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Feb 07
Over 40,000 childhood cancer cases in India every year: Experts
Over 40,000 cases of cancer in children are being reported in India every year, experts said here Sunday, adding that only a fraction of them manage to receive proper treatment.

'The number of cases of childhood cancer is increasing in India. Of the 40,000 that is reported, only 20-30 percent manage to get proper treatment,' senior consultant pediatric oncologist at the Rajiv Gandhi Cancer Institute Gauri Kapoor said at the institute's 10th annual conference here.

'Unlike cancer in adults, childhood cancers have a higher cure rate. But, this is only possible if the cancer is diagnosed at the right stage and the child is given right mode of treatment,' added Kapoor.

The common cancers among children are acute lymphoblastic leukemia or blood cancer, germ cell tumour, brain tumour and liver and kidney cancer, among others.

The annual conference saw participation from over 100 experts from the All Institute of Medical Sciences (AIIMS), Tata Memorial hospital in Mumbai, St. Jude Children's Research Hospital in the US, and various other hospitals from across the world.

The three-day conference culminated in a 'walk on awareness of childhood cancer' in the central Delhi area Sunday that saw nearly 2,000 people participate.

'The idea is to spread awareness on children who have survived the battle of cancer. Once they grow up, they are made to face discrimination due to the existent stigma in the society,' additional secretary of the Indian Cancer Society Jyotsna Govil told IANS.

'The cure rate for childhood cancer is high and we must make an effort to make life easy for these children who have won the battle,' added Govil.

The conference also included an interactive workshop of 25 cancer survivors and doctors.

'The need is to develop more on dedicated pediatric oncology units that are equipped with adequate infrastructure and are viable to the masses,' said Kapoor.

Feb 07
A 30-minute daily walk cuts cancer risk
A new study has found that walking for 30 minutes a day could lower the risk of death from colon cancer.

According to researchers, such a simple routine could also reduce the risk of heart disease, diabetes and other cancers and can even be beneficial after cancer diagnosis, reports the Daily Express.

Researchers examined data from more than 150,000 people between 1982 and 2005. Those who exercised consistently for at least 10 years showed the lowest risk of colon cancer death.

The most benefits showed in those who exercised most, said lead author Kathleen Wolin, of Washington University.

"You get enormous 'bang for the buck'. You go for a 30-minute walk every day and you're going to reduce your risk of a number of diseases.

"It's never too late but it's also never too early to start being active.

Even those who haven't can begin after diagnosis and see some real benefits as well," she said.

Feb 05
Spanish researchers develop new Aids treatment
Researchers at Barcelona's Hospital Clinic said they were able to reduce the level of the virus in infected patients using a personalised treatment that they hope could eventually replace expensive antiretroviral drug treatment currently used to keep it at bay.

Twenty-four people with Aids took part in a clinical trial and after 24 weeks the majority had shown a "significant" decrease in their viral load, the hospital said, although it cautioned that it is still not enough as a treatment.

"This decrease was very significant is some of them but in no case did the virus become undetectable," the hospital statement said.

"However this is a very important improvement with respect to previous initiatives where with a similar vaccine there was a modest response in 30 percent of the treated patients. No therapeutic vaccine has achieved up to now the same level of response as in this study."

The vaccine was made from each person's own dendritic cells, a special type of cell that is a key regulator of the immune system. The cells were extracted and "reeducated" to attack the virus using samples of HIV also taken from individual patients.

The adjusted cells were then injected back into them in three stages, two weeks apart.

At 3,000 Euros (2,500 pounds) the new treatment is significantly less expensive than antiretrovirals which cost an estimated 8,000 Euros a year (6,800 pounds) and must be taken daily and for life.

The results of the clinical trial were announced Tuesday and published in the Journal of Infectious Diseases.

An estimated 33.3 million people worldwide have the HIV virus that causes Aids, according to the United Nations Aids agency UNAIDS.

Since the beginning of the epidemic in the 1980s, more than 60 million people have been infected with HIV and nearly 30 million have died of HIV-related causes.

Deborah Jack, Chief Executive of the National AIDS Trust, said: "This was an extremely small scale study so it's important to recognise that there is a long way to go before drawing any conclusions from this research.

