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Nov 12
India in grip of obesity epidemic'
India is now in the grip of an obesity epidemic and the trend needs to be immediately arrested by taxing junk food, restricting food ads and making food labelling clearer, according to a study.

The study that looked at the burden of overweight citizens in six countries -- Brazil, China, India, Mexico, Russia and South Africa -- has found that between 1998 and 2005, India's overweight rates increased by 20%.

Currently, almost 1 in 5 men and over 1 in 6 women are overweight. In some urban areas, the rates are as high as 40%.

Published in the Lancet on Thursday by the Organisation for Economic Co-operation and Development (OECD), the study warns that low-income countries cannot cope with the health consequences of wide scale obesity.

When compared to the other five countries, the percentage of adult women and men who are overweight in India was found to be lowest -- 14% and 18%, respectively. In comparison, 23% women and 32% men are overweight in China.

"However in absolute numbers, the burden would be mammoth in India and China," experts said.

According to estimates in the study, the annual cost of broad-based prevention strategies tackling obesity and other health threats, such as alcohol consumption, smoking, high blood pressure and cholesterol, would be less than $2 per person per year in India and China, less than $3 per head in Brazil and around $4 per person in South Africa, Russia and Mexico.

Upto 4,42,000 life years could be gained through a combination of prevention programmes in India every year. The cost-effectiveness ratio of a prevention strategy would be $268 per life year gained in good health in India and $380 in China, the study said.

OECD lead author Michele Cecchini said, "The results varied across countries surveyed. Seven in 10 Mexican adults are overweight or obese, while nearly half of all Brazilians, Russians and South Africans are also in this category. China and India report lower levels of obesity, but are also rapidly moving in the wrong direction. Low- and middle-income countries have far fewer health care resources to deal with the consequences of obesity, which include higher rates of cardiac disease, cancer and diabetes."

Obesity is the root for several non-communicable diseases (NCDs). Another study in the Lancet on Thursday predicts that by 2030, nearly 70% of all global deaths will be from non-communicable diseases like cancer, diabetes, and respiratory and heart disease. Of these 70% of deaths, 80% will be in the less wealthy nations like India.

According to WHO, NCDs -- principally cardiovascular diseases, diabetes, cancers and chronic respiratory diseases -- caused an estimated 35 million deaths in 2005. This figure represents 60% of all deaths globally, with 80% of deaths due to noncommunicable diseases occurring in low- and middle-income countries, and approximately 16 million deaths involving people under 70 years of age.

The total deaths from NCDs are projected to increase by a further 17% over the next 10 years. The greatest increase will be seen in the African region (27%) and the Eastern Mediterranean region (25%). The highest absolute number of deaths will occur in South-East Asia.

Up to 80% of heart disease, stroke and type-2 diabetes and over a third of cancers can be prevented by eliminating shared risk factors, mainly tobacco use, unhealthy diet, physical inactivity and the harmful use of alcohol.

Nov 10
UN to vaccinate 134 million Indian children from measles
The UN Children's Fund ( UNICEF) and the World Health Organization on Tuesday launched a campaign to provide 134 million children in India with a second does of a vaccination against measles, UN spokesman Farhan Haq told reporters here.

Measles is a highly contagious disease that is caused by a virus and spreads through contact with droplets from the nose, mouth, or throat of an infected person. According to the UN, the illness claims the lives of around 400 million children per day. In 2008, three out of four children who died of measles were from India.

"The campaign now under way in 14 high-risk Indian states aims to prevent up to 100,000 child deaths annually," said the spokesman.

Children not vaccinated are at risk of the disease and its severe health complications such as pneumonia, diarrhoea and encephalitis.

India introduced two-dose measles vaccinations a year ago, in line with advice on immunization from the Strategic Advisory Group of Experts (SAGE), the principal advisory body to WHO, which recommends all children should receive two doses of measles vaccination.

Between 2000 and 2007 two-dose vaccinations were reported to have averted around 3.4 million measles deaths worldwide.

Nov 10
Social connections affect sensitivity to physical pain: Study
A new study from University of Toronto has identified the influence of human social interaction on sensitivity to physical pain.

"Our study is among the first to show in humans that the perception of physical pain can be immediately impacted by the types of social experiences that people have in their everyday lives," said Terry Borsook.

