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Dr.A.Mohan Krishna.
M.S.Ortho., M Ch Orth (U.K).
Consultant Orthopaedic Surgeon
Arthroplasty, Arthroscopy & Trauma Surgeon
Apollo Hospitals, Jubille Hills,
Fehmi care Hospitals, Yousufguda,
Bone & Joint clinic, Yousufguda.
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AVASCULAR NECROSIS OF FEMORAL HEAD (AVN)
AVASCULAR NECROSIS OF FEMORAL HEAD

Introduction

Bone is a living tissue and it needs blood supply to survive. If there is damage to one of the blood supply, bone may depend on the accessory blood supply for the survival. But certain bones in our body have precarious unidirectional blood supply like Head of femur, scaphoid, and talus.
When there is damage to blood supply to the head of femur it results in the death of cells in the femoral head. Gradually there is collapse of femoral head with loss of sphericity. This condition is referred to as Avascular necrosis of femoral head or Osteonecrosis (bone death) of femoral head.

How AVN develops in femoral head?

Hip joint is a ball and socket type of synovial joint. The socket is formed by cup shaped acetabulum which surrounds the ball (femoral head - upper end of thigh bone). The surface of femoral head and socket is lined by thick articular cartilage and then lined by synovial membrane. All together with the surrounding joint capsule and muscles form a hip joint.

The ball of hip joint receives most of its blood supply through the neck of thigh bone. If there is damage to this blood supply there is no accessory blood supply to the femoral head.
There is gradual death of cells in femoral head due to loss of blood supply. Due to death of bone cells, there is no reparative process of bone formation and resorption. Gradually the bony structure in the femoral head weakens and starts to collapse. When AVN develops in the head femur, the weight bearing area of the head is the first place to collapse. The rounded contour of the femoral head is lost and it becomes flattened causing abnormal movement in the hip joint.
Secondary osteoarthritis develops, as there is gradual wear in ball and socket of the hip joint.

Causes:
Many causes have been identified

Trauma: Fractures
Damage to the blood supply of femoral head usually occurs following a trauma or fractures to the bones in and around the hip joint.
 Fracture of Femoral neck, Femoral head
 Hip Dislocations
 Bad fractures of acetabulum
AVN can develop months or some times after initial injury.

Drugs:
Steroids:
Some steroids like cortisone, prednislone or methyprednisolone are known to cause AVN. In certain conditions like bronchial asthma, skin diseases, some auto immune disorders, inflammatory arthritis and in cases of organ transplant to prevent rejection, use of steroids is must to control or treat these conditions. Orally prescribed steroid are notorious in producing AVN of femoral head. There have been studies to show that steroid given in the form of injections into the joints or bursa does not cause any AVN of femoral head.

Blood disorders:
Some blood diseases like sickle cell disease, Leukemia’s, Gauchers disease and diseases related to blood coagulation can cause AVN of femoral head.

Lifestyle:
Studies have shown that alcohol and smoking can cause AVN in femoral head. Chronic alcohol intake can damage blood vessels leading to AVN. Smoking cause narrowing of small blood vessels and thereby reducing blood supply to the femoral head.

Others:
Deep see divers and miners are more prone develop AVN. Due to high atomospheric pressure tiny air bubbles are formed inside the blood stream which can block the tiny blood vessels in the femoral head there by resulting in AVN.

Symptoms

What does AVN feel like?
1. Pain:
Initially patient complains of pain in the affected hip which gradually increases on weight bearing. As the disease progresses patient complains of pain at rest and at night.
2. Limping
3. Stiffness
4. Difficulty in sitting cross legged and squatting
5. Shortening of affected limb

Diagnosis

How do doctors identify the condition?
1. History: doctor enquires about
- Occupation
- Medical problems and any medications like steroids
- Alcohol and smoking

2. Examination: doctor examines hip for
- Range of movements
- Stiffness

3. X-rays:
X - rays do not show any changes of AVN in the early stages of disease even though patient is having pain in the hip. It may take few months to observe changes of AVN and make diagnosis on X - ray.

