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Sep 09
Eat hot chillies daily to stay in shape
If you love to include chillies in your diet, you have another healthy reason to do so. According to a study, consumption of hot chillies can prevent overeating via an action on nerves in the stomach, thus curbing obesity in chilli lovers.

Researchers from University of Adelaide discovered that a high-fat diet may impair important hot chilli receptors located in the stomach that signal fullness.

The stomach stretches when it is full, which activates nerves in the stomach to tell the body that it has had enough food.

"We found that this activation is regulated through hot chilli pepper or TRPV1 receptors in the stomach," said associate professor Amanda Page from University of Adelaide's school of medicine.

The team also found that TRPV1 receptors can be disrupted in high fat diet-induced obesity.

It is known from previous studies that capsaicin, found in hot chillies, reduces food intake in humans.

"We discover that deletion of TRPV1 receptors dampens the response of gastric nerves to stretch - resulting in a delayed feeling of fullness and the consumption of more food," Page explained.

Therefore, part of the effect of capsaicin on food intake may be mediated via the stomach.

"It is exciting that we now know that the consumption of capsaicin may be able to prevent overeating through an action on nerves in the stomach," added Dr Stephen Kentish, National Health and Medical Research Council (NHMRC) fellow from University of Adelaide.

The next stage of research will involve investigation of the mechanisms behind TRPV1 receptor activation with the aim of developing a more palatable therapy.

"We will also do further work to determine why a high-fat diet de-sensitises TRPV1 receptors and investigate if we can reverse the damage," he concluded.

Sep 09
How physical activity helps the elderly stay sharp
Older adults who regularly engage in moderate to vigorous physical activity perform better in mental tasks as they are more flexible in terms of brain functions, a new study says.

The findings could soon help doctors determine how physically active you are simply by imaging your brain.

"We looked at 100 adults between the ages of 60 and 80, and we used accelerometres to objectively measure their physical activity over a week," said one of the lead researchers Agnieszka Burzynska, professor at Colorado State University in the US.

The researchers also used functional magnetic resonance imaging (MRI) to observe how blood oxygen levels changed in the brain over time, reflecting each participant's brain activity at rest.

They evaluated the microscopic integrity of each person's white-matter fibers, which carry nerve impulses and interconnect the brain.

"We found that spontaneous brain activity showed more moment-to-moment fluctuations in the more-active adults," Burzynska noted.

"In a previous study, we showed that in some of the same regions of the brain, those people who have higher brain variability also performed better on complex cognitive tasks, especially on intelligence tasks and memory," Burzynska pointed out.

The researchers also found that, on average, older adults who were more active had better white-matter structure than their less-active peers.

The new findings were reported in the journal PLOS ONE.

Sep 09
Red wine research in dogs can help treat humans
Researchers have discovered that a compound found commonly in grape skins and red wine affects the immune systems of dogs in different ways.

The researchers believe that the findings could eventually lead to the use of the red wine compound, resveratrol, in treatments of cancer and other diseases in dogs and humans.

"This study makes it clear that resveratrol does cause the immune systems of dogs to change," said Sandra Axiak-Bechtel, assistant professor in oncology at University of Missouri College of Veterinary Medicine in the US.

"We found that resveratrol simultaneously causes dogs' immune systems to increase and decrease in different ways," Axiak-Bechtel noted.

"If we can better understand why resveratrol makes these changes and learn to control them, the chemical may have valuable uses in treatments of cancer and other diseases in dogs and humans," she explained.

For their study, Axiak-Bechtel, and colleagues added resveratrol to canine blood and measured innate immune system function.

They found that resveratrol caused the stimulated white blood cells to release more pro-inflammatory and fewer anti-inflammatory cytokines, which are signals cells use to communicate with each other during infection and inflammation.

These cytokines point to a stimulated immune system. However, the researchers also observed a decrease in the ability of neutrophils, which are immune cells that help fight diseases, to kill bacteria.

This points to decreased immune system strength, Axiak-Bechtel said.

"Seeing a decrease in neutrophil function typically means an immune system is losing the ability to kill invaders like bacteria," Axiak-Bechtel noted.

"It is clear that resveratrol is having a distinct effect on how the immune system reacts, but we still do not fully understand how this reaction can be best used to fight disease," Axiak-Bechtel said.

"Once we have a better understanding of this process, resveratrol could be a valuable supplementary treatment in fighting diseases like cancer," she pointed out.

This study was published in the journal Veterinary Immunology and Immunopathology.

Sep 09
Spinal manipulation relieves back pain for some, study says
Manipulating the spine can help people with lower back pain - but it doesn't work for everyone, according to a new study.

