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Dec 25
How the gym boosts brain, not brawn, power
You all are aware of the plethora of health benefits that regular exercise brings. Now add enhanced intelligence to that list.

According to a new study, fitness has a long-term effect on a wide range of cognitive abilities like reasoning, remembering, understanding and problem solving.

For John Ratey, a neuropsychiatrist at Harvard Medical School, regular physical activity may also play a vital role in enhancing brainpower as we reach an advanced age.

"It's a really amazing effect," added David Raichlen, a biological anthropologist at the University of Arizona in Tucson, in a report that appeared in the Washington Post.

Raichlen is currently investigating whether our ancestors' athleticism may have accelerated the evolution of their intelligence millions of years ago.

Another study, which followed a group of nearly 1,500 people for 20 years, showed that those who exercised at least twice a week during middle age were much less likely to develop dementia by the time they reached their 60s and 70s.

"People really enjoy that euphoric aspect of a runner's high and the clarity of mind you get from a routine workout," Brian Christie, a neuroscientist at the University of Victoria in British Columbia, was quoted as saying.

Although there are fewer studies done on younger people, the available evidence suggests that physical activity enhances brain health at every stage of life, says the report.

What kind of exercise is ideal? An aerobic workout is essential, but it doesn't have to be too strenuous. Even gentle activities, such as taking a walk a few times a week, worked wonders for the elderly, concluded the report.

Dec 25
Small lifestyle changes can help 'lower type 2 diabetes risk'
Researchers have suggested that South Asian families could help improve their chance to lower their risk of type 2 diabetes by making modest lifestyle changes in diet and activity.

The three-year-old- Edinburgh University study monitored 171 people of Indian and Pakistani background residing in Scotland, who were at high risk of diabetes as shown by blood tests done at the beginning of the trial, the BBC reported.

Study participants were given advice by dieticians and offered culturally-appropriate resources to help them manage their weight through diet and exercise.

At the same time, control groups received basic advice that was not culturally specific.

Professor Raj Bhopal , from Edinburgh University's centre for population health sciences, said that the differing approaches show that a more family-centred strategy, in addition with culturally tailored lifestyle advice, could produce significant benefits to people's health through weight loss.

The trial has been published in the journal Lancet Diabetes and Endocrinology.

Dec 24
Is it safe for pregnant women to eat peanuts?
So long as they don't have nut allergies themselves, pregnant women shouldn't be afraid that eating nuts might trigger allergies in their child, according to a large new study.

In fact, when women ate nuts more than five times a month during pregnancy, their kids had markedly lower risk of nut allergies compared to kids whose mothers avoided nuts, researchers found.

"The take-home message is that the previous concerns or fears of the ingestion of nuts during pregnancy causing subsequent peanut or nut allergy is really unfounded," Dr. Michael Young said.

Young is the study's senior author and an attending physician in allergy and immunology at Boston Children's Hospital.

He cautioned that pregnant women shouldn't start eating peanuts and tree nuts to prevent their children from developing nut allergies, however.

"Even though our study showed a reduction of risk, I really have to emphasize that the way our study was done only shows an association," he said.

He and his colleagues write in JAMA Pediatrics that between 1997 and 2010 the prevalence of peanut allergies tripled to 1.4 percent of U.S. children.

For the new study, the researchers used data from a national study of female nurses between the ages of 24 and 44 years old. Starting in 1991, the women periodically reported what they ate.

The researchers then combined information on the women's diets from around the time of their pregnancies with data from another study of their children.

In 2009 the women completed a questionnaire that asked whether their children had any food allergies. Of 8,205 children in the study, 308 had food allergies, including 140 who were allergic to peanuts or tree nuts.

Tree nuts include walnuts, almonds, pistachios, cashews, pecans, hazelnuts, macadamias and Brazil nuts.

Overall, the researchers found that eating nuts while pregnant was not tied to an increased risk of nut allergies among children. On the contrary, the more nuts women reported eating during pregnancy, the less likely their children were to have nut allergies.

About 1.5 percent of children of women who ate less than one serving of nuts per month during pregnancy developed nut allergies. That compared to about 0.5 percent of children of women who ate five or more servings per week.