Participants who experienced the indifferent social exchange reported less sensitivity to pain after the interaction when compared to that measured before the exchange. Participants exposed to the positive social interaction, however, exhibited no change in pain sensitivity.

"While the analgesic effect resulting from a socially disconnecting event might seem like a good thing, we know from a great deal of research in animals and humans that social threats provoke the well-known fight-or-flight stress response, of which pain inhibition is a typical component," said Borsook.

The results may be of such critical importance to human health and well-being that even a mild threat of disconnection can be stressful.

"What is remarkable about our results is that analgesia occurred in response to a type of experience that people experience in daily life, perhaps several times a day," said Borsook.

He added that the results also have important clinical implications when it comes to seeing your doctor.

"Health practitioners who are aloof, lack understanding, or are generally unresponsive to patients may provoke an analgesic response resulting in underestimated reports of pain, with insufficient pain control measures being a possible consequence."

The findings are published in the November issue of PAIN. (ANI)

Nov 09
India, US eye new healthcare targets
A new disease centre and increased collaboration in the field of healthcare have been the highlights of US President Barack Obama's health sector agenda during his India visit.

A memorandum of understanding has been signed for setting up a global disease detection centre in Delhi, while Obama especially mentioned support towards dealing with diseases like HIV/AIDS and tuberculosis in his speech to MPs.

'Because the wealth of a nation also depends on the health of its people, we'll continue to support India's efforts against diseases like tuberculosis and HIV/AIDS,' Obama said during his address.

'As global partners, we'll work to improve global health by preventing the spread of pandemic flu,' he said.

The disease centre in Delhi was announced by Obama while addressing a joint press conference Monday with Prime Minister Manmohan Singh.

'To promote global health, we are setting up a new disease detection centre here at New Delhi,' Obama said during the press conference.

According to government officials, the new centre will facilitate development of human resource in the field of healthcare. It is aimed at sharing best practices for detection and response to emerging infections, also giving advance training for it.

Building laboratory capacity for diagnosis of emerging infectious diseases using advanced technology will be the other main aim of the centre.

'We look forward to a greater engagement to improve the health of citizens, both in India and the US,' said Preetha Reddy, managing director of Apollo hospitals group and member of the India-US CEOs forum. She was among the CEOs who met Obama.

She said that harnessing potential telecom technologies and developing human resource in health were the priorities.

'The future demands a renewed focus on wellness and preventive healthcare. We are keen on bi-national partnerships to battle chronic diseases. Diseases do not recognize boundaries and therefore it is important that we foster greater research collaboration,' she added.

Nov 08
Facial reflexology: The latest fad in Britain
Suffering from stress, insomnia, or memory loss? Don't pop a pill, instead press your face, say experts, who have come out with a complementary therapy called facial reflexology - the latest fad in Britain. The therapy works by stimulating pressure points on the face that correspond with
particular parts of the body. In fact, it's effective because the face has a large number of nerves and blood vessels, say its advocates.

According to them, facial reflexology combines massage with theories based on acupuncture and Chinese concepts of energy lines, or meridians, the Daily Mail reported.

The facial reflexologists say they can feel a change of texture as a result of these "imbalances" under the upper layer of skin on the face. They are said to feel like lumps of porridge or grains of sand. By working over the face with the fingertips, they can, the experts claim, break down these deposits, boosting the energy, circulatory and nervous systems.

"The brain is the control centre of the body and the face is much closer to it than the feet are, so face reflexology can work faster than foot reflexology," leading facial reflexologist Nikke Ariff as saying. Arif, one of the estimated 35,000 reflexologists now practising in Britain, says that each session begins by stimulating the acupuncture points on face using acupressure. As well as being "energy points" they are important blood circulation and nerve supply areas, she says.

Nov 08
New drug for worldwide malaria treatment
The largest clinical trial ever conducted has concluded that the drug artesunate should now be the preferred treatment for the disease in both children and adults everywhere in the world.

Professor Nick White of the Wellcome Trust-Mahidol University-Oxford Tropical Medicine Research Programme in Bangkok, Thailand, and his colleagues conducted the trial called African Quinine v. Artesunate Malaria Trial (AQUAMAT).

Artesunate is derived from a Chinese herb called qinghao (Artemisia annua).

AQUAMAT found that treatment with artesunate reduced the number of deaths from severe malaria by 22.5per cent compared with quinine. With artesunate treatment 8.5 per cent of the patients died, compared to 10.9 per cent with quinine.