"However, as HIV treatment has evolved hugely over the past ten years, we always welcome new research which sheds new light on effective treatment options for people living with HIV."

Lisa Power, Policy Director at HIV and sexual health charity Terrence Higgins Trust, said: "Therapeutic vaccines are an exciting area of research. Current drug treatment is good at keeping HIV in check, but as people with HIV now routinely live well into old age, the lifetime cost of treatment can be high. An effective therapeutic vaccine could not only be less expensive, but people living with HIV might find it easier to manage.

"This trial is a step in the right direction, but until we find a vaccine that controls the virus as well as antiretroviral treatment does, we're not there yet. This research give us a good idea of where to concentrate efforts in the future."

Feb 04
Strong Coffee Helps Working Women in Stressful Situations
For all of you working women out there who face stressful situations on a daily basis - a cup of joe might be just the thing you need to get through the day.

In a study by psychologists at Bristol University in the U.K., researchers found caffeinated coffee helped to boost a woman's performance in high-pressure environments, the Telegraph reported.

But the same does not hold true for men. In fact, male participants in the study who drank several cups of strong coffee became less confident and took longer to complete tasks.

The researchers said the findings suggest "the key to coffee's effects on the sexes lies in the way men and women respond differently to stress."

It's estimated that 100 million Americans consume about 350 cups of coffee a day.

The findings are published in the Journal of Applied Social Psychology.

Feb 04
City docs can now spot your bad gene
Basic gene profiling to single out the gene responsible for causing cancer and curing the disease now possible at select labs

Cancer treatment in the city is set to get personal in nature.

In a bid to improve the efficacy of cancer treatment, city doctors are now opting for gene profiling technique, which allows for identifying the gene responsible for the cancerous growth.


By isolating the gene, the doctors will not only be able to predict the growth of the cancer but also be able to devise a personalised treatment for you.

"From the available diagnostic tests, at times it becomes difficult for the doctors to distinguish the type of cancerous tumour. With gene expression profiling the doctor can actually detect the exact type of cancer," said Dr Mukesh Desai, haematologist, BJ Wadia Hospital for Children, Parel.

"Once the nature of the cancer is understood a specific treatment which best suits the patient can be selected from various treatments," he added.

Terming it a personalised cancer treatment, Dr Suresh Advani, chief oncologist of Jaslok Hospital, said, "The course of treatment can be selected by understanding the nature of tumour, whether it is aggressively spreading or not.

For instance, usually people who land up at my clinic and are diagnosed with stage one breast cancer have to undergo chemotherapy."

"But, with gene profiling, we can avoid chemotherapy in many cases as drugs might work better," he added.

Conventionally, medicos follow a group-specific treatment applicable to cancers of varied nature, but with gene profiling, there is an element of individual care.

No chemo

According to medical literature, there are reversible side effects of chemotherapy like hair loss, nausea, vomiting, weakness, and a lowered immunity, which can be avoided with the help of the new technique.

"To avoid the side effects and reduce the burden of various unnecessary drugs which take a toll on the human body, it is good to have a personalised treatment," said Dr Advani, adding that such basic tests cost anywhere between Rs 10,000 to Rs 50,000.

Currently a few private laboratories are equipped to do basic gene profiling but advanced testing is yet not possible in the country, say experts.

Dr Anil Heroor, onco-surgeon at Fortis Hospital, said, "The advanced 21-type gene testing is yet not available in the country.

But we can send samples from those patients who can afford it to the US for testing. Going by the scientific trials, the profiling helps doctors select a specific treatment, doing more good to the patient at large."

Feb 03
Study: High cholesterol often goes untreated
Majority of people with high cholesterol levels do not receive the treatment they need to reduce the risk of cardiovascular diseases such as heart attack and stroke, an international study has found.

"Many of these people - living in England, Germany, Japan, Jordan, Mexico, Scotland, Thailand and the United States of America - are unaware that they need treatment, which is easily accessible in the form of low-cost medicines," says the study published in the International Public Health Journal, the bulletin of the World Heath Organisation (WHO).

