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Jun 27
Lithium prevents brain damage
A study has found that lithium profoundly prevents the aggregation of toxic proteins and cell loss associated with Parkinson's disease (PD).

The Buck Institute for Research, which carried out the study on a mouse model of the condition, is currently working toward initiating a Phase IIa clinical study of lithium in humans in conjunction with standard PD drug therapy.

"This is the first time lithium has been tested in an animal model of PD," lead author and Buck Professor Julie Andersen, PhD, said.

"The fact that lithium's safety profile in humans is well understood greatly reduces trial risk and lowers a significant hurdle to getting it into the clinic," she stated.

Jun 25
'People in metros suffer from tooth sensitivity'
Two out of every five people residing in the top six metro cities of the country suffer from tooth sensitivity, a survey has revealed.

The survey, conducted by research firm Nielsen for a leading oral care company and covering 1,800 respondents, was commissioned to gauge the existing condition of tooth sensitivity in Indian metro cities -- Mumbai, New Delhi, Bangalore, Kolkata, Chennai and Hyderabad.

The findings reveal that although tooth sensitivity is increasingly becoming a common oral health problem, awareness about this condition is fairly low.

Tooth sensitivity is the condition of a short, sharp pain experienced on consumption of hot or cold food and liquids.

Of the six cities surveyed, the incidence of sensitivity was recorded highest in Hyderabad with 55 percent of the population claiming to suffer from the problem. This was followed by Chennai, where 53 percent respondents had the problem.

46 percent respondents from New Delhi, 42 percent from Mumbai and 36 percent from Kolkata claimed to suffer from sensitivity. The incidence of sensitivity is lowest in Bangalore with only 18 percent of the respondents claiming to suffer from the problem.

"Most Indians tend to follow a remedial path where they seek professional dental care only at the time of severe toothaches as a result of which such problems go ignored," said Indian Dental Association (IDA) secretary Dr Ashok Dhoble.

"Some common causes of tooth sensitivity include receding gums or loss of enamel, incorrect brushing technique, tooth decay, fracture of teeth, teeth grinding and improper oral hygiene," he said.

Overall, over 40 percent of the respondents claimed to suffer from tooth sensitivity but only 21 percent of the respondents knew that they could get instant and lasting sensitivity relief, the survey said.

31 percent of the respondents suffering from tooth sensitivity think it is just toothache, said the survey.

Also, the incidence of sensitivity increases from 33 percent at the age group of 18-25 years to 54 percent for the age group of 51-55 years, it added.

Jun 24
Weight loss surgery may cure obese diabetics: study
The report in Archives of Surgery concerned a review of earlier studies led by Rick Meijer, at the Institute for Cardiovascular Research at Vrije Universiteit in Amsterdam, who said the findings exceeded what was possible with more conventional diabetes treatments.

"In standard practice, only a very minor group of individuals with an iron will can lose enough weight to be cured from type 2 diabetes mellitus," Meijer said in an email to Reuters Health, referring to the most common type of diabetes.

Meijer and his colleagues pooled data from nine studies of diabetics who underwent either a gastric bypass -- which makes the stomach smaller and allows food to bypass part of the small intestine -- or gastric band surgery, in which the capacity of the stomach is reduced by using an adjustable band.

Eight of the studies included between 23 and 177 patients, while the last one traced 82,000 people. Each followed patients for at least a year.

After gastric bypass, 83 percent of patients could stop taking their diabetes medications, some within days of the surgery. After gastric banding, 62 percent could stop.

"Surgery ought to be considered front line therapy for diabetes among obese people," said Jon Gould, who heads the weight loss surgery program at the University of Wisconsin and was not involved in the study.

Meijer said about 90 percent of cases of diabetes are due to excessive weight, though not all diabetics would be eligible for the weight loss surgery.

It's also unclear how long surgery's impact on diabetes can last. One study included in the review found that 10 years after surgery, just one third of people whose diabetes had abated still had good control of their blood sugar.

Surgery of course has the potential for complications that wouldn't occur with drugs.

