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Mar 16
Medical students at higher alcohol abuse risk: Study
A team of US researchers has found that medical students, especially who are young, single and under high debt are twice as likely to abuse alcohol than their peers who are not attending medical school.

Burnout factors such as emotional exhaustion or feelings of depersonalisation were highly associated with alcohol abuse or dependence among the medical students.

"Our findings clearly show there is reason for concern," said Liselotte Dyrbye from Mayo Clinic in the US.

"We recommend institutions pursue a multifaceted solution to address related issues with burnout, the cost of medical education and alcohol abuse," Dyrbye added in the paper published in the journal Academic Medicine.

The researchers surveyed 12,500 medical students and one-third of those responded. Approximately 1,400 of that subgroup experienced clinical alcohol abuse or dependence.

The results indicate three factors that were independently associated -- a younger age than most peers in medical school, being unmarried and amount of educational debt.

No statistical difference was found between differing years of medical school or between men and women.

"In our paper we recommend wellness curricula for medical schools, identifying and remediating factors within the learning environment contributing to stress and removal of barriers to mental health services," added first author Eric Jackson.

Mar 15
Disposable biochip for simpler, affordable HIV diagnosis
Researchers have developed a highly sensitive disposable biosensor that can detect sub-populations' white blood cells that are key to diagnosis of HIV/AIDS.

The new biosensor could not only make HIV diagnosis possible in places that lack testing facilities but also bring down the cost of the diagnosis, according to the researchers.

"There are 34 million people infected with HIV/AIDS worldwide, many in places that lack testing facilities," explained one of the researchers Rashid Bashir, professor at University of Illinois at Urbana-Champaign, US.

"An important diagnostic biomarker for HIV/AIDS is the absolute count of the CD4+ and CD8+ T lymphocytes (white blood cells) in the whole blood. The current diagnostic tool - a flow cytometre--is expensive, requires large blood volume, and a trained technician to operate," Bashir said.

"We have developed a microfluidic biosensor based on a differential immuno-capture electrical cell counting technology to enumerate specific cells in 20 minutes using 10 microliters of blood," Bashir noted.

There are about 50 microliters in a drop of blood.

In clinical trials, the differential immuno-capture biochip achieved more than 90 per cent correlation with a flow cytometer for both CD4 T cells for CD8 T cell counts using HIV infected blood samples, according to the study published in the journal Nature Protocols.

The biochip can also be adapted to enumerate other specific cell types such as somatic cells or cells from tissue or liquid biopsies.

The novel biosensor has the potential to be an automated portable blood cell counter for point-of-care applications in developed and resource-limited regions worldwide, the study said.

The researchers are now working on miniaturising the setup to make the technology handheld, as well as designing a cartridge that can be mass-produced.

Mar 14
Gum disease linked with memory decline in Alzheimer's
A team of British researchers has found a link between gum disease and greater rates of cognitive decline in people with early stages of Alzheimer's disease.

According to researchers, periodontists or gum disease is associated with increased dementia severity and subsequent greater progression of cognitive decline in people with Alzheimer's disease.

"However, if there is a direct relationship between periodontists and cognitive decline, as this current study suggests, then treatment of gum disease might be a possible treatment option for Alzheimer's," added senior author Clive Holmes from the University of Southampton in Britain.

In the observational study, published in the journal PLOS ONE, 59 participants with mild to moderate Alzheimer's disease were cognitively assessed and a blood sample was taken to measure inflammatory markers in their blood.

A dental hygienist who was blind to cognitive outcomes assessed participants' dental health.

The majority of participants (52) were followed-up at six months when all assessments were repeated.

The presence of gum disease at baseline was linked to six-fold increase in the rate of cognitive decline in participants over the six-month follow-up period of the study.

Periodontitis at baseline was also associated with a relative increase in the pro-inflammatory state over the six-month follow-up period.

The authors conclude that gum disease is associated with an increase in cognitive decline in Alzheimer's disease, possibly via mechanisms linked to the body's inflammatory response.

However, growing evidence from a number of studies links the body's inflammatory response to increased rates of cognitive decline, suggesting that it would be worth exploring whether the treatment of gum disease might also benefit the treatment of dementia and Alzheimer's disease.

We also believe, based on various research findings that the presence of teeth with active gum disease results in higher body-wide levels of the sorts of inflammatory molecules which have also been associated with an elevated risk of other outcomes such as cognitive decline or cardiovascular disease, the researchers stated.

Research has suggested that effective gum treatment can reduce the levels of these molecules closer to that seen in a healthy state.

Mar 12
Daily exercise can cut Alzheimer's risk
Older adults who burn calories in moderate physical activities like jogging, swimming, gardening and dancing are likely to have lower risk of developing Alzheimer's disease, says a study.

Exercise-associated calorie-burn can increase the level of grey matter volume in key brain areas which are responsible for memory, enabling the active adults to protect their brain from cognitive decline.