Children treated with artesunate were also less likely to slip into a deeper coma or have seizures after the treatment was started. Severe hypoglycaemia - dangerously low blood sugar - was also less common in children treated with artesunate. In addition, artesunate was easy to administer, well tolerated, and proved very safe.

"Thanks to the development of the artemisinin compounds, we now have a safer and much more effective treatment. We recommend that artesunate should now replace quinine for the treatment of severe malaria in both children and adults everywhere in the world," Lancet quoted White as saying.

"For those of us who treat malaria in Africa, this trial is a turning point. Finally we have a better treatment to offer to our malaria patients," agreed Dr Olugbenga Mokuolu from the University of Ilorin in Nigeria.

"There are still many hurdles to overcome and we must be vigilant to protect against resistance to these new drugs and against a market in counterfeit drugs. But Professor White and colleagues have shown that we have the potential to save the lives of hundreds of thousands of children," said Sir Mark Walport, Director of the Wellcome Trust, which supported the study.

Nov 05
Drastic drop in sperm count among City men
Men who are hooked to their black-coated laptops run the risk of becoming infertile. For, the black coating on the laptop has estrogen degradation products that harm the sperm production in the body. Even men, who are overweight, smoke, drink or binge on processed food, are also equally at risk.

According to Dr Kamini Rao, Medical Director, Bangalore Assisted Conception Centre, among the couples who have been coming to her Centre, the sperm count in the men have reduced from 60-65 million per ml to 20-22 million per ml which is nearly 50-60 percent drop in a matter of a decade. She further observed that this is a trend particularly noticed among men in the age group of 25 to 35 years.

"An increasing number of men coming with decreasing sperm count is a worrying sign. Apart from lifestyle changes, industrial pollutants and consumption of poultry fed with estrogen filled food has worsened the problem," said Dr Rao.

Considering that environmental pollutants - air as well as water - affect in low sperm generation, she felt that the government must undertake pilot projects in congested areas to identify pollutants which are in high concentration. The local authorities can work on reducing these pollutants, Dr Rao suggested. However, she emphasised that low sperm count did not mean poor libido.


How to avoid low sperm count
1. Give up smoking and alcohol, which effect rise in estrogen levels
2. Exercise regularly
3. Eat nutritious food
4. Reduce caffeine intake
5. Avoid frequent hot baths and sauna sessions
6. Lose any excess weight as it tends to cause testosterone/estrogen imbalances
7. Reduce stress levels by learning relaxation techniques

Nov 05
New target for diabetes treatment
Researchers have identified a hormone produced and secreted by the liver as a previously unknown cause of insulin resistance.

The discovery may be a new target for the treatment of insulin resistance and type 2 diabetes.

"The current study sheds light on a previously underexplored function of the liver; the liver participates in the pathogenesis of insulin resistance through hormone secretion," said Hirofumi Misu of Kanazawa University in Japan.

The researchers had discovered earlier that genes encoding secretory proteins are abundantly expressed in the livers of people with Type 2 diabetes.

Now, the researchers reported the results of comprehensive gene expression analyses, revealing that the liver expresses higher levels of the gene encoding selenoprotein P (SeP) in people with type 2 diabetes who are more insulin resistant.

Further studies in mice added support to the notion that the connection between SeP and insulin resistance is causal. When the researchers gave normal mice SeP, they became insulin resistant and their blood sugar levels rose.

A treatment that blocked the activity of SeP in the livers of diabetic and obese mice improved their sensitivity to insulin and lowered blood sugar levels.

Misu said that SeP was known previously as a protein produced mainly in the liver, where it transports the essential trace element selenium from the liver to other parts of the body.

But the protein's clinical significance and, more specifically, its role in glucose homeostasis weren't known.

In the development of insulin resistance, the researchers don't think SeP acts on its own.

"Our study raises the possibility that the liver functions as an endocrine organ by producing a variety of hepatokines and that the dysregulation or impairment of hepatokine production might contribute to the development of various diseases," said the researchers.

The findings were published in the Cell Metabolism .

Nov 04
Autism study reveals how genetic changes rewire the brain
Scientists have demystified how genetic variants rewire the brain and it could help in finding therapies for rebalancing the brain's circuitry in early development.

