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Jun 17
reduce threat to wildlife movements
New approach to beef trade could positively transform livelihoods for farmers, reduce threat to wildlife movements

A new study by the Wildlife Conservation Society's Animal & Human Health for the Environment And Development (AHEAD) Program, World Wildlife Fund (WWF), and regional partners finds that a new approach to beef production in southern Africa could positively transform livelihoods for farmers and pastoralists, while helping to secure a future for wildlife and wildlife-based tourism opportunities.

Market access for livestock and livestock products from Africa is constrained by the presence of foot and mouth disease (FMD). Fear of the FMD virus largely precludes large-scale beef exports from Africa to potentially lucrative overseas markets and hinders trade within Africa itself. Wild buffalo, an ecologically and economically critical species in the region, can transmit the FMD virus to livestock but are not themselves affected.

The study looked at new commodity-based (value chain) approaches to beef trade (commodity-based trade or CBT) that focus on the safety of the process by which products are produced rather than on whether a given cow was raised in a location where wildlife like buffalo also roam. This food safety-type approach offers the potential for export of meat products that are scientifically demonstrable as safe from animal diseases for importing countries, while also diminishing the need for at least some of the veterinary fencing currently aimed at separating livestock and wildlife and constraining the Southern African Development Community's vision for regional transboundary wildlife conservation, which has in some places begun to surpass livestock agriculture in terms of its contribution to regional GDP through tourism and related industries.

Working in close coordination with Namibian authorities, economist Dr. Jonathan Barnes led a comprehensive cost-benefit analysis evaluating policy options related to animal disease management and land-use decisions in Caprivi, Namibia. Caprivi is a core part of the Kavango Zambezi ("KAZA") transfrontier conservation area (TFCA) that is home to extraordinary wildlife including the largest population of elephants in the world (approximately 250,000). KAZA includes contiguous portions of Angola, Botswana, Namibia, Zambia and Zimbabwe, and may become the largest terrestrial area available to migratory wildlife on the planet if FMD-related land-use conflicts can be resolved.

Caprivi was selected for study in part because it is currently classified as an FMD-infected zone as its livestock and wildlife populations have co-existed for many years. The study found that economic costs associated with development of CBT in Caprivi would be outweighed by economic gains in terms of enhanced wildlife-based income generation, abattoir viability, and livestock-based incomes. Further, income growth is more diversified when CBT is applied, therefore less risky. CBT, because of its emphasis on science-based approaches to ensure that the meat produced is free of dangerous pathogens, helps assure product safety regardless of whether wildlife like buffalo also live in the area of livestock origin and therefore makes more conventional approaches that rely on fences to physically separate livestock and wildlife less necessary.

In contrast, the analysis showed that a scenario using spatially segregated, fenced FMD-free livestock compartments is technically impractical and would be economically undesirable. Here, significant loss of growth in wildlife-based incomes, and significant costs for fencing and maintenance, would outweigh any new economic gains in abattoir viability and / or livestock farming incomes.


"By carefully looking at the economics of different land-use planning options, it appears the way to optimize economic development in this case is through a value-chain approach to beef production," said Dr. Jon Barnes. "This would open up new markets for southern African farmers and reduce the threat to key wildlife movements brought about by fencing-based approaches to disease management."

The authors believe that the findings have important implications for development policy in and around the KAZA TFCA, and possibly other TFCAs in southern Africa. They strongly suggest that initiatives aimed at introduction of CBT to underpin sanitary risk management offer significant economic potential. At the same time, this approach can assist in meeting other TFCA objectives, such as the restoration of diverse ecosystems by re-opening corridors that allow for wildlife movements across large, historically connected landscapes. This will provide greater resilience in the face of natural catastrophes, disease outbreaks and /or climatic challenges.

"By working proactively to improve the health and productivity of animals and people, recognizing up front that livestock and wildlife depend on a much more unified approach to land-use management, we believe we're onto what had been an elusive but highly prized 'win-win' solution to the age-old problem of getting beef out of areas where wildlife is also allowed to thrive- a win for wildlife as well as for communities who have long relied on domestic animals both economically and culturally," said Dr. Steve Osofsky, Director of the WCS AHEAD program.