"Grey matter houses all of the neurons in your brain, so its volume can reflect neuronal health," said study lead author Cyrus Raji from University of California, Los Angeles.

The findings showed that people with highest calorie expenditure had larger grey matter volumes in key areas on initial brain scans and were half as likely to have developed Alzheimer's disease five years later.

Also, the individuals who burned the most calories had larger grey matter volumes in the frontal, temporal and parietal lobes of the brain -- areas that are associated with memory, learning and performing complex cognitive tasks.

"Rather than wait for memory loss, we might consider putting the patient on an exercise programme and then rescan later to see if there are any changes in the brain," Raji noted.

For the study, published in the Journal of Alzheimer's Disease, the team examined the data obtained over five years from nearly 876 people 65 year or older participating in the multicenter Cardiovascular Health Study.

All participants had brain scans and periodic cognitive assessments. They also were surveyed about how frequently they engaged in physical activities, to assess their calorie expenditure or energy output per week.

Mar 10
Women experience more neck pain than men
Shedding new light on how differently men and women experience pain, researchers, including one of Indian-origin, have found that women are 1.38 times more likely than men to report neck pain due to cervical degenerative disc disease.

Cervical degenerative disc disease is a common cause of neck pain. Symptoms include stiff or inflexible neck, burning, tingling and numbness. Pain is most prevalent when the patient is upright or moving the head.

The study by Meda Raghavendra and Joseph Holtman from Loyola University Chicago Stritch School of Medicine included 3,337 patients who were treated at Loyola's Pain Management Centre.

The findings were presented at the annual meeting of the American Academy of Pain Medicine in Palm Springs, California, US.

The study adds to the growing body of research on the differences in which men and women experience pain.

Previous studies have found that females are more likely to be treated at pain clinics for chronic pain and that certain painful conditions, such as migraine headaches and fibromyalgia, are more common in women.

Various explanations have been proposed, including hormonal differences and the belief that men may be less willing to report pain.

Raghavendra and Holtman also conducted a similar study of patients who were treated at Loyola's Pain Management Centre for lumbosacral degenerative disc disease or lower back pain.

The prevalence in females was slightly higher than the prevalence in males, but this difference was not statistically significant, the researchers said.

Mar 09
Lack of stem cells leads to repeat miscarriages: Study
In a development that could lead to new treatment for those who have suffered failed pregnancies, researchers have discovered that a lack of stem cells in the womb lining causes thousands of women to suffer from recurrent miscarriages.

"We have discovered that the lining of the womb in the recurrent miscarriage patients we studied is already defective before pregnancy," said lead researcher Jan Brosens, professor at University of Warwick in England.

"I can envisage that we will be able to correct these defects before the patient tries to achieve another pregnancy. In fact, this may be the only way to really prevent miscarriages in these cases," Brosens noted.

The findings were published in the journal Stem Cells.

Between 15-25 percent of pregnancies end in miscarriage and one in 100 women trying to conceive suffer recurrent miscarriages, defined as the loss of three or more consecutive pregnancies, the study pointed out.

The researchers examined tissue samples from the womb lining, donated by 183 women.

The team found that an epigenetic signature -- which is typical of stem cells -- was absent in cultures established from womb biopsies taken from women suffering recurrent miscarriages.

Indeed, fewer stem cells could be isolated from the lining of the womb from recurrent miscarriage patients when compared to women in the study's control group.

The researchers further found that a stem cell shortage accelerates cellular ageing in the womb.

"Cultured cells from women who had had three or more consecutive miscarriages showed that ageing cells in the lining of the womb don't have the ability to prepare adequately for pregnancy," Brosens explained.

Mar 08
Broccoli can ward off liver cancer risk
You may want to start including broccoli in your diet as a recent study has shown that it can reduce the risk of liver cancer and preventing the development of fatty liver.

Since broccoli consumption has previously been linked to reducing the risk of certain cancers, including breast, colon and prostate cancers, researchers at the University of Illinois wanted to see if there was a link between the vegetable and liver cancer and fatty liver, or nonalcoholic fatty liver disease (NAFLD).

Researcher Elizabeth Jeffery says that the majority of the U.S. population eats a diet high in saturated fats and added sugars. However, both of these are stored in the liver and can be converted to body fat. Consuming a high-fat, high-sugar diet and having excess body fat is linked with the development of NAFLD, which can lead to diseases such as cirrhosis and liver cancer.

"We called this a Westernized-style diet in the study because we wanted to model how so many of us are eating today," Jeffery says.

The team wanted to find out the impact of feeding broccoli to mice with a known liver cancer-causing carcinogen and so they studied four groups of mice; some of which were on a control diet or the Westernized diet and some were given or not given broccoli.

The study shows that in mice on the Westernized diet both the number of cancer nodules and the size of the cancer nodules increased in the liver. But when broccoli was added to the diet, the number of nodules decreased. Size was not affected.

