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Aug 25
Three Steps For Healthy Feet
We ask a lot of our feet, we take them for granted and scarcely give a thought to how best to keep them healthy until something goes wrong. In this month's Harvard Health Letter, there is a four page article about how feet work and "three steps" on how to look after them from Dr. James Ioli, chief of podiatry at Harvard-affiliated Brigham and Women's Hospital in Boston and colleagues.

Our feet provide us with a steady base on which to stand or walk, they act as levers for forward and backward and sideways moves, and they absorb shock, for instance when we run and jump the impact of landing is a force equal to many times our body weight.

Our feet do all this with just 26 bones (one less than in our hands) and 33 joints all lashed together by an intricate architecture of 100 ligaments and extrinsic and intrinsic muscles and tendons that orchestrate the movement of the feet.

The extrinsic muscles start in the lower leg, wrap in a crisscross fashion around the ankle and finish in the foot, like a kind of sock, and enables the foot to articulate in several directions.

The intrinsic muscles, which start and end in the foot itself, comprise several layers across the sole and help to form an elegant and graceful arch along the length of the foot.

When a person walks normally, the weight starts in the heel and moves to the front of the foot. The heel hits the ground first and the shock of impact is absorbed by the heel or calcaneus bones and a layer of fatty tissue beneath. Then the foot rolls forward on its outside edge and causes the plantar fascia, a band of tissue along the bottom of the foot, to stretch out.

All this happens without thinking about it, and it's only when something goes wrong, and there is plenty that can, that we become aware of how much we rely on our feet.

Some people are born with foot problems like high arches (pes cavus) or clubfoot (talipes equinovarus) and in many cases these problems can be surgically treated.

Others are born with minor defects that can become more serious as we get older and especially if we put on weight.

One problem is overpronation, where the person walks or runs on the inside of their feet. This is not uncommon and for the most part people aren't bother by it, but some can end up with a range of problems like sore knees, sore ankles, fallen arches, or inflamed and worn out foot tissue.

The opposite of overpronation, called oversupination, or walking too far onto the outside edge of the foot, can also lead to similar problems.

Another problem is flexible flat feet, which affects around 1 in 5 adults. This is when the arches in the feet flatten out under weight but then return to their normal arched shape when the weight is taken off. Again, this does not usually affect many people who have it, but it can get worse as they age, and especially if they put on weight.

Then there is a range of problems that can be described as "self inflicted" because they arise from doing things like wearing high heels and badly fitting shoes. These include hammertoes and bunions which result from squeezing toes into too-narrow shoes, and we can also damage metatarsals (the long bones of the foot before the toes) and Achilles' tendons by over use of high heels.

Many people don't realize that as they age, the ligaments and tendons in their feet stretch out, causing them to grow by a half size or even more.

Also we tend to wear shoes far beyond their replacement stage, by which time the heel is no longer held firmly in place at the back, and the sole no longer absorbs shock effectively.

The authors recommend a three step approach to keeping feet healthy:

1. WEAR GOOD SHOES: Buy low-heeled shoes that fit well and make sure there is plenty of room for your toes. Replace them regularly.
2. STAY TRIM: Too much weight on your feet wears them out, and keeping to a healthy weight will benefit the rest of your body too.
3. WALK: Not only is walking good general exercise, it strengthens and stretches the feet (and remember to change your shoes regularly).

Aug 25
World Bank pats HP for focused AIDS programme
Shimla, (PTI) : Himachal Pradesh has been praised by the World Bank for running "effective and focused" programmes to check HIV/AIDS in the state, which has witnessed a surge in the number of positive cases in the last three years.

A six-member team of the World Bank, which had toured the state recently, assessed the HIV/AIDS control measures in different parts of the state and praised the state government for running "effective and focused" programmes in this direction, Director Health Sulakshna Puri told PTI today.

The state has also won accolade from National AIDS Control Organisation (NACO) in this regard, Puri, who is also the Project director of the State AIDS control society, said.

Particularly impressed with the transparency in financial monitoring of the AIDS programmes in HP, the NACO said the tiny Himalayan state should serve as a "pilot site" for other states, she added.

Aug 25
H1N1 virus may remain active in winter: experts
Chandigarh: Even as suspected cases of swine flu continue to be reported, experts say it will be several months before the virus stabilises. It is likely, they add, that the virus continues to affect people in the coming winters.

