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Nov 07
Discovery on measles virus could help spur less toxic cancer cure
A new discovery about the measles virus, arguably the most virulent pathogen which afflicts 10 million children worldwide, could also help spur less toxic cancer treatments.

The discovery by Roberto Cattaneo of the Mayo Clinic in the US and Veronika von Messling of Canada's INRS-Institut Armand-Frappier research centre and others showed that measles virus exits its human host via protein nectin-4, which is found in the windpipe, the journal Nature reports.

Because the measles virus actively targets nectin-4, measles-based cancer therapy may be more successful in patients whose cancers express nectin-4. Such therapy could be less toxic than chemotherapy or radiation, according to a Mayo Clinic statement.

Nov 07
Lifelong traumas spur irritable bowel syndrome
Lifelong traumas sparked by natural disasters, housefires or the abuse or the death of a loved one may bring on irritable bowel syndrome (IBS), a painful chronic condition.

IBS is marked by abdominal discomfort, bloating, constipation or diarrhoea, caused by changes in the nerves and muscles that control bowel sensation and movement.

IBS is 1.5 times more common in women than in men, more prevalent among people under 50 years, says Yuri Saito-Loftus, from Mayo Clinic, Rochester, who led the study, according to a Mayo statement.

Besides, general life traumas were more commonly reported than physical, emotional or sexual abuse. Of the 2,623 participants, patients reported more traumas over a lifetime than controls with traumas common before age 18 as well as after age 18.

"While stress has been linked to IBS, and childhood abuse has been reported to be present in up to 50 percent of patients with IBS, at a prevalence twice that of patients without IBS. Most studies of abuse have focused on sexual abuse with sparse detail and also have not looked at other forms of psychological trauma," said Saito-Loftus.

"This is the first study that looks at multiple forms of trauma, the timing of those traumas, and traumas in a family setting," he added.

Saito-Loftus said the results of this study indicate that patients with IBS experience or report traumas at a level higher than patients without IBS.

These findings were presented at the American College of Gastroenterology's (ACG) 76th Annual Scientific meeting in Washington, DC.

Nov 05
Organ Transplant Recipients at Increased Risk of 32 Types of Cancer
People who receive an organ transplant have an increased risk of developing 32 types of cancer, a new study finds.

Some of the most common cancers in transplant recipients include kidney, liver and lung cancer and non-Hodgkin lymphoma, the results show.

Transplant recipients have double the risk of developing any cancer, compared with people who have not had a transplant, the researchers said.

The increased risk of cancer comes, in part, from the medications transplant recipients must take to avoid rejecting the transplanted organ. These medications suppress the immune system, and may elevate the risk for infection-related cancers, said study researcher Dr. Eric Engels, of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute. In some cases, immune-suppressing medications may act as carcinogens and directly contribute to cancer's development, the researchers suggest.

"Clearer understanding of the pattern of cancer risk associated with solid organ transplantation may help future patients have better, healthier outcomes," Engels said.

Meds reduce risk of organ rejection

In 2010, a total of 28,664 organ transplants were performed in the U.S., including 16,899 kidney, 6,291 liver, 2,333 heart and 1,770 lung transplants.

Previous studies have suggested that transplant recipients are at a higher risk for cancer than the general population. However, these studies focused mainly on those who received kidney transplants, and some studies were too small to accurately estimate risk for all but the most common cancer types.

In the new study, Engels and colleagues evaluated medical data from more than 175,700 U.S. transplant recipients, accounting for about 40 percent of all people who received transplanted organs from 1987 through 2008. The data came from the U.S. registry of transplant recipients and 13 state or regional cancer registries.

About 14 percent of transplant recipients developed non-Hodgkin lymphoma, a cancer of the white blood cells. The risk of this cancer was seven times higher in transplant recipients than in the general population, and was highest for lung recipients. Non-Hodgkin lymphoma is known to be related to immune suppression and infection with Epstein-Barr virus, the researchers said.

Lung, liver and kidney cancers

Lung cancer was the second most common cancer, found in 12.6 percent of recipients. This may be because the patients already had smoking-related diseases, the researchers said. In cases involving a single lung transplant, lung cancer typically arises in the recipient's remaining diseased lung rather than the transplanted one.

Liver cancer occurred in 8.7 percent of recipients. The increased risk for liver cancer may be due to recurrent hepatitis B or C infection in the transplanted liver.

And 7.1 percent of recipients had kidney cancer. Recipients of kidney transplants have damaged kidneys, frequently including multiple kidney cysts, which can become cancerous.

