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May 04
Study claims genetic switches can increase lifespan
Recently discovered genetic switches that increase lifespan and boost fitness in worms are now being linked to increased lifespan in mammals and are offering hope that drugs to flip these switches could improve human metabolic function.

These so-called epigenetic switches are enzymes that are ramped up after mild stress during early development and continue to affect the expression of genes throughout the animal's life.

When the researchers looked at strains of inbred mice that have radically different lifespans, those with the longest lifespans had significantly higher expression of these enzymes than did the short-lived mice.

Researcher Andrew Dillin said that two of the enzymes they discovered are highly, highly correlated with lifespan; it is the biggest genetic correlation that has ever been found for lifespan in mice, and they're both naturally occurring variants.

He added that based on what they see in worms, boosting these enzymes could reprogram a person's metabolism to create better health, with a possible side effect of altering lifespan.

These are the first epigenetic modifiers known to affect metabolic function and longevity though others are known to affect either metabolism or lifespan.

The study appears in the Journal Cell.

May 03
Smoking inside home makes kids ill
Children who live with a smoker or have exposure to tobacco smoke inside the home become frequently ill and are more likely to have pediatric health care visits, including sick care, say researchers.

"Our findings indicate that tobacco smoke exposure has a significant impact on demand for health care services," said lead study author Ashley Merianos from University of Cincinnati.

The team analysed 2011-2012 data from the National Survey on Children's Health and looked at newborn to 17-years-old children, living with smokers compared with those who not exposed to tobacco smoke at home.

The results revealed a total of 24 percent of the children lived with smokers.

Children who live with smokers end up in the doctor's office or hospital more often than those not exposed to tobacco smoke.

"Pediatric emergency departments could serve as effective outlets for health messages to inform caregivers about the dangers of smoking around children and help decrease these potentially preventable tobacco smoke exposure-related visits and associated costs," Merianos added.

The study was presented at the Pediatric Academic Societies 2016 meeting in Baltimore recently.

May 02
One minute of intense exercise can help you stay fit!
Everyone wants to shed those extra kilos but it is not an easy task and one often gets tired thinking about the work out.

Well, science have good news for all those who wants to lose weight as they can be fit and make a difference by doing intense exercise for 60 seconds.

According to researchers at McMaster University, doing intense exercise for one minute produces health benefits similar to longer, traditional endurance training.

"This is a very time-efficient workout strategy," says lead author Martin Gibala. "Brief bursts of intense exercise are remarkably effective."

Scientists set out to determine how sprint interval training (SIT) compared to moderate-intensity continuous training (MICT), as recommended in public health guidelines. They examined key health indicators including cardiorespiratory fitness and insulin sensitivity, a measure of how the body regulates blood sugar.

"Most people cite 'lack of time' as the main reason for not being active", according to Gibala. "Our study shows that an interval-based approach can be more efficient, you can get health and fitness benefits comparable to the traditional approach, in less time."

The findings are published online in the journal PLOS ONE.

Apr 30
Peppermint tea boosts memory in adults!
A new study suggests that drinking peppermint tea can improve long-term and working memory in healthy adults.

For the research, the team randomly allocated a total of 180 participants to take a drink of peppermint tea, chamomile tea or hot water.

They found that participants who took peppermint tea showed significant improvement in long term memory, working memory and alertness.

However, participants who took chamomile tea exhibited slowed memory and attention speed compared to both who took peppermint and hot water.

"It's interesting to see the contrasting effects on mood and cognition of the two different herbal teas. The enhancing and arousing effects of peppermint and the calming/sedative effects of chamomile observed in this study are in keeping with the claimed properties of these herbs and suggest beneficial effects can be drawn from their use," said Mark Moss, researcher at Northumbria University in Britain.

Before the participants consumed their drink they completed questionnaires relating to their mood.

After a twenty minute rest the participants completed tests that assessed their memory and a range of other cognitive functions.

The findings have been presented recently at the British Psychological Society's Annual Conference in Nottingham.

Apr 29
Sniffing rosemary helps improve brain power of old people
Do you think sniffing rosemary is beneficial for us?

Well, a new study have shown that sniffing the aroma of rosemary could be beneficial for elderly people as it can help improve the brain power.

