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Feb 08
Slow poison, but who cares?
Seems like smokers have thrown caution to the wind. Even the ''harsh and gory'' pictures carried on cigarette packets since December last year, have not deterred them. According to statistics by World Health Organisation (WHO) provided to Tobacco Control in India that is supported by the Ministry of Health & Welfare, Government of India, five million people die prematurely every year in the world due to the use of tobacco, mostly cigarette smoking. By 2030, it is estimated that the number of premature deaths due to tobacco consumption would double to ten million deaths every year, with about seven million deaths taking place in developing countries. Among people alive today in the world, about 500 million would die prematurely due to tobacco use and most of them are children and young adults.

Cigarette smoking kills one in two smokers prematurely and half of these deaths occur during middle age (35 to 69 years). "I really do not care about the picture on the packet.

I have been smoking for the past eight years and all these signs will definitely not affect me. I am addicted to it and cannot quit," said Duhita Jagtiani, who works with a production house. She also added, "These caution signs will help starters and not addicts." Ankit Bhattacharya, a video editor said, "All these pictures do not matter to me as I am an addict and cannot quit smoking. I don't notice these signs. These would not work for me at all."

Seema Gupta, regional director of Voluntary Health Association of India said, "These factories glamourise the packets and do not comply by the rule which state that 50 per cent of the packet on both sides should have the caution sign or the picture but our cigarette packets do not have it." She added, "The enforcement mechanism is very weak in India. Almost 2,500 people die every day due to smoking. We haven't yet seen a single mobile van on roads to challan those caught smoking."

Entrepreneur Kaushik Sen Sharma said, "These tactics by the government of India will help those who have just started smoking and not those like us who are addicted to it. I don't even see the packets, it's the cigarette which matters to me and not these caution signs or any pictorial representation." Another matter of concern is children consuming chewing tobacco, usually in the form of gutka, which is sold near schools and colleges despite the sale of tobacco products being banned within 100 yards of a school, college or hospital, under the Cigarettes and Other Tobacco Products Act, 2003.

Feb 07
Tips for acne-free skin
One should always keep his/her skin clean and clear as pimples and acne occur when the pores in your skin get clogged up with oil and dirt. Bacteria infects that pore, leading to acne.

Always try to avoid touching the face with your hands. Your hands touch surfaces like the phone, the computer keyboards, your bag, the table and basically everything around you and as a result pick up germs. Touching your face with your hands before washing them is a big no-no. Try to keep your hair off your face. Oily skin usually means oily hair. You have enough natural oil on your face. You do not need to add more oil and hair care products to your skin, which is what happens when your hair covers any part of your face.

Wash your face three times a day with a good cleanser. Try to avoid make-up, fried food and sweets as these things double your skin problem.

Stress is also a big cause for acne outbreaks. So, try to relax as much as possible and do whatever works for you to ease the stress. Your body needs sleep as this helps to keep your skin free from pimples and acne. Oily, acne prone skin needs a lot of care. The bright side is that oily skin is slower to show signs of ageing than dry skin. Take care of your skin to look younger every single day.

Feb 07
Diabetes quadruples birth defects risk, say researchers
The risk of birth defects increases four-fold if the pregnant mother has diabetes, researchers say.

The risk of defects such as congenital heart disease and spina bifida were increased.

National guidelines already recommend having good control over blood sugar levels before trying to conceive.

Both Type 1 diabetes, which tends to appear in childhood, and Type 2 diabetes, largely as a result of diet, lead to problems controlling the amount of sugar in the blood.

This is known to cause problems in pregnancy, such as birth defects, miscarriage and the baby being overweight due to too much sugar.

There is concern that rising levels of diabetes, particularly Type 2, could make the issue worse.

Researchers analysed data from 401,149 pregnancies between 1996 and 2008 - 1,677 women had diabetes.

The risk of birth defects went from 19 in every 1,000 births for women without pre-existing diabetes to 72 in every 1,000 births for women with diabetes.

Their report said that sugar levels in the run-up to conception were the "most important" risk factor which could be controlled.

The lead researcher, Dr Ruth Bell from Newcastle University, told the BBC: "Many of these anomalies happen in the first four to six weeks."

She said the number of pregnancies with poor sugar control were "more than we would like".

"It is a problem when the pregnancy is not intended or when people are not aware they need to talk to their doctors before pregnancy," she said.

Guidelines from the National Institute of Health and Clinical Excellence say women should reduce their blood sugar levels to below 6.1% before trying to have a baby.

Feb 06
Discovered: Why do cells age?
Why do cells age? The biological mystery seems to have been solved, thanks to scientists who`ve discovered a weakness in a component of brain cells which they claim may be responsible for ageing process occurring in mind.

