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Jul 27
6,000 affected with dengue in Dominican Republic
Over 6,000 people have been affected with dengue in the Dominican Republic, out of which 24 have died, a minister has said. But the number of cases reported in hospitals and clinics has declined over the past few days, which shows people have become aware of the danger and are seeking medical help
and taking necessary precautions, Public Health Minister Bautista Rojas Gomez said.

Authorities are also trying to stop the spread of other diseases like malaria, he said.

Jul 26
Most patients with cardio problems can fly safely
Most people with cardiovascular diseases who are not critically ill can safely fly, a new report says.

The study, conducted by the British Cardiovascular Society, says that such people can undertake air travel provided they drink plenty of fluids, wear compression stockings and take a blood thinner.

However, the fluid intake should exclude alcohol, tea and coffee.

Consultant cardiologist David Smith of National Health Service (NHS) Foundation and colleagues explain that the main impact of air travel is the inhalation of air with reduced oxygen content in a pressurized environment.

This results in lower circulating oxygen levels in the blood, known as hypobaric hypoxia, says a society release.

Passengers already at high risk of angina, heart failure or abnormal heart rhythms might be adversely affected by hypoxia.

Otherwise, the blood oxygen levels induced by flying appear to have little or no adverse circulatory effects, certainly not for short-and medium-haul flights, for heart patients, the report says.

Jul 26
Doubt cast on arthritis-related back pain management
A new research suggests that slavishly following long-held guidelines for diagnosing the cause of arthritis-related back pain is resulting in excessive tests, delays in pain relief and wasteful spending of as much as 10,000 dollars per patient.

Arthritis is a common cause of back pain, though difficult to precisely diagnose, experts say, because of the poor correlation between a finding of arthritis on an X-ray or MRI and the degree of a patient's back pain.

"The whole way we're doing this is wrong," says study leader Steven P. Cohen, M.D., an associate professor of anaesthesiology and critical care medicine at the Johns Hopkins University School of Medicine.

"If we just do the radio frequency procedure first, we're going to help more people and we're going to save a lot of money."

The study revealed that among those who had radio-frequency treatment, success rates were higher in those who had the diagnostic blocks first because they were more likely to actually have arthritis.

"When you do two blocks, you may be wrongly weeding out many people who would actually benefit from radio-frequency denervation," said Cohen.

Cohen notes that radiofrequency denervation is as safe as giving a diagnostic block and need only be done once for relief of symptoms.

The relief can last many months and sometimes years, but often must be repeated when pain returns.

Cohen and colleagues believe that making diagnostic accuracy a higher priority than pain relief may be misguided.

"If you ask patients what their main goal of treatment is, the answer is typically that they want to be able to pick up their grandkids or play golf. It's not, 'I want to know if it's my arthritic joints or my discs.'"

Cohen cautions that diagnostic nerve blocks are called for in some cases.

For example, they should be used to determine whether surgery is the right option for relieving certain kinds of back pain in people without a clear-cut anatomical problem in order to avoid an unnecessary, risky operation.

The new study is published in the August issue of the journal Anaesthesiology.

Jul 24
Eye stem cell therapy shows promise
Want to go in for stem cell therapy for your eye ailment but wary of the risk of infection? Help may be at hand. For, a new procedure, developed and patented by Sankara Nethralaya and Nichiin Bio Sciences of Japan, offers promise to treat ailments like corneal ulcers and StevensJohnson Syndrome.

To avoid viral infection and contamination, researchers used a synthetic material to grow corneal limbal stem cells of a rabbit. Being a nonbiological material, it also prevented rejection caused in the case of the biological one.

This material is actually a gel called Mebiol Gel. It gets liquefied when cooled. The Mebiol Gel helps rapid multiplication of cells. Once enough cells are grown, the cell culture dish is put in a refrigerator. After the gel liquefies, the stem cells are separated. They are then loosely injected into the eyes of rabbits.

"The cells that are cultivated within the Mebiol Gel can be used for therapeutic purposes, instead of human tissues like the amniotic membrane," says Dr H N Madhavan, President, Vision Research Foundation, and Director and Professor of Microbiology, Sankara Nethralaya.