Researcher Lauren Bussey of Northumbria University said that during the study, they focused on the prospective memory that involves the ability to remember to complete tasks at particular times and also to remember events that will occur in the future.

Around 150 people aged over 65 took part in the study and were randomly allocated to either the rosemary or lavender-scented room or to another room with no scent.

Before the participants entered the testing room, rosemary and lavender essential oil were diffused in the room by placing four drops on an aroma stream fan diffuser and switching this on five minutes.

Once in the room, they undertook tests designed to assess their prospective memory functions. These included remembering to pass on a message at a given time during the procedure, and switching tasks when a specific event occurred. These tasks represent the two components of prospective memory: time-based and event-based.

Participants also completed mood assessment before and after undertaking tests in the scented or non-scented rooms.

Analysis of the results showed that the rosemary aroma significantly enhanced prospective memory compared to the room with no aroma. In terms of mood, rosemary significantly increased alertness and lavender significantly increased calmness and contentedness compared to the no aroma control condition

Bussey noted that further investigation is required to understand the potential benefits of these aromas throughout the life span.

The study has been presented at the British Psychological Society's Annual Conference in Nottingham.

Apr 27
Combined dietary supplement likely to help fight heart disease
A new study was found by a team of researchers, including an Indian-origin scientist which suggests that combining a marine fish oil, cocoa extract and phytosterols into a dietary supplement may cut down the risk of developing heart disease.

The researchers examined that the potential of combining dietary supplement as a means of preventing atherosclerosis or 'furring' of the arteries.

Dipak Ramji from Cardiff University in Britain, one of the researchers said that a variety of active food ingredients have been shown to impart beneficial effects on cardiovascular disease although little is known regarding their actions when taken in combination.

The findingd showed that in cell-based models, combining the three ingredients could, potentially, help halt the key processes associated with the progression of atherosclerosis.

It was published in the journal PLOS ONE.

Using a series of cell-based experimental models, the team examined what happens when omega-3 polyunsaturated fatty acids (found in marine fish oil), flavanols (found in cocoa) and phytosterols are combined.

"The challenge now is to take our findings and examine whether they translate into humans," researchers suggested.

Atherosclerosis is the major cause of heart disease, killing approximately one individual every 34 seconds and responsible for around a third of all deaths worldwide.

Current therapies against atherosclerosis are not fully effective and there have been numerous recent disappointments on promising agents that have been identified through various drug discovery programs.

Apr 25
Novel method to track autism in boys identified
Researchers have developed a new method to map and track the function of brain circuits affected by autism spectrum disorder (ASD), especially in boys and identify the most effective treatment for an individual.

The functional biomarker physically measures the progress of patients with behavioural problems -- a tool that has been elusive in autism treatment.

"This is significant because biomarkers give us a 'why' for understanding autism in boys that we haven't had before," said one of the researchers Kevin Pelphrey, professor and director of the Autism and Neurodevelopmental Disorders Institute at the George Washington University in the US.

The team found that the brain scan data could be an effective indicator of the function of the circuit in younger children and older patients alike.

It is particularly relevant for ASD patients who are difficult to diagnose and treat by providing a more definitive diagnosis and in developing a treatment programme when it is not clear if behavioural, drug or a combination of the treatments will be most effective.

"The behavioural symptoms of ASD are so complex and varied it is difficult to determine whether a new treatment is effective, especially within a realistic time frame," said led author Malin Bjornsdotter, assistant professor at the University of Gothenburg in Sweden.

"Brain function markers may provide the specific and objective measures required to bridge this gap," she added in the paper published in the journal JAMA Psychiatry.

In addition, the study also provides evidence that brain imaging is an important intervention tool for autism than the currently used functional MRI.

The team analysed a series of 164 images from each of 114 individuals and discovered the brain scans of the social perception circuits only indicated ASD in boys.

As the method only works for boys with autism, the researchers are leading a large-scale, nationwide study of girls with autism to identify equivalent techniques that will work for them.

Apr 20
Blocking a hormone may help treat type 1 diabetes: Study
Blocking the hormone that raises sugar levels in the blood could increase insulin levels while keeping blood sugar levels down, which may help treat type 1 diabetes, a new study has found.

The findings point to a novel way to treat diabetes - but only in some patients, researchers said.