4. MRI:
MRI can detect early changes of AVN in the femoral head that cannot be seen on X- ray. It helps to detect damaged areas of blood supply to the hip. AVN of femoral head can be graded as mild, moderate and severe depending on the size location of these damaged areas and if any collapse has occurred in the MRI images. MRI can also help to detect AVN changes in the opposite hip even though there are no symptoms.

5. Bone scan:
Bone scan involves injecting a radioactive chemical into the blood. Hours after injection a special camera is used to take pictures of your skeleton. The picture shows blank spot in the areas of femoral head which is devoid of blood supply. MRI has replaced Bone scan in diagnosing the cases of AVN of femoral head.

Treatment
What are the treatment options for AVN of femoral head?
AVN of femoral head is irreversible resulting in arthritic hip. Some drugs and salvage procedures can help in delaying the progress of disease. The choice of treatment depends upon the stage of the disease. Some factors like age of the patient, general health of patient and activity level also determines the treatment methods.

Nonoperative treatment:

If avascular necrosis of femoral head is diagnosed in early stages, some of following treatment methods can help in delaying the progress

1. Protected weight bearing on the affected limb with the help of crutches or walker can help reduce pain. The idea behind it is, it permits healing and prevents further damage.
2. Exercises and stretches prevent stiffness in the hip and helps to maintain range of motion.
3. Medications:
A. Bisphosphnates : This group of drugs help to reduce the risk of femoral head collapse in patients with Avascular necrosis.
B. Blood thinners: They are given in view of improving blood circulation to the femoral head.
C. Anti-inflammatory medications / simple analgesics to reduce pain.

The above mentioned treatment modalities may delay the progression of disease, but not completely reverse the Avascular necrosis.

Surgical management:

Salvage procedures: Some surgical procedures can try to decrease the pressure in femoral head and increase the blood supply. The main prerequisite for such surgeries is that there should not be any collapse in the femoral head. Many procedures have been designed to improve the blood supply of femoral head. Your surgeon can choose and suggest appropriate procedure.

Core decompression of femoral head:

The most common surgical procedure is to drill one or several holes into the femoral neck and head trying to enter into areas of poor blood supply. The idea behind this procedure is one that it creates a new path for new blood vessels to grow into areas of poor blood supply and it relieves pressure inside the femoral head. The other advantage of this procedure is that there is pain relief secondary to relieving pressure in the femoral head.
Core decompression of femoral head can be supplemented with bone grafting with or without stem cells injection

Core Decompression and Bone grafting of femoral head:

Following core decompression procedure bone graft is packed into the dead part of femoral head and channel created in the femoral head and neck. The bone graft can be taken from the patient or from the bone bank. The bone graft is made into tiny pieces and packed into the channel created in the femoral head and neck.

Stem cells treatment:

Stem cells obtained from the patient body can be injected into the channel created for core decompression of femoral head. Stem cells injection can be done along with bone grafting also. There are studies showing that stem cells help to stimulate new bone formation in the diseased areas of the femoral head.

Postoperative rehabilitation after core decompression surgery:
This surgical procedure is done through a very small incision from the side of thigh. Surgeon guides the drill into the femoral head with help of intraoperative X - ray machine (C-Arm). This procedure is usually done as outpatient procedure and patient can go back to the house on the same day with help of crutches or walker.

Following core decompression surgery the drill holes in the femoral neck and head may weaken the bone, making it susceptible to fracture. So patients are advised to use crutches or walker to move around for six weeks. After six weeks, patient patients are advised to put full weight on operated leg and take advice of physiotherapist to regain hip range of motion and strength.

Advantages of core decompression surgery:
Core decompression of femoral head is NOT A DEFINITIVE procedure. It is a salvage procedure to delay the process of Avascular necrosis probably by increasing blood supply and also preventing further collapse.
After the core decompression procedure it is necessary to continue, the medications explained above as they also help in delaying the progress of disease.