"We received a patent in July for the process... It was a great struggle to get the patent, with challenges posed by many countries... and the next step is to take up human trial," he informs.

The success of the therapy would be known only after one year of regular checkups and followups once the patients undergo therapy. The Nethralaya would have a registry of patients, who meet the qualifications to undergo the procedure.

"The Mebiol Gel will not be priced over Rs 5,000. But the cost of the entire operation is yet to be decided," Dr Madhavan says.

Dr S S Badrinath, Chairman Emeritus, said the new procedure would help those suffering from corneal blindness. At the Sankara Nethralaya's Ocular Surface Clinic, approximately 6,000 cases are seen a year. Also, 125 new patients with the Stevens Johnson syndrome seek services every year. Of this, 25 per cent would benefit from the cultured corneal epithelial transplant. Similarly, 75 new patients with thermal or chemical injury come to hospital every year. Almost 80 per cent of them will benefit from the corneal limbal stem cell transplantation, he said.

Dr Samuel Abraham, Director, Nichiin Bio Sciences, Japan, and Consul General of Japan Yoshiaki Kodaki were present.

Jul 24
Pune: 60 students fall ill after eating mid-day meal
About 60 students of a municipal school at Bopodi near Pune were hospitalised on Friday with symptoms of food poisoning after having mid-day meal, police said.

The students in the 8-10 years age group took ill after eating 'Khichdi" as mid-day meal in the Dr Zakir Hussain School, Education Department officials said.

None of the students admitted to a private hospital was in a serious condition, police said.

An official said a case would be registered against the caterer which the supply the food to the school.

Jul 22
Why AIDS is spinning out of control
Vienna: For a while now, the AIDS epidemic was believed to have stabilised but now there's concern that it may be on the rise once again. Countries in Eastern Europe and former CIS states are now reporting an exponential rise in HIV cases all because of unsafe injectible drug use.

Injecting drug users or IDUs, whose numbers are rising alarmingly across the globe are now believed to be driving the AIDS epidemic. A majority of users are young and often poor and end up sharing syringes. Eastern Europe and Russia are the hubs. Russia has reported that 75% of IDUs are HIV positive.

"There is a problem of selling syringes. There is only one drug store that is far away that sells syringes. So people are going through the city looking for used syringes," said Aleksandra Osin, Journalist & Outreach worker, Russia.

Nina Ferencic, Senior Regional Advisor, HIV/AIDS UNICEF added," Sharing of injections is a very effective way of transmission, so you can have rapid increases in the epidmeic. When HIV enters a drug using population, the chances of the virus spreading rapidly is very high.

"So you can have scenario that from one year to the next you can have a group of drug users, in whom the infection rate has gone up from non-existent to almost 60% so it is a very effective route of HIV transmission."

A new study done by UNICEF shows that illegal drug trade is fuelling HIV/AIDS. It found that all along the illegal drug routes from Afghanistan to western Europe, there are mini -outbreaks of the disease and the worst affected are children.

"What happens is that you have an active drug trade or a drug route and there are a lot of people addicted to drugs themselves. When that enters into the hospital system where there is insufficient equipment and lack of infection control measures and when children get into the hospital, they get infected so there have been outbreaks in hospital settings," Ferencic added.

In India, too, there has been an upsurge of HIV among IDUs. In states like Punjab and Delhi, both seen as transit points of the drug trade, there are a number of families who have lost their relatives to drug use and HIV but so far there are no services for IDUs who are seen as outcasts and criminalised.

At the international aids conference, countries will pledge not only to curb this organised crime but also provide essential services such as harm reduction and treatment to drug users who are also HIV positive.

Jul 21
Now microneedles for painless immunisation
American scientists have successfully developed a new technology using "microneedles" to deliver painless immunisation. Experiments conducted on mice have proved that instead of a shot, people also might get immunised in future through a "stick-on" skin patch containing tiny microneedles, the lead
author of the study, Sean Sullivan, was quoted as saying by Xinhua.

Sullivan and other experts from Emory University and Georgia Institute of Technology conducted the study.