A team at Salk Institute for Biological Studies says that the findings may pave the way for better understanding of diseases like Alzheimer`s and Parkinson`s, the latest edition of the `Science` journal reported.


In the research, the scientists have in fact discovered that certain proteins, called extremely long-lived proteins (ELLPs), found on surface of the nucleus of neurons, have a remarkably long lifespan.

While the lifespan of most proteins totals two days or less, the scientists identified ELLPs in the rat brain that were as old as the organism, they say.

ELLPs make up the transport channels on the surface of the nucleus; gates that control what materials enter and exit.

Damage to the ELLPs weakens the ability of three- dimensional transport channels composed of these proteins to safeguard the cell`s nucleus from toxins, said Prof Martin Hetzer, who led the team.

These toxins may alter the cell`s DNA and thereby the activity of genes, resulting in cellular ageing.

Prof Hetzer added: "The fundamental defining feature of ageing is an overall decline in the functional capacity of various organs such as the heart and the brain. This decline results from deterioration of the homeostasis, or internal stability, within the constituent cells of those organs.

"Recent research has linked breakdown of protein homeostasis to declining cell function. Our results also suggest that nuclear pore deterioration might be a general ageing mechanism leading to age-related defects in nuclear function."

Feb 06
Playing in the sun reduces risk of eczema and food allergies in children
Playing in the sunshine reduces the risk of children developing eczema and food allergies, researchers claim.

Those living in areas with lower levels of sunlight are at greater risk of developing food allergies and the skin condition, compared to those in areas with higher UV.

Scientists used data from analysis of Australian children and how rates of food allergies, eczema and asthma varied throughout the country.
On average children in the south of the country were twice as likely to develop eczema as those in the north.

There was also a link between latitude and allergies to peanuts and eggs.

Sunlight is important because it provides the fuel to create vitamin D in the skin.

Australia is a particularly good place for this type of study as it spans nearly 3,000 miles from north to south, with a large variation in climate, day length and sun strength.

Dr Nick Osborne, who led the researchers at the European Centre for Environment and Human Health, a joint initiative between Plymouth and Exeter universities, warned: 'This investigation has further underlined the association between food allergies, eczema and where you live.

'We are now hoping to study these effects at a much finer scale and examine which factors such as temperature, infectious disease or vitamin D are the main drivers of this relationship.

'As always, care has to be taken we are not exposed to too much sunlight, increasing the risk of skin cancer.'

Feb 04
Delhi men and women most prone to lung and breast cancer
Cancer of the lung is the commonest cancer among men in Delhi, while that of the breast is way ahead of all other forms of cancer among women in the national Capital.

Indian Council of Medical Research's (ICMR) latest data on the 10 leading sites of cancer in Delhi shows that prevalence of breast cancer among women in Delhi stands at almost 27%, followed by cervix, whose recurrence is almost half of breast cancer cases at 14.6%. Among men, lung cancer is the most common at 10%, while 7% of all cancers are of the prostate.

According to the ICMR data, cancer of the tongue was the third commonest cancer (6.8%) among men, followed by larynx (5.9%). In women, cancer of the ovary (7.6%) has the highest prevalence after breast and cervix, followed by gall bladder (6.9%). As far as "sites of cancer associated with the use of tobacco" is concerned, the prevalence is high among men in Delhi.

Two in every five cases of cancer among men in Delhi is due to tobacco (39.4%), while it is one in every 10 women (11%). Dr Harit Chaturvedi, director of surgical oncology at Max Hospital, said, "Cancer of the prostate is on the rise among men and that of breast is increasing among women. In northern India cancer of the gall bladder is very common. This could be due to chemicals and fertilizers in the water."

Dr Amit Aggarwal from Fortis Hospital, Noida, added, "We are seeing a major trend of mouth cancer among youngsters due to smoking and chewing of gutka. Oral cancers in Delhi are becoming common."

"It is depressing to see increasing number of young cancer victims. We hope the states implement the Food Safety and Standards Authority law in the larger interest of this generation falling prey to the tobacco menace," said Bhavna Mukhopadhyay, executive director of Voluntary Health Association of India.

FSSAI has notified the Food Safety and Standards (Prohibition and Restriction on sales) Regulation, 2011, mandating prohibition and restriction on sale of food products having tobacco and nicotine as their ingredients.

ICMR has also come out with the "possibility of one in number of persons developing cancer of any site" score. The calculation is age specific - 0-64 years and 0-74 years.

For Delhi, it says that one in 13 men and one in 11 women run the risk of developing cancer by the time they attain 64 years. The probability becomes more acute: one in seven men and one in eight women before they turn 74 years.

In other metros like Mumbai and Kolkata, one in 19 men and one in 14 women run a similar risk of developing cancer before their 64th birthday.