Core decompression and Vascularized fibular grafting:

In the first step surgeons drills a hole into the femoral neck and head. In the next step surgeon removes small part of fibula (Thin bone by the side of shin bone in leg) along with its blood vessels. This is referred as vascularized fibular graft because it has its own blood supply. Fibular graft is inserted into the channel created in the neck and head of the femur. Vascular surgeon attaches the blood vessels from the fibula to one of the blood vessels in the hip. This procedure does two things
1. Fibular graft acts as structural support preventing collapse of femoral head.
2. The newly connected blood vessels try to increase blood supply to the femoral head.
This is a very complicated procedure and needs special expertise. The success of the surgery depends on the viability of newly created blood supply. It is rarely practiced nowadays.

TOTAL HIP REPLACEMENT:

The process of Avascular necrosis of femoral head invariably ends in arthritic hip. In arthritic hip, joint surfaces of femoral head and acetabulum becomes irregular with loss of motion in the joint. The treatment choice is total hip replacement.

Total hip replacement is procedure in which the surgeon replaces the damaged femoral head and damaged joint surface of acetabulum (socket) with prosthetic components. Damaged femoral head is removed and replaced with metallic stem and ball. Damaged cartilage of the socket of hip joint is replaced with metal socket.

Prosthetic components:
Total Hip replacement can be either cemented or uncemented.

Cemented Total hip replacement: In this procedure, cement is used for fixation of the prosthetic components into the bone.
Uncemented Total Hip replacement: In this technique, the fixation of components is by “pressfit” into the bone which allows bone to grow onto the components.

Prosthetic materials:
Total hip replacement has wide range of designs and materials.
The stem component and socket components in the total hip arthroplasty are invariably medical grade steel or titanium alloys. There is choice of material selection for the prosthetic head and liner of socket. Prosthetic heads can be metallic or ceramic. Socket liners are available in plastic, metallic and ceramic materials.
Different combinations of metal heads and liners can be made depending on needs of the patient.
Metal on plastic (Metal head / Plastic liner)
Ceramic on plastic (Ceramic head / Plastic liner)
Metal on metal (Metal head / Metal liner)
Metal on ceramic (Metal head / ceramic liner)
Ceramic on ceramic (Ceramic head / Ceramic liner)

The decision to use cemented or uncemented components and various combination of head and socket liners are based on various factors such as age, bone quality and sometimes surgeons choice.

RESURFACING ARTHROPLASTY:
In certain patients with limited damage to the part of femoral head surgeon may consider resurfacing arthroplasty. In this procedure surgeon replaces only damaged femoral head with metallic implant.

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OSTEOARTHRITIS OF KNEE
OSTEOARTHRITIS OF KNEE

Osteoarthritis can affect any joint in the body. It is like wear and tear which develops over many years. It is common in people over 50 years of age, particularly in women. Both knees need not be affected at the same time.
The cartilage gradually roughens and becomes thin exposing the underlying bone. The wear is more common on the inner side of the knee.
Osteoarthritis of the knee joint produces:
• Bone wear leading to asymmetric shape and movements
• Weak ligaments, and
• Changes to articular cartilage and tears of the menisci.
Risk factors :
1. Sportsmen who played contact sports.
2. Previous injury to the knee.
3. Obese people with Body Mass Index>30
4. Occupations involving prolonged squatting or kneeling, carrying heavy weights regularly, repetitive strain to knees.
5. Crystal Deposits such as uric acid in the joint is a chemical risk factor and may damage the joint fast.

Symptoms: Develops slowly over several years.
*In the beginning there may be some discomfort after a long walk or exertion. *Later stages: Stiffness after rest / sitting for some time and early in the mornings.
*Swelling of the joint
*Clicks or grinding noises from joint
*As the condition progresses, pain can interfere with simple daily activities and can disturb sleep.
* Muscles may become weak and thin. *Patient may also develop bow legs or knock knees.
Treatment Options:
Treatment depends up on the stage of the OA. It cannot be cured at once but one should not consider this as a disease. We can slow down the progression of the disease and to make life more comfortable:
• Knee Supports/Braces – Some splints provide pain relief with external support but can be uncomfortable to wear
• Assistive Devices – Such as cane or walker can be used to help in walking
• Medications – To control pain and to nourish cartilage (dietary supplements).
• Topical Creams/gels - Topical creams provide an alternative to oral medications.

