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Feb 17
Menopause plays no role in sleep difficulties
Menopause neither increases nor creates any difficulty in sleeping amongst women, says a University of Pennsylvania study.

According to the researchers, women in their late thirties and forties who have trouble sleeping are more than three times more likely to suffer sleep problems during menopause than women who have an easier time getting shut-eye.

Only 25 percent of women who had reported no earlier sleep problems developed moderate or severe insomnia or other sleep disturbances during a 16-year period around menopause. What's more, the researchers say that these sleep woes did not appear to be caused by menopause itself, which may quell common fears about symptoms associated with this phase of life. The study is among the first to document long-term sleep patterns in women in the years before, during and after menopause.

Lead author, Ellen W. Freeman, said that a small subgroup of women with only mild sleep disturbance prior to menopause also experienced worsening sleep disturbance during the transition, but their results show that for the majority of women, menopause does not further exacerbate existing sleep problems or cause new ones.

The study assessed annually the sleep patterns of 255 women participating in the Penn Ovarian Aging Study who reached natural menopause during a 16-year period (1996-2012). At enrollment, all women were aged 35 to 48 years and premenopausal, with 28 percent reporting moderate-to-severe sleep disturbances, which is similar to the prevalence of insomnia symptoms among adults, and 56 percent reporting no sleep disturbances at all. Over the 16 year period, 82 percent of the sample experienced moderate-to-severe issues with sleep, while only 7 percent had no poor sleep.

The study also found that hot flashes are strongly associated with poor sleep as expected, but a large proportion of poor sleep in menopausal women occurred without hot flashes. The finding, Freeman says, indicates that sleep difficulties in the transition to menopause in generally healthy women should not automatically be imputed to ovarian decline.

Freeman added that clinicians should be alert to the strong possibility that poor sleep in women approaching menopause is not simply caused by menopause or hot flashes.

Possible reasons for poor sleep instead may include health problems, anxiety, and stress, Freeman said.

The study is published in the journal Menopause.

Feb 16
HPV vaccine may prevent multiple cancer types
The human papilloma virus (HPV) vaccine, Cervarix, not only has the potential to prevent cervical cancer but also other HPV-caused common cancer types, shows a multinational clinical trial, involving nearly 20,000 young women.

That effectiveness endured for the study's entire follow-up, of up to four years, the researchers noted.

"The study confirms that targeting young adolescent girls before sexual debut for prophylactic HPV vaccination has a substantial impact on the incidence of high grade cervical abnormalities," said corresponding author Dan Apter, director, The Sexual Health Clinic, Family Federation of Finland, Helsinki.

The vaccine was extremely effective in young women who had never been infected with HPV.

It protected nearly all from HPV-16 and 18, and protected 50-100 percent against different grades of precancerous transformation of cervical cells caused by other strains of HPV.

The women were followed for up to four years post-vaccination.

The vaccine was distinctly more effective among those aged 15-17 than those aged 18-25, underscoring the value of vaccinating young adolescents, Apter added.

The lower efficacy in the oldest age group may result from a larger proportion of women in that age group having had persistent infections at the time of vaccination, he said.

The study is the final report from the Papilloma Trial Against Cancer in Young Adults (PATRICIA), a multinational clinical trial, encompassing 14 countries in Europe, the Asia-Pacific region, North America, and Latin America, and it confirms previous reports in this trial.

The study appeared in the journal Clinical and Vaccine Immunology.

Feb 13
Coming soon, juicy steaks made of plants
Now, foodies might be in for a treat as one might be able to gorge on juicy steaks made of plants.

A new research has shed light on meat-like foods produced by plants suggesting that many people crave requires a lot of animals raised on huge, unsustainable amounts of plant protein.

The research conducted by American Chemical Society is trying to focus that plant protein should be consumed by humans itself instead of giving so much of it to animals as feed.

Melody M. Bomgardner, a senior editor at C and EN, notes that they need protein, which their bodies break down into essential amino acids, to maintain good health.

Low-carb diets and research showing the benefits of protein have boosted the trendiness of this macronutrient and as a result, on average Americans consume more protein than they need and raising livestock, the major source of dietary protein in the U.S., puts a tremendous strain on water resources and arable land.

Americans are increasingly turning to plants for protein out of concern that red meat can lead to heart disease and obesity. Food manufacturers are paying attention. They have quickly responded with a growing range of protein-packed soy, pea and algae products but to win over more steak lovers, scientists are still working toward the ultimate goal: plant protein that looks, feels and tastes like meat.

The study is published in journal Chemical and Engineering News (C and EN).

Feb 12
Here's why antibiotics can have unwanted side effects
A new study has revealed that antibiotics have an impact, which is broader and more complex than previously known, on the microorganisms that live in an animal's gut.