In other words, kids whose mothers ate nuts most often had about a third of the risk compared to kids whose mothers ate nuts least often.

The exception was children of women who themselves had a history of nut allergies. In those cases, when women ate nuts five or more times a week during pregnancy, their children had about two and a half times the risk of nut allergies compared to the kids of allergic mothers who avoided nuts during pregnancy.

"Certainly this is reassurance that eating nuts during pregnancy will not increase your child's risk of allergy," Dr. Loralei Thornburg said. "In fact, it may be tied to a decreased risk of nut allergies."

Thornburg was not involved in the new study but is a high-risk pregnancy expert at the University of Rochester Medical Center in New York.

However, "if there is a strong family history at all or if the mother herself has any food allergy, then she should go talk to her physician, because there is not clear data on that," Dr. Ruchi Gupta said.

Gupta is an associate professor of pediatrics at the Northwestern University Feinberg School of Medicine in Chicago and an expert on food allergies and asthma.

In an editorial accompanying the new study, Gupta wrote that it will take additional studies and research to understand why a growing number of children are developing food allergies and how to prevent it.

"What I do like about the study is it adds evidence that mothers-to-be should eat whatever they wish and not worry that the consumption of certain foods will result in allergies," she said.

Dec 24
China investigates after hepatitis B vaccine suspected in 7 infant deaths
Chinese health authorities are investigating after seven infants died following inoculation with a hepatitis B vaccine, state media reported on Monday.

China has been beset by a series of product safety scandals over the past few years.

At least six children died in 2008 after drinking milk contaminated by the industrial chemical melamine, and there have also been reports of children dying or becoming seriously ill from faulty encephalitis, hepatitis B and rabies vaccines.

State news agency Xinhua said that of the seven deaths from the hepatitis B vaccine in the latest case, four were in the southern province of Guangdong. The other cases were in the provinces of Hunan and Sichuan.

The official China Daily said that all hospitals using the vaccine, made by Shenzhen-based BioKangtai, had been ordered to take it off their shelves while the Health Ministry investigates the company's products and the deaths.

The company said in a statement last week, carried by state media, said that it rigorously followed safety rules but that they were testing the batches suspected of causing the deaths.

The topic has been widely discussed on China's popular Twitter-like microblogging service Sina Weibo, with many people worried about the safety of China's vaccines and calling on the government to make more information public.

"Why was this allowed onto the market? The government needs to come clean about this," wrote one Weibo user.

Many Chinese people are suspicious that the government tries to cover up bad news about health problems, despite assurances of transparency. In 2003, the government initially tried to cover-up the outbreak of the SARS virus.

Dec 23
New vaccine to protect against deadly pneumonia developed
A team of researchers has developed a new vaccine that protects against lethal pneumonia caused by Staphylococcus aureus (staph) bacteria, including drug-resistant strains like MRSA.

The new vaccine by the research team, led by Patrick Schlievert, professor and chair of microbiology in the University of Iowa's Carver College of Medicine, targets toxins that are made and secreted by staph bacteria.

The researchers believed a vaccine that blocked the action of these toxins might prevent the serious illness caused by the bacteria.

Using an animal model that closely resembles human staph infection the researchers showed that vaccination against three staph toxins provided almost complete protection against staph infections.

The vaccinated animals were protected from disease even when they were infected with very high doses of bacteria.

Furthermore, not only did the vaccine protect the animals from dying, but seven days after vaccination there were no disease-causing bacteria remaining in the animals' lungs.

"Our study suggests that vaccination against these toxins may provide protection against all strains of staph. If we can translate this finding into an effective vaccine for people it could potentially prevent millions of cases of serious and milder skin and soft tissue infections yearly," Schlievert said.

The team also found that passive immunization- using serum from vaccinated animals to immunize other animals- was successful. This finding suggests that antibodies induced by the vaccination are the protective factor.

The study is published in the Journal of Infectious Disease.

Dec 23
Older men who ignore knee pain risk worse problems
Shrugging off chronic knee pain as an inevitable part of aging puts men in their 70s at risk for accelerated muscle loss, falls and generally reduced quality of life, a new study suggests.

