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Sep 11
Half of all women could have sleep apnoea and stop breathing at night for 10 seconds at a time
Half of all women given overnight sleep tests for a new study were found to have mild-to-severe sleep apnoea.

Scientists in Sweden monitored the sleep patterns of 400 adult women overnight and found that half experienced at least five episodes an hour when they stopped breathing for longer than 10 seconds - the minimum definition of sleep apnoea.

Among women with hypertension or who were obese - two risk factors for sleep apnoea - the numbers were even higher, reaching 80 to 84 per cent of women.

Many of the women in the study represent mild cases of sleep apnoea.

'How important is the mild sleep apnoea, we don't know,' said Dr. Karl Franklin, the lead author of the study and a professor at Umea University in Sweden.

Terry Young, a professor in the School of Medicine and Public Health at the University of Wisconsin, said mild sleep apnoea is important to pay attention to.

'We see that it doesn't go away and it gets worse,' she said.

Sleep apnoea is tied to a higher risk of stroke, heart attack and early death.

One recent study also found that women who have sleep apnoea are more likely to develop memory problems and dementia.

Franklin said his group wanted to get updated evidence of how common the condition is.

The researchers selected 400 women between the ages of 20 and 70 from a larger population sample of 10,000, and asked them to sleep overnight at home with sensors attached to their bodies.

The sensors measured heart rate, eye and leg movements, blood oxygen levels, air flow and brain waves.

Each apnoea event was defined by at a least a 10-second pause in breathing accompanied by a drop in blood oxygen levels.

Women who had an average of five or more of these events during each hour of sleep were considered to have sleep apnoea.

The study, which was funded by the Swedish Heart Lung Foundation, found that apnoea became more common in the older age groups.

Among women aged 20-44, one quarter had sleep apnoea, compared to 56 percent of women aged 45-54 and 75 per cent of women aged 55-70.

Young said these numbers are higher than her own estimate, but that's likely because she used a more strict definition of sleep apnea than Franklin's group.

Franklin also said his equipment, being newer, is more sensitive in detecting interruptions in breathing.

Severe sleep apnoea, which involves more than 30 breathing disruptions per hour, was far less common.

Just 4.6 per cent of women 45-54 and 14 per cent of women 55-70 had severe cases.

Among women of all ages with hypertension, 14 per cent had severe sleep apnoea, and among women who were obese, 19 per cent had severe apnoea.

Franklin said that if physicians are looking for sleep apnoea among women, examining those who are obese, over 55 or have hypertension is a good place to start.

Young said sleep apnoea is often thought of as a condition of men, but identifying women with it is especially beneficial, because her research has shown that women are good at sticking with treatment.

'The prejudice of excluding women (as potentially having sleep apnoea) has been rampant for a long time. It's gotten better, however, and the (public health) gain in identifying women with sleep apnoea is great,' she said.

Sep 10
Breastfeeding in infancy can protect adults from depression
People who were breast-fed as infants may have a lower risk of depression in adulthood, a new study has claimed.

German researchers looked at 52 people, whose average age was 44, who were being treated for major depression at an inpatient facility, and compared them with 106 healthy people who had never been diagnosed with depression.

Participants were considered to have been breast-fed if either they or their mothers said they had nursed for at least two weeks, MyHealthNewsDaily reported.

Results showed that 73 per cent of those without depression had been breast-fed, whereas 46 per cent of people with depression were breast-fed.

The association held when researchers took into account factors that could affect participants' risk of depression, such as age, gender and mother's level of education.

Additionally, the researchers found that how long a person had been breast-fed did not matter in terms of their depression risk.

While the finding suggests a link, it does not suggest a cause-and-effect relationship between breast-feeding and depression, the researchers said.

Breast-feeding could indicate the general quality of the mother-infant relationship, and other aspects of this relationship could be protective against depression, the researchers said.

They also suggested that breast-feeding could increase the behaviours in mothers that have been linked with the hormone oxytocin. Such behaviors are believed to protect against stress.

It could also be that components of breast milk promote brain development in a way that helps prevent depression, they said.

The study was published in the journal Psychotherapy and Psychosomatics.

Sep 10
Sleep disruption may be the earliest sign of Alzheimer's, scientists say
Sleep disruption may be the earliest sign of Alzheimer's, scientists say.

Clumps of sticky protein forming in the brain, called plaques, are thought to be a key feature of the disease.

