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Jan 25
Five new genes linked to belly fat identified
In a breakthrough, that could help in treating obesity, scientists have identified five new genes linked to belly fat.

A person's measure of belly fat is reflected in the ratio of waist circumference to hip circumference, and it is estimated that genetics account for about 30-60 per cent of waist-to-hip ratio (WHR).

Kira Taylor, assistant professor, University of Louisville School of Public Health and Information Sciences, and her research team have identified five new genes associated with increase of waist-to-hip ratio.

In the study, researchers looked at more than 57000 people of European descent and searched for genes associated with abdominal fat, independent of overall obesity. They investigated more than 50 000 genetic variants in 2000 genes.



Out of which,researchers identified three new genes linked with increased WHR in both men and women, and two new genes that appear to affect WHR in women only.

The research, published in the journal Human Molecular Genetics, is being seen as an important factor in developing medicines for obesity or obesity-related diseases such as cardiovascular disease, type 2 diabetes and cancer.

Of the latter, one gene, SHC1, appears to interact with 17 other proteins known to have involvement in obesity, and is highly expressed in fat tissue.

'This is the first time SHC1 has been associated with abdominal fat,' said Taylor.

'If scientists can find a way to fine-tune the expression of this gene, we could potentially reduce the risk of excessive fat in the mid-section and its consequences, such as cardiovascular disease,' she added.

Jan 25
Diabetes runs at home: Indian-origin researcher
You are at a higher risk of developing type 2 diabetes if your spouse has it.

According to a new research led by an Indian-origin scientist at the McGill University Health Centre (MUHC) in Montreal, Canada, living together under one roof could also imply sharing diabetes.

"We found a 26 percent increase in the risk of developing type 2 diabetes if your spouse also has type 2 diabetes," says senior author Kaberi Dasgupta, an associate professor of medicine at McGill University.

"This may be a platform to assist clinicians to develop strategies to involve both partners. Changing health behaviour is challenging and if you have the collaboration of your partner it's likely to be easier," she added.

Dasgupta's team wanted to see if risk behaviours like poor eating habits and low physical activity could be shared within a household, said the study published in the journal BMC Medicine.

They analysed results from six selected studies that were conducted in different parts of the world and looked at key outcomes such as age, socio-economic status and the way in which diabetes was diagnosed in over 75,000 couples.

Most of the studies relied on health records which may not always accurately record diabetes.

Those that used direct blood testing suggested that diabetes risk doubles if your partner has diabetes. A strong correlation with pre-diabetes risk was also found.

"When we look at the health history of patients, we often ask about family history. Our results suggest spousal history may be another factor we should take in consideration," said Dasgupta.

According to Dasgupta, spousal diabetes is also a potential tool for early diabetes detection.

"The results suggest that diabetes diagnosis in one spouse may warrant increased surveillance in the other," stressed Dasgupta.

Moreover, it has been observed that men are less likely than women to undergo regular medical evaluation after childhood and that can result in delayed diabetes detection.

As a result, men living with a spouse with diabetes history may particularly benefit from being followed more closely, the study concluded.

Jan 24
Magnetic therapy can help ease migraine symptoms
A new magnetic device can offer people who suffer from migraine a spot of relief, according to a research.

UK watchdog National Institute for Health and Care Excellence (NICE) said there is limited evidence that transcranial magnetic stimulation (TMS) may help ease symptoms in some patients.

Although, the procedure is still relatively new, it may be useful for patients for whom other treatments have failed, according to reports.

It said that more data is needed about its long-term safety and efficacy.

Clinical trials were conducted on 164 patients and it was found that 39 percent of them were pain free even after two hours.

"Huge numbers of sufferers find their lives blighted by migraine," said Wendy Thomas, chief executive at the charity the Migraine Trust. "We welcome NICE guidance that may help deliver brighter futures to many people for whom other treatments have not worked."