The study appears in Journal of Nutrition.

Mar 07
Why you should not sit too much during the day
Sleeping more than nine hours and sitting too much during the day -- along with a lazy lifestyle -- can send you to an early grave, warn researchers.

According to the findings from non-profit organisation Sax Institute's "45 and Up Study", a person who sleeps too much, sits too much and is not physically active enough is more than four times as likely to die early as a person without those unhealthy lifestyle habits.

Too much sitting equates to more than seven hours a day and too little exercise is defined as less than 150 minutes a week.

"This is the first study to look at how those things (sleep and sitting) might act together," said lead author Dr Melody Ding.

When you add a lack of exercise into the mix, you get a type of "triple whammy" effect.

"Our study shows that we should really be taking these behaviours together as seriously as we do other risk factors such as levels of drinking and unhealthy eating patterns," Dr Ding added.

Dr Ding and her colleagues from University of Sydney analysed the health behaviours of more than 230,000 of the participants in the "45 and Up Study".

They looked at lifestyle behaviours like smoking, high alcohol intake, poor diet and being physically inactive and added excess sitting time and too little/too much sleep into the equation.

The team found another problematic triple threat: smoking, high alcohol intake and lack of sleep (less than seven hours a night) is also linked to a more than four-times greater risk of early death.

"The take-home message is that if we want to design public health programmes that will reduce the massive burden and cost of lifestyle-related disease we should focus on how these risk factors work together rather than in isolation," explained study co-author professor Adrian Bauman.

The non-communicable diseases (such as heart disease, diabetes and cancer) now kill more than 38 million people around the world and cause more deaths than infectious disease.

"Better understanding what combination of risk behaviours poses the biggest threat will guide us on where to best target scarce resources to address this major - and growing - international problem," the authors noted in a paper published in the journal PLOS Medicine.

Mar 05
Broccoli can ward off liver cancer risk
You may want to start including broccoli in your diet as a recent study has shown that it can reduce the risk of liver cancer and preventing the development of fatty liver.

Since broccoli consumption has previously been linked to reducing the risk of certain cancers, including breast, colon and prostate cancers, researchers at the University of Illinois wanted to see if there was a link between the vegetable and liver cancer and fatty liver, or nonalcoholic fatty liver disease (NAFLD).

Researcher Elizabeth Jeffery says that the majority of the U.S. population eats a diet high in saturated fats and added sugars. However, both of these are stored in the liver and can be converted to body fat. Consuming a high-fat, high-sugar diet and having excess body fat is linked with the development of NAFLD, which can lead to diseases such as cirrhosis and liver cancer.

"We called this a Westernized-style diet in the study because we wanted to model how so many of us are eating today," Jeffery says.

The team wanted to find out the impact of feeding broccoli to mice with a known liver cancer-causing carcinogen and so they studied four groups of mice; some of which were on a control diet or the Westernized diet and some were given or not given broccoli.

The study shows that in mice on the Westernized diet both the number of cancer nodules and the size of the cancer nodules increased in the liver. But when broccoli was added to the diet, the number of nodules decreased. Size was not affected.

The study appears in Journal of Nutrition.

Mar 04
Peanut butter can help keep extra kilos at bay
What if there was a weight loss therapy you can spoon straight out of a jar? A new study has revealed that snacking on peanut butter or peanuts up to four times a week could be the key to fighting obesity.

The 12-week study from the University of Houston Department of Health and Human Performance (HHP), Baylor College of Medicine and Texas Woman's University showed that Hispanic middle school children, at high risk for being overweight or obese, reduced their Body Mass Index (BMI) when they adhered to a nutrition intervention that included a snack of peanuts, compared to those children who did not.

"Obesity is the most pressing health issue facing us today," said researcher Craig Johnston, HHP assistant professor. "We'd like to think it's preventable, but from where I sit right now, there hasn't been a lot shown to be very effective on a large scale."

The study acknowledged that snacking is more common during the adolescent years and that the unhealthy eating habit can lead to an unhealthy weight. This is especially true if a student doesn't have access to other meals during the school day.

Instructors guided 257 Latino adolescents from three Houston-area charter schools through a program of physical activity and nutrition education. About half the students received a snack of peanuts or peanut butter three to four times a week, while the rest received the snack fewer than once a week.

Following the 12-week intervention, students spent 12 more weeks maintaining the healthy snacking habit. At the end of the period, those students who received the snack more regularly experienced a decrease in their overall BMI compared to those who did not receive the regular peanut snack.

The researchers conclude that afterschool programs and schools can replace energy dense, unhealthy snacks with peanuts to provide a healthier alternative for children (researchers in the study ensured students did not suffer from nut allergies).

Johnston says the fight against obesity needs creative solutions that help people manage their weight, appetite and hunger by offering socially acceptable food choices.

The findings are published in the Journal of Applied Research on Children.

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