Researchers found when the first signs of these plaques appeared in the brains of mice their sleep/wake cycle was significantly disrupted.

This could provide an easily detectable early warning sign, according to the study in Science Translational Medicine.

Author Dr David Holtzman, from Washington University said: 'If sleep abnormalities begin this early in the course of human Alzheimer's disease, those changes could provide us with an easily detectable sign of pathology.

'As we start to treat Alzheimer's patients before the onset of dementia, the presence or absence of sleep problems may be a rapid indicator of whether the new treatments are succeeding.'

Dr Holtzman's lab has previously shown that levels of a main 'ingredient' of the plaques - amyloid beta - rise when healthy mice are awake and drop when they are asleep. The same was later found to be true in humans.

The new research showed that when the first indicators of brain plaques appear, the natural fluctuations in amyloid beta levels stop in both mice and humans.

Dr Holtzman said: 'We suspect that the plaques are pulling in amyloid beta, removing it from the processes that would normally clear it from the brain.'

With mice, this meant that their sleep dropped from an average 40 minutes per hour of daylight to 30 minutes once plaques began to form.

To confirm that amyloid beta was directly linked to the changes in sleep, researchers gave a vaccine against amyloid beta to a new group of mice.

As these mice grew older, they did not develop brain plaques and their sleeping patterns remained normal while amyloid beta levels in the brain continued to rise and fall regularly.

Scientists now are evaluating whether sleep problems occur in patients who have markers of Alzheimer's disease, such as plaques in the brain, but have not yet developed memory or other cognitive problems.

Dr Holtzman said: 'If these sleep problems exist, we don't yet know exactly what form they take-reduced sleep overall or trouble staying asleep or something else entirely.

'But we're working to find out.'

Dr Marie Janson of Alzheimer's Research UK said: 'There has already been research linking changes in sleep patterns to a decline in thinking skills, but these results suggest that disrupted sleep may also be a warning sign of Alzheimer's.

'Changes to sleeping patterns can occur for many reasons and are very common in the elderly. If research confirms specific sleep changes as a possible early marker of Alzheimer's, it could prove a useful strategy for doctors to identify patients at risk of the disease.

'It's thought that any new treatments for Alzheimer's will need to be given as early as possible, so detecting the disease early is crucial allowing potential new drugs to be trialled in the right people at the right time.'

Half a million people are affected by Alzheimer's in the UK, which is the most common form of dementia. It is a progressive condition and 98 per cent of cases are detected in patients aged over 65.

Sep 08
Marriage the new miracle cure for cancer: Study
Being married helps patients with lung cancer live significantly longer than if they were single, according to a new research.

Similar benefit has been seen in other cancers, including those of the prostate, and head and neck, the independent reported.

A study of 168 patients with advanced lung cancer who were treated with chemotherapy and radiation over a decade from 2000 to 2010 found a third of those who were married were still alive after three years compared with 10 per cent of those who were single.

Previous research has shown marriage benefits men more than women, but among these survivors it was women who fared best. Almost half (46 per cent) lived for at least three years if they were married, compared with just 3 per cent of single men.

Cancer patients need support with daily activities, with proper follow up care and help travelling to and from hospital for appointments.

The researchers from the University of Maryland said this was the likely explanation of why married patients did better.
"Marital status appears to be an important independent predictor of survival in patients with locally advanced non-small cell lung cancer. The reason for this is unclear, but our findings suggest the importance of social support in managing and treating our lung cancer patients," the paper quoted Elizabeth Nichols, a radiation oncology who led the study, as saying.

"We believe that better supportive care and support mechanisms for cancer patients can have a greater impact on increasing survival than many new cancer therapy techniques.

"Not only do we need to continue to focus on finding new drugs and cancer therapies, but also on ways to better support our cancer patients," she added.

The researchers presented their findings at the 2012 Symposium on Thoracic Oncology in Chicago.

Sep 08
Bad sleep may predict Alzheimer's, says study
Problems sleeping may be an early sign of Alzheimer's if a study in mice also applies to people, say researchers.

Clumps of protein, called plaques, in the brain are thought to be a key component of the illness.

A study, published in the journal Science Translational Medicine, showed that when plaques first developed, the mice started having disrupted sleep.

Alzheimer's Research UK argued that if the link was proven it could become a useful tool for doctors.

The hunt for early hints that someone is developing Alzheimer's is thought to be crucial for treating the disease.