According to the largest-ever study - covering 147 million people - 78 per cent of adults who were surveyed in Thailand had not been diagnosed, while 53 per cent of Japanese who had been diagnosed remained untreated.

"Cholesterol-lowering medication is widely available, highly effective and can play an essential role in reducing cardiovascular disease around the world," says co-author, Gregory A Roth, from the Institute for Health Metrics and Evaluation in USA. "Despite this, effective medication coverage for control of high cholesterol remains disappointingly low." he added.

Feb 03
Sleeping enhances important memories--study
Researchers delving into the relationship between sleep and memory found that when we doze our brain prunes out unimportant memories but enhances those that need to be retrieved and are relevant to complete a task in the future.

Though, the human brain encodes and stores daily experiences in the form of memory, this information is quickly erased.

Lead author of the study, Dr. Jan Born of the University of Lubeck in Germany stated, "Our results show that memory consolidation during sleep indeed involves a basic selection process that determines which of the many pieces of the day's information is sent to long-term storage.

"Our findings also indicate that information relevant for future demands is selected foremost for storage."

Study details
In a bid to determine how the brain decides which memories to retain and which to forget, the researchers conducted study.

For the purpose of the study, they recruited 191 volunteers for a couple of experiments to test their memory retrieval.

The study subjects were split into two groups. The first was asked to memorize 40 pairs of words while the second group had to match photos of animals and objects.

Half of participants in both groups were told they would be re-tested within 10 hours on the material they had learned while the remaining were told to expect another task later.

During the 10-hour interval some members of both the groups were allowed to sleep.

Findings of the study
The researchers found that people who slept performed better when re-tested. However, the volunteers who went to sleep anticipating a test post the nap exhibited a better memory recall.

They remembered 12 percent more words as opposed to those who were not expecting a test.

The brain waves of the volunteers were also monitored by electroencephalograms (EEG) while they slept.

The study found that the participants who were aware that they would be tested displayed an increase in brain activity during deep or "slow wave" sleep that is known to be linked to memory consolidation.

Dr Gilles Einstein, an expert in memory at Furman University stated, "These results suggest that sleep is critical to this memory enhancement.

"This benefit extends to both declarative memories (memory for a road detour) and procedural memories (memory for a new dance step)."

The findings were reported in the 'Journal of Neuroscience.'

Feb 01
Fast, accurate test to diagnose CJD developed
Researchers have developed a highly sensitive assay that could change the way to diagnose the degenerative neurological condition Creutzfeldt-Jakob Disease (CJD), providing a fast, accurate alternative for early diagnosis of this rare but deadly condition.

The assay has been developed by microbiologist Ryuichiro Atarashi of Nagasaki University, Japan, and his team.


CJD is a prion disease, in which an isomer of a common protein known as the prion protein (PrP) takes on an abnormal shape and becomes an infectious variant called PrPSc. This variant is thought to trigger the subsequent malformation of other PrP proteins. Unlike their normal counterparts, PrPSc prions cannot be broken down, and instead accumulate - often clustering in brain tissue.

The pockets of abnormal tissue that result cause brain tissue to develop a sponge-like appearance, and because prion conditions can be spread by affected humans or animals, the diseases are often referred to as transmissible spongiform encephalopathies (TSEs).

One problem that has plagued developers of non-biopsy diagnostic techniques is that it is often difficult to avoid false positives among samples taken from patients with neurodegenerative disorders other than CJD.

So Atarashi and his colleagues used a new assay known as a real-time quaking-induced conversion (RT-QUIC) assay. 'Quaking-induced' refers to in vitro shaking, which researchers believe helps to accelerate the reactions, enabling the assay to produce results more quickly.

The team tested cerebrospinal fluid samples from 18 people with CJD and 35 people with other neurodegenerative diseases. This pilot group produced no false positives, and CJD was correctly diagnosed more than 83 pc of the time.

"This technique allows definitive ante-mortem confirmation of CJD," Nature quoted Atarashi, who added that this is currently difficult because it demands the detection of PrPSc in patients' biopsy specimens, as saying.