"We wish to understand how medical conditions, and individual immunosuppressive medications, may contribute to cancer risk. In addition, we hope our findings will stimulate other research into the carcinogenic mechanisms associated with organ transplantation," Engels said.

The study was published today (Nov. 2) in the Journal of the American Medical Association.

Nov 04
Soon, new material for air cleaner filters to capture influenza viruses
Scientists have now come up with a new material that teams up with the fiber in face masks, air conditioning and air cleaning filters to capture flu viruses before they can get into people's eyes, noses and mouths and cause infection.

Xuebing Li, Peixing Wu and colleagues explain that in an average year, influenza kills almost 300,000 people and sickens millions more worldwide.

The constant emergence of new strains of virus that shrug off vaccines and anti-influenza medications has led to an urgent need for new ways of battling this modern-day scourge.

So, the scientists sought a new approach, using a substance termed chitosan made from ground shrimp shells.

The scientists combined chitosan with substances that the flu virus attaches to in order to infect cells.

They found that this new version of chitosan ideal for attaching to fibers of face masks and air filters was highly effective in capturing flu virus.

The material could become an important addition to vaccinations, anti-influenza medications, and other measures in battling flu, they suggest.

The report has been published in ACS' journal Biomacromolecules.

Nov 03
Slowing Down the Ageing Process is in Your Hands
Most people these days attach a lot of importance to looking young and it is no exaggeration that looking younger than one's age gives people an unbeatable high. To achieve this dream, many are willing to go any length just to knock off years from their looks.

One does not need to very far to look for those magic potions or pills to slow down ageing, for the secret may just lie in one's own hands.

Recent research has claimed that eating fewer calories can retard the ageing process and offset many age-associated diseases such as cancer, dementia and type-2 diabetes.

Researchers also found that cutting the consumption of sugar and protein and ensuring intake of vitamins and minerals holds the secret to longevity.

This point was amply proved during research on animals which showed that reduced calorie intake added years to animals' lifespan.

Cutting calorie intake improved levels of an enzyme called peroxiredoxin [Prx1], which offers protection against the effects of ageing.

'We are able to show that caloric restriction slows down ageing by preventing an enzyme, peroxiredoxin, from being inactivated. This enzyme is also extremely important in counteracting damage to our genetic material. Impaired Prx1 function leads to various types of genetic defects and cancer. Conversely, we can now speculate whether increased repair of Prx1 during ageing can counteract," researchers said.

Nov 02
Indians' growing healthcare expenses concern WHO
The World Health Organization (WHO) is worried about Indians' high out-of-pocket (OOP) expenses to buy medicines.

WHO says, 3.2% Indians will fall below the poverty line because of high medical bills. About 70% of Indians spend their entire income on healthcare and purchasing drugs, WHO suggests.

Dr Kathleen A Holloway, regional adviser of WHO, said, "About 70% Indians are spending their out-of-pocket income on medicines and healthcare services in comparison to 30%-40% in other Asian countries like Sri Lanka, and are still suffering from infected diseases due to lack of best quality drugs and healthcare facilities."

She stressed the need for effective monitoring system in India, while expressing concern about the lack of Drugs and Therapeutics Committee (DTC) and Pharmacy and Therapeutics Committee (PTC) in Indian hospitals. WHO has been urging for the setting of these panels for the past 10 years.

"These committees can play an effective role to provide patients more efficient and rational use of medicines," Dr Kathleen added.

The Planning Commission accepts that OOP to pay for healthcare costs is a growing problem in India. It says 39 million Indians are pushed to poverty because of ill health every year. Around 30% in rural India didn't go for any treatment for financial constraints in 2004. In urban areas, 20% of ailments were untreated for financial problems the same year, said a recent study in the Lancet.

About 47% and 31% of hospital admissions in rural and urban India, respectively, were financed by loans and sale of assets. States have cut down on spending to purchase drugs, adding to aam aadmi's woes.

Maharashtra spent 5.2% of its health expenditure last year on purchasing drugs as against 11.3% a decade ago. Rajasthan, Haryana, Karnataka and Madhya Pradesh too followed suit during the same period.

Or, consider the case of Kerala. Even though the state spent the highest in India on drug procurement last year -12.5% on health expenditure - the figure is still far less than what it had in 2001 (17%). While, Tamil Nadu's expenses on buying medicines came down from 15.3% (2001) to 12.2% (2010).

The Planning Commission's high-power expert group on universal health coverage has recommended ensuring availability of free essential medicines by increasing public spending on drug procurement.