The microneedles - less than 1 mm in length - dissolve into the skin and are small enough that they don't draw blood or cause pain. If the patches are found to work on humans, getting an immunisation may be as simple as stopping by the pharmacy, picking up your patch and slapping it on, he said.

"There are so many little annoyances with the standard vaccination process that could go away," he said.

Because the patch appeared to work using less vaccine than in a typical shot, the discovery has the potential to reduce the amount of vaccine that needs to be produced, which could alleviate shortages in case of pandemic flu, other experts said.

Jul 21
Star shaped brain cells regulate breathing
Astrocytes, the brain cells named after their characteristic star-shape, play a key role in the regulation of breathing.

Scientists at the University College London and the University of Bristol demonstrated that astrocytes are able to sense the levels of carbondioxide in the blood, reports Science Express. They then activate brain neuronal (nerve cell) respiratory networks to increase our breathing in accord with prevailing metabolism and activity.

Astrocytes are a subtype of a group of brain cells known as glia ('glue' in Greek), according to a Cambridge statement.

Now, astrocytes have been found to have a unique ability to 'taste' the composition of arterial blood entering the brain by sensing increases in arterial levels of carbon dioxide.

They then release a chemical messenger called ATP, which stimulates brain respiratory centres to increase our breathing in order for extra carbon dioxide to be removed from the blood and exhaled.

Jul 20
Vitamin C blocks tumour growth: study
New Zealand researchers have established that vitamin C can help to block the growth of cancer cells - an important experimental finding they expect could be quickly adopted into cancer treatment.

The role of vitamin C in cancer treatment has been controversial for decades, with contradictory findings from various studies. In an international review of 20 human trials of vitamin C and other "anti-oxidant" supplements, the influential Cochrane Collaboration found no convincing evidence that they could prevent gastro-intestinal cancers - and said they "even seem to increase mortality".

But now a team from Otago University at Christchurch, in a paper published in leading international journal Cancer Research, have shown that vitamin C has a role in controlling tumour growth.

They say their study of tumorous and normal tissue samples from women with cancer of the uterine lining provides the first direct evidence of a link between vitamin C and a protein called HIF-1.

HIF (hypoxia inducible factor)-1 is considered a key protein in tumour survival. High activity of it promotes tumour growth and resistance to chemotherapy and radiotherapy and is linked with a poor prognosis for patients.

The Christchurch study, led by Associate Professor Margreet Vissers, of the university's Free Radical Research Group, found that high-grade tumours had around 40 per cent less vitamin C than matched, adjacent, normal tissue.

The researchers say their study suggests that restoring the vitamin C levels in tumours would limit factors that promote tumour growth, and recommend animal trials to test the hypothesis.

Professor Vissers said the study suggested it would be beneficial for people with cancer cells to have more vitamin C. It could help restrict the rate of tumour growth, increase responsiveness to chemotherapy and might prevent formation of solid tumours.

"There's enough information now for people to be seriously thinking about doing this, to apply this to the clinic or be setting up some clinical trials," she told the Herald yesterday.

"Anti-oxidant supplementation may not end up delivering any more vitamin C to the tumour.

"Just supplementing people may not actually have the effect that you want because you haven't done it in the right way," Professor Vissers said.

She said vitamin C levels in the body could be raised only to a certain level by oral supplementation.

Intravenous injections could achieve a higher level.

"That's the question: what's the best way to deliver vitamin C to the tumour."

Jul 20
Beware steroid-laced food supplements
The Food Safety and Standards Authority of India has warned the public against using some steroid-containing products available as 'dietary supplements.' These could find their way into the country from the United States, where the products have already been banned.

The warning follows a communication from the Food and Drug Administration of the U.S. Some of these products are Mastavol and Hyperdrol syrups and Dienedrone and D-Drol, both capsules.

The products were subject to class-I recall in the U.S. as some of these were marketed, without an approved New Drug Application or a Generic Drug Application, as dietary supplements.

The products were found to contain steroid or steroid-like substances, making them unapproved new drugs. Most of these products were distributed through the Internet rather than through a distributor network.

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