The research at Oregon State University helps explain in much more detail why antibiotics can have unwanted side effects, especially in disrupting the natural and beneficial microbiota of the gastrointestinal system, and also suggests that powerful, long-term antibiotic use can have even more far-reaching effects.

Scientists now suspect that antibiotic use, and especially overuse, can have unwanted effects on everything from the immune system to glucose metabolism, food absorption, obesity, stress and behavior.

The issues are rising in importance, since 40 percent of all adults and 70 percent of all children take one or more antibiotics every year, not to mention their use in billions of food animals. Although when used properly antibiotics can help treat life-threatening bacterial infections, more than 10 percent of people who receive the medications can suffer from adverse side effects.

Researcher Andrey Morgun said that prior to this most people thought antibiotics only depleted microbiota and diminished several important immune functions that take place in the gut, which actually is only about one-third of the picture.

Morgun added that they also kill intestinal epithelium and destruction of the intestinal epithelium is important because this is the site of nutrient absorption, part of our immune system and it has other biological functions that play a role in human health.

The research also found that antibiotics and antibiotic-resistant microbes caused significant changes in mitochondrial function, which in turn can lead to more epithelial cell death.

Morgun concluded that when the host microbe communication system gets out of balance it can lead to a chain of seemingly unrelated problems.

The work is published online in the journal Gut.

Feb 11
Now simple blood test to detect risk of dementia
Now you can test the possibility of developing dementia with a prick of a needle.

As opposed to cardiovascular diseases, where the level of cholesterol in our blood indicates the risk of cardiac arrest, there are no such trustworthy markers in our blood in terms of diagnosing the risk of dementia setting in. However, Scientists at Rigshopitalet, Herlev Hospital and the University of Copenhagen have now identified a new biomarker, measurable in a simple blood test, which will help predict the onset of dementia.

Assistant clinical and research professor Ruth Frikke-Schmidt, said that the blood test would help provide a more precise risk evaluation of a citizen's risk of developing dementia later in life.

The blood test would enable an earlier and more focused prevention effort, thus prolonging the onset of the illness and raising the individual's quality of life, she added. Researchers hope that with time, this new blood test will be applicable in clinical practice.

In the study, researchers show that a low level of the biomarker, the so-called apolipoprotein E, in our blood, increases the risk of developing dementia in the future. This was revealed in comprehensive studies of the general public, the Herlev-Oesterbro Study and the Oesterbro Study, involving 76,000 people.

The study is published in th internationally acclaimed journal, the Annals of Neurology.

Feb 10
How to stop common cold, HIV virus in their tracks found
Scientists have cracked the code used by a major group of viruses to spread infections such as the common cold, HIV, hepatitis C and polio in the human body, a finding that could lead to new drugs to combat the diseases.

Until now, scientists had not noticed the code, which had been hidden in plain sight in the sequence of the ribonucleic acid (RNA) that makes up this type of viral genome.

Researchers from the University of Leeds and University of York unlocked its meaning and demonstrated that jamming the code can disrupt virus assembly. Stopping a virus assembling can stop it functioning and therefore prevent disease.

"If you think of this as molecular warfare, these are the encrypted signals that allow a virus to deploy itself effectively," said Peter Stockley, Professor of Biological Chemistry in the Leeds' Faculty of Biological Sciences.

"Now, for this whole class of viruses, we have found the 'Enigma machine' - the coding system that was hiding these signals from us. We have shown that not only can we read these messages but we can jam them and stop the virus' deployment," said Stockley, who led the study.

Single-stranded RNA viruses are the simplest type of virus and were probably one of the earliest to evolve. However, they are still among the most potent and damaging of infectious pathogens, researchers said.

Rhinovirus (which causes the common cold) accounts for more infections every year than all other infectious agents put together (about 1 billion cases), while emergent infections such as chikungunya and tick-borne encephalitis are from the same ancient family.

Other single-stranded RNA viruses include the hepatitis C virus, HIV and the winter vomiting bug norovirus.

The group used single-molecule fluorescence spectroscopy to watch the codes being used by the satellite tobacco necrosis virus, a single stranded RNA plant virus.

"We have understood for decades that the RNA carries the genetic messages that create viral proteins, but we didn't know that, hidden within the stream of letters we use to denote the genetic information, is a second code governing virus assembly," said Dr Roman Tuma, Reader in Biophysics at Leeds.

The research was published in the journal PNAS.

Feb 09
Drinking green tea better than taking supplements
If you are planning to take supplements based on green tea extracts as a measure to lose weight, think again. Researchers have warned that the supplements could result in harmful side effects including liver toxicity.