People do not show problems with their memory or clarity of thought until very late on in the disease. At this point, parts of the brain will have been destroyed, meaning treatment will be very difficult or maybe even impossible.
'Detectable sign'

It is why researchers want to start early, years before the first symptoms.

One large area of research is in plaques of beta amyloid which form on the brain.

Levels of the beta amyloid protein naturally rise and fall over 24 hours in both mice and people. However, the protein forms permanent plaques in Alzheimer's disease.

Experiments at Washington University showed that nocturnal mice slept for 40 minutes during every hour of daylight. However, as soon brain plaques started to form the mice were sleeping for only 30 minutes.

One of the researchers, Prof David Holtzman, said: "If sleep abnormalities begin this early in the course of human Alzheimer's disease, those changes could provide us with an easily detectable sign of [the disease]."

"If these sleep problems exist, we don't yet know exactly what form they take, reduced sleep overall or trouble staying asleep or something else entirely."

However, findings in mice do not always apply to people as there are many reasons for disrupted sleep.

Dr Marie Janson, from the charity Alzheimer's Research UK, called for more studies in people to see if there was a link between sleeping patterns and Alzheimer's.

She added: "There has already been research linking changes in sleep patterns to a decline in thinking skills, but these results suggest that disrupted sleep may also be a warning sign of Alzheimer's.

"If research confirms specific sleep changes as a possible early marker of Alzheimer's, it could prove a useful strategy for doctors to identify patients at risk of the disease."

Sep 07
Green tea isn't just good for your heart, it's good for your brain too
Sipping green tea is not just good for you heart - it could boost the memory as well, say researchers.

A study from China found that the chemical properties of the healthy beverage promotes the generation of brain cells, providing benefits for memory and spatial learning.

Study leader Professor Yun Bai from the Third Military Medical University, Chongqing, China, said: 'There has been plenty of scientific attention on its use in helping prevent cardiovascular diseases, but now there is emerging evidence that its chemical properties may impact cellular mechanisms in the brain.'

Professor Bai's team focused on the organic chemical EGCG that is found in green tea.

'We proposed that EGCG can improve cognitive function by impacting the generation of neuron cells, a process known as neurogenesis,' said Prof Bai.

'We focused our research on the hippocampus, the part of the brain which processes information from short-term to long-term memory.'

The team found that ECGC boosts the production of neural progenitor cells, which like stem cells can adapt into various types of cells. The team then used laboratory mice to discover if this increased cell production gave an advantage to memory or spatial learning.

'We ran tests on two groups of mice, one which had imbibed ECGC and a control group,' said Prof Bai.

'First the mice were trained for three days to find a visible platform in their maze. Then they were trained for seven days to find a hidden platform.'

The team found that the ECGC treated mice required less time to find the hidden platform. Overall the results revealed that EGCG enhances learning and memory by improving object recognition and spatial memory.

'We have shown that the organic chemical EGCG acts directly to increase the production of neural progenitor cells, both in glass tests and in mice,' concluded Prof Bai.

'This helps us to understand the potential for EGCG, and green tea which contains it, to help combat degenerative diseases and memory loss.'

The research is published in Molecular Nutrition & Food Research.

Sep 07
Two-minute workouts as good as 90 minute run
It may sound like a couch potato's dream, but two-and-a-half minutes of exercise could be just as good as a 90-minute run, a study has revealed.

Research suggests that short, sharp bursts of exercise are better at warding off heart disease than much longer but less strenuous sessions, the Daily Mail reported.

Academic Stuart Gray asked a group of men aged between 18 and 35 to either do high-intensity sprints on an exercise bike, or walk for half an hour on a treadmill.

Those on the exercise bike pedalled as hard as they could for 30 seconds, rested for up to four minutes and then repeated the pattern four times.

This meant that, in all, they did two and a half minutes of exercise strenuous enough to make them sweat and leave them out of breath

The others walked at the sort of brisk pace recommended in government health guidelines.

A day later, they came back into the lab and ate a fatty breakfast and lunch consisting of bread, mayonnaise and cheese

Their blood was then tested to see how quickly the levels of fat in their blood fell as fat lingering in the blood after eating is known to trigger the first in a series of steps that can lead to clogging of the arteries and heart disease.

The results revealed that walking cut fat by 11%, compared with not doing any exercise.