The Wildlife Conservation Society would like to thank the Rockefeller Foundation, the US Agency for International Development, and the World Wildlife Fund for the financial support that made this study possible.

Source: Wildlife Conservation Society

Jun 14
People with obstructive sleep apnea have a risk of sudden cardiac death
People who have obstructive sleep apnea -- when a person stops breathing for periods during sleep -- have a greater risk of sudden cardiac death, according to a study published online today in the Journal of the American College of Cardiology. An estimated 12 million American adults have obstructive sleep apnea, and many of them are undiagnosed, according to the National Heart, Lung and Blood Institute (NHLBI).

In the study, funded by the NHLBI, 10,701 people who participated in sleep studies were followed for an average of 5.3 years for incidence of sudden cardiac death. In that time, 142 patients died of sudden cardiac death. The most common predictors were an age of 60 or older, 20 or more apnea episodes per hour of sleep, and an oxygen saturation below 78 percent during sleep.

"What we found that is new with this study is that if you have sleep apnea, your risk of sudden death increases almost twofold, particularly if you stopped breathing more than 20 times per hour of sleep and if you had severe falls in oxygen saturation during sleep," says senior author Virend Somers, M.D., Ph.D., a Mayo Clinic cardiologist.

When a person is breathing properly, the oxygen saturation level -- when air flows through the lungs -- during sleep is 100 percent, Dr. Somers says. This study showed that if a person is not breathing properly and the oxygen saturation level falls to as low as 78 percent, the risk of sudden cardiac death significantly increases, he says.

Lead author Apoor Gami, M.D., says Mayo Clinic's previous research showed that people with sleep apnea have a much higher risk of sudden cardiac death between midnight and 6 a.m., when people are typically asleep, while people without sleep apnea die more often from sudden cardiac death between 6 a.m. and noon.


"So we knew that sleep apnea changed the time of sudden cardiac death, but we didn't know if it changed the overall risk," Dr. Gami says. "This new study shows that sleep apnea does indeed increase the overall risk of sudden cardiac death independently of other important risk factors.

"The prevalence of obstructive sleep apnea in Western populations is high, and because of the relationship between weight and sleep apnea, the current obesity epidemic is going to further increase the scope of this problem," noted Dr. Gami, formerly at Mayo Clinic and now a cardiologist at Midwest Heart Specialists-Advocate Medical Group in Elmhurst, Ill.

Research has shown that sleep apnea is potentially an important cause of cardiovascular conditions, such as high blood pressure, atrial fibrillation, heart attacks and strokes, Dr. Somers says. Sleep apnea is treatable. In addition to weight loss, physicians also can recommend sleep posture changes and devices, such as a machine that delivers air pressure through a mask placed over the nose while a person sleeps, he says.

Source: Journal of the American College of Cardiology

Jun 13
Diabetes Calculator for Kids
Nationwide Children's Hospital recently developed an online resource to help parents manage their child's diabetes more effectively and care for their health at home. The "Diabetes Calculator for Kids," a first of its kind electronic tool geared toward the pediatric patient, allows parents, caregivers and the adolescent patient themselves to create an individualized chart which calculates the correct insulin dosage that should be given prior to eating.

Diabetes, which affects nearly 1 in every 400 children and adolescents in the United States, is a disease that is characterized by a high blood glucose or "sugar" level. Managing a child's diabetes requires the proper balance between insulin dose, food and activity on a daily basis. It is important to keep the child's blood sugars within a target range at all times. Modern insulin therapy involves administering rapid-acting insulin before each meal and adjusting the dose based on the current blood glucose level and how much food will be eaten.

The Diabetes Calculator for Kids, available for any patient who uses insulin, creates an individualized chart for rapid-acting insulin bolus dosage in five easy steps. After the parent or patient completes those steps online, a customized chart is produced that can be emailed or printed off. It provides the parent, caregiver or patient an easy way to look up the correct insulin dosage based on current blood glucose, without having to do the math each time.