It says low public spending on drugs and non-availability of free medicines in government healthcare facilities are major factors discouraging people from accessing public sector health units.

"We estimate that an increase in the public procurement of medicines from around 0.1% to 0.5% of GDP would ensure universal access to essential drugs, greatly reduce the burden on private out-of-pocket expenditures and increase the financial protection for households," the report says.

It adds, "Public spending on drugs is extremely low, with huge variation between states and across districts within a state. Data from 2010-11 indicates that about 10%-12% of the health spending in the states of Tamil Nadu and Kerala goes towards procuring drugs as against the 2%-3% spent on drugs by states like Jharkhand, Punjab and Rajasthan. While there has been a significant improvement in drug procurement in the state of Bihar as a result of increased allocation of NRHM funds, it is still spending a very little (Rs 8 per capita) on drugs."

Nov 01
Ovarian cancer feeds on fat cells in abdomen
A research team based at the University of Chicago has found that large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer.

In 80 per cent of women, by the time ovarian cancer is diagnosed, it has spread to the pad of fat cells, called the omentum. Often, cancer growth in the omentum exceeds the growth of the original ovarian cancer.

"This fatty tissue, which is extraordinarily rich in energy-dense lipids, acts as a launching pad and energy source for the likely lethal spread of ovarian cancer," said study author Ernst Lengyel, MD, PhD, professor of obstetrics and gynecology at the University of Chicago.

"The cells that make up the omentum contain the biological equivalent of jet fuel. They feed the cancer cells, enabling them to multiply rapidly. Gaining a better understanding of this process could help us learn how to disrupt it," Lengyel stated.

The researchers found that ovarian cancer cells injected into the abdomen of healthy mice find their way to the omentum within 20 minutes.

Once ovarian cancer cells reach the omentum, they quickly develop the tools to devour the sustenance provided by this fatty tissue, reprogramming their metabolism to thrive on lipids acquired from fat cells.

Ovarian cancer can rapidly convert the entire omentum, a soft fat pad, into a solid mass of cancer cells.

The researchers believe that a protein known as fatty acid binding protein (FABP4), a fat carrier, may be crucial to this process and could be a target for treatment.

When the researchers compared primary ovarian cancer tissue with ovarian cancer tissue, which had spread to the omentum, they found that tumour cells next to omental fat cells produced high levels of FABP4.

When they inhibited FABP4, the transfer of nutrients from fat cells to cancer cells was drastically reduced. Inhibition of FABP4 also reduced tumour growth and the ability of tumours to generate new blood vessels.

"Therefore," the authors wrote, "FABP4 emerges as an excellent target in the treatment of intra-abdominally disseminating tumours, which preferentially metastasises to adipose tissue such as ovarian, gastric, and colon cancers."

The finding was reported in the journal Nature Medicine, published online October 30th, 2011.

Oct 31
US study hails power of yoga
Are you suffering from acute back pain? Instead of relying on pain killers which can have side effects, try a daily yoga session, a best method to treat all the critical back pain, as has been found by a team of US researchers.

Main author, Karen J Sherman, senior investigator at Group Health Research Institute (GHRI) and his associates after conducting one of the largest US studies on yoga, certifies that it does ease chronic back pain and other associated symptoms.

"We found yoga classes more effective than a self-care book," the researchers said in the study published in the latest issue of journal Archives of Internal Medicine.

At least 228 adults in six cities were randomly assigned to 12 weekly 75-minute classes of either yoga or stretching exercises or a comprehensive self-care book. Researchers noted that back-related function was better and symptoms diminished with yoga in 12 weeks with benefits, including less use of painkillers. It lasted at least... six months for both yoga and stretching, with a thorough follow-up of more than nine in 10 participants, the study says.

"After some weeks, when the researchers were about to conclude their study, they were surprised to find that almost 50 per cent of the participants who attend yoga classes admitted that they felt much better and only 20 per cent of the participants from the self-care group felt better with the offered guidelines," it said.

The researchers also noted that in comparison to the generally prescribed painkillers which may have some side effects, yoga and stretching classes positively helped patients reduce their chronic back pain.

"People may have actually begun to relax more in the (yoga) stretching classes than they would in a typical exercise class," Sherman said adding that the results suggest that both yoga and stretching can be good, safe options for people who are willing to try physical activity to relieve their moderate low back pain.

Dr Ishwar V Basavaraddi, Director of Delhi-based Morarji Desai National Institute of Yoga, an autonomous body under Health Ministry agreed that yoga can cure many disorders with backache being just one. "Backache is due to structural disorders when an individual does not take care of body postures or due to some glandular disorders in young age. In young adults it can be because of digestive or sexual problems."