• Heat and Cold Treatments - Local application of heat or cold can help with relief from pain and inflammation after exercise.
• Weight Loss - Weight loss can have a significant effect on slowing the disease progression.
• Exercise Program - A specific exercise program can help to maintain healthy cartilage and range of motion of the joint. In addition, keeping the attaching muscles and tendons conditioned and strong will aid in the joint's stability. If exercising is difficult, hydrotherapy may be useful to reduce the stress on the joints.
• Viscosupplementation - A ‘joint lubricant’ can be administered as an injection. This substance helps to lubricate and nourish the knee joint and can decrease the amount of inflammation.
• Arthroscopy – This procedure takes care of locking symptoms.
• Knee Replacement Surgery- Has proven it’s place and is hugely successful all over the world in relieving the symptoms from advanced osteoarthritic knees.


Exercise Program:
1. Heel slides: sit or lie on your back and gradually bend your knee by sliding the heel on the mattress.

2. Static quadriceps exercises: Sit with your legs straight and keep a rolled towel under your knee. Press the knee against the towel while tightening the thigh muscles. Hold this for count of 5 to 10.

3. Hamstring strengthening exercises: Sit with your legs straight and keep a rolled towel under your heel. Press the heel against the towel while pressing the knee to the ground. Hold this for count of 5 to 10.

4. Hamstring stretching exercises: Sit on a chair with your back straight. Lift the foot up by pulling it towards you and straighten the knee. Hold this for count of 5 to 10.

NOTE: Each exercise should be repeated atleast 10- 20 times and should be done within your pain limits.

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ARTIFICIAL LIMBS
It would be nightmare to any human being to think about a lost hand, foot or an entire arm or leg or to be born with any of limb defects. How these human beings with lost limbs (physically challenged) can carry out normal activities like walking, picking objects, writing etc. To overcome this, doctor can provide artificial armamentarium called prosthesis or artificial limbs, though they are not superior to original flesh and bones. The prostheses aid in replacing the lost gross functions of limbs in addition improves cosmetic appearance of the patients, thereby building self confidence.
The design of prosthesis had undergone many changes with modern advancement in sciences. Peg leg like prosthesis had been around for centuries. But today we have much wider range of products encompassing plastics and carbon fibre which are stronger, lighter and more durable.
Artificial limb helps to regain the normalcy of life both physically and psychologically. They make the ‘dependent’ people ‘ independent’. In people with lower limb loss these prostheses help to provide mobility. In those with bilateral lower limb loss artificial limbs are far more better than wheel chair. Also they provide access to areas that are not accessible to wheelchairs. The prosthetic legs allow amputees the option of going up stairs. Prosthetic legs provide a greater sense of independence. In case of upper limb loss they help to regain gross function of the hand. But with the advancement of technology we have prosthesis which are electrically controlled and perform near normal functions.
Prosthetic limbs aid the disabled to have satisfactory gait pattern and utilize less energy while walking.

Disabled people can have better psychological outlook on life by the use of prosthetic legs, whether they have one or two prosthetic legs. In a study carried out by the Amputee Coalition of America they found out the physically impaired with artificial limbs, feel less discomfort with their conditions because of the ability to mingle with the crowd. They also observed that in those who do not have the opportunity to wear prosthetic legs feel depressed and mentally disabled.

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PREGNANCY AND BACK PAIN
Back pain is the most common orthopedic complaint in most of the pregnant women. According to the scientific literature 50% to 80% of the pregnant women complain of back pain at sometime during their pregnancy. Out of the different back pains it is the lower back pain which most of the pregnant mothers suffer.
Number of factors can be attributed for the cause of low back pain in the pregnancy. Hormonal and postural changes play a major role in the cause.
During pregnancy many hormones are produced out of which Relaxin is the one which is of our concern. The function of hormone Relaxin is to loosen the joints and ligaments in your body. This helps to relax the ligaments in the pelvis which in turn makes room for your baby inside and also helps during delivery of your baby.
Since the hormone have no selective role in relaxing the ligaments and joints of the pelvis only, all the ligaments and joints in the body are stretched. Laxity of the ligaments which support the spine results in the instability which can cause back pain.
As the baby grows and size of the uterus expands, the posture of your body is altered resulting in forward bending of lower spine and compensatory backward bending of upper spine. Abdomen shifts forwards and downwards altering the normal biomechanics of the spine. This in turn adds on strain to back muscles which may become sore and tired.
Two types of lower back pain are observed during pregnancy,
1. Lumbar pain
2. Posterior pelvic pain
Lumbar pain
It is similar to the kind of back pain that you may have experienced before the pregnancy. It is caused by sitting or standing for prolonged periods. It presents as pain in the lower back, just slightly above the waist line.
Posterior pelvic pain
It is the pain experienced at the back of the pelvis, below the waist line, across the buttocks and near the tail bone. It is the most common type experienced by pregnant women. It can be aggravated by bending twisting, climbing stairs, or leaning forwards.