"Inhibiting the hormone glucagon has recently been explored as an alternative or supplement to insulin injection, but it has limitations," said Pedro Herrera from the University of Geneva.

"Our research reveals why - the body needs to have some residual insulin production in order for a treatment blocking glucagon to work," said Herrera.

Other recent studies have suggested that diabetes is caused solely by an excess of glucagon rather than a deficiency of insulin. These studies found that blocking glucagon prevents excessively high blood glucose levels, despite a complete lack of insulin.

They suggested that blocking glucagon rather than regularly injecting insulin could be a treatment for hyperglycemia. However, the current findings indicate that the models used were not totally lacking in insulin and that just blocking glucagon was only effective if some insulin was still being produced.

For the new research, scientists used transgenic mice in which insulin could be more efficiently eliminated. These mice became severely diabetic.

Around three quarters of patients with type 1 diabetes possess a small number of the beta cells needed to produce insulin. In these patients, blocking glucagon, in addition to insulin replacement, could help keep blood sugar levels in check.

It could also result in some glucagon-producing alpha cells converting into beta cells and producing more insulin.

Sugar accumulates in the blood after a meal, triggering the release of insulin from the pancreas to allow tissues to use and store it. During fasting or exercising, glucagon is released and opposes the action of insulin, researchers said.

The balance between the two pancreatic hormones keeps blood sugar levels steady, they said. Using insulin therapy and blocking glucagon as a combined treatment could in some cases provide a more effective and safer way to maintain a healthy balance and avoid the peaks and troughs of blood sugar levels, researchers said.
The findings were published in the journal eLife.

Apr 19
Waist not weight puts you at greater liver disease risk
Washington: When it comes to non-alcoholic fatty liver disease complications, it is waist that matters, not the weight, according to a recent study.

The study demonstrated that a build-up of fat around the waist can cause more serious complications than obesity in the development of non-alcoholic fatty liver disease (NAFLD).

While NAFLD is commonly associated with obesity, research has highlighted that a percentage of patients are not actually obese, said lead author Dr Rosa Lombardi from the University of Milan.

Lombardi added that this is the first study to show that patients with lean-NAFLD who have increased levels of waist fat can in fact be at greater risk than obese patients with NAFLD.

The researchers in the Italian study evaluated the features of lean-NAFLD in 323 patients with biopsy-proven NAFLD. Subjects were divided according to BMI, waist circumference and abdominal fat.

The research also suggested that metabolic, cardiovascular and tissue complications caused by NAFLD can be more effectively detected by combining Body Mass Index (BMI) and waist measurements.

Professor Frank Tacke, EASL Governing Board Member, said that the results have highlighted the need for additional research into why analysing someone's waist, and not just their weight, is important in detecting individuals at risk for complications associated with this disease.

The study was presented at The International Liver CongressTM 2016 in Barcelona, Spain

Apr 18
Cartilage protein may lead to breast cancer development
Swedish researchers have identified a protein commonly found in connective tissue that contributes to the development as well as spread of breast cancer.

Cartilage Oligomeric Matrix Protein (COMP) is a protein that has been found in cartilage -- a connective tissue found in many areas of the body including joints between bones of elbows, knees and ankles.

"We did not expect to find COMP in connection with breast cancer, and we were also surprised by the strong effect it had on the development of breast cancer in mice," said Emelie Englund, researcher at Lund University in Sweden.

The findings revealed that women, who had higher levels of COMP, experienced an increase in the spread of breast cancer, to the surrounding tissues and also showed an increase in the mortality rate.

COMP not only contributed to a more rapid growth of the primary tumour, but also to the formation of metastases.

Further, COMP affects the cell metabolism and makes the breast environment less favourable to healthy cells.

It makes the cancer cells more resistant to natural cell death.

"We saw a clear association between high levels of COMP and a worse breast cancer prognosis", explained Anna Blom, professor, in the paper published in the journal Oncogene.

Various amounts of COMP were found in both the tumours and the surrounding tissue, but never in healthy breast tissue.

With more research, COMP has the potential of becoming an indicator of aggressive breast cancer, and thereby providing early and valuable information before deciding on an appropriate treatment, the researchers indicated.

The results are based on a clinical study of breast tissue from a little more than 600 women with breast cancer.

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