery has clinical potential.

"Chronic pain resulting from major medical procedures such as amputation, chest and breast surgery is a serious problem," he said.

Current treatment options for neuropathic pain include gabapentin and various opioids, which may lead to addiction and destruction of the sensory nerves.

On the other hand, NPD1=PD1 can relieve neuropathic pain at very low doses and, more importantly, mice receiving the treatment did not show signs of physical dependence or enhanced tolerance toward the lipid compound.

The research is published online in the Annals of Neurology.

Jul 19
Poor sleep in pregnancy could lead to complications
Scientists have shown that inadequate sleep during pregnancy can lead to complications and hinder normal immune processes, says a study.

Women with depression are more likely than non-depressed women to suffer from disturbed sleep and adverse pregnancy outcomes.

Scientists at the University of Pittsburgh School of Medicine conducted the research and the study was published in the journal "Psychosomatic Medicine".

"Our results highlight the importance of identifying sleep problems in early pregnancy, especially in women experiencing depression, since sleep is a modifiable behaviour," said Michele Okun, Ph.D., assistant professor of psychiatry at Pitt`s School of Medicine and lead author of the report. "The earlier that sleep problems are identified, the sooner physicians can work with pregnant women to implement solutions."

There is a dynamic relationship between sleep and immunity, and this study is the first to examine this relationship during pregnancy as opposed to postpartum," added Dr. Okun.

Jul 18
Stroke risk rises if blood pressure drugs not taken rightly
Hypertension patients who do not take their blood pressure medications systematically have a greatly increased risk of suffering a stroke and dying from it compared to those who take their medication correctly, a study has shown.

A study of 73,527 patients with high blood pressure, published online Wednesday in the European Heart Journal, found that patients who did not adhere to their medication had a nearly four-fold increased risk of dying from stroke in the second year after first being prescribed drugs to control their blood pressure, and a three-fold increased risk in the tenth year, compared with adherent patients.

"These results emphasise the importance of hypertensive patients taking their ant-hypertensive medications correctly in order to minimise their risk of serious complications such as fatal and non-fatal strokes," Dr Kimmo Herttua said.

Dr Herttua, the first author of the study, is a senior fellow in the Population Research Unit at the University of Helsinki, Finland.

"Non-adherent patients have a greater risk even 10 years before they suffer a stroke. We have also found that there is a dose-response relationship. The worse someone is at taking their anti-hypertensive therapy, the greater their risk," Herttua wrote.

The researchers, including scientists from Finland and University College London, UK, used nationwide registers in Finland that give details of prescriptions, admissions to hospital and deaths.

Jul 18
Need some mental boost? Drink water
Drinking plain water may help boost your mental performance, a new study has claimed.

According to the study published in the journal Frontiers in Human Neuroscience, participants who drank about three cups of water (775 millilitres) before taking a battery of cognitive tests performed better on a test that measured reaction times compared with those who did not drink water.

This finding was particular true for thirsty people. The researchers speculate that the sensation of thirst may take some attention away from the task at hand, and thus impair response time.

For the reaction test, 34 adult participants had to press a button as soon as they saw an object on a computer screen. Reaction times were 14 percent faster among the water group than the no water group.

Water consumption did not significantly affect performance on other tests of cognition, such as memory of words, researchers found.

The study results suggest that a "freeing up of attention resources" occurs when people quench their thirst, the researchers wrote.

However, water consumption may not always improve cognition. In another test of rule-learning, participants actually fared better if they did not drink water before the test.

Future research should try to explain why drinking water appears to have beneficial effects on some cases, but negative effects in others, the researchers said.

"It might be that physiological processes [of drinking or not drinking water] affect performance on different tasks in different ways," said study researcher Caroline Edmonds, of the University of East London School of Psychology in England.

"Thirst might lead to better performance on some tasks, because the hormone vasopressin, which activates the thirst response, has also been linked to attention and arousal," Edmonds told a website.

Jul 17
Aspirin could lower women's colorectal cancer risk
Women who take aspirin every other day could lower their risk of developing colon cancer by 20 percent, new research has suggested.

For the study, researchers at the Brigham and Women`s Hospital in Boston, looked at 39,876 women in the age group of 45 and older.

For the study, participants took a 100 mg dose pill of aspirin or a placebo every other day from when they were enrolled in the study until 2004.

The participants also completed questionnaires about their cancer status, how often they took their medication, any negative effects, any additional aspirin use and other risk factors.

After the study, researchers followed 33,682 participants, who were not given additional aspirin or placebos for this additional time frame, through March 2012.

After nearly two decades, women in the aspirin group had a 20 percent less chance of developing colon cancer than those who were taking placebos.

And women who continued taking aspirin after the end of the trial had the lowest colon cancer risk, CBS News reported.

The study, funded by the U.S. National Cancer Institute and U.S. National Heart, Lung, and Blood Institute, appeared in the Annals of Internal Medicine.

Jul 17
Missing brain enzyme found to cause abnormal levels of fear
A new research from neuroscientists and molecular biologists at University of Southern California has shown that a missing brain protein may be the culprit in cases of severe over-worry, where the fear perseveres even when there`s nothing of which to be afraid.

The researchers examined mice without the enzymes monoamine oxidase A and B (MAO A/B), which sit next to each other in our genetic code as well as on that of mice.

Prior research has found an association between deficiencies of these enzymes in humans and developmental disabilities along the autism spectrum such as clinical perseverance - the inability to change or modulate actions along with social context.

"These mice may serve as an interesting model to develop interventions to these neuropsychiatric disorders," senior author Jean C. Shih, USC Professor and Boyd and Elsie Welin Professor of Pharmacology and Pharmaceutical Sciences at the USC School of Pharmacy and the Keck School of Medicine of USC, said.

"The severity of the changes in the MAO A/B knockout mice compared to MAO A knockout mice supports the idea that the severity of autistic-like features may be correlated to the amounts of monoamine levels, particularly at early developmental stages," Shih said.

The study is published in the Proceedings of the National Academy of Sciences.

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