The most popular yoga for treating backache are bhujangasan, uthaan mandook aasan, shalabhasana followed by bhramari and pranayam. During our various studies at the institute we have found that such asanas have power to cure the disorder permanently unlike modern medicine which just give temporary relief to the patient, noted the director.

Oct 29
New health scheme for Delhi school children
The Chacha Nehru Health Scheme, under which free medical check-up and treatment will be provided to all the school children, will be launched by the Delhi Government on Children's Day, November 14. At a meeting chaired by Chief Minister Sheila Dikshit on Friday, it was stated that to begin with the scheme will cover 100 schools.

The scheme had been announced by the Delhi Government in the Budget speech for the year 2011-22 that was made by Ms. Dikshit, who also holds the Finance portfolio. The Delhi Government has since then completed the formalities pertaining to the scheme and is now prepared to implement it.

In the meeting, Ms. Dikshit instructed the Health Department and the Education Department to work in tandem to ensure proper implementation of the scheme. She directed the Health Department to see to it that the proposed health check-up was comprehensive and included all diseases while also taking care of the immunisation gaps.

The Chacha Nehru Health Scheme intends to address the deficiencies and symptoms of disease in children right from the beginning to ensure that they remained healthy.

Ms. Dikshit said it has been decided to launch this scheme on the birth anniversary of first Prime Minister of India Pandit Jawaharlal Nehru and to begin with the scheme would be launched in over 100 schools.

It would later be expanded in a phased manner to cover all the 954 Delhi Government schools. She said the scheme would be closely monitored to prepare a comprehensive computerised health profile of school children.

To implement the scheme, that would ultimately cover about 14 lakh school children, around 117 teams consisting of a doctor, primary health nurse and computer data entry operator will be required. Each team will be able to screen 60 children for all diseases including general check-up in one day.

Since the total number of working days in a year is about 200, each team would be able to cover about 12,000 children in a year. So to meet the target of reaching out to about 14 lakh students, 117 teams would be deployed.

Delhi Health Minister A.K. Walia said apart from providing free general check-up to school children, the Delhi Government will also provide free medicines to them and will their treatment if they are diagnosed with any disease. He added that the Health Department will also ensure that all bottlenecks, if any, are cleared immediately so that the scheme could take off smoothly.

The meeting, which was also attended by Chief Secretary P.K. Tripathi, Principal Secretary Health Anshu Prakash, Principal Secretary Finance D.M. Sapolia and Director Health Services Dr. N.V. Kamath, also discussed the spade work that has been done and the infrastructure that has been created to ensure that the scheme succeeds in achieving its goal of having healthy children for a healthy society.

Oct 28
Breakthrough 'in Alzheimer's research'
In what is being hailed as a major breakthrough, scientists claim to have unravelled the precise function of genes which are known to make people more at risk of developing Alzheimer`s disease.


A team at Massachusetts Institute of Technology says that its findings may soon pave the way for early detection of the crippling brain disease and also of potential new treatments for the most common form of dementia.

There is no cure or effective treatment for Alzheimer`s and current drugs help people manage some of their symptoms.

In their research, the scientists used yeast to unravel how the genes known to affect the risk of Alzheimer`s work on cells in the brain. They show for the first time that the risk genes affect a hallmark protein in Alzheimer`s called amyloid.

The research discovered that amyloid was disrupting a vital process in yeast called endocytosis, which transports important molecules into and around cells. It found a number of the genes, including one called Picalm, could influence amyloid`s ability to disrupt endocytosis.

It provides a previously unknown link between the genes and the amyloid protein, and sets a new direction for treatment research, say the scientists who worked on the role of the Alzheimer`s risk genes not only in yeast, but also in more complex models using worms and rat brain cells.

Prof Julie Williams of Cardiff University, chief scientific adviser to Alzheimer`s Research UK, has welcomed the findings published in the `Science` journal.

"In 2009 we discovered that the gene Picalm affected the risk of developing Alzheimer`s disease. We`ve since identified a further three genes which, together with Picalm, show for the first time that the process of endocytosis may play an important role in Alzheimer`s.

"This study now brings the pieces of the puzzle together and shows that Picalm influences the damaging effects of amyloid. Our genetic discoveries are now pinpointing new disease mechanisms which can lead to the development of new treatments. This is enormously exciting," Williams was quoted by the `Daily Express` as saying.

Dr Marie Janson from Alzheimer`s Research UK, added: "We are very excited by these promising results."

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