However, while one in 10 men and one in nine women in Mumbai face the possibility of suffering from cancer by the time they are 74 years, and the risk is faced by one in 10 men and women in Kolkata. In Chennai, one in 14 men and one in 12 women are prone to develop cancer before turning 64, while the probability is one in eight men and women before turning 74.

The report looked at incidents of cancer and probability rates for three years (2006-08). Dr A Nandakumar, in charge of the report, says that since the establishment of the national cancer registry programme in 1982, this is the maiden report of 20 population-based cancer registries covering 7% of the population.

India has the highest prevalence of oral cancer globally, with 80,000 new cases every year. National Institute of Health and Family Welfare (NIHFW) says India alone accounts for 86% of the total oral cancer figure across the world.

Feb 04
Non-surgical cure for uterine fibroids
For women who suffer from uterine fibroids (non-cancerous tumours), the new MRI- Guided High Intensity Focused Ultrasound (HIFU) solution is surely a blessing without disguise.

This non-invasive, scar-free option to women is an alternative to other traditional treatments for uterine fibroids. Dr Prathap Reddy, Chairman, Apollo Group of Hospitals, speaking at the launch of MRI- HIFU in the city on Thursday said, "Four out of every 10 women suffer from uterine fibroids. This MRI-HIFU will bring a big symptomatic relief to women across the country."

Talking about future plans he said, "Right now it is launched in our Delhi hospital. We plan to make this option available at all our hospitals across India soon, by constituting fibroid clinics, where our gynaecologists sit."

The MRI Guided HIFU equipment manufactured by Philips combines magnetic resonance (MR) imaging, with high intensity focused ultrasound (HIFU).

The MR-HIFU system uses safe and focused ultrasound waves to heat and coagulate tumour tissue deep inside the body without damaging the intervening tissue. The temperature is monitored.

The procedure takes about three hours and is not done under anaesthesia. In a few hours after the treatment, the patients can return home.

Those who had undergone the procedure had reported great symptomatic relief .

This procedure costs anywhere between 70,000 and 90,000, and doctors said for young women who have fibroids, this treatment allows them to conceive, unlike in other traditional methods of surgical procedures.

Krishna Kumar, president, Philips Healthcare India, was also present.

Feb 03
Documentary on cancer to be screened
Pain Relief and Palliative Care Society, Hyderabad, is screening a multi-award winning documentary 'Life Before Death' on the occasion of World Cancer Day 2012 on Saturday, February 4 from 5.30 p.m. at Taj Banjara, a press release stated.

The documentary 'Life before Death' is an award winning film that traverses 11 countries and follows the journey of terminally ill patients and their families.

It also charts the extraordinary health care professionals fighting to change the culture of medicine to be more focused on care, rather than on cure.
Objective

The objective of the documentary is to raise awareness on crisis of untreated pain and the lack of access to palliative care to scores of people suffering from cancer.

Feb 03
How antipsychotic medications lead to obesity and diabetes
A number of antipsychotic drugs are known to cause the metabolic side effects of obesity and diabetes, leaving patients with a difficult choice between improving their mental health and damaging their physical health, researchers say.

Now, a new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) reveals how antipsychotic drugs interfere with normal metabolism by activating a protein called SMAD3, an important part of the transforming growth factor beta (TGFbeta) pathway.

The finding that could lead to safer therapeutics for bipolar disorder and schizophrenia patients.

The TGFbeta pathway is a cellular mechanism that regulates many biological processes, including cell growth, inflammation, and insulin signaling.

In this study, all antipsychotics that cause metabolic side effects activated SMAD3, while antipsychotics free from these side effects did not. What's more, SMAD3 activation by antipsychotics was completely independent from their neurological effects, raising the possibility that antipsychotics could be designed that retain beneficial therapeutic effects in the brain, but lack the negative metabolic side effects.

"We now believe that many antipsychotics cause obesity and diabetes because they trigger the TGFbeta pathway. Of all the drugs we tested, the only two that didn't activate the pathway were the ones that are known not to cause metabolic side effects," said Fred Levine, M.D., Ph.D., director of the Sanford Children's Health Research Center at Sanford-Burnham and senior author of the study.

In a previous study aimed at developing new insights into diabetes, Dr. Levine and his team used Sanford-Burnham's high-throughput screening capabilities to search a collection of known drugs for those that alter the body's ability to generate insulin, the pancreatic hormone that helps regulate glucose.

That's when they first noticed that many antipsychotics alter the activity of the insulin gene.

In this current study, the researchers set out to connect the dots between antipsychotics and insulin. In doing so, experiments in laboratory cell-lines showed that antipsychotics known to cause metabolic side effects also activated the TGFbeta pathway-a mechanism that controls many cellular functions, including the production of insulin-while the drugs without these side effects did not.

