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May 07
Diabetes accelerates brain ageing, reveals new study
A new study has indicated that brains of people with type 1 diabetes show signs of accelerated ageing that correlate with slower information processing.

The study conducted at University of Pittsburgh Schools indicate that clinicians should consider screening middle-aged patients with type 1 diabetes for cognitive difficulties.

Senior author Caterina Rosano, MD, MPH, associate professor in Pitt Public Health's Department of Epidemiology, said that severity of cognitive complications and cerebral small vessel disease which can starve the brain of oxygen is much more intense than they expected, but it can be measured in a clinical setting. Rosano continued that further study in younger patients is needed, but it stands to reason that early detection and intervention such as controlling cardiometabolic factors and tighter glycemic control, which help prevent microvascular complications also could reduce or delay these cognitive complications.

The people with type 1 diabetes were all participants in the Pittsburgh Epidemiology of Diabetes Complications Study.

The MRIs showed that 33% of the people with type 1 diabetes had moderate to severe levels of white matter hyperintensities (markers of damage to the brain's white matter, present in normal aging and neurological disorders) compared with 7% of their non-diabetic counterparts.

On three cognitive tests that measure abilities such as information-processing speed, manual dexterity and verbal intelligence, the people with type 1 diabetes averaged lower scores than those without the condition. Among only the participants with type 1 diabetes, those with greater volumes of white matter hyperintensities averaged lower cognitive scores than those with smaller volumes, though the difference was less pronounced.

Lead author Karen A Nunley, Ph D , postdoctoral fellow in Pitt Public Health's neuroepidemiology program said that people with type 1 diabetes were living longer than ever before, and the incidence of type 1 diabetes was increasing annually.

The research will be published in the May 19 issue of the journal Neurology.

May 06
Sleepwalking may run in family: Study
Children are seven times more likely to sleepwalk if both their parents have a history of sleepwalking, according to a new study.

More than 60 per cent of children developed sleepwalking when both their parents were sleepwalkers in a study among kids born in the Canadian province of Quebec, researchers said.

The study also found that children with one parent who was a sleepwalker had three times the odds of becoming a sleepwalker compared with children whose parents did not sleepwalk.

Sleepwalking is a common childhood sleep disorder that usually disappears during adolescence. Sleep terrors are another early childhood sleep disorder often characterised by a scream, intense fear and a prolonged period of inconsolability.

The two disorders (also known as parasomnias) share many of the same characteristics and arise mainly from slow-wave sleep, according to the study.

Jacques Montplaisir, of the Hopital du Sacre-Coeur de Montreal, looked at the prevalence of sleepwalking and sleep terrors during childhood; any link between early sleep terrors and sleepwalking later in childhood; and the degree of association between parental history of sleepwalking and the presence of sleepwalking and sleep terrors in children.

Montplaisir and team analysed sleep data from a group of 1,940 children born in Quebec in 1997 and 1998 and studied in 1999 to 2011.

The authors found an overall childhood prevalence of sleep terrors (ages one and a half to 13 years) of 56.2 per cent. There was a high prevalence of sleep terrors (34.4 per cent) at one and a half years of age but that prevalence decreased to 5.3 per cent at age 13.

The overall childhood prevalence of sleepwalking (ages two and a half to 13 years) was 29.1 per cent. Sleepwalking was relatively infrequent during the preschool years but the prevalence increased steadily to 13.4 per cent by age 10 years.

Study results showed that children who had sleep terrors during early childhood were more likely to develop sleepwalking later in childhood at age 5 years or older than children who did not experience sleep terrors in early childhood (34.4 per cent vs 21.7 per cent).

Children's odds of sleepwalking increased based on the sleepwalking history of their parents.

Children with one parent who was a sleepwalker had three times the odds of becoming a sleepwalker compared with children whose parents did not sleepwalk; and children whose parents both had a history of sleepwalking had seven times the odds of becoming a sleepwalker, according to the results.

"These findings point to a strong genetic influence on sleepwalking and, to a lesser degree, sleep terrors. This effect may occur through polymorphisms in the genes involved in slow-wave sleep generation or sleep depth," researchers said.

May 05
Exercise key to healthy brain among the ageing
Physical activities such as walking helps older adults lessen age-related decline in brain structure, says a new research.

The researchers found the relationship between fitness and brain structure only in older adults, but not younger adults.

"We found that higher levels of cardiorespiratory fitness were associated with enhanced brain structure in older adults," explained study author Scott Hayes, assistant professor of psychiatry at Boston University School of Medicine.

"We found that physical activities that enhance cardio-respiratory fitness, such as walking, are inexpensive, accessible and could potentially improve quality of life by delaying cognitive decline and prolonging independent function," he noted.

Cardio-respiratory fitness refers to the ability of the circulatory and respiratory systems to supply oxygen to skeletal muscles during sustained physical activities.

For the study, the researchers compared younger adults (age 18-31) to older adults (age 55-82). All participants had magnetic resonance imaging (MRIs) taken of their brains and their cardiorespiratory (heart and lung) fitness was measured while they exercised on a treadmill.

The researchers found cardio-respiratory fitness was positively linked to the structural integrity of white matter fiber bundles in the brain in the older adults, while no such association was observed in younger adults.

"We hope this study provides additional motivation for older adults to increase their levels of physical activity, which positively impacts health, mood, cognition and the brain," Hayes said.

The findings appeared online in the journal Annals of Clinical and Translational Neurology.

May 04
Asthma may be easier to control than previously believed
If you suffer from asthma then you know that controlling the condition is the key to ensuring good quality of life. Now, scientists have come up with a bunch of tips and to help you do just that.