One study followed patients up to a month after surgery found that 7 percent experienced some problems, mainly minor wound infections. But massive bleeding, kidney failure and other serious complications occurred in more than 2 percent of patients.

Other side effects include nausea and some food intolerance, with some patients also gaining weight back over time.

Gould said the initial cost of the surgery, compared to the extended costs of diabetes care and other health effects of being obese, can be recouped after 18 months to two years.

"It would be a huge upfront cost, but looking at this from the bigger picture, I think if we can cure instead of manage the complications, we will save money in the long run," he told Reuters Health.

Jun 23
The Odds Of Surviving Colon Cancer Improve If You Are Married
A new study shows that being married boosts survival odds for both men and women with colon cancer at every stage of the disease.

Married patients had a 14 percent lower risk of death according to researchers at Penn State's College of Medicine and Brigham Young University. That estimate is based on analysis of 127,753 patient records.

Similar to studies of other types of cancers, the researchers did find that married people were diagnosed at earlier stages of colon cancer and sought more aggressive treatment. The researchers took those and other factors into account before calculating the benefit of marriage on survival odds.

"Controlling for the stage that the cancer was detected is key," said Sven Wilson, a study coauthor and professor at Brigham Young University. "Without that, it's hard to know whether the analysis is just picking up a diagnosis effect."

Colon cancer is the fourth most common type of cancer in the United States for both men and women. Curiously, the marriage benefit seen in the new study was nearly identical for both men and women.

So what's driving the different survival rates? Marriage is a self-selected group, and Wilson is careful to note that the selection process makes it difficult to sort out the root cause. One intuitive idea is that spouses serve as an important informal caregiver during a critical time, and that extra support may translate into better disease management and, hence, better outcomes.

Jun 22
Mystery disease kills two more in Bihar
Two more children have died of a mysterious disease in Bihar, taking the toll to 34 in the state, officials said on Wednesday.

The children died after reporting high fever followed by convulsions and unconsciousness in Muzaffarpur district late on Tuesday.

Locals have termed the disease as 'chamki ki bimari' and said the symptoms were similar to encephalitis - a disease that causes inflammation of the brain.

However, state Health Minister Ashwani Kumar Choubey said experts were in the process of identifying the disease and it was 'not proper to term it encephalitis'.

Two expert teams - one from Pune-based National Institute of Virology and another from the union health ministry - visited a hospital in Muzaffarpur Tuesday where dozens of children are undergoing treatment.

"Both teams along with local health officials will also visit the villages where the children have died," Gopal Shankar Shahni, a doctor at the Sri Krishna Medical College and Hospital (SKMCH) in Muzaffarpur said on telephone.

Principal secretary, health, Amarjeet Sinha said the experts would collect samples of animals to identify the cause of the disease.

The teams will Wednesday visit Kejriwal Hospital in Muzaffarpur. Over three dozen children are undergoing treatment in various hospitals in Muzaffarpur, Motihari and Patna.

Jun 22
Delhi bans use of calcium carbide for ripening fruits
The Delhi government has banned the use of calcium carbide for artificial ripening of fruits, recognising its harmful effects of health, and suggested ethylene gas as an alternate technique.

"Use of calcium carbide for artificially ripening the fruits is banned in Delhi under the PFA (Prevention of food adulteration) Act," Delhi Health Minister A K Walia has said.

Walia had chaired a meeting of state officials, scientists from ICAR and mango traders here yesterday to discuss the alternate techniques for maturing of fruits.

Officials from department of prevention of food adulteration, scientists from Shri Ram Institute of Industrial research and representatives of Mother Dairy were also present.

Based on inputs provided by the experts, the minister said ethylene gas can be used as alternate technique for ripening of fruits, which is not harmful.

"The fruits ripened with Ethylene have more acceptable colour than naturally ripened fruits and have more shelf-life than fruits ripened with calcium carbide," Walia had said.

Horticulture experts say that calcium carbide used for ripening of the king of fruits is carcinogenic and thus the final product is cancerous.