According to Prof Rajesh Kumar, Head of Department of Community Medicine at PGI, cooler weather of the monsoons flares up flu and other respiratory diseases. This could be the reason, he says, for the sudden surge of cases in August.

But he is quick to add that the H1N1 virus has not shown any adherence to weather so far and is expected to continue in winters.

“At this moment it is difficult to predict how the virus will behave. But traditionally, common flu rises in autumn, spring and winters. Going by that logic, the H1N1 virus should be active in winters and stabilise only by next summers,” Prof Kumar says.

Every new virus causes epidemics. It takes time before human beings develop resistance to it, he says. “Take the case of common flu. It is also a virus but not that harmful as human beings have developed resistance to it. Once the same happens in case of H1N1, it will be like any other flu,” Prof Kumar adds.

Chandigarh’s count of cases has been 11 so far. The eight samples sent to NICD last week were tested negative and no fresh suspected cases were reported on Monday.

Central Nodal Officer satisfied with hospital arrangements

Arun Kumar, Joint Secretary-cum-Central Nodal Officer (Swine Flu), Ministry of Health and Family Welfare, visited the city hospitals on Monday for assessment of their preparedness. He expressed satisfaction over the arrangements after he was apprised of the facilities being provided in the isolation wards of PGIMER-12, GMCH-32 and GMSH-16.

Aug 22
Researchers Confirm That Genes Increase Risk Of Lung Cancer In Smokers
UK researchers who searched the DNA of over 5,000 smokers and non-smokers have found more evidence that inherited genes can increase a smoker's risk of developing lung cancer and also decide the type of cancer that develops.

The study was the work of researchers from the Institute of Cancer Research and is published in the 15 August issue of Cancer Research. The lead author was Professor Richard Houlston, a Cancer Research UK funded scientist at The Institute of Cancer Research.

Houlston and colleagues conducted the genome-wide association (GWA) study in two phases.

First they scanned the genomes of 1,900 people with lung cancer and compared them to those of 1,400 people without lung cancer to find differences in DNA that were linked to an increased risk of the disease.

Then they looked for these same changes in the genomes of another 2,000 people with lung cancer and compared them to the genomes of around the same number of people without lung cancer.

They found differences in three regions of the genome, at chromosomes 5, 6, and 15, that appeared to be more common in the people with lung cancer than the people who did not have it. Some of these links were already known about before.

Houlston said in a press statement that:

"This research confirms work done at the ICR and elsewhere that has previously implicated these areas in lung cancer risk and the type that develops."

But in this study, Houlston and colleagues discovered more detail. For instance, they found that the link between chromosome 15 and lung cancer is more complex than originally thought.

Confirming that there are two sites in this location that influence lung cancer risk, they also calculated that people with one copy of each variant who smoke or used to smoke have a 28 per cent increased risk of developing lung cancer, whereas current or former smokers who carry both copies of each variant have an 80 per cent higher risk.

People who do not smoke can also carry these changes, but the risk is only higher for those who smoke.

These genetic variants are in a family of genes that are known to influence smoking behaviour and consumption of tobacco. They also play a role in cell growth and death.

Houlston and colleagues also found that the variant at chromosome 5 influenced what type of lung cancer developed. People with the variant are more likely to develop a type of non-small cell lung cancer (NSCLC) known as adenocarcinoma, which accounts for 27 per cent of lung cancer cases in the UK. It is also the most common lung cancer in non-smokers.

The variant that they found on chromosome 6 appears to influence whether the type of NSCLC that develops is either adenocarcinoma or squamous cell carcinoma.

Houlston said the next step is to:

"Dig deeper to pin point which gene, or genes in these regions, cause the increased risk of developing lung cancer and how they actually trigger this increase."

Dr Lesley Walker, director of cancer information at Cancer Research UK, said:

"Smoking greatly increases the risk of lung cancer -- causing nine out of ten cases of the disease. This research shows that inherited genetic variation accounts for some of this risk and the type of lung cancer that develops."

"It's important to remember that smoking also increases the risk of other life-threatening diseases including heart disease, stroke and a dozen other cancers. The best thing a smoker can do to reduce their risk of lung cancer, and a range of other life-threatening conditions, is to quit," she added.

Aug 22
Expect Explosion In Swine Flu Cases, Warns WHO
Countries are warned to expect further cases and deaths as the spread of pandemic H1N1 swine flu virus speeds up, and there will come a point when case numbers will seem to explode, a World Health Organization director said on Friday.