Allergist James Sublett, MD, at the American College of Allergy, Asthma and Immunology (ACAAI), said that patients were prone to hospitalization because they weren't aware of simple measures that can asthma under control. He added that sufferers are also not aware that uncontrolled asthma is dangerous and far costlier.

ACAAI has put together this list of facts to help you understand how you can not only achieve better outcomes with your asthma, but also start breathing easier.

Asthma sufferers may not realize that getting their symptoms under control can improve their overall health. Controlled asthma means:

No or fewer asthma symptoms even at night or after exercise.

Prevention of all or most asthma attacks.

Participation in all activities, including exercise.

No emergency room visits or hospital stays.

Less need for quick-relief medicines.

Minimize side effects from asthma medications.

Immunotherapy (allergy shots) can reduce sensitivity to the allergens that trigger asthma attacks and significantly reduce the severity of the disease. It might even prevent the development of asthma in some children with seasonal allergies.

Asthma is a complex condition, and exists in a variety of forms, including allergic asthma, exercise-induced asthma and work-related asthma. Each type can have different symptoms and triggers, and each requires a different approach to diagnosis and treatment. Similarly, each patient also has a different set of symptoms and triggers, which sets off an asthma attack.

According to the newly updated ACAAI Asthma Management and the Allergist: Better Outcomes at Lower Cost, asthma care provided by allergists is associated with better patient outcomes across a range of important markers.

May 02
Swap one daily sugary drink for water to cut type 2 diabetes risks
If you want to stay away from type 2 diabetes, choose water instead of sugary drink everyday, as per a new study.

The research indicated that for each 5 percent increase of a person's total energy intake provided by sweet drinks including soft drinks, the risk of developing type 2 diabetes may increase by 18 percent.

However, the study also estimates that replacing the daily consumption of one serving of a sugary drink with either water or unsweetened tea or coffee can lower the risk of developing diabetes by between 14percent and 25 percent.

In this research based on the large EPIC-Norfolk study which included more than 25,000 men and women aged 40-79 years, study participants recorded everything that they ate and drank for 7 consecutive days covering weekdays and weekend days, with particular attention to type, amount and frequency of consumption and whether sugar was added by the participants. During approximately 11 years of follow-up, 847 study participants were diagnosed with new-onset type 2 diabetes.

Lead scientist Nita Forouhi from University of Cambridge said that by using this detailed dietary assessment with a food diary, they were able to study several different types of sugary beverages, including sugar-sweetened soft drinks, sweetened tea or coffee and sweetened milk drinks as well as artificially sweetened beverages (ASB) and fruit juice, and to examine what would happen if water, unsweetened tea or coffee or ASB were substituted for sugary drinks.

In an analysis that accounted for a range of important factors including total energy intake the researchers found that there was an approximately 22% increased risk of developing type 2 diabetes per extra serving per day habitually of each of soft drinks, sweetened milk beverages and ASB consumed, but that consumption of fruit juice and sweetened tea or coffee was not related to diabetes.

Forouhi added that the good news is that the study provides evidence that replacing a daily serving of a sugary soft drink or sugary milk drink with water or unsweetened tea or coffee can help to cut the risk of diabetes, offering practical suggestions for healthy alternative drinks for the prevention of diabetes.

The study is published in Diabetologia.

May 01
Binge drinking dramatically ups mortality rate
A new study has provided a link between drinking behaviors with the overall mortality rate.

A new University of Colorado Boulder study involving some 40,000 people indicates that social and psychological problems caused by drinking generally trump physically hazardous drinking behaviors when it comes to overall mortality rates.

The study showed, for instance, that participants who had experienced an intervention by physicians, family members or friends had a 67 percent greater risk of death over the 18-year study period, said sociology Professor Richard Rogers, lead study author. Those who reported cutting down on social or sports activities because of alcohol use had a 46 percent higher risk of death over the same period.

In contrast, issues like driving after drinking too much or engaging in other physically risky behaviors did not result in a significant uptick in mortality rates.The new study also showed social risks of drinking, from losing jobs to having spouses threaten to leave, were equally or more strongly linked to mortality than physiological consequences of alcohol abuse like withdrawal jitters or becoming physically ill.

One of the most unexpected findings was that of those who identified themselves as light drinkers, consuming less than one drink a day, 48 percent reported having some problem with alcohol in the 12 months prior to the survey.

The research data allowed the CU-Boulder team to investigate the mortality associated with 41 separate drinking problems including drinking more than intended, unsuccessfully trying to cut back, driving a car after drinking too much, losing ties with friends and family, missing work with hangovers, drinking more to get the same effect, depression and arrests.

It was also found that 23 percent started drinking without intending to, 20 percent drank longer than expected and 25 percent experienced a strong urge to drink. For those who experienced a strong urge to drink over the past year, 19 percent were light drinkers, 40 percent were moderate drinkers and 57 percent were heavy drinkers.

Current drinkers who found it difficult to stop once they started had a 15 percent higher risk of death over the follow-up period; those who acknowledged going on a drinking bender during the past 12 months had a 54 percent higher mortality rate; and those who blacked out during the previous 12 months prior to the assessment had a 22 percent higher mortality rate over the 18-year study period.

The new study also showed those who reported attending Alcoholics Anonymous meetings in the past year had a 45 percent higher risk of mortality.

But those results likely are somewhat misleading in that some of those people could have recently have been diagnosed as alcoholics or were more likely to have severe health, social or legal problems, including required AA attendance. In addition, those who reported attending AA might have had increased risk of mortality due to smoking or may have had other substance abuse problems.

The study is published in the journal Drug and Alcohol Dependence.

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