The minister said the government is soon going to organise special awareness campaign to spread awareness among the fruit traders and merchants for the adoption of ethylene as an alternative medium for ripening of fruits.

"The technique is also said to be very cost effective, so it won't affect the customer," Walia said, adding, similar technique is already being used by Mother Dairy and a few states.

Sudesh J Schdeva, President of Mango Merchant Association at Azadpur (Asia's biggest fruit and vegetable wholesale market) said a group of ICAR scientists are expected to visit the market tomorrow to educate mango merchants about advantages of ethylene gas for artificial ripening of the fruit.

The national capital receives over 200 trucks of mangoes containing about 10 tonnes of the fruit daily from Uttar Pradesh, Bihar, Himachal Pradesh and South India, Sachdeva added.

Jun 21
Indian biotechnology market to reach over $11 billion by 2017
The Indian biotechnology market is set to reach over $11 billion by 2017, according to a new report available on companiesandmarkets.com. The market will be driven by foreign investment, growing R&D and infrastructure investment, an emerging contract research market, drug discovery and growth in manufacturing outsourcing to India.

Biotechnology In India: A Market Report

The Indian biotechnology market accounts for around 2% of the global market and ranks amongst the leading twelve biotechnology industries globally. The Indian biotechnology market is the third largest in Asia, after Japan and South Korea.

Exports continue to account for the largest share in the revenues of the Indian biotechnology industry, reflecting the continued focus of Indian biotech companies on the international markets. While segments such as bio-pharma, bioinformatics and bio-services represented a substantial chunk of the export market, bio-industrial and bio-agriculture generated a major share of revenues serving the domestic market.

Western India's domination of the Indian biotech industry continues, accounting for the largest share in the industry in terms of revenues. However, the southern region, with biotech hubs such as Bangalore and Hyderabad, represent the largest in the country when it comes to the number of companies. The number of companies in the Southern region reached 172 in 2010.

Over 350 companies operate in the biotechnology sector in India. Leading the suite include Biocon, Serum Institute of India, and Panacea Biotech. Major players profiled in the report include Biocon, Serum Institute of India, Panacea Biotec, Nuziveedu Seeds, Reliance Life Sciences, Quintiles, Rasi Seeds, Novo Nordisk, Shantha Biotechnics and Mahyco.

Jun 21
Healthcare law seen aiding employer coverage
About 61 percent of non-elderly Americans got their healthcare coverage through employers in 2009, down from 69 percent in 2000, according to a study sponsored by the non-partisan Robert Wood Johnson Foundation. Low and moderate-income families employed by small firms were the most likely to be affected by a loss of employer-sponsored coverage.

Julie Sonier, a senior researcher at the University of Minnesota who helped write the report, said the erosion in employer-sponsored insurance in the decade before the healthcare law was enacted underscored the need for action.

"When people don't have access to employer coverage, they might get public coverage, they might be uninsured, there might be a higher uncompensated care burden at their local hospital. The costs are in the system somewhere," she said in a telephone interview.

A second study by the centrist Urban Institute said it expects the healthcare overhaul signed into law last year by President Barack Obama to help small businesses provide medical coverage to employees.

"Our results show significant health care cost savings (under the law) to firms with fewer than 50 workers, as well as a small increase in the number of people covered by their employer-sponsored plans," the Urban Institute study said.

The law includes some tax incentives for small employers to provide coverage and penalties for large employers with employees who receive subsidized medical coverage on state-based exchanges that will go into operation in 2014.

"The evidence suggests the Affordable Care Act may have a stabilizing influence on small firm coverage," the study said.

The studies counter a recent report by Chicago consulting firm McKinsey that said about 30 percent of employers will "definitely" or "probably" stop offering health coverage once the state insurance exchanges begin operation, which are to provide a place for small businesses and individuals to shop for health insurance coverage.

That report sparked a fresh round of criticism of Obama's healthcare law by Republicans who are pushing to repeal it. Democrats demanded an explanation of the methodology, since other reports, including the Congressional Budget Office, said the law would have a small impact on employer coverage.

