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Oct 18
How your knees can predict the weather
The Wolff family of Paramus, N.J., was eyeing the gathering clouds and debating whether to cancel a planned park trip when 6-year-old Leora piped up with an idea: "Let's call Grandma. Her knees always know when it's going to rain!"

Leora's grandmother, Esther Polatsek, says she started being sensitive to the weather in her 20s, when a fracture in her foot would ache whenever a snowstorm approached. Now 66 and plagued by rheumatoid arthritis, Mrs. Polatsek says she suffers flare-ups whenever the weather is about to change.

"It's just uncanny. Sometimes it'll be gorgeous out, but I'll have this awful pain. And sure enough, the next morning it rains," she says. "It may be just a few drops, but it makes my body crazy."

Do weather conditions really aggravate physical pain? It is one of the longest running controversies in medicine.

Hippocrates in 400 B.C. noticed that some illnesses were seasonal. The traditional Chinese medicine term for rheumatism (fengshi bing) translates to "wind-damp disease."

But modern scholars have gotten inconsistent results in studies that tried to match weather patterns to reported pain symptoms-leading some to dismiss the connection as highly subjective or all in sufferers' minds.

"People's beliefs about arthritis pain and the weather may tell more about the workings of the mind than of the body," concluded the late Stanford psychologist Amos Tversky in the mid-1990s, after comparing the pain reports of 18 rheumatoid-arthritis patients with local weather conditions for a year and finding no connection.

Still, other studies have linked changes in temperature, humidity or barometric pressure to worsening pain from rheumatoid arthritis and osteoarthritis, as well as headaches, tooth aches, jaw pain, scar pain, low-back pain, pelvic pain, fibromyalgia, trigeminal neuralgia (a searing pain in the face), gout and phantom-limb pain.

Scientists don't understand all the mechanisms involved in weather-related pain, but one leading theory holds that the falling barometric pressure that frequently precedes a storm alters the pressure inside joints. Those connections between bones, held together with tendons and ligaments, are surrounded and cushioned by sacs of fluid and trapped gasses.

"Think of a balloon that has as much air pressure on the outside pushing in as on the inside pushing out," says Robert Jamison, a professor of anesthesia and psychiatry at Harvard Medical School. As the outside pressure drops, the balloon-or joint-expands, pressing against surrounding nerves and other tissues. "That's probably the effect that people are feeling, particularly if those nerves are irritated in the first place," Dr. Jamison says.

Not everyone with arthritis has weather-related pain, says Patience White, a rheumatologist at George Washington University School of Medicine and a vice president of the Arthritis Foundation. "It's much more common in people with some sort of effusion," an abnormal buildup of fluid in or around a joint that frequently occurs with inflammation.

Many patients swear that certain weather conditions exacerbate their pain. Consequently, orthopedists, rheumatologists, neurologists, family physicians, chiropractors, physical therapists-even personal trainers-report an increase in grousing among their clients when the temperature drops or a storm approaches.

"I can tell you emphatically there are certain days where practically every patient complains of increased pain," says Aviva Wolff, an occupational therapist at the Hospital for Special Surgery in New York City, and Mrs. Polatsek's daughter. "The more dramatic the weather change, the more obvious it is."

Oct 18
New blood test can detect lung and prostate cancers
A new blood test can help detect the presence of early-stage lung and prostate cancers - as well as any recurrences of these diseases.

In a new study presented at the Anesthesiology 2013 annual meeting, researchers have found that an increased level of serum-free fatty acids and their metabolites in the blood stream can help indicate the presence of lung cancer in the body.

According to the study's authors, such a test could be extremely beneficial for the detection and management of the disease.

"Lung cancer is the leading cause of cancer death in the U.S., and unlike some other cancers, there is no easy way to diagnose it," senior author Dr. David Sessler, professor and chair of the department of outcomes research at the Cleveland Clinic, told FoxNews.com. "The current standard is a spiral CT, which works well, but they are expensive, and they expose patients to radiation. So having a blood test for lung cancer would be very helpful."

Sessler said that he and his research team stumbled upon these biomarkers for lung cancer while conducting an entirely different experiment.

"It was complete serendipity," Sessler said. "We were looking for inflammatory markers associated with a particular type of anesthesia - general anesthesia versus epidural anesthesia. There was no difference in inflammation, but we noticed that patients with lung cancer had higher incidences of these fatty acids and their metabolites."

After making this discovery, the researchers decided to further analyze these potential biomarkers. They examined blood samples from 55 patients with lung cancer and 40 patients with prostate cancer, comparing them to samples from people without cancer. The blood samples from the cancer patients had one- to six-times greater amounts of the serum-free fatty acids and their metabolites than the samples from cancer-free patients.

In a second phase of the study, the researchers examined blood samples from 24 patients with lung cancer before they underwent curative surgery. They then analyzed the patients' blood at six and 24 hours after surgery. The level of serum-free fatty acids and their metabolites decreased three to 10 times within 24 hours after the cancerous tumors were removed.

