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Oct 16
Weight loss surgery tied to increase in drinking
People who had weight loss surgery reported greater alcohol use two years after their procedures than in the weeks beforehand, in a new study.

"This is perhaps a risk. I don't think it should deter people from having surgery, but you should be cautious to monitor (alcohol use) after surgery," Alexis Conason, who worked on the study at the New York Obesity Nutrition Research Center at St. Luke's-Roosevelt Hospital Center, told Reuters Health.

Researchers said it's possible some patients may turn to drinking if surgery successfully stops their ability to overeat without addressing their underlying issues. Or, the effects of certain types of stomach-shrinking procedures on alcohol tolerance may influence drinking habits.

Still, the new study can't show whether people were drinking in a dangerous way - and there was no clear increase in drug use or smoking after surgery.

"This does not mean that everyone who has gastric bypass surgery has problems with alcohol or becomes an alcoholic," said Conason.

Her team's study involved 155 people getting gastric bypass or gastric banding surgery, mostly women. Participants started the study with an average body mass index, or BMI, of 46 - equivalent to a five-foot, six-inch person who weighs 285 pounds.

Surgery is typically recommended for people with a BMI of at least 40, or at least 35 if they also have health problems such as diabetes or severe sleep apnea.

Alcohol use dropped immediately following surgery, from 61 percent of people who initially reported drinking to 20 percent at one month post-surgery.

But by three months, drinking rates had started to creep back up. And at two years out, people were drinking significantly more often than before their procedures, according to findings published Monday in the Archives of Surgery.

That was primarily the case for those who had gastric bypass surgery, not banding. On a scale from 0 to 10 of drinking frequency, where 0 represented never, 5 was sometimes and 10 always, gastric bypass patients reported an increase from 1.86 before surgery to 3.08 two years later.

CHANGES IN TOLERANCE

Conason said gastric bypass, in particular, has been shown to drastically lower alcohol tolerance - to the point that some post-surgery patients have a blood alcohol content above the legal driving limit after just one drink. For some, that could make drinking more appealing, she added.

The new findings are "proving more support for the idea that we really need to talk to patients about alcohol use, especially those undergoing (gastric bypass)," said Wendy King, an epidemiologist and weight loss surgery researcher at the University of Pittsburgh, who wasn't part of the study team.

According to the American Society for Metabolic and Bariatric Surgery, about 200,000 people have weight loss surgery every year. The procedures cost about $20,000 each.

Although some researchers have questioned the long-term benefits of surgery, one recent study found three-quarters of people who'd undergone gastric bypass had lost and kept off at least 20 percent of their initial pre-surgery weight six years later (see Reuters Health story of September 18, 2012).

One limitation of the new study is that only one-quarter of the initial participants were still in touch to report their current alcohol and drug use at the two-year mark - so the researchers don't know how everyone else fared.

Psychiatrist Dr. James Mitchell, who has studied alcohol use after weight loss surgery at the University of North Dakota School of Medicine and Health Sciences in Grand Forks, said there's also a need for research going out more than two years - to see if alcohol use keeps increasing.

Researchers said people who've had weight loss surgery should talk with their doctors soon if they notice themselves wanting to drink more.

"The health risks of obesity are such that people with severe obesity should not forgo bariatric surgery because of this," Mitchell, who was not involved in the new study, told Reuters Health.

But he said everyone should be warned about this possibility - and people with a history of alcohol abuse should be particularly careful.

"I don't have the impression (doctors) are talking a tremendous amount about these things," Conason said. "I think we should be. I think we should be educating patients about all the potential risks and benefits."

Oct 16
Pregnant women who sleep on their back risk stillbirth
Pregnant women who sleep on their back may increase the risk of miscarriage or stillbirth, a five-year Australian study has found.

The research titled the "Sydney Stillbirth Study" looked at pregnancies of 295 women from eight hospitals around Australia, the Daily Mail reported.


The study found that women who sleep on their back are six times more likely to have a stillborn baby.

A stillborn baby is a baby born dead after 24 weeks of pregnancy. If the baby dies before 24 completed weeks, it is known as a late miscarriage.

Lead researcher Adrienne Gordon, from Sydney`s Royal Prince Alfred Hospital, said previous research suggested prolonged periods of lying in this position restricted blood flow to the baby.

It is believed that sleeping on the right side or on the back reduces blood flow through a major vein from the legs to the heart, which affects the supply to the womb, the study said.

However, the researchers said it was important that women who are currently pregnant "don`t become alarmed if they sometimes sleep on their back".

Experts said three-quarters of pregnant women sleep mostly on the left side.

The daily said this may suggest they instinctively choose a sleeping position that works best for the baby.

In almost half of stillbirths, the direct cause of the baby`s death cannot be established.