Wondering whether their initial laboratory observations were relevant to the human experience, the researchers reanalysed previously published gene expression patterns in brain tissue from schizophrenic patients treated with antipsychotics.

What they found supported their earlier findings-TGFbeta signaling was activated only in those patients receiving antipsychotic treatment. Looking further, they found that the extent to which each antipsychotic drug activated the TGFbeta pathway in human brains correlated very closely with the extent to which those same drugs activated SMAD3 and affected the insulin promoter in their cell culture experiments.

The TGFbeta pathway also plays an important role in metabolic disease in people who don't take antipsychotic medications.

"It's known that people who have elevated TGFbeta levels are more prone to diabetes. So having a dysregulated TGFbeta pathway-whether caused by antipsychotics or through some other mechanism-is clearly a very bad thing," said Dr. Levine.

"The fact that antipsychotics activate this pathway should be a big concern to pharmaceutical companies. We hope this new information will lead to the development of improved drugs," Dr. Levine added.

Feb 02
Early Nurturing Boosts Brain Development
Early maternal support and nurturing has a strong positive effect on brain development in young children, new research shows.

In a longitudinal study, researchers found that supportive caregiving during the preschool years predicted larger hippocampal volume at school age in nondepressed children.

"This particular publication is unique in that it combines observational data of parent-child interaction at preschool with structural brain outcomes at school age," Dr. Joan Luby, MD, professor of child psychiatry and director of the Early Emotional Development Program at Washington University School of Medicine in St. Louis, who led the study, told Medscape Medical News.

"It's the first finding in humans of a clear link between early nurturance and hippocampal volume. A well-established link has been known in animals for more than 20 years," Dr. Luby added. "This has very important general public health implications about the importance of attention to early parenting."

The study was published online January 30 in Proceedings of the National Academy of Science (PNAS) .

Unique Focus

Commenting on the study for Medscape Medical News, Charles A. Nelson III, PhD, professor of pediatrics and neuroscience from Harvard Medical School in Boston, Massachusetts, said "a unique element of this study is that it focuses on positive outcomes rather than negative."

"There is an abundance of work showing reductions in hippocampal volume when children, or even adults, experience adversity," explained Dr. Nelson, who was not involved in the study. "This turns that issue on its head and shows that hippocampal volume actually increases as a function of increases in maternal warmth."

The 92 children in the study were originally recruited between the ages of 3 and 6 years from daycare centers and preschools in the St. Louis, Missouri, metropolitan area. The sample included 51 healthy nondepressed children and 41 with early-onset depression.

Between the ages of 4 and 7 years, the children were closely observed and videotaped interacting with a parent, almost always a mother, during a challenging and mildly stressful task.

How much or how little the parent was able to support and nurture the child in this stressful situation, which was designed to approximate the stresses of daily parenting, was evaluated by raters blind to the child's health or the parent's temperament.

"Whether a parent was considered a nurturer was not based on that parent's own self-assessment. Rather, it was based on their behavior and the extent to which they nurtured their child under these challenging conditions. It was very objective," said Dr. Luby.

Magnetic resonance imaging (MRI) scans of the brain obtained at school age revealed that children without depression who had very nurturing mothers in preschool had a hippocampus almost 10% larger than their peers whose mothers were not as nurturing. The estimated increase in hippocampal volume by unit of increased maternal support was 13.4 mm3, the researchers report.

Robust Finding

Notably, say investigators, the link between healthy maternal nurturing and increased hippocampal volume remained robust even after accounting for other factors known to affect hippocampal volume, such as stressful life events, comorbid internalizing and externalizing symptoms, and a history of maternal depression.

Maternal nurturing did not have a strong impact on hippocampal volume in the children with early-onset depression.

"The fact that this association was only observed among the nondepressed children argues, and is consistent with, the fact that early-onset depression may limit a child's ability to benefit from warm, maternal care," Dr. Nelson said. "This is quite unfortunate."

Dr. Luby and colleagues think their findings could have "profound public health implications and suggest that greater public health emphasis on early parenting could be a very fruitful social investment."

"The finding that early parenting support, a modifiable psychosocial factor, is directly related to healthy development of a key brain region known to impact cognitive functioning and emotion regulation opens an exciting opportunity to impact the development of children in a powerful and positive fashion," they write.

"This finding, when replicated, would strongly suggest enhancement of public policies and programs that provide support and parenting education to caregivers early in development," they add.

The study, Dr. Nelson commented, has a "few limitations, but nothing serious, just the nature of research such as this." He noted that the investigators focus exclusively on the hippocampus and do not report on whether other structures benefit from increases in maternal care. They also do not address whether increases in hippocampal volume affect behavior; for example, do these children show improvements in learning and memory?

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