Jan 24
Omega-3 fatty acids can protect against ageing brain
Women, who include foods rich in fatty acids in their diet, can look forward to a nimble mind even in old age, according to a new study.

Researchers looked into the levels of omega-3 fatty acids in blood of older women and found that people with higher levels of the omega-3 fatty acids may have larger brain volumes in old age equivalent to preserving one to two years of brain health.

Shrinking brain volume is a sign of Alzheimer's disease as well as normal ageing.

James Pottala, an assistant professor at the University of South Dakota Sanford School of Medicine in Sioux Falls and chief statistician for the Health Diagnostic Laboratory in Richmond, Virginia, and his colleagues analyzed data from the Women's Health Initiative Memory Study to see whether omega-3s were associated with brain shrinkage in general, and in specific brain regions involved in memory and other cognitive processes.

The data covered 1,111 women who were, on an average, 70 years old and had no signs of dementia at the beginning of the study. At that time, the amount of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in their red blood cells was measured.

DHA accounts for 30 percent to 40 percent of the fatty acids found in brain cell membranes, and it's especially concentrated near the synapses where the cells communicate with one another, according to the study published in the journal Neurology.

The level of Red blood cells of the omega-3s is good indicators of how much a person has consumed, the researchers add.

The researchers used an omega-3 index to describe the fatty acid levels seen among women in the study and to divide them into four groups: women with the highest levels had an average index reading of around 7.5 percent, while women with the lowest levels had an average of 3.4 percent.

Eight years after the women's blood was tested, they underwent MRIs to measure the volume of gray matter and white matter in their brains.

The researchers found that women with the highest EPA and DHA blood levels at the study's outset had brains that were about two cubic centimeters larger overall than women with the lowest levels.

In addition, the hippocampus, a brain region critical to forming and storing memories, was 2.7 percent larger in women who had fatty acid levels twice as high as the average.

Of 13 specific brain regions the researchers looked at, the hippocampus was the only one where they saw a significant difference.

The analysis adjusted for other factors that could influence the women's brain size, including education, age, other health conditions, smoking and exercise.

"These higher levels of fatty acids can be achieved through diet and the use of supplements, and the results suggest that the effect on brain volume is the equivalent of delaying the normal loss of brain cells that comes with ageing by one to two years," said Pottala.

Jan 23
Reducing fevers raises spread of flu: Study
Taking over-the-counter medication to reduce a fever might help a person to feel better, but may also be increasing the spread of the virus, according to a new Canadian study.

Higher body temperatures help to kill viral and bacterial infections and prevent bacteria and viruses from replicating.

But people are increasingly taking medications that contain ingredients including ibuprofen, acetaminophen and acetylsalicylic acid to suppress fevers and other flu symptoms.

And this may increase both the rate and duration of "viral shedding," allowing sick people to pass more of the virus to others through coughing or sneezing.

According to the study published in Proceedings of the Royal Society, an individual whose fever has been reduced is also likely to feel better and is therefore more likely to interact with others, and spread the pathogen.

"Even when treatment is not aimed at fever specifically, fever is likely to be reduced, because most common drugs that relieve other typical symptoms of infectious diseases also contain an antipyretic component," said the study.

Researchers at McMaster University in Hamilton, Ontario, looked at several studies and crunched the data to conclude that up to five percent more people contract influenza each year because of widespread use of drugs to suppress fevers.

The percentage may seem small, they commented, but consider the number of people who contract the flu each year.

The researchers, in another example, suggested that widespread use of Aspirin during the 1918 Spanish flu pandemic "may have increased the disease severity and consequently death rates."

The Spanish flu killed an estimated 50-100 million people.

Jan 23
Genetic causes of schizophrenia are multiple
Schizophrenia is caused by a large number of rare genetic mutations rather than a few, easily-identifiable faulty genes, said scientists who compiled the world's largest database on the debilitating disorder.