On Monday, McKinsey clarified that its report was a survey of employer attitudes and "was not intended to be a predictive economic analysis" of the impact of the new healthcare law.

The two studies sponsored by the Robert Wood Johnson Foundation that were released on Tuesday said most of the erosion in employer sponsored healthcare since 2000 was by small businesses.

Four states, Mississippi, Indiana, Michigan and Minnesota saw a loss in employer-sponsored coverage that was twice as large a the national average, according to the studies.

(Reporting by Donna Smith; Editing By Cynthia Osterman)

Jun 21
Abbott Laboratories Inc announced a deal for rights to Biotest AG's experimental rheumatoid arth
Biotest shares were up more than 20 percent in Frankfurt after the announcement on Tuesday.

Under the agreement, Abbott will pay Biotest a fee of $85 million for rights to BT-061, which is currently in Phase II clinical trials for rheumatoid arthritis and psoriasis. Biotest is also eligible for payments of up to $395 million should the drug achieve milestones, as well as royalties.

Abbott and Biotest will co-promote BT-061 in five major European markets -- Germany, France, the United Kingdom, Italy and Spain -- and Abbott will have exclusive global rights to commercialize the drug outside those countries.

Known as an anti-CD4 antibody, BT-061 is designed to work by activating the body's T-regulatory cells, strengthening a natural function of the body that prevents excessive immune reactions.

Humira ranked as the ninth-biggest-selling drug in the world last year with nearly $6 billion in sales, according to pharmaceutical information company IMS Health. However, Wall Street is concerned about looming competition, including from an oral drug in development by Pfizer Inc.

Abbott shares were up 0.4 percent in morning trading on the New York Stock Exchange.

(Reporting by Lewis Krauskopf, additional reporting by Sue Kelly in Chicago)

Jun 20
Cancer death rates continue drop: report
Cancer death rates are continuing to fall, but not all segments of the population are benefiting, the American Cancer Society said on Friday.

Overall, the group predicts 1,596,670 new cancer cases in the United States and 571,950 deaths in 2011.

Death rates for all cancer types fell by 1.9 percent a year from 2001 to 2007 in men and by 1.5 percent a year in women from 2002 through 2007.

Steady overall declines in cancer death rates have meant about 898,000 who would have died prematurely from cancer in the past 17 years did not, the organization said.

Americans with the least education are more than twice as likely to die from cancer as those with the most education, according to the group's annual cancer report.

Death rates for all cancer types have fallen in all racial and ethnic groups among both men and women since 1998 with the exception of American Indian/Alaska Native women, among whom rates were stable.

Black and Hispanic men have had the largest annual decreases in cancer death rates since 1998, falling by 2.6 percent among blacks and 2.5 percent among Hispanics.

New cases of lung cancer among women fell after rising steadily since the 1930s. The decline comes more than a decade after lung cancer rates in men started dropping and reflects differences in smoking trends among U.S. men and women, who took up smoking later in the last century than men.

Lung cancer is expected to account for 26 percent of all cancer deaths among women in 2011 and remains the No. 1 cancer killer of both men and women in the United States.

Breast cancer comes in No. 2 for women. Prostate cancer is the second most common killer of men, and colon cancer is the third-leading cause of cancer deaths for both sexes.

These four cancers account for almost half the total cancer deaths among men and women.

Cancer rates vary considerably among racial and ethnic groups. For all cancer types, black men have a 14 percent higher rate of new cases and a 33 percent higher death rate than white men, while black women have a 6 percent lower rate of new cancer cases and a 17 percent higher death rate than white women.

The report found cancer rates in the least educated were 2.6 times higher than in the most educated. This was most pronounced in lung cancer, reflecting higher smoking rates among those with less education.

Thirty-one percent of men with 12 or fewer years of education are smokers, compared with 12 percent of college graduates and 5 percent of men with advanced degrees.

(Editing by Todd Eastham)

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