Spinal manipulation, or applying force to the joints of the spine, is a technique commonly used by chiropractors and physical therapists, according to the National Center for Complementary and Integrative Health. However, there is conflicting evidence about whether the treatment actually helps people, the researchers wrote in their study.

In the new study, the researchers found that spinal manipulation therapy (SMT) provided relief for some patients with lower back pain, but not for others. [5 Surprising Facts About Pain]

"The big finding is that both sides have been right all along," said Greg Kawchuk, a professor of rehabilitation medicine at the University of Alberta and co-author of the study. It's not a matter of whether the treatment works or doesn't work, but rather, figuring out the best way to care for each patient, he said.

In the study, 32 people with lower back pain received two spinal manipulation treatments over the course of a week. They told researchers how much pain they felt, and the researchers also looked at objective measures of improvement, including measurements of muscle activity, disc hydration and spinal stiffness. A control group of 16 people underwent similar physical examinations, but did not receive treatment. A third group, of 59 people who did not have back pain, was also included, to provide another comparison.

Among the participants who underwent the spinal manipulation treatments, 15 said that they felt better, and the researchers found that their physical measurements all improved as well, Kawchuk told Live Science. For example, their measurements of disc hydration and spinal stiffness were nearing those of the people without any back pain at the end of the study, he said.

The people who said they did not feel any better did not have those physical changes, Kawchuk said.

It's unclear why the treatment worked for some patients but not others, but one idea is that the people who felt that the treatment worked have different spinal characteristics, Kawchuk said. The researchers need to do a much larger study to see whether that may be the case, he added.

The new study "is the beginning of an attempt to understand why some patients respond to SMT and others do not," said Dr. Allyson Shrikhande, a rehabilitation physician at Lenox Hill Hospital in New York City, who was not involved with the study.

Previous studies have looked at how SMT can affect people's pain levels and degree of disability, but they didn't include the physical measurements, Shrikhande told Live Science in an email.

She added that it would have also been beneficial if the researchers had examined how the treatment affected patient's hamstring flexibility, because this can significantly affect people's bodies.

For the people who were not helped by the spinal manipulation treatments, it's not all bad news.

Future research will be aimed at figuring out what does work for these people, such as massage or surgery, Kawchuk said. The ultimate goal is to be able to match patients with the treatments that work best for them, he said.

"Back pain is not one problem - it's a group of problems," so there won't be one treatment that works for everyone, Kawchuk said.

The study was published on Aug. 31 in the journal Spine.

Sep 07
Novel genes found in gut disease under age five
Researchers analysing the complicated genetic influences in inflammatory bowel disease (IBD) have discovered new gene variants associated with an often-severe type of the disease that affects children under the age of five.

"As we continue to understand the specific functions of these genes in this type of childhood-onset disease, we are working to design more effective therapies," said study leader Judith Kelsen from The Children's Hospital of Philadelphia (CHOP), US.

Inflammatory bowel disease (IBD) is a painful, chronic inflammation of the gastrointestinal tract.

In fact, very early-onset IBD (VEO-IBD), diagnosed under age five, is often more severe than IBD that starts later in childhood.

"There has been extensive research in the genes contributing to adult-onset IBD and in children aged 10 and older but relatively little research has been performed in the very-early onset subtype of the disease," Kelsen said.

The study team analysed DNA from 125 children with VEO-IBD, all of them under age four, along with DNA from 19 of their parents.

A control group of 210 participants included 145 healthy individuals, 45 patients with pediatric IBD and 20 with adult-onset Crohn's disease (one of the two major types of IBD).

The researchers found rare and novel variants in genes that regulate B-cells and T-cells -- immune cells with important roles in immunodeficiency disorders.

They also discovered rare variants in the IL10RA gene, a member of a key immune function pathway.

The findings were published online in the journal Gastroenterology.

Sep 04
Blueberry extract could treat gum infection
Scientists have discovered that wild blueberry extracts help prevent dental plaque formation and treat severe gum diseases.

The findings could lead to reduced use of antibiotics to treat the serious gum infection disease called periodontitis.

The researchers from Laval University in Quebec City, Canada, said they were developing an oral device that could slowly release the blueberry extract after deep cleaning to help treat periodontitis.

Gum disease is a common condition among adults that occurs when bacteria form biofilms or plaques on teeth, and consequently the gums become inflamed.

Many people have had some degree of gum inflammation, or gingivitis, caused by dental plaque. The gums get red and swollen, and they bleed easily.

If left unchecked, the condition can progress to periodontitis. The plaque hardens into tartar, and the infection can spread below the gum line and destroy the tissue supporting the teeth.