Using a blend of brain imaging and genetic detective work, the discovery of the scientists at the University of California has offered the missing physical evidence that links altered genes to modified brain function and learning.

"This is a key piece of the puzzle we've been searching for. Now we can begin to unravel the mystery of how genes rearrange the brain's circuitry not only in autism, but in many related neurological disorders." said co-principal investigator Daniel Geschwind.

The UCLA team scrutinized the differences in brain connectivity and function that result from two forms of the CNTNAP2 gene, one of which boosts risk for autism.

Suspecting that CNTNAP2 might influence brain activity, the researchers used functional magnetic resonance imaging (fMRI) to scan the brains of 32 children as they performed learning-related tasks. Half of the children had autism, and half did not.

Regardless of their diagnosis, the children carrying the risk variant showed a disjointed brain. The frontal lobe was over-connected to it and poorly connected to the rest of the brain. Communication with the back of the brain was particularly diminished.

"In children who carry the risk gene, the front of the brain appears to talk mostly with itself," explained first author Ashley Scott-Van Zeeland, of the Scripps Translational Science Institute.

"It doesn't communicate as much with other parts of the brain and lacks long-range connections to the back of the brain," said Zeeland.

Depending on which CNTNAP2 version the child carried, the researchers also observed a difference in connectivity between the left and right sides of the brain. In most people, the left side processes functions tied to language, like speech and understanding.

In the children with the non-risk gene, communication pathways in the frontal lobe linked more strongly to the left side of the brain.

By enhancing understanding of the relationship between genes, the brain and behavior, the UCLA finding could lead to earlier detection for autism, and new interventions to strengthen connections between the frontal lobe and left side of the brain.

"If we determine that the CNTNAP2 variant is a consistent predictor of language difficulties, we could begin to design targeted therapies to help rebalance the brain and move it toward a path of more normal development," said Zeeland.

The findings were published in the online edition of Science Translational Medicine. (ANI)

Nov 03
Snacking on almonds may boost immunity--study
A key ingredient to most Indian delicacies, almond might be effective in guarding against common viral infections like common cold and flu along with reducing inflammation, a recent study has revealed.

Researchers have found that the naturally occurring chemicals present in the almond skin might prove beneficial in fending off viral infections and boosting immune system [complex network of specialized cells and organs that work together to defend the body against attacks by ] altogether.

According to the findings published in the journal 'Immunology Letters,' these compounds may improve the ability of body's fighter cells or white blood cells to counteract foreign bodies like viruses.

It does so by increasing one's ability to obstruct viruses from replicating and spreading throughout the body.

The study also found that even after digestion of the nut, it was able to trigger immune response against invading microorganisms, the Reuters Health reported on Tuesday.

Study details and findings
For the study purpose, researchers from the Institute of Food Research in Norwich and the Policlinico Universitario in Messina, Italy tested the effect of almond skin extract on immunological compounds released by cells infected or not infected with genital herpes [a sexually transmitted disease caused by the herpes simplex virus] virus HSV-2.

Herpes Simplex Virus 2 is a sexually transmitted virus which is difficult-to-treat due to its ability to trick the immune system by dampening down the body's inflammatory response.

"The addition of natural almond skins to the cells led to a significant decrease in HSV-2 replication, whereas other extracts did not significantly influence the replication of the virus," the study authors stated.

Study presenter Dr. Giuseppina Mandalari said that almonds may have a "helpful impact on the treatment of infective and chronic diseases" and "are able to stimulate the immune response and thus contribute to an antiviral immune defence."

On the other hand, blanched almonds, where almond skin is removed by boiling in water, were found to have a lesser effect on the immune system.

More research needed
Though researchers are not clear as to which compounds in the almond skin possess antiviral activity, but propose that it could be polyphenols.

Dr Martin Wickham, who was also involved in the study at the Institute of Food Research, said, "It is an area of huge interest to find natural alternatives that will have an antiviral activity.

"Nutritional guidelines recommend eating around three ounces a day to benefit from the fibre and other nutritional components in almonds, but we have still to do the work to see whether this would be enough to have an antiviral affect.

"This was just an initial study to find out if almond skins have this antiviral activity.

"The herpes simplex virus is a very good model of viral infection
because it is known to evade the immune system, so because the almonds had an impact on this virus, it is fair to assume that it will have an impact on other viruses," Wickham added.

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