The findings have been published online in Nature Medicine. (ANI)

Feb 01
Deadly 'Congo fever'' kills one more in India
A rare deadly virus has killed its four victim in India, health officials said.

A 25-year-old doctor died from the Crimean Congo Haemorrhagic Fever, also known as the 'Congo fever', in the western city of Ahmedabad.

The dead earlier included a woman who was infected with the virus, and the doctor and the nurse who treated her at a hospital in the city.

The virus has been detected in India for the first time ever, health officials say.

The doctor who died on Monday was an intern working in a government hospital.

It is not clear whether he came in contact with any of the previous victims of the disease.

Twenty teams of health officials fanned out within 5km area from the Kolat village in Gujarat state last month after the disease was detected, but no fresh cases were found.

Crimean Congo Haemorrhagic Fever is a viral haemorrhagic fever transmitted by ticks and causes bleeding from the skin, mouth and nose.

The virus can also transmit from animals to humans

Jan 29
Early mammograms save more lives--study
Although, the US Preventative Services Task Force recommends breast cancer [abnormal cells that divide without control, which can invade nearby tissues or spread through the bloodstream and lymphatic system to other parts of the body. ] screenings for women every other year in the later stages of their lives, a new study claims frequent mammograms that begin at a younger age can save thousands of lives.

According to researchers, women who get screened for malignancy every year after the age of 40 cut their risk of dying of breast cancer [abnormal cells that divide without control, which can invade nearby tissues or spread through the bloodstream and lymphatic system to other parts of the body. ] by 71 percent as opposed to those who undergo mammograms less frequently after the age of 50 years.

According to experts, the fact that young women too can get breast cancer is underestimated. As a result of earlier mammograms, younger women receive more treatment options which in turn leads to better chances of survival.

Co-author of the research, Mark Helvie, director of breast imaging at the University of Michigan Comprehensive Cancer Center stated, "Task force guidelines have created confusion among women, leading some to forego mammography altogether.

"Mammography is one of the few screening tools that has been proven to save lives and our analysis shows that for maximum survival, annual screening beginning at 40 is best. This data gives women more information to make an informed choice about the screening schedule that's best for them."

Comparison of guidelines
For the purpose of the study, the researchers compared the guidelines issued by the task force on mammography for screening every other year in women 50-74 with those of the American Cancer Society that recommending an annual screening exam in women 40-84.

The experts used a total of six model scenarios of screening mammography designed by the Cancer Intervention and Surveillance Modeling Network.

It was noted that if women opt for breast cancer detection at age 40, they cut the risk of death from malignant tumors by 40 percent.

In contrast, when mammography begins at 50 and occurs every other year, breast cancer deaths go down by 23 percent. The difference translates into 71 percent more lives saved with annual screening starting at 40.

The investigators noted that on average women aged 40-49 years who go for an annual ritual of cancer detection will have a false-positive mammogram once in every 10 years.

R. Edward Hendrick, Ph.D., clinical professor of radiology at the University of Colorado School of Medicine, lead investigator stated, "The task force overemphasized potential harms of screening mammography, while ignoring the proven statistically significant benefit of annual screening mammography starting at age 40.

"In addition, the panel ignored more recent data from screening programs in Sweden and Canada showing that 40 percent of breast cancer deaths are averted in women who get regular screening mammography.

"Our modeling results agree completely with these screening program results in terms of the large number of women lives saved by regular screening mammography."

The study will be published in the February issue of the 'American Journal of Roentgenology.'

The benefits of mammogram
According to experts, women should undergo a clinical breast exam not only to save their life, but also to avert a mastectomy and avoid other radical cancer treatments.

The aim of cancer screening is to detect the malignancy before it starts to cause symptoms.

The tumors found in the advanced stage are larger and are more likely to have already spread. On the other hand, breast cancers found during mammography are generally smaller and still confined to the breast.

Finding the cancer at the initial stage means a better prognosis [a prediction of the course of the disease] . Smaller tumors can be effectively treated with a lumpectomy [a surgical procedure in which only the tumor and a small area of surrounding tissue are removed] , a type of breast conserving therapy which removes the cancerous lump while sparing the rest of the breast.

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