"The goal is to provide an additional tool to empower families to successfully manage their child's diabetes at home in order to provide as normal a life as possible for that child," said David Repaske, MD, PhD, chief of Endocrinology, Metabolism & Diabetes at Nationwide Children's and also a faculty member at The Ohio State University College of Medicine. "The chart can also be printed out and taken to school or given to a sitter to ensure accurate insulin dosing without the need to learn the formula and do the math for each dose."

Nationwide Children's always recommends that parents consult with their child's physician first with any questions related to their child's individual diabetes management plan.

SOURCE Nationwide Children's Hospital

Jun 11
CTP-354 Phase 1 trial in healthy volunteers
Concert Pharmaceuticals, Inc. today announced that it has initiated a Phase 1 clinical trial with CTP-354. CTP-354 is a novel GABAA receptor subtype-selective modulator that has demonstrated no sedation at therapeutic doses in preclinical models in contrast to existing GABAA receptor non-selective agonists, such as benzodiazepines. Concert is developing CTP-354 for the potential treatment of spasticity and chronic pain. The Phase 1 single ascending dose study will evaluate the safety, tolerability and pharmacokinetics of CTP-354 in healthy volunteers. The company also intends to conduct a Positron Emission Tomography (PET) study to assess brain receptor occupancy of CTP-354 in healthy volunteers. Concert expects to report top-line results of the Phase 1 single ascending dose study by year-end.

"Based on CTP-354's preclinical profile, we believe it has the potential to offer patients effective treatment for these chronic conditions with an improved therapeutic profile. We look forward to assessing CTP-354 in our clinical program."

"There is a significant unmet need for effective and better tolerated agents in the treatment of both spasticity and chronic pain, particularly treatments that would reduce or avoid the adverse events of sedation and ataxia that are commonly associated with existing treatments," said Roger Tung, Ph.D., President and Chief Executive Officer of Concert Pharmaceuticals. "Based on CTP-354's preclinical profile, we believe it has the potential to offer patients effective treatment for these chronic conditions with an improved therapeutic profile. We look forward to assessing CTP-354 in our clinical program."

The Phase 1 study is a randomized, double-blind, placebo controlled study to assess single ascending doses of CTP-354 in healthy adult volunteers in the United States. The program advanced into Phase 1 clinical testing following successful preclinical studies with CTP-354 (previously referred to as C-21191). CTP-354 was developed based on an earlier generation of investigational GABAA receptor modulators that demonstrated promising receptor subtype selectivity, but lacked a favorable pharmacokinetic profile. Concert's selective incorporation of deuterium in CTP-354 significantly improved pharmacokinetic properties in preclinical models while maintaining the desirable pharmacological activity seen with the earlier generation modulators.

SOURCE Concert Pharmaceuticals Inc.

Jun 08
Breastfeeding benefits baby`s brain
A new study has found more evidence that breastfeeding is good for the baby`s brain.

The study by researchers from Brown University, made use of specialized baby-friendly magnetic resonance imaging (MRI) to look at the brain growth in a sample of children under the age of 4.

The research found that by age 2, babies who had been breastfed exclusively for at least three months had enhanced development in key parts of the brain compared to children who were fed formula exclusively or who were fed a combination of formula and breast milk.

The extra growth was most pronounced in parts of the brain associated with language, emotional function, and cognition, the research showed.

This isn`t the first study to suggest that breastfeeding aids babies` brain development.

Behavioural studies have previously associated breastfeeding with better cognitive outcomes in older adolescents and adults.

But this is the first imaging study that looked for differences associated with breastfeeding in the brains of very young and healthy children, Sean Deoni, assistant professor of engineering at Brown and the study`s lead author said.

The findings are published in the journal NeuroImage.

Jun 08
25% of men under 40 suffer from newly-diagnosed ED
A new study has found that one in four men seeking medical help for newly-developed erectile dysfunction (ED) was younger than 40 years, and nearly half of young men with the condition had severe ED.

While larger population-based studies are needed, the findings suggest that erectile dysfunction in young men may be more prevalent and more serious than previously thought.

Erectile dysfunction is a common complaint in men over 40 years of age.