"This study confirms the findings of many studies indicating that chronic knee pain will seriously impact quality of life in older people," lead author Marlene Franzen said.

Franzen is an associate professor of physiotherapy at the University of Sydney in Australia.

Nearly half of men over 70 have chronic knee pain, according to her team's report in the journal in Age and Ageing.

"Chronic knee pain is not a 'benign' disease," she said. "It does lead to a greatly increased risk of falls and developing mobility disability, and therefore increased risk of early mortality."

Mobility disability means being unable to walk up or down stairs to the first floor without help and being unable to walk about half a mile without help, according to Franzen.

She and her coauthors tracked 1,587 men over age 70 for two years. About 640 of the men said they suffered from chronic knee pain at the start of the study. Two years later, another 150 reported experiencing bouts of chronic knee pain as well.

The researchers found that men with knee pain were nearly two and a half times more likely to have mobility disability than those without pain.

"Mobility disability among older people with chronic knee pain is serious as it has been associated with early mortality," Franzen said.

The men with knee pain were also more likely to experience falls, which can be serious for people over 70, and to have reduced strength and mass in the muscles, tendons and ligaments that extend the knee, according to diagnostic scans.

The link between decreased leg muscle strength and chronic knee pain had only previously been established for women, Franzen said.

While some loss of muscle mass - about 1 percent a year - is typical with aging, Franzen's team also measured changes in the strength of leg muscles that control the knee.

Past research has found the strength of those muscles drops by about 3.4 percent a year, and that was the rate Franzen's group saw among men without knee pain. But for men who developed knee pain during the two-year study, muscle strength dropped by 4.5 percent a year.

"I think the evidence from this study and previous research would suggest that knee pain in older adults is associated with increased mobility problems, and this may be at least partly related to muscle strength declines," David Scott said.

Scott studies the gradual loss of muscle mass that usually begins after age 30 at the University of Melbourne in Victoria, Australia, but was not involved in the new study.

"This might indicate that methods to improve lower-limb muscle strength in older adults, such as supervised exercise training, may have potential benefits both in decreasing the disability associated with knee pain, and also in preventing development of pain itself," he said.

In the new study, obesity, back pain and higher levels of physical activity were more common in the group of men with knee pain. Men in their 80s, however, were less likely to have knee pain, which the authors attributed to their probably being more sedentary.

Knee pain usually becomes troublesome many years earlier than age 70, when people often have more physically demanding lifestyles or occupations, often in their 50s, Franzen said. Knee pain with age is even more common among women, she said.

For the obese, losing weight can help alleviate some knee pain, she said.

Otherwise, patients should see their doctors for an effective and safe pain management strategy, and a physiotherapist for a recommended physical activity program, Franzen said.

Dec 21
Fibre-rich diet helps cut heart disease risk
A new study has revealed that dietary fibre or fibre-rich foods are associated with lower risk of heart disease.

Researchers at the University of Leeds reviewed literature published since 1990 in healthy populations concerning dietary fibre intake and CVD risk. They took data from six electronic databases. Cohorts of data were used from the US, Europe, Japan and Australia.

They looked at the following fibre intake: total, insoluble (whole grains, potato skins etc), soluble (legumes, nuts, oats, barley etc), cereal, fruit, vegetable and other sources.

Results from analyses of total, insoluble, fruit and vegetable fibre intake showed that the likelihood of a CVD or CHD event steadily lowers with increasing intake.

In soluble fibre, a higher reduction was seen in CVD risk than CHD risk and for cereal fibre, the reduced risk of CHD was stronger than the association with CVD.

A significantly lower risk of both CVD and CHD was observed with every additional 7g per day of fibre consumed.

The researchers concluded that "diets high in fibre, specifically from cereal or vegetable sources are significantly associated with lower risk of CHD and CVD and reflect recommendations to increase intake."

Greater intake from fruit fibre was associated with lower CVD risk. They recommend further work on the association with soluble or insoluble types of fibre.

Dec 21
Ageing can be reversed, say scientists
The ageing process is like the married couple next door -- when young, they communicate well, but over many years the communication breaks down.