Shin Young-soo, Director of the WHO Western Pacific region, told an assembly of health delegates meeting in Beijing that we can be certain there will be more cases and more deaths, reported the Associated Press, who quoted the director as saying:

"At a certain point, there will seem to be an explosion in case numbers."

Shin said governments must prepare their health systems, educate the public and protect the most vulnerable and they must act quickly because "we only have a short time period" to ensure that communities are made aware of how to reduce spread and how to get early treatment for severe cases.

He said developing countries are under the greatest threat because they don't have enough resources.

According to the latest WHO figures, as of 13 August, nearly 1,800 people have died from the 2009 swine flu, which reached pandemic status in June this year.

Individual cases are no longer tracked, so the total number of lab-confirmed infections, which has reached over 182,000 worldwide is likely to be a gross underestimate, said the WHO.

The Americas have reported 105,882 cases and 1,579 deaths; Europe 32,000 cases and 53 deaths; Western Pacific 27,111 cases and 50 deaths; South East Asia 13,172 cases and 106 deaths; Eastern Mediterranean 2,532 cases and 8 deaths; and Africa 1,469 cases and 3 deaths.

The WHO predicts that nearly one third of the world's population will be infected over the next two years, that is around 2 billion people.

The vast majority of cases are expected to be mild, but because of the large numbers involved, where cases are severe they are likely to overwhelm hospitals and health infrastructures, especially in poorer nations.

Experts are watching the pattern that the virus is following in the southern hemisphere in the hope of being able to anticipate how it might spread in the northern hemisphere when the flu season starts.

Unlike seasonal flu, where cases drop significantly during the summer and then resurge in the winter, the novel H1N1 swine flu has proved more resilient and is still spreading in the northern hemisphere.

However, northern countries are gearing up for a significant resurge as students and workers return from summer vacations. Vaccine makers are fast tracking production in an effort to get people vaccinated in time. Some are saying the first batches will be ready in October, but it is not clear how many doses will be available.

WHO Director-General Dr Margaret Chan said earlier this year that pregnant women and people with underlying medical conditions are two of the groups at higher risk of severe infection.

One study, by researchers in the US and Japan, has suggested that the novel H1N1 pandemic strain is more virulent than previously thought. It found that the virus infects cells deep inside the lungs, which can lead to pneumonia and in more severe cases, death, whereas seasonal flu viruses tend only to infect cells in the upper respiratory tract.

They found that the new pandemic swine flu strain spreads much more efficiently in the respiratory system than the seasonal flu virus, causing severe lesions in the lungs, more like the damage caused by other pandemic strains.

WHO and other experts have warned that the virus might also change quite suddenly, as Chan explained in June, when she announced the virus had reached pandemic status:

"The virus writes the rules and this one, like all influenza viruses, can change the rules, without rhyme or reason, at any time."

The last flu pandemic was the Hong Kong flu which globally killed around 1 million people in 1968 and 1969. It was the first known outbreak of the H3N2 strain. Seasonal flu kills around 250,000 to 500,000 people every year worldwide.

Aug 22
Ayurveda to fight flu
The health ministry indicated yesterday it wanted to add traditional ayurvedic prescriptions to its arsenal against the pandemic flu virus which has so far infected 2,401 people in India.

Traditional ayurveda and unani interventions can be used to increase immunity to fight flu-like conditions, the ministry said after consulting experts from private and public institutions and research councils of traditional medicines.

The ministry said traditional medicine interventions may be used by healthy persons and patients with mild symptoms such as cold and cough.

But patients with severe symptoms, as well as persons at high risk of developing complications, should approach government screening centres for standard management with antiviral oseltamivir and other supportive therapy.

Among the prescriptions the ministry has listed are consumption of decoctions of tulsi, turmeric and pepper each morning, avoiding cold drinks, fermented food and ice creams, and drinking hot water instead of cold water.

The ministry has also cited a number of ayurvedic and unani preparations that traditional medicine experts believe increase the body’s immunity.

A PTI report tonight put the number of deaths at 50.

A senior doctor at the All India Institute of Medical Sciences said the ministry should initiate research on the impact of traditional interventions on flu-like illnesses.

The ministry has also asked hospitals screening patients with flu symptoms to apply triage, a battlefield and emergency practice aimed at allocating resources to patients who need it the most.

Aug 22
Back to Google News Swine flu vaccines found safe in early trials
WASHINGTON — Early indications are a new swine flu vaccine is safe and is on track to be made available to the public by mid-October, US health officials said Friday.