To treat this condition, dentists scrape off the tartar and sometimes have to resort to conventional antibiotics.

But recently researchers have started looking at natural antibacterial compounds to treat gum disease.

Daniel Grenier and colleagues from Laval University wanted to see if blueberry polyphenols, which work against foodborne pathogens, could also help fight Fusobacterium nucleatum, one of the main species of bacteria associated with periodontitis.

In the lab, the researchers tested extracts from the wild blueberry against F. nucleatum.

The polyphenol-rich extracts successfully inhibited the growth of F. nucleatum, as well as its ability to form biofilms.

It also blocked a molecular pathway involved in inflammation, a key part of gum disease.

The findings were reported in the Journal of Agricultural and Food Chemistry.

Sep 03
Vitamin A linked to alcoholic liver disease development
Counteracting alcohol's effect on vitamin A levels in the liver may lead to novel treatments for alcoholic liver disease, suggests new research.

In particular, the research found that chronic alcohol consumption has a dramatic effect on the way the body handles vitamin A.

Long-term drinking lowers vitamin A levels in the liver, which is the main site of alcohol breakdown and vitamin A storage, while raising vitamin A levels in many other tissues.

"We hope this study will lead to a broader understanding and appreciation of the fact that excessive consumption of alcohol has a negative effect on vitamin A function in the body," said one of the researchers Robin Clugston from Columbia University Medical Center in New York, New York.

"Ultimately, we hope that vitamin A will be seen as a broad target for alcohol in multiple tissues of the body and that our understanding of alcohol-induced disease will be linked together by its effects on vitamin A," Clugston noted.

Clugston and colleagues conducted multiple experiments using several groups of mice including those who received alcohol-containing food and alcohol-free food.

They analysed the liver and other organs (kidney, spleen, heart, lung, white adipose, brown adipose and blood), from both groups of mice and measured tissue vitamin A levels.

The alcohol-fed mice had distinct changes in how their body handled vitamin A. In general, vitamin A levels were lower in the liver and higher in other tissues.

This strongly suggests that vitamin A in the liver is reduced by excessive alcohol consumption and that these findings are important in the development of alcoholic liver disease.

The findings appeared in the FASEB Journal.

Sep 02
Vehicular air pollution increases heart attack risk
Even short term exposure to particulate matter and nitric dioxide (NO2) air pollution, that originate predominantly from the combustion of fossil fuels such as emissions from industrial plants or vehicles increases risk of severe heart attacks, research has found.

The study investigated the effect of short term exposure to air pollution on the risk of ST-segment elevation myocardial infarction (STEMI), a deadly type of heart attack caused by a prolonged blockage of blood supply in the heart.

"The association between STEMI and air pollution was observed within one day of exposure," said researcher Jean-Francois Argacha, cardiologist at University Hospital Brussels in Belgium.

"This was despite the fact that concentrations of air pollutants were within the European air quality standard," Argacha noted.

The researchers used a statistical model to evaluate real-time exposure to air pollution in each part of Belgium with adjustments for population density.

The researchers looked at records of hospitalisations for STEMI in Belgium between 2009 and 2013.

They found that 10 micrograms per cubic metre increases in ambient PM2.5 concentrations were associated with a 2.8 percent increase in STEMI while 10 micrograms per cubic metre rises in NO2 were associated with a 5.1 percent increased risk.

These associations were only observed in men.

"It is possible that only men were affected because of the under representation of women in our study population (less than 25 percent)," Argacha said.

The findings were presented at European Society of Cardiology (ESC) Congress 2015 in London this week.

Sep 01
Develop close friendships to stay fit
Developing close friendships early in life may help children stay physically fit later in their adulthood, suggests new research.

"These results indicate that remaining close to -- as opposed to separating oneself -- from the peer pack in adolescence has long-term implications for adult physical health," said one of the researchers Joseph Allen from University of Virginia in the US.

"In this study, it was a robust predictor of increased long-term physical health quality," Allen noted.

The findings indicate that adolescent relationship qualities may come to influence adult health through decreased levels of later anxiety and depressive symptoms.

The researchers recruited a diverse group of 171 seventh- and eighth-graders and followed them from ages 13 through 27 years old.

From ages 13 through 17, the participants' best friend filled out a questionnaire assessing the overall quality of the friendship, including the degree of trust, communication, and alienation in the relationship.

Friends also provided information about how much participants' focused on fitting in with their peers.

Participants' health quality was then assessed annually at ages 25, 26, and 27 years old with questions about their overall health, anxiety and depression symptoms, and body mass index.

Results indicated that both high-quality close friendships and a drive to fit in with peers in adolescence were associated with better health at age 27.

The study was published in the journal Psychological Science.

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