Ten percent of stillborn babies have some kind of abnormality and other possible causes include problems with the mother`s health or problems with the placenta, which links the baby`s blood supply to that of the mother.

Stillbirth Foundation Australia, which funded the study, said the research was unique as it looked exclusively at women who were more than 32 weeks pregnant.

In 2011, a University of Auckland study found that mothers who slept on their back or right-hand side on the night before giving birth were twice as likely to have a stillborn child compared to those who slept on their left.

Oct 15
New Test Helps Diagnose Alzheimer's Disease
Doctors at Baylor Irving hope new technology can pave the way for earlier detection of Alzheimer's disease.

Select patients' brains can be scanned for amyloid plaque, which is associated with the neurological disorder. Previously, it could only be detected during autopsies.

"This is the first biomarker we have for determining if amyloid plaque is present in the brain," radiologist Dr. Michael Stewart said.

Doctors inject patients with a radioactive substance called Amyvid and can scan for the specific type of plaque.

"The test by itself is not enough to make a diagnosis, but the test plus your physical exam and your memory testing can diagnose Alzheimer's earlier," neurologist Dr. Karen Bontia said.

Patients can then seek treatment options as soon as possible.

Because the process is so selective, doctors at Baylor Irving have only tested a couple of patients since the test became available in June.

Each test using costs around $5,000.

Bontia said the technology also will allow doctors to gather more data for future developments.

Doctors say their primary focus is to slow the development of Alzheimer's disease and to diagnose it as early as possible.

One out of eight adults who are 65 years old will develop Alzheimer's disease. This year, 78 million baby boomers will be 65 years old.

Lee and Pat Sneller, who celebrated their 48th wedding anniversary on Sept. 5, have been fighting an uphill battle with the debilitating disease.

"Once I found out that I had Alzheimer's, I was devastated," said Lee Sneller, who was diagnosed on Feb. 6, 2009. "I mean, it was really, really hard. I didn't know what to do and how to deal with it."

More than three and a half years later, the ailment has taken its toll on him.

"He processes things so much more slowly," Pat Sneller said. "He is a smart guy. I mean, he went to Stanford, he's an engineer, he has an MBA, and he just can't process it anymore."

The couple agreed that early detection is key and said they hope others diagnosed with Alzheimer's disease can benefit from the future developments.

"If we can delay the onset of it by five years, billions of dollars can be saved -- billions in our health care," Stewart said.

Oct 15
Women's hearts 'get twice the benefit from fish oil than men's
Eating oily fish may boost women's heart health more than men's, claim researchers.

The oils - found in fish like salmon, mackerel and tuna - are known to improve chances of surviving a repeat heart attack.

But a new study suggests women could benefit more from their effect on the heart.

Researchers at the University of Reading found fish oils have a direct impact on the muscle cells that control the elasticity of our blood vessels.

In tests, women got double the benefit compared with men as elasticity improved four-fold in women compared with two-fold in men.

In fact the beneficial effect of the fish oil in women was as potent as that of drugs that are prescribed to people with poor blood vessel elasticity, such as those with diabetes.

At least 39,000 women a year in the UK suffer heart attacks and their chances of dying are higher than a man's.

Study leader Professor Christine Williams, the University's first Hugh Sinclair Professor of Nutrition and Pro Vice-Chancellor for Research and Innovation, said: 'Studies examining women's heart health are much less common than those which study men, partly because the studies are harder to carry out in women due to the varying effects of hormones during the menstrual cycle.

'In addition, many believe men are the only ones to suffer from heart disease.

'However nearly 40,000 women die of coronary heart disease each year in the UK and we do not yet know whether all the diet recommendations which we currently advise are as effective for women as for men.

'The good news here is that current recommendations that we should all eat more oily fish appears to be more effective for women than men.'

However, two thirds of Britons never eat oily fish even though official guidelines recommend its consumption at least once a week.

In the study around 60 people, half men and women, were given test drinks containing either saturated fats or a combination with omega 3 fish oils, equivalent to a 200g portion of oily fish.

Imaging was used to check the reaction of the blood cells to the different drinks, says a report in the Journal of Lipid Research.

Prof Williams said 'As well as discovering the effect of fish oils is greater in women we also found that people with a gene variation that produces the protein eNOS, which helps to increase blood flow, also benefitted more.

'Our study showed that people who carry the rarer form of the protein, which is about 10 per cent of the UK population, respond twice as well to fish oils, suggesting they would particularly benefit from additional oily fish intake.

'This research supports the view that the effects of diets vary, being more effective in certain genders and genotypes. Our study was very carefully designed to include equal numbers of men and women and also equal numbers of people with the two types of gene variants, so that the results are very unlikely to be due to chance. 'Although the responses varied, all the subjects in the study benefitted from taking fish oils with a meal.