The researchers didn't assess why the level of these compounds increased, but they said their findings are consistent with previous research on the relationship of serum-free fatty acids and cancer.

"The three fatty acids are necessary for cancer cell growth, and some cancers stimulate the release of these fatty acids," Sessler said.

Though the blood test was shown to be effective in detecting the disease, the researchers argue that it should not be used as the go-to test for lung cancer screenings. However, it could be helpful for a certain population of patients.

"It's by no means a perfect test; blood tests rarely are," Sessler said. "It is about 75 percent for sensitivity and specificity. It is probably not a good enough test to use for routine screening, but it well could be helpful for high risk patients or patients who have found a nodule but don't know if it's cancerous enough."

Sessler also said the blood test could be helpful for those who have already undergone lung cancer surgery to better understand if they will suffer recurrence.

"If someone who has lung cancer and has surgery, you might use this as a follow up," Sessler said. "Presumably the fatty acids go down after surgery, and an increase in concentration might tell you if patient is having a relapse."

While other blood tests do exist for some cancers - most notably the prostate-specific antigen (PSA) test for prostate cancer - Sessler said this is still an exciting discovery for the future of lung cancer treatment.

"Yes, there are some biomarkers for some cancers, but there's no general cancer biomarker, nor has there ever been an established biomarker for lung cancer," Sessler said.

Oct 17
Sons of older fathers have normal brainpower: Study
By the time they reach their 20s, sons born to older fathers and those who were born to younger men score about the same on intelligence tests, a new Danish study finds.

Whatever negative biological effects a father's age might have on his child may be offset by the benefits of being raised by a better educated and financially stable older father, researchers said.

"Our results are reassuring for older fathers," Liselotte Petersen, the study's lead author, told Reuters Health in an email.

"Our finding is that any potentially deleterious effects of older fathers on general cognitive ability, as young adults may be counter-balanced," Petersen, an associate professor at Aarhus University in Denmark, said.

Previous studies have suggested that the children of older fathers are more likely to be diagnosed with autism and schizophrenia. That led Petersen and her colleagues to suspect that the children of older fathers may also have lower intelligence scores.

For the study, they used data collected from 169,009 men born after 1955. The goal was to see if there were any differences in intelligence related to how old their fathers were at the time of their birth.

The researchers used the participants' scores from the intelligence test that's required for military service in Denmark. Each participant took the test when he was about 20 years old.

The participants' average score was 42, which is about the same as that of the general Danish population.

Initially, it appeared that the children born to teenagers or to fathers over age 35 scored lower on the intelligence test, compared to the kids of fathers in their mid to late 20s.

But the difference disappeared when Petersen and her colleagues adjusted those scores to account for the parents' education levels, the children's birth order, the mother's age and the year the test was administered.

Children of teenage fathers, however, scored on average about one point lower, compared to the kids of fathers aged 25 to 29.

Small changes in intelligence may impact people in subtle ways, the researchers write in PLOS ONE. But that difference would be magnified if it were applied across the entire population.

The new study, however, can't prove that a father's age will directly impact his child's intelligence.

Also, it's hard to compare the intelligence scores used in this study to scores in previous research, according to NYU Langone Medical Center's Dr. Dolores Malaspina, because the intelligence test used is unique to Denmark.

But, Malaspina, who has done similar work but wasn't involved in the new study, wrote in an email that this is a "compelling area of research."

Oct 17
Sleep very important to maintain healthy lifestyle
Three new studies have shown that in order to maintain a healthy lifestyle, it is important for adults to seek treatment for a sleep illness and aim for 7 to 9 hours of sleep each night.

One study of 2,240 adults is the first to examine the link between obstructive sleep apnea (OSA) and mortality in Asians.

Results showed that all-cause mortality risk was 2.5 times higher and cardiovascular mortality risk was more than 4 times higher among people with severe OSA.

Another study of 2,673 patients in Australia found that untreated OSA is associated with an increased risk of motor vehicle crashes in very sleepy men as well as near-misses in men and women.

Participants with untreated OSA reported crashes at a rate three times higher than the general community.

That last study examined the relationship between sleep duration and self-rated health in Korean adults.

Results showed that short sleep duration of 5 hours or less per day and long sleep duration of 9 hours or more per day was associated with poor self-rated health.

All three of the studies are published in the Journal of Clinical Sleep Medicine.

Oct 16
Why heart rate decreases with age
Researchers have tried to look into the age-old question as to why maximum heart rate (maxHR) decreases with age.

According to researchers at the University of Colorado, this decrease in maxHR not only limits the performance of aging athletes but it is also a leading cause for nursing home admittance for otherwise-healthy elderly individuals who no longer have the physical capacity required for independent living.

We say we're just getting old and slowing down, but exactly what is it that is slowing down?

Everybody knows that aerobic capacity decreases with age. You know that chart in your gym that shows your target heart rate decreasing as you get older?

Well, that's not a senior discount to let the elderly get off easy on their treadmill workouts. It's because older hearts simply can't beat as fast as younger hearts.