Drinking green tea, instead of taking the supplements, could help you enjoy the benefits associated with the beverage while avoiding the risk of liver toxicity, they pointed out.

Also, drinking green tea in the weeks before taking supplements likely reduces risk of side effects, the findings showed.

"Drinking green tea rather than taking supplements will allow you to realise the benefits and avoid the risk of liver toxicity," explained Josh Lambert, associate professor of food science at College of Agricultural Sciences, Pennsylvania State University.

Tea is rich in catechins, polyphenols that are natural antioxidants. A number of animal studies have shown the preventive effects of green tea polyphenols against obesity.

For the new study, the researchers gave mice high doses of the green tea polyphenol epigallocatechin-3-gallate (EGCG).

The dosage was equivalent to the amount of the polyphenol found in some dietary supplements taken by humans.

Dietary pretreatment with the green tea polyphenol protects mice from liver toxicity caused by subsequent high oral doses of the same compound, the findings showed.

"We believe this study indicates that those who are chronic green tea consumers would be less sensitive to potential liver toxicity from green-tea-based dietary supplements," Lambert noted.

He, however, added that the beneficial effects that people have reported as being associated with green tea are the result of dietary consumption rather than the use of supplements.

The study appeared in the journal Food and Chemical Toxicology.

Feb 06
Red wine, peanuts may help prevent age-related memory loss
A new study has recently revealed that compound found in grapes, red wine and peanuts may help prevent age-related memory loss.

Ashok K Shetty, Ph.D., a professor in the Department of Molecular and Cellular Medicine and Director of Neurosciences at the Institute for Regenerative Medicine, has been studying the potential benefit of resveratrol, an antioxidant that is found in the skin of red grapes, as well as in red wine, peanuts and some berries.

Resveratrol has been widely touted for its potential to prevent heart disease, but Shetty and a team that includes other researchers from the health science center believe it also has positive effects on the hippocampus, an area of the brain that was critical to functions such as memory, learning and mood.

Resveratrol might even be able to help people afflicted with severe neurodegenerative conditions such as Alzheimer's disease.

The study is published in the Scientific Reports.

Feb 05
Whole grains, polyunsaturated fats help keep lung diseases at bay
If you want to keep your lungs healthy and disease free, consume diet rich in whole grains, polyunsaturated fats and nuts, and low in red and processed meat, refined grains and sugary drinks, claims a study.

Eating a diet rich is associated with a lower risk of chronic lung disease (chronic obstructive pulmonary disease or COPD), such as emphysema and bronchitis, which block the airways and restrict oxygen flow around the body. It is currently ranked the third leading cause of death worldwide.

A team of researchers based in France and the USA, set out to investigate the association between the Alternate Healthy Eating Index 2010 (AHEI-2010) - a measure of diet quality based on current scientific knowledge - and the risk of COPD.

They analyzed data for more than 120,000 US men and women taking part in the Nurses' Health Study from 1984 to 2000 and the Health Professionals Follow-up Study from 1986 to 1998.

The AHEI-2010 diet score is based on 11 components, with a higher score reflecting high intakes of vegetables, whole grains, polyunsaturated fats, nuts, and long chain omega-3 fats - moderate intake of alcohol - and low intakes of red and processed meats, refined grains, and sugar sweetened drinks.

Over the study period, 723 cases of newly diagnosed COPD occurred in women and 167 in men.

After adjusting for 12 factors such as age, physical activity, body mass index, smoking and ethnicity, the risk of newly diagnosed COPD was one third lower in participants who ate the healthiest AHEI-2010 diet compared with those who ate the least healthy diet. The findings were similar in ex-smokers and current smokers - and in both women and men.

By contrast, the AHEI-2010 diet score was completely unrelated to incident asthma.

Authors said that, it was a novel finding that supports the importance of diet in the pathogenesis of COPD. Although efforts to prevent COPD should continue to focus on smoking cessation, these prospective findings support the importance of a healthy diet in multi-interventional programs to prevent COPD.

The study is published in The BMJ.

Feb 04
Slimy snail facials latest beauty regimen for perfect skin
Snail facial has come out to be the latest beauty craze among the ladies across Thailand, it has been revealed.

Two Frenchmen opened the first such spa in Chiang Mai, Thailand, with just 100 of the garden creatures initially but now they have upgraded it with 30,000 snails on their organic farm, the Daily Express reported.

In this treatment around 30,000 snails are being used that helps to get a youthful glow and heals all the burns, acne, stretch marks, scars and wrinkles.

Luc Champeyroux, a co-founder said that they take care of the snails as their own family or babies, and always keep them in good condition.

This slimy skin regime could be under threat as public health inspectors descended on the Thai spa to investigate whether the treatment was safe or are they harmful, but the results are yet to be disclosed.

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