Two studies published Wednesday in the journal Nature said the genetic triggers for the mental illness that affects about one in 100 people were far more complex than previously thought.

Gathering data from nearly 7,000 people in Bulgaria and Sweden, two teams of scientists said genes implicated in schizophrenia worked in clusters to disrupt specific proteins.

They tend to be part of gene networks that govern signalling between brain cells, or deal with learning and memory, the researchers said.

The "finding is sobering but also revealing: it suggests that many genes underlie risk for schizophrenia and so any two patients are unlikely to share the same profile of risk genes," said Shaun Purcell of the Broad Institute in Massachusetts.

"These types of studies should provide a firm base from which we can chart a course toward the ultimate goal of subtyping patients and offering a more personalised treatment path than the one-size-fits-all approach currently used."

One of the studies compared the genetic sequences of 2,500 schizophrenia patients in Sweden with the same number of healthy individuals, looking for sites and patterns of mutations.

The other compared the gene sequences of more than 600 sufferers and their parents in

"Both studies yielded further evidence that the disorder arises from the combined effects of many genes -- a condition known as 'polygenicity'," said a Broad Institute statement.

"The studies also suggest that genetic alterations tended to cluster in a few networks of functionally-related genes."

Schizophrenia is a chronic, often debilitating illness, afflicting about 2.4 million adults in the United States alone.

Symptoms include hallucinations, delusions and paranoia.

Jan 22
Sunshine reduces BP and cuts risk of heart attack and stroke
A new study has revealed that exposing skin to sunlight may help to reduce blood pressure and thus cut the risk of heart attack and stroke.

Research carried out at the Universities of Southampton and Edinburgh showed that sunlight alters levels of the small messenger molecule, nitric oxide (NO) in the skin and blood, reducing blood pressure.

Martin Feelisch, Professor of Experimental Medicine and Integrative Biology at the University of Southampton, said: "NO along with its breakdown products, known to be abundant in skin, is involved in the regulation of blood pressure. When exposed to sunlight, small amounts of NO are transferred from the skin to the circulation, lowering blood vessel tone; as blood pressure drops, so does the risk of heart attack and stroke."

While limiting sunlight exposure is important to prevent skin cancer, the authors of the study, including Dr Richard Weller of the University of Edinburgh, suggested that minimising exposure may be disadvantageous by increasing the risk of prevalent conditions related to cardiovascular disease.

The results suggested that UVA exposure dilates blood vessels, significantly lowers blood pressure, and alters NO metabolite levels in the circulation, without changing vitamin D levels.

Further experiments indicated that pre-formed stores of NO in the upper skin layers are involved in mediating these effects.

The study was published in the Journal of Investigative Dermatology.

Jan 22
Useful safety tips for epilepsy patients
Suffering from epilepsy doesn't mean you can't enjoy your life and live happily. You may have epilepsy, but if have a good health and good mental powers, and with proper measures and necessary precautions, you have the ability to live independently well into adulthood.

However, it is important to note that all the suggested tips may not be equally right or helpful for every person. Some tips may not be applicable to you although it is relevant to others.

For example, people who have frequent seizures without warning may need to take extra precautions and care than those who get a useful warning sign of seizures. Here are some useful safety tips for epilepsy patients.



-Try to find a place or a house that does not have stairs. This will help avoid any accidental falls or injuries caused by a seizure.

-Buy electric and home appliance devices that have automatic shut-off switches.

-Place padding around table corners or any furniture that has sharp areas to prevent hitting them during seizure.

-Family members should never leave a person who has uncontrolled seizures alone in the room, especially when there is a fire in the fireplace.

-Always have a plan of action ready so that you can alert your family, friends or neighbours even when you are alone at home.

-Try to cook in a microwave rather than a stove for safety purpose.

-Use plastic utensils and containers.

-Try to use precut meat so that you not not require using a knife.

-In the bathroom, make sure that the doors are not locked from inside, someone from outside should always be able to get in, if you need help.