So the older person who's doing 120 beats per minute is probably working harder - at a higher percentage of maximum heart rate - than the younger person who is at 150 beats per minute.

A new study by a group led by Catherine Proenza, PhD and Roger Bannister, PhD from the University of Colorado School of Medicine reports that one of the reasons for the age-dependent reduction in maximum heart rate is that aging depresses the spontaneous electrical activity of the heart's natural pacemaker, the sinoatrial node.

Like most initial discoveries in basic science, this study opens many more questions and avenues for further research. But the significance of the study is that it raises the possibility that sinoatrial ion channels and the signaling molecules that regulate them could be novel targets for drugs to slow the loss of aerobic capacity with age.

Proenza notes that "although maximum heart rate goes down for everybody equally, regardless of physical conditioning, people can improve and maintain their aerobic capacity at all ages by exercising."

This study is set to be published in the journal Proceedings of the National Academy of Sciences of the United States of America.

Oct 16
Sleeping habits affect children's behaviour
Children with irregular bedtime habits are more prone to behavioural problems but adhering to a defined sleep regime improves behaviour, says a study.

The study published in the Journal Paediatrics, found that irregular bedtimes could disrupt natural body rhythms and cause sleep deprivation, undermining brain maturation and the ability to regulate certain behaviours.

"Not having fixed bedtimes, accompanied by a constant sense of flux, induces a state of body and mind akin to jet lag" and this affects healthy development and daily functioning, said Yvonne Kelly, professor at University College London Epidemiology and Public Health.

Jet lag is a physiological condition which results from alterations to one's daily cycle of activity. It is classified as one of the circadian rhythm sleep disorders.

"We know that early child development has profound influences on health and well-being on life. It follows that disruptions to sleep, especially if it occurs at key times during development, could have lifelong impacts on health," said Kelly.

As children progressed without a regular bedtime, their behavioural scores -- which include hyperactivity, behaviour, problems with peers and emotional difficulties -- worsened.

However, children who switched to a more regular bedtime had clear improvements in their behaviour, reports a Science Daily.

Oct 15
Air pollution ups risk of underweight babies
A new study has revealed that pregnant women exposed to even low levels of air pollution are at a higher risk of delivering low birth weight babies.

The study, drawn from data on 74,000 pregnant women in 12 European countries gathered between 1994 and 2011, showed that air pollutants increases the risk of low birth weight and reduces average head circumference of babies born at term.

The study led by Centre for Research in Environmental Epidemiology in Barcelona found that for every increase of five micrograms per cubic metre in exposure to fine particulate matter during pregnancy, the risk of low birth weight in the baby rose by 18 percent.

Lead author Dr Marie Pedersen and his team estimated that if levels of fine particulates were reduced to 10 micrograms per cubic metre, 22 percent of cases of low birth weight among term deliveries could be prevented.

The study is published in the Lancet Respiratory Medicine.

Oct 15
Cancer cure being developed from human breast milk
Scientists have claimed that a cure for cancer is being developed from human breast milk.

A protein in human milk, lactaptin, was found to destroy diseased cells in tests at a Siberian medical institute.

Project leader Valentin Vlasovs said that the two medications are going through the pre-clinical trial now.

During analyses of the milk proteins they detected a tiny peptide that affected cancer cells. It destroyed cancer cells and left the healthy ones alive, Vlasovs said.

Tests on mice showed the drug works especially well on liver and lung cancers.

Oct 14
Peanut butter can help save millions of malnourished kids
Peanut butter has the potential to save lives of severely malnourished children every year, a new study has revealed.

While working in a Malawi village in 1999, Pediatrician Dr Mark Manary found that peanut butter, which is full of vitamins and nutrients, can be a solution to save millions, News.com.au reported.

Manary made a ready-made mixture, or ready-to-use therapeutic food (RUTF), and found 95 per cent of children had recovered from malnutrition within six weeks of eating the peanut butter paste.

He told the publication that RUTF can treat severe malnutrition anywhere on the planet.

The research said that his team has treated more than 100,000 severely malnourished children with on average 90 per cent recovery.

His nutrient-rich mixture has even been endorsed by the World Health Organisation (WHO) as the best way to treat malnutrition.

Manary said the peanut butter paste, which contains easy to digest mono-unsaturated fats and is rich in zinc and protein, also meant mothers could treat their children in the own home.

Project Peanut Butter is aiming to save two million children by 2015.

Oct 14
Parkinson's drug could help treat Multiple Sclerosis
Scientists have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way.

Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can in turn repair MS-damaged nerve fibers.

One of the newly identified compounds, a Parkinson's disease drug called benztropine, was highly effective in treating a standard model of MS in mice, both alone and in combination with existing MS therapies.

"We're excited about these results, and are now considering how to design an initial clinical trial," Luke L. Lairson, an assistant professor of Chemistry at TSRI and senior author of the study, said.

Lairson cautioned that benztropine is a drug with dose-related adverse side effects, and has yet to be proven effective at a safe dose in human MS patients.

"People shouldn't start using it off-label for MS," he said.

The study is published online in the journal Nature.

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