But the short sharp bursts of exercise cut it by 33% the sort of effect expected from a 90-minute run.

Dr Gray, of Aberdeen University, told the British Science Festival in the city that short bursts of intensive exercise may somehow spur the liver into taking in more fat from the blood, before storing it or burning it off.

He said that, while the high intensity training "won't necessarily" improve strength, it does boost endurance.

He added that the short duration of the exercise was "highly important as time is often cited as the main barrier to taking part in exercise."

Sep 06
The secret of beating fear? Just talk about your emotions, say researchers
Simply describing your feelings at stressful times can make you less anxious, researchers have claimed.

UCLA research into people who were terrified of spiders found that by simply talking about their fear, they were able to deal with it - and even touch a tarantula.

The psychologists asked 88 people with a fear of spiders to approach a large, live tarantula in an open container outdoors.

The participants were told to walk closer and closer to the spider and eventually touch it if they could.

The subjects were then divided into four groups and sat in front of another tarantula in a container in an indoor setting.

In the first group, the subjects were asked to describe the emotions they were experiencing and to label their reactions to the tarantula - saying, for example, 'I'm anxious and frightened by the ugly, terrifying spider.'

'This is unique because it differs from typical procedures in which the goal is to have people think differently about the experience - to change their emotional experience or change the way they think about it so that it doesn't make them anxious,' said Michelle Craske, a professor of psychology at UCLA and the senior author of the study.

'Here, there was no attempt to change their experience, just to state what they were experiencing.'

In a second group, the subjects used more neutral terms that did not convey their fear or disgust and were aimed at making the experience seem less threatening.

They might say, for example, 'That little spider can't hurt me; I'm not afraid of it.'

'This is the usual approach for helping individuals to confront the things they fear,' Craske said.

In a third group, the subjects said something irrelevant to the experience, and in a fourth group, the subjects did not say anything - they were simply exposed to the spider.

'All the participants were re-tested in the outdoor setting one week later and were again asked to get closer and closer to the tarantula and potentially touch it with a finger.

The researchers measured how close subjects could get to the spider, how distressed they were and what their physiological responses were, focusing in particular on how much the subjects' hands sweated, which is a good measure of fear, Craske said.

The researchers found that the first group did far better than the other three.

These people were able to get closer to the tarantula - much closer than those in the third group and somewhat closer than those in the other two groups - and their hands were sweating significantly less than the participants in all of the other groups.

The results are published in the online edition of the journal Psychological Science and will appear in an upcoming print edition.

'They got closer and they were less emotionally aroused,' Craske said.

'The differences were significant.

'The results are even more significant given the limited amount of time involved.

'With a fuller treatment, the effects may be even larger.

'Exposure is potent,' she added. 'It's surprising that this minimal intervention action had a significant effect over exposure alone.'

'If you're having less of a threat response, which is indicated by less sweat, that would allow you to get closer; you have less of a fear response,' said study co-author Matthew Lieberman, a UCLA professor of psychology and of psychiatry and biobehavioral sciences.

'When spider-phobics say, 'I'm terrified of that nasty spider,' they're not learning something new; that's exactly what they were feeling - but now instead of just feeling it, they're saying it. For some reason that we don't fully understand, that transition is enough to make a difference.'

The scientists also analyzed the words the subjects used.

'Those who used a larger number of negative words did better, in terms of both how close they were willing to get to the tarantula and their skin-sweat response.

'In other words, describing the tarantula as terrifying actually proved beneficial in ultimately reducing the fear of it.'

Sep 06
Just one abortion could lead to women giving birth prematurely later in life
Having just one abortion could raise the risk of potentially life-threatening problems in future pregnancies, young women were warned last night.

Those who terminate their first pregnancy could be risking not only their own health but that of their next baby, a study has found.

They are at higher risk of a range of problems, from their next child being born prematurely to pre-eclampsia, a complication of pregnancy that can be fatal to mother and baby.

Crucially, just one abortion appeared to be enough to do the damage, with subsequent terminations not being any more dangerous.

This differs from previous studies that found the risks rise with each abortion.

Most of the risks were linked to surgical abortions and not those that use pills, which are becoming increasingly common.

Almost 200,000 abortions are carried out in England and Wales each year, with the highest rates among women in their late teens and early 20s. In Scotland, 40 per cent of around 13,000 abortions are carried out in the under-25s.

Abortion has been linked to premature births before but some previous studies have been small and the results have been mixed.