Management
Back pain during pregnancy could be controlled and prevented by taking necessary precautions and following regular exercise protocol. Exercises help to strengthen, stretch the back muscle. These include pelvic tilt exercises, back stretches, hamstring stretches and kegel exercises.
Walking and swimming are the two preferred exercises during pregnancy to maintain the tone of back muscles. Walking helps to maintain flexibility of muscles of lower back, hips and knee. Swimming and other aquatic exercises allows full body work out with minimal stress and strain to the body. Prenatal yoga or pregnancy yoga helps to stretch and strengthen the back muscles and aid in relieving the pain.
It is not only exercises which help in controlling the back pain, but maintaining proper posture while standing and sitting will help. When you stand try to tuck your hips and pelvis, try resting one foot on a stool. Prolonged sitting can hurt you back, so take frequent breaks if you plan to sit for long times. Safe lifting and bending practices help you to prevent undue strain on your back. When bending over to lift any object, bend at the knees instead at waist and use your thigh muscles to push yourself up instead of back muscles. Try not to lift heavy objects. Wearing low heeled shoes with good arch support may help to alleviate back pain.
Sleeping posture most favorable for pregnant women is to sleep sideways, preferably on left side. Try sleeping with your knees and hip bent, with pillows between knees and one under the belly.
Note:
If you are pregnant with sever back pain, which is rhythmic and feels like menstrual cramps consult your doctor. If you have back pain with numbness or weakness in both lower limbs it needs urgent evaluation by your doctor. Dull back pain during late stages of pregnancy could be signs of preterm labour.

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PAIN IN THE TAIL BONE
Pain in the tail bone can frustrate, irritate and embrace many patients for getting the treatment. This condition can be curable and prevented if proper care is taken.
Any irritation (inflammation) of the bony area (tail bone) situated between the folds of the buttocks is referred as Coccydynia. The usual complaint is pain at the bottom region of the back on sitting.
It is usually caused by injury, during pregnancy, chronic pressure on the tail bone due to sitting for long hours as of in those involved in driving occupation. Sometimes tail bone pain occurs in patients with chronic constipation. In one third of the cases the cause is not known.
Coccydynia is usually diagnosed based on the typical complaints and sometimes by an x-ray. Clinician can diagnose by examination and eliciting tenderness at the local region. It is necessary to directly visualize the tailbone region to rule out other causes and any infection. Sometimes infection of the hair follicles at the tailbone region can mimic coccydynia.
This condition usually frustrate patients and impair the quality of life. Sometimes patients feel embarrassed to get the treatment.

Treatment is usually by activity modification, anti inflammatory medications and local injections. Surgery is rarely indicated in non responsive cases.
Since long hours of sitting may aggravate the condition, a modified padded cushion with cut out at the back could relieve the pressure on the coccyx. (Doughnut cushion). Pelvic floor exercises could help to get relief from pain. Use of stool softeners and laxatives in cases of constipated patients could help to relive pain. Seitz bath by sitting in tub of hot water may provide pain relief.
Oral anti inflammatory medications and local application of pain gels may tries to relive the symptoms. Local trigger injections with low dose steroid preparations will aid in complete relief in majority of cases. These local injections can be given by the doctor in the outpatient department. In rare case surgical treatment by removal of coccyx may be required in those cases not responding to conservative methods.

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