'However, for women and those with the gene variant, the responses were very marked indeed, and when it comes to their diet could give them considerable health benefits in the future.' The work was funded by the Biotechnology and Biological Sciences Research Council.

Fish oil is known to increase the release of nitric oxide from the lining of the blood vessel wall which causes relaxation of the vessel and increases blood flow.

However the researchers found that some of the relaxation effect on the blood vessel wall may be due to direct actions of the fish oil acting on the muscle cells themselves, rather than on the cells lining the blood vessel wall.

Professor Williams added 'This is an exciting discovery which gives us a new way of looking at how our diet affects the health of our blood vessels, and possibly more effective ways of improving heart health in the future.' The best dietary source of omega 3 fatty acids is oily fish because the human body cannot produce omega-3 fatty acids.

There has been an explosion in the number of foods fortified with omega-3 oils, such as chickens, margarine, eggs, milk and bread, but they contain only small amounts.

Types of fish that contain high levels include tuna, salmon, mackerel, herring, sardines, and anchovies.

White fish is also a healthy food including cod, haddock and plaice although it contains lower levels of essential fatty acids.

Fish oil supplements are recommended as protection against repeat heart attacks, with regular fish eaters a third more likely to survive a heart attack.

Fish oil supplements are approved for prescribing on the NHS to patients after a heart attack, or who have metabolic syndrome or high triglycerides - unhealthy blood fats.

Omacor, which is licensed for post-heart attack treatment, has been shown in clinical trials to cut the risk of sudden death by up to 45 per cent.

Omega-3 fats are important throughout adult life for mental wellbeing but in particular help heart patients, and those with arthritis, by blocking the body's response to inflammation.

They work in several ways to reduce heart attack risk by cutting blood fats, reducing the chances of a blood clot and blocking dangerous heart rhythms that might otherwise prove fatal.

Oct 13
Smiley (female) face: Women are more than twice as likely to use emoticons in text messages
Women are twice as likely as men to use emoticons in text messages, according to a new study from Rice University.

The symbols, which began as happy and sad smiling faces but have since morphed into dozens of expressions, have become hugely popular in text messages and email.

The new study used smartphone data from men and women over six months and analysed 124,000 text messages.

The participants were given free iPhones to use for the test period but didn't know what researchers were investigating.

The team says the study was unique.

'We believe that our study represents the first naturalistic and longitudinal study that collects real emoticon use from text messages 'in the wild,'' said Philip Kortum, assistant professor of psychology at Rice and one of the study's authors.

Texting has become one of the most popular forms of communication in society worldwide.

This year alone, it is estimated that 8 trillion text messages will be tapped out across the world.

In the Rice study, 100 percent of the participants used emoticons, but they did not use them very often, with only 4 percent of all their sent text messages containing one or more emoticons.

'Texting does not appear to require as much socio-emotional context as other means of nonverbal communications,' Kortum said.

'It could be due to texting's simplicity and briefer communication, which removes some of the pressures that are inherent in other types of non-face-to-face communication, like email or blogs.'

The study also confirms previous research that women are more emotionally expressive in nonverbal communication; however, in this research, the authors found that while women may use emoticons more than men, the men used a larger variety of emoticons to express themselves.

Participants in the Rice study texted a wide variety of emoticons.

Seventy-four different emoticons were used, but the top three emoticons happy, sad and very happy made up 70 percent of the total emoticons sent by the study participants.

Kortum and his co-authors pointed out that their study is a glimpse into the complex nature of real mediated communications.

They said that additional inquiry in real-world settings are needed to understand the complexities of human communications through technology.

Oct 13
New machine to improve heart disease diagnosis
A new cardiac CT scan machine, which reduces radiation exposure and displays better images, has been installed at a South Delhi-based imaging centre. It is expected to improve diagnosis of coronary heart disease (CHD).

Experts at Mahajan Imaging Centre in Hauz Khas said it was India's first dual energy CT scan machine with cardiac spectral imaging capabilities. Known as the 'Discovery CT750-HD FREEdom Edition' by GE Healthcare, this machine will help doctors diagnose CHD.

CHD occurs when arteries near the heart are narrowed or blocked by deposits of fatty plaque and calcium in vessels. If left unchecked, these blockages can lead to heart attacks.

Dr Harsh Mahajan, president of Indian Radiological and Imaging Association, said, "With most CT scan machines it is difficult to see the condition of the heart vessels because calcium deposits would obscure our view. Even if we managed to see the blockage, it was difficult to identify the nature of deposit."

Dr JPS Sawhney, cardiology department chairman at Sir Ganga Ram Hospital, said, "The machine will let radiologists see if the heart tissue is living or not. It will help us take correct decisions about further course of treatment."