To build a clearer picture, researchers at Aberdeen University analysed the medical records of more than 600,000 Scottish women, including many who had aborted their first baby.

The data, spanning three decades, showed a woman who had an abortion the first time she conceived was 37 per cent more likely to give birth prematurely the next time she became pregnant, compared with one who was having her first child.

She was also 67 per cent more likely to give birth early than a woman who had already started her family.

However, the risks were still lower than those faced by a woman who had suffered a miscarriage, the British Science Festival in Aberdeen heard.

A woman who aborted her first pregnancy was also at higher risk of having a baby of low weight and of developing pre-eclampsia than one who was pregnant for the first time or already had a child.

Pre-eclampsia causes high blood pressure, blood clots and kidney damage, and leads to the deaths of up to 1,000 babies and at least six mothers a year.

Medical abortions using pills are normally used early in pregnancy and account for almost half of terminations in England and Wales, and 70 per cent in Scotland.

Researcher Professor Siladitya Bhattacharya said surgical abortions may be more likely to damage the womb, leading to later problems.

He added women seeking abortions should be made aware of the potential risks and medical terminations should be available to all who would benefit from them.

The British Pregnancy Advisory Service, which carries out almost a third of abortions in the UK, says the leaflets it gives to patients mention the link with premature birth.

But they do not say abortion is the cause because some of the reasons women choose to terminate a pregnancy such as unemployment, smoking or poor diet are also linked to early births.

However, Philippa Taylor of the Christian Medical Fellowship said: 'This study confirms many previous findings... that all show a clear link between abortion and an increased risk of a later pre-term birth.'

Sep 05
The pacemaker that can fit on a pinhead: Researchers unveil tiny implants that could revolutionise m
A wireless medical implant that could replace pacemakers with a gadget small enough to fit on the head of a pin has been shown off.

A team of engineers at Stanford has demonstrated the feasibility of a super-small, implantable cardiac device that gets its power not from batteries, but from radio waves transmitted from outside the body.

The breakthrough could lead to a plethora of new medical sensors and even 'smart pill' that can be swallowed without having to include batteries.

The implanted device is contained in a cube just eight-tenths of a millimeter in radius, and could fit on the head of pin.

It is hoped they could revolutionise medicine by allowing devices such as pacemakers to be implanted without the need for large battery packs which need surgery to replace them.

Instead, wearers would wear wireless battery packs which transmit power to the implant.

"Wireless power solves both challenges," said Ada Poon, a professor of electrical engineering at Stanford, who led the research.

Last year, Poon made headlines when she demonstrated a wirelessly powered, self-propelled device capable of swimming through the bloodstream.

The findings were published in the journal Applied Physics Letters.

Beyond the heart, they believe such devices might include swallowable endoscopes so-called "pillcams" that travel the digestive tract permanent pacemakers and precision brain stimulators; virtually any medical applications where device size and power matter.

In their paper, the researchers demonstrated wireless power transfer to a millimeter-sized device implanted five centimeters inside the chest on the surface of the heart a depth once thought out of reach for wireless power transmission.

The device works by a combination inductive and radiative transmission of power.

Both are types of electromagnetic transfer in which a transmitter sends radio waves to a coil of wire inside the body.

The radio waves produce an electrical current in the coil sufficient to operate a small device.

'For implantable medical devices, therefore, the goal is a high-frequency transmitter and a small receiver, but there is one big hurdle,' said Kim.

Existing mathematical models have held that high frequency radio waves do not penetrate far enough into human tissue, necessitating the use of low-frequency transmitters and large antennas too large to be practical for implantable devices.

However, this turned out to be untrue.

'In fact, to achieve greater power efficiency, it is actually advantageous that human tissue is a very poor electrical conductor,' said Kim.

'If it were a good conductor, it would absorb energy, create heating and prevent sufficient power from reaching the implant.'

According to their revised models, the researchers found that the maximum power transfer through human tissue occurs at about 1.7 billion cycles per second.

'In this high-frequency range, we can increase power transfer by about ten times over earlier devices.'

The discovery meant that the team could shrink the receive antenna by a factor of ten as well, to a scale that makes wireless implantable devices feasible.

At that the optimal frequency, a millimeter-radius coil is capable of harvesting more than 50 microwatts of power, well in excess of the needs of a recently demonstrated eight-microwatt pacemaker.

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