And as in relationships, says a new study, restoring communications reverses the ageing process, at least in mammals.

A series of molecular events in our body enable communication inside cells between the nucleus and mitochondria, also called "cell's powerhouse".

As communication breaks down, ageing accelerates. By administering a molecule naturally produced by the human body, scientists restored the communication network in older mice.

"Subsequent tissue samples showed key biological hallmarks that were comparable to those of much younger animals," said David Sinclair, senior author on the study and Harvard Medical School Professor of Genetics.

Mitochondria generate chemical energy to carry out essential biological functions. As these self-contained organelles become increasingly dysfunctional over time, many age-related conditions such as Alzheimer's disease and diabetes occur.

Sinclair and his team primarily focused on a group of genes called sirtuins. Previous studies from his lab showed that one of these genes, SIRT1, was activated by the compound resveratrol, which is found in grapes, red wine and certain nuts.

They studied mice in which this SIRT1 gene had been removed. While they accurately predicted that these mice would show signs of ageing, including mitochondrial dysfunction, they were surprised to find that most mitochondrial proteins coming from the cell's nucleus were at normal levels.

Cells stay healthy as long as coordination between the genomes remains fluid. SIRT1's role is that of an intermediary, akin to a security guard, said Sinclair.

"There's clearly much more work to be done here, but if these results stand, then many aspects of ageing may be reversible if caught early," said Sinclair.

This study was a joint project between Harvard Medical School, the National Institute on Ageing, and the University of New South Wales, Sydney.

The findings of the study have been published in the latest edition of the journal Cell.

Dec 20
BP of 150/90 new normal for people over 60
New guidelines suggest that people over 60 can have a higher blood pressure than previously recommended.

Until now, people were told to strive for blood pressures below 140/90, with some taking multiple drugs to achieve that goal.

But the guidelines committee, which spent five years reviewing evidence, concluded that the goal for people over 60 should be a systolic pressure of less than 150. And the diastolic goal should remain less than 90.

Systolic blood pressure, the top number, indicates the pressure on blood vessels when the heart contracts. Diastolic, the bottom number, refers to pressure on blood vessels when the heart relaxes between beats.

Essentially, the committee determined that there was not strong evidence for the blood pressure targets that had been guiding treatment and that there were risks associated with the medications used to bring pressures down.

The committee, composed of 17 academics, was tasked with updating guidelines last re-examined a decade ago.

The group added that people over 60 who are taking drugs and have lowered their blood pressure to below 150 can continue taking the medications if they are not experiencing side effects.

But, it cautioned, although efforts to lower blood pressure have had a remarkable effect, reducing the incidence of strokes and heart disease, there is a difference between lowering blood pressure with drugs and having lower pressure naturally.

The report has been published online in The Journal of the American Medical Association.

Dec 20
Diet rich in tomatoes may cut breast cancer risk in postmenopausal women
A new study has revealed that a diet rich in tomato may help protect at-risk postmenopausal women from breast cancer.

The study found eating a diet high in tomatoes had a positive effect on the level of hormones that play a role in regulating fat and sugar metabolism.

"The advantages of eating plenty of tomatoes and tomato-based products, even for a short period, were clearly evident in our findings," the study's first author, Adana Llanos from Rutgers University, said.

"Eating fruits and vegetables, which are rich in essential nutrients, vitamins, minerals and phytochemicals such as lycopene, conveys significant benefits. Based on this data, we believe regular consumption of at least the daily recommended servings of fruits and vegetables would promote breast cancer prevention in an at-risk population," Llanos said.

The longitudinal cross-over study examined the effects of both tomato-rich and soy-rich diets in a group of 70 postmenopausal women. For 10 weeks, the women ate tomato products containing at least 25 milligrams of lycopene daily.

For a separate 10-week period, the participants consumed at least 40 grams of soy protein daily. Before each test period began, the women were instructed to abstain from eating both tomato and soy products for two weeks.

When they followed the tomato-rich diet, participants' levels of adiponectin - a hormone involved in regulating blood sugar and fat levels - climbed 9 percent. The effect was slightly stronger in women who had a lower body mass index.

The study is published in journal of Clinical Endocrinology and Metabolism.

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