Oct 12
Micro Labs makes tablet to treat low sugar
Healthcare firm Micro Labs Ltd Thursday unveiled a dextrose drug Hypotab to treat low blood sugar in diabetic patients.

"Hypotab is meant for type two diabetes patients who suddenly face hypoglycaemia (low sugar) in the body and those who take insulin, which makes them prone to develop the symptom," Micro Labs vice-president B.R. Srinath told reporters here at a preview of the drug.

Priced at Rs.7 per strip of four tablets, the carbohydrate drug, to be bought only on prescription by a qualified doctor, will restore normal blood glucose levels in diabetic patients soon after it is consumed.

"Hypotab is the first standardised therapy to treat low blood sugar and manufactured using the advanced technology of AbMax Biotechnology Co Ltd in China, as it offers 20 micron particle size for faster absorption in the body and gives quick relief," said Srinath.

The city-based pharma firm has invested Rs.5.5 crore to set up the drug plant in Puducherry, with an installed capacity of one million tablets per month.

The Rs.1,646-crore company is targeting Rs.4.2 crore revenue in this fiscal (2012-13) from Hypotab, Rs.12 crore in next fiscal (2013-14) and Rs.24 crore in 2014-15, as the market for treating low sugar remains untapped.

According to a company study, of the Rs.3,800-crore diabetic care market across the country, oral hypoglycaemic agents like candies, sugar cubes, honey, etc., account for Rs.2,800 crore.

"Of the estimated 62 million diabetic patients in India, 25 percent of them are prone to suffer low sugar due to various factors, including stress, lack of discipline in maintaining diet, timely intake of food, obesity and lack of exercise," observed noted diabetologist Vijay Viswanathan.

Oct 12
Online test to check your eye power
Now you can undergo an eye test from the comfort of your home. Titan Eye Plus has launched Vision Check, a new online facility where you need to spend just five minutes to undergo a self-administered vision test to find out whether you need spectacles or whether the power of your current one is adequate.

Though it cannot be used as a substitute for a formal eye test, nor does it prescribe power, nonetheless the test detects any vision defects.

At the launch, Ravi Kant, CEO of Titan Industries eyewear division, said that roughly one third of the population in the country need vision correction and only 25-30% have taken the necessary steps. Others are ignoring and living with the problem and many are not even aware of it. Through Vision Check facility, we are making eye tests accessible to them, he added.

Titan Industries MD Bhaskar Bhat said vision check tests in vernacular languages would be launched at a later stage.

Oct 11
UC Irvine opens clinical trial of novel treatment for brain cancer
"Our goal is to train the immune system to recognize and attack the cancer," said Dr. Daniela Bota, neuro-oncologist and co-director of UC Irvine's Comprehensive Brain Tumor Program. She will lead the Phase II trial at UC Irvine of DCVax, which was associated with increased survival in a previous study. The vaccine is prepared in a lab and combines protein antigens extracted from the patient's tumor with some of his or her white blood cells. These grow into dendritic cells that, when injected back into the patient, target the protein antigens and prompt the immune system's T cells to identify and attack remaining cancer cells. "Cancer cells are like crabgrass: Once they take root, they're hard to eradicate, even after brain surgery," Bota said. The current treatment for patients with glioblastoma multiforme involves surgery to remove as much of the tumor as possible, followed by radiation and chemotherapy. "The standard of care prolongs survival, but it does not fully destroy the cancer," Bota said. She believes the vaccine can help eliminate remaining tumor cells and further extend patients' lives. Only 10 percent of the 12,000 to 14,000 people annually found to have glioblastoma multiforme survive five years. Patients 18 to 70 newly diagnosed with this brain tumor (also called grade IV astrocytoma) may be eligible to enroll in the trial.

Oct 11
Eating lunch at your desk could increase your risk of DVT
You might often be too busy at work to take an hour-long lunch break, but working 10-hour days without a break could double your chances of deep vein thrombosis.

Almost 75 per cent of office staff aged 21-30 who work 10-hour days don't get up to take a break. This could double chances of a fatal blood clot.

As lunch breaks increasingly become a thing of the past, ten people a day on average have been dying from DVT.

There has been a rapid rise in the number of DVT victims under 40, with 94 dying in 2010 up 40 per cent from 67 in 2007 according to figures released yesterday.

According to the Office for National Statistics 3,798 people died of DVT in 2010.

Spokesperson for DVT charity Lifeblood, Annya Stephens-Boal, said: 'We all do it, work long hours and grab a sandwich at our desk.

'We believe there are 60,000 DVT cases a year throughout the UK.

'The scariest part is that 80% have no signs at all, no swelling, redness or pain. We call it the silent killer.'

The best way to avoid DVT, which can kill when blood clots move to the lungs, is to keep mobile and eat a low salt, low fat diet.

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