"There are no red flags regarding safety," said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, noting that a series of clinical trials were being conducted on the vaccine with results due out between mid September and late October.

Adult volunteers participated in the first of five trials starting on August 7, and only reported arm swelling or redness where they received the injection.

Encouraged by the results, health officials went ahead this week with vaccine trials on children aged six months to 17 years, Fauci told reporters.

Additional experiments on about 120 pregnant women -- who are particularly at risk of infection from the influenza A(H1N1) virus and are high on the federal government's priority list for vaccines -- are to begin in September.

Officials expect that between 4,500 and 4,600 people will eventually take part in the vaccine studies.

Between 45 and 52 million doses of the vaccine are expected to be available by mid-October, said Jay Butler, who heads the H1N1 Vaccine Task Force of the US Centers for Disease Control and Prevention (CDC).

The CDC, which had made plans to distribute the vaccine once available, has issued its final recommendations for which groups of people should receive the shot.

The priority groups include "pregnant women, children, and young adults aged 6 months through 24 years, as well as persons aged 25 through 64, who have medical conditions that put them at higher risk for influenza-related complications," he said.

Health care workers, emergency medical service workers and people who take care of infants younger than six months -- too young to be administered a vaccine, should be vaccinated, Butler said.

The novel flu strain, which the CDC says has killed 522 people and caused 7,963 hospitalizations so far in the United States, has generally continued to spread, albeit at a slower speed.

Most of the cases occurred in people under the age of 49.

New infection cases have also decreased in South America and Australia during their seasonal flu season.

Aug 21
Half of swine flu deaths in high-risk people - study
About half of people who have died from swine flu have been pregnant or had other health conditions, especially diabetes and conditions linked with obesity, French researchers reported on Thursday.

And although older people seem to be less likely than others to get infected, if they do get the new H1N1 flu, they are more likely to die, the team at the French Institute for Public Health Surveillance in St. Maurice, France, reported.

"Most deaths (51 percent) occurred in the age group of 20-49 year-olds, but there was considerable variation depending on country or continent," the researchers wrote in Eurosurveillance.

"There was documented underlying disease in at least 49 percent of documented fatal cases worldwide to date," they added. "Two risk factors are noticeable: pregnancy and obesity."

Several governments have said pregnant women should be first to be immunized when vaccines become available.

The study also suggested children are not as hard-hit as feared. "Although previous reports suggested that cases of pandemic H1N1 influenza 2009 occurred mainly in children, the mean and median age of the 343 fatal cases in our analysis were 37 years," they wrote.

Twelve percent of people who died were 60 or older. In contrast, more than 90 percent of deaths from seasonal influenza are in people over the age of 65.

HEALTHY VICTIMS

"A high proportion of young children (27 percent of the 0-9 year-olds) and young adults (22 percent of the 20-29 year-olds) had no documented underlying disease, while 60 percent of people over the age of 60 years had heart or respiratory disease," the French team added.

"Diabetes and obesity were the most frequently identified underlying conditions and were found in fatal cases over the age of 20 years."

Several reports have suggested a link with obesity but researchers are not clear whether obesity itself raises the risk of severe complications from H1N1 swine flu, or whether obese people have other conditions that have not been diagnosed.

The case fatality rate for H1N1 swine flu is less than 1 percent -- about 0.4 percent, the researchers said. This is a little higher than for seasonal influenza but lower than the 2 percent to 3 percent fatality rate estimated for the 1918 Spanish influenza pandemic.

They also noted that it is difficult and dangerous to try to estimate fatality rates while an epidemic is ongoing, in part because serious cases and deaths get reported first.

First reports in New York, for instance, suggested a case fatality rate of 0.2 percent, they wrote. But later reports took into account mild cases.

"A telephone survey estimated that in fact 250,000 cases had occurred in that city of 8.3 million inhabitants, resulting in an estimated case fatality rate of 0.0008 percent," they added.

"The pandemic, however, is far from over, and deaths will unfortunately continue to occur."

Companies making vaccines include AstraZeneca's MedImmune unit, CSL, GlaxoSmithKline Plc, Novartis AG and Sanofi-Aventis SA.

Roche AG and Gilead Sciences Inc's Tamiflu and Glaxo's Relenza can treat influenza, and are currently recommended for people who have a high risk of complications or death.