Prevalence increases with age, but the prevalence and risk factors of erectile dysfunction among younger men have been scantly analyzed.

The research that has been done paints a vague picture, reporting prevalence rates ranging between two percent and nearly 40 percent.

To provide more clarity, Paolo Capogrosso, MD, of the University Vita-Salute San Raffaele, in Milan, Italy, and his colleagues assessed the sociodemographic and clinical characteristics of 439 men seeking medical help for newly-developed erectile dysfunction between January 2010 and June 2012 at a single academic outpatient clinic.

Of the 439 patients, 114 (26 percent) were aged 40 years or younger.

Compared with older patients, younger patients had a lower average body mass index, a higher average level of testosterone in the blood, and a lower rate of other medical conditions. (Only 9.6 percent of younger patients had one or more concomitant medical conditions compared with 41.7 percent among older patients.)

Younger ED patients smoked cigarettes and used illicit drugs more frequently than older patients.

Premature ejaculation was more common in younger men, whereas Peyronie`s disease (bent erection from scar tissue) was more prevalent in older patients.

Severe erectile dysfunction was found in 48.8 percent of younger patients and 40 percent of older patients while the rates of mild, mild-to-moderate, and moderate erectile dysfunction were not significantly different between the two groups.

The findings are published in The Journal of Sexual Medicine.

Jun 07
Cheese can help prevent cavities
A new study led by an Indian researcher has found that consuming cheese and other dairy products may help protect teeth against cavities.

The study sampled 68 subjects ranging in age from 12 to 15, and the authors looked at the dental plaque pH in the subjects` mouths before and after they consumed cheese, milk, or sugar-free yogurt.
A pH level lower than 5.5 puts a person at risk for tooth erosion, which is a process that wears away the enamel (or protective outside layer) of teeth.

"The higher the pH level is above 5.5, the lower the chance of developing cavities," Vipul Yadav, MDS, lead author of the study, said.

The subjects were assigned into groups randomly.

Researchers instructed the first group to eat cheddar cheese , the second group to drink milk, and the third group to eat sugar-free yogurt.

Each group consumed their product for three minutes and then swished with water.

Researchers measured the pH level of each subject`s mouth at 10, 20, and 30 minutes after consumption.

The groups who consumed milk and sugar-free yogurt experienced no changes in the pH levels in their mouths.

Subjects who ate cheese, however, showed a rapid increase in pH levels at each time interval, suggesting that cheese has anti-cavity properties.

The study indicated that the rising pH levels from eating cheese may have occurred due to increased saliva production (the mouth`s natural way to maintain a baseline acidity level), which could be caused by the action of chewing.

Additionally, various compounds found in cheese may adhere to tooth enamel and help further protect teeth from acid.

The study is published in General Dentistry, the peer-reviewed clinical journal of the Academy of General Dentistry (AGD).

Jun 07
Origin of wide range of brain disorders pinpointed
Scientists have discovered a mechanism that guides the exquisite wiring of neural circuits in a developing brain-gaining unprecedented insight into the faulty circuits that may lead to brain disorders ranging from autism to mental retardation.

The researchers at Weill Cornell Medical College explained that faulty wiring occurs when RNA molecules embedded in a growing axon are not degraded after they give instructions that help steer the nerve cell. So, for example, the signal that tells the axon to turn-which should disappear after the turn is made-remains active, interfering with new signals meant to guide the axon in other directions.

The scientists said that there might be a way to use this new knowledge to fix the circuits.

"Understanding the basis of brain miswiring can help scientists come up with new therapies and strategies to correct the problem," said the study`s senior author, Dr. Samie Jaffrey, a professor in the Department of Pharmacology.

"The brain is quite `plastic` and changeable in the very young, and if we know why circuits are miswired, it may be possible to correct those pathways, allowing the brain to build new, functional wiring," he said.

Disorders associated with faulty neuronal circuits include epilepsy, autism, schizophrenia, mental retardation and spasticity and movement disorders, among others.

In this study, researchers investigated neurons that travel up the spinal cord into the brain.