-All electrical appliances should be kept away from the sink or bathtub.

-Always keep the water heater temperature low to prevent burning if a seizure should occur.

-Plan your activities when seizures are less likely to occur, if seizures usually occur at a certain time.

-While exercising, avoid extreme heat and keep yourself hydrated by taking lots of water to reduce seizure risks.

-Before starting any new fitness program, make sure you talk to your doctor/neurologist.

Epilepsy is a neurological condition that affects the nervous system. It is also known as a seizure disorder. A person is considered to have epilepsy when he/she has two or more unprovoked seizures.

Jan 21
Links between alcoholic liver disease, circadian clock revealed!
Researchers have revealed a putative role for the circadian clock in the liver in the development of alcohol-induced hepatic steatosis, or fatty liver disease.

The team from the University of Notre Dame and the Indiana University School of Medicine has shown that the development of liver steatosis produced by alcohol abuse is intertwined with disturbances of the normal operation of the 24-hour clock system located in the cells of the liver.

The study has suggested that either the circadian clock is important in the actual development of the liver disease or that the development of steatosis disrupts the normal pattern of the clock mechanism.

The researchers said that the mechanism by which chronic alcohol intake is thought to alter the control of fat metabolism in the liver is also a shared signal to the circadian clock mechanism, this being the ratio of production of reduced nicotinamide adenine dinucleotide, and may be a key to the shared disturbance to the two biological mechanisms of lipid metabolism and the circadian clock.

The study was published this week in the journal Nature: Scientific Reports.

Jan 21
Good night's sleep may lower prostate cancer risk
Sleeping well may prevent prostate cancer in men, a new study has claimed.

Men with higher levels of melatonin, a hormone involved in the sleep-wake cycle, had a 75 percent reduced risk for developing advanced prostate cancer compared with men who had lower levels of melatonin, researchers found.

Melatonin is produced exclusively at night in the dark and is an important output of the circadian rhythm.

"Sleep loss and other factors can influence the amount of melatonin secretion or block it altogether, and health problems associated with low melatonin, disrupted sleep, and/or disruption of the circadian rhythm are broad, including a potential risk factor for cancer," said Sarah C Markt, doctoral candidate in the Department of Epidemiology at Harvard School of Public Health in Boston.

"We found that men who had higher levels of melatonin had a 75 percent reduced risk for developing advanced prostate cancer compared with men who had lower levels of melatonin," Markt said.

"Our results require replication, but support the public health implication of the importance of maintaining a stable light-dark and sleep-wake cycle.

"Because melatonin levels are potentially modifiable, further studies of melatonin and prostate cancer risk and progression are warranted," added Markt.

To investigate the association between urine levels of the main breakdown product of melatonin, 6-sulfatoxymelatonin, and risk of prostate cancer, Markt and colleagues conducted a case-cohort study of 928 Icelandic men from the AGES-Reykjavik cohort between 2002 and 2009.

They collected first morning void urine samples at recruitment, and asked the participants to answer a questionnaire about sleep patterns.

The researchers found that one in seven men reported problems falling asleep, one in five men reported problems staying asleep, and almost one in three reported taking sleeping medications.

The median value of 6-sulfatoxymelatonin in the study participants was 17.14 nanogrammes per millilitre of urine.

Men who reported taking medications for sleep, problems falling asleep, and problems staying asleep had significantly lower 6-sulfatoxymelatonin levels compared with men without sleep problems, according to Markt.

Of the study participants, 111 men were diagnosed with prostate cancer, including 24 with advanced disease.

The researchers found that men whose 6-sulfatoxymelatonin levels were higher than the median value had a 75 per cent decreased risk for advanced prostate cancer.

A 31 per cent decreased risk for prostate cancer overall was observed as well, but this finding was not statistically significant.

The study was presented at a meeting of the American Association for Cancer Research.

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