Aug 19
High fever, sore throat? No need for H1N1 testing
Exasperated over complaints from hundreds of hospitals across the country which are unable to control the H1N1 panic and rush to
hospitals, the Union health ministry has clearly spelt out as to who should go for the testing. Accordingly, even those with high fever or sore throat need not go for the test. Only those with breathlessness, chest pain and low BP must undergo the test.

To prevent and contain Influenza-A H1N1 virus for screening, testing and isolation, the following guidelines are to be followed. At first, all individuals seeking consultations for flu-like symptoms should be screened at healthcare facilities — both government and private — or examined by a doctor. These will be categorized as under:

Category A

Patients with mild fever plus cough/sore throat with or without body ache, headache, diarrhoea and vomiting will be categorised as Category-A. They do not require Oseltamivir and should be treated for these symptoms. The patients should be monitored for their progress and reassessed at 24 to 48 hours by the doctor.

No testing of the patient for H1N1 is required.
Patients should stay home and avoid mixing up with public and high-risk members in the family.

Category B

In addition to all the signs and symptoms mentioned under Category-A, if the patient has high-grade fever and severe sore throat, may require home isolation and Oseltamivir

In addition to all the signs and symptoms mentioned under Category-A, individuals having one or more of the following high-risk conditions shall be treated with Oseltamivir.

Children less than 5 yrs old

Pregnant women

Persons aged 65 or more

Patients with lung diseases, heart disease, liver disease, kidney disease, blood disorders, diabetes, neurological disorders, cancer and HIV/AIDS; patients on long-term cortisone therapy.

No test for H1N1 is required for Category-B (children below 5 yrs) and (pregnant women).

These patients should stay home and avoid mixing with public and high risk members in the family.

Category C

In addition to the above signs and symptoms of Category-A and B, if the patient has one or more of the following:

Breathlessness, chest pain, drowsiness, fall in blood pressure, sputum mixed with blood, bluish discolouration of nails

Irritability among small children, refusal to accept feed

Worsening of underlying chronic conditions

All these patients mentioned above in Category-C require testing, immediate hospitalization and treatment.

Aug 19
Living And Non-Living Objects Separated By Brain For Processing
For unknown reasons, the human brain distinctly separates the handling of images of living things from images of non-living things, processing each image type in a different area of the brain. For years, many scientists have assumed the brain segregated visual information in this manner to optimize processing the images themselves, but new research shows that even in people who have been blind since birth the brain still separates the concepts of living and non-living objects.

The research, published in Neuron, implies that the brain categorizes objects based on the different types of subsequent consideration they demand - such as whether an object is edible, or is a landmark on the way home, or is a predator to run from. They are not categorized entirely by their appearance.

"If both sighted people and people with blindness process the same ideas in the same parts of the brain, then it follows that visual experience is not necessary in order for those aspects of brain organization to develop," says Bradford Mahon, postdoctoral fellow in the Department of Brain and Cognitive Sciences at the University of Rochester, and lead author of the study. "We think this means significant parts of the brain are innately structured around a few domains of knowledge that were critical in humans' evolutionary history."

Previous studies have shown that the sight of certain objects, such as a table or mountain, activate regions of the brain other than does the sight of living objects, such as an animal or face - but why the brain would choose to process these two categories differently has remained a mystery, says Mahon. Since the regions were known to activate when the objects were seen, scientists wondered if something about the visual appearance of the objects determined how the brain would process them. For instance, says Mahon, most living things have curved forms, and so many scientists thought the brain prefers to processes images of living things in an area that is optimized for curved forms.

To see if the appearance of objects is indeed key to how the brain conducts its processing, Mahon and his team, led by Alfonso Caramazza, director of the Cognitive Neuropsychology Laboratory at Harvard University, asked people who have been blind since birth to think about certain living and non-living objects. These people had no visual experience at all, so their brains necessarily determined where to do the processing using some criteria other than an object's appearance.

"When we looked at the MRI scans, it was pretty clear that blind people and sighted people were dividing up living and non-living processing in the same way," says Mahon. "We think these findings strongly encourage the view that the human brain's organization innately anticipates the different types of computations that must be carried out for different types of objects."

Mahon thinks it's possible that other parts of the human brain are innately structured around categories of knowledge that may have been important in human evolution. For instance, he says, facial expressions need a specific kind of processing linked to understanding emotions, whereas a landmark needs to be processed in conjunction with a sense of spatial awareness. The brain might choose to process these things in different areas of the brain because those areas have strong connections to other processing centers specializing in emotion or spatial awareness, says Mahon.

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