"It is very critical that axons are precisely positioned in the spinal cord. If they are improperly positioned, they will form the wrong connections, which can lead to signals being sent to the wrong target cells in the brain," Dr. Jaffrey said.

The team found that RNA molecules embedded in the growth cone are responsible for instructing the axon to move left or right, up or down. These RNAs are translated in growth cones to produce antenna-like proteins that steer the axon like a self-guided missile.

"As a circuit is being built, RNAs in the neuron`s growth cones are mostly silent. We found that specific RNAs are only read at precise stages in order to produce the right protein needed to steer the axon at the right time. After the protein is produced, we saw that the RNA instruction is degraded and disappears," he said.

"If these RNAs do not disappear when they should, the axon does not position itself properly-it may go right instead of left-and the wiring will be incorrect and the circuit may be faulty," Dr. Jaffrey explained.

The research finding answers a long-standing puzzle in the quest to understand brain wiring, added Dr. Dilek Colak, a postdoctoral associate in Dr. Jaffrey`s laboratory.

The study was published in the journal Cell.

Jun 06
Reduction in BMI cuts diabetes risk in obese teens
Researchers found that obese teenagers who reduced their body mass index (BMI) by 8 percent or more had improvements in insulin sensitivity, an important metabolic factor related to the later development of type 2 diabetes.

The teens followed a family-based, lifestyle-modification weight loss program that offers the potential to become a broader model.

BMI is a measure of body weight adjusted for height.

"This threshold effect that occurs at 8 percent suggests that obese adolescents don`t need to lose enormous amounts of weight to achieve improvements," said pediatric endocrinologist Lorraine Levitt Katz, M.D., of the Diabetes Center for Children at The Children`s Hospital of Philadelphia.

"The improvements in insulin sensitivity occurred after four months of participating in a lifestyle-modification program," Katz stated.

The study team analyzed results in 113 primarily urban adolescents, aged 13 to 17, of whom 81 percent were female, and 62 percent were African American. At the start of the study, their mean BMI was 37.1, placing them in the severely obese range. None had type 2 diabetes, but their obesity placed them at high risk to develop the disease in the future.

An important goal of the study was to determine the threshold of weight loss that significantly impacted insulin sensitivity, glucose tolerance and the presence of metabolic syndrome (MS). MS, as well as abnormal values in insulin sensitivity and glucose tolerance, is associated with the development of type 2 diabetes. In type 2 diabetes, the body is unable to produce enough, or to properly use, insulin. Improved insulin sensitivity reflects a better ability to process insulin.

The main finding of the current study was a significant improvement in all measures of insulin sensitivity. There was also a trend toward improvement in metabolic syndrome.

The threshold of 8 percent-the level at which a decreased BMI showed improved insulin sensitivity-was consistent with results found previously in adults.

Importantly, said first author Pamela Abrams, while the ideal goal is to achieve normal weight levels, you don`t need to be skinny to see improvements. This 8 percent reduction in BMI is achievable, and BMI is easy for primary care physicians to track."

The authors added that this study was relatively small, and that future research in larger numbers of patients is needed to reveal longer-term results, and to investigate further effects on adolescent metabolism and health.

The findings appeared online last month in The Journal of Pediatrics.

Jun 06
People need to get less emotional about antibiotics
People need to talk about excessive use of antibiotics without getting emotional or mixing politics into the discussion, Ada Yonath, who won the 2009 Nobel Prize in Chemistry, said.

"Perhaps we committed errors in using antibiotics for treating viral diseases ... but we learned that that does not work. We learned a bunch of things ... so it is incorrect to say we are abusing antibiotics," Yonath said.

Yonath is one of the scientists participating in the 3rd World Summit on Evolution on Ecuador`s Galapagos Islands.

The summit, which ends Thursday, is taking place in Puerto Baquerizo Moreno, where leading scientists are discussing evolution, genomics, microorganisms and diseases, among other topics.

Yonath said antibiotics were extremely useful, but she criticized the "political" use of the issue.

The use of antibiotics to fight bacterial infections has allowed average life expectancies to rise from 40 or 50 years to double that in just a few decades, Yonath said.

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