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Jul 17
Discovery Of Fetal Short-Term Memory In 30-Week-Old Fetuses
Memory probably begins during the prenatal period, but little is known about the exact timing or for how long memory lasts. Now in a new study from the Netherlands, scientists have found fetal short-term memory in fetuses at 30 weeks.

The study provides insights into fetal development and may help address and prevent abnormalities. Published in the July/August 2009 issue of the journal Child Development, it was conducted by researchers at Maastricht University Medical Centre and the University Medical Centre St. Radboud.

The scientists studied about 100 healthy pregnant Dutch women and their fetuses, measuring changes in how the fetus responds to repeated stimulation. After receiving a number of stimuli, the fetus no longer responds to the stimulus as observed by ultrasonography and the stimulus is then accepted as "safe." This change in response is called "habituation." In a second session, the fetus "remembers" the stimulus and the number of stimuli needed for the fetus to habituate is then much smaller.

Based on their research, the scientists found the presence of fetal short-term memory of 10 minutes at 30 weeks. They determined this because a significantly lower number of stimuli was needed to reach habituation in a second session, which was performed 10 minutes after the first session. They also found that 34-week-old fetuses can store information and retrieve it four weeks later. Fetuses were tested at 30, 32, 34, and 36 weeks, and again at 38 weeks. The 34- and 36-week-old fetuses habituated much faster than the 38-week-old fetuses that had not been tested before. This implies that these fetuses have a memory of at least 4 weeks - the interval between the test at 34 weeks and that at 38 weeks.

"A better understanding of the normal development of the fetal central nervous system will lead to more insight into abnormalities, allowing prevention or extra care in the first years of life and, as a consequence, fewer problems in later life," according to the study's authors.

Jul 17
India Reduces Rate Of HIV Transmission In Some States, UNAIDS Report Says
India has managed to reduce the rate of HIV transmission in some states through increased awareness, resources and legislation, according to a report released Monday by India's Prime Minister Manmohan Singh, Reuters reports.

According to the report, titled "Redefining AIDS in Asia: Crafting an Effective Response," about 440,000 people die annually of AIDS-related causes in Asia, and the rate is expected to rise to about 500,000 by 2020 if measures are not taken (Majumdar, Reuters, 6/30). The report -- conducted by a UNAIDS-supported independent group called the Commission of AIDS on Asia and the Pacific -- noted that $3.1 billion annually would be required to effectively respond to the epidemic on the continent, United News of India reports.

According to the report, India accounts for about half of the estimated five million HIV-positive people in Asia (United News of India, 6/30). The report warned that India must be extremely cautious because many people are still unaware about the benefits of condom use in preventing HIV transmission, especially among injection drug users and women in rural parts of the country. India's efforts are garnering positive results in the southern states of Tamil Nadu and Andhra Pradesh and Maharashtra in the west, according to the report.

Denis Broun, head of UNAIDS in India, said the country "has managed to slow down the epidemic in some states with more decisive planning." He added, "We have really worked a lot in mobilizing politicians and they have been able to visit around the country and understand the realities of AIDS and interact with people." Broun said that new HIV diagnoses are "dropping in Tamil Nadu and it has been successful in Maharashtra," and "[w]e are sure we are going to see success in Andhra Pradesh before a year".

Jul 17
Swearing Appears To Lessen Effects Of Pain
A new UK study found that swearing appeared to lessen the effects of pain, perhaps because it invokes a similar response as that which occurs in fight or flight when it breaks the link between fear of pain and the perception of pain, concluded the researchers.

The study was the work of psychologists Richard Stephens, John Atkins and Andrew Kingston at Keele University in Staffordshire, and was recently published in the journal NeuroReport.

Although swearing is a common response to pain, whether it actually alters our experience of it is somewhat of a mystery.

According to a Reuters news agency report, Stephens said:

"Swearing has been around for centuries and is an almost universal human linguistic phenomenon."

"Our research shows one potential reason why swearing developed and why it persists," he added.

Stephens said it appears to arise in the right brain, whereas most language tends to arise in the left cerebral hemisphere.

For this study, the researchers investigated the extent to which swearing altered the ability of 64 volunteers to withstand immersing their hand in water (cold-pressor pain tolerance). They also measured pain perception and heart rate.

The researchers asked the volunteers to repeat a swear word while they immersed their hand in water. And then they asked them do the experiment again, except this time they repeated a neutral word that described a table.

Stephens and colleagues also examined sex differences, the role of pain catastrophizing, fear of pain and trait anxiety.

They found that compared with not swearing, swearing increased pain tolerance and heart rate, and decreased perception of pain.

However, "swearing did not increase pain tolerance in males with a tendency to catastrophise," they wrote.

They concluded that:

"The observed pain-lessening (hypoalgesic) effect may occur because swearing induces a fight-or-flight response and nullifies the link between fear of pain and pain perception."

"What is clear is that swearing triggers not only an emotional response, but a physical one too", he added, explaining that perhaps this is why the practice of swearing has survived for centuries.

Jul 17
Many People Can Cope With Knowing They Have Alzheimer's Risk
Many people who discover that they have inherited a higher risk of developing Alzheimer's can cope with the news, especially if they receive the it through genetic counseling: they may experience depression or anxiety at first, but it does not last long, according to a new study from the US.

The study was the work of co-author Scott Roberts, now a researcher at the University of Michigan School of Public Health in Ann Arbor, and colleagues, and is published in the New England Journal of Medicine, NEJM.

Roberts did the research while he was at Boston University. He is also co-principal investigator on the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) study, a series of randomized clinical trials that are looking at the impact of a genetic susceptibility testing program for adult children of people with Alzheimer's.

The NEJM study addresses a debate that has been going on for some time, about whether being told they have an inherited predisposition to Alzheimer's disease causes psychological harm to people, especially if there is a history of it in the family.

People with a family history of Alzheimer's disease are already at higher risk. But the risk is even higher if they also carry a certain variant of the APOE gene (Apolipoprotein E).

Having a parent with Alzheimer's is thought to increase one's risk of developing the disease by age 85 to between 30 and 35 per cent, compared with a general population risk of 10 to 15 per cent, said the authors. If you also carry the APOE variant the risk is 50 per cent.

For the study Roberts and colleagues recruited 162 participants with at least one parent who had been diagnosed with Alzheimer's disease.

The participants first took part in an education session about Alzheimer's and were then offered a genetic test that looked for presence of the APOE variant that conferred higher risk of Alzheimer's.

The participants that agreed to have the test were given their results by trained genetic counselors.

The researchers then followed them for about 12 months and assessed the psychological impact of the revelation. The participants completed tests for depression, anxiety and test-related distress before disclosure, and then 6 weeks, 6 months, and 12 months after.

The results showed that for the participants who were told they had the risk-increasing gene, the test-related distress level was slightly higher at the 6 week point, but not at the 6 month or 12 month point.

Anxiety and depression levels remained stable, said Roberts, who told the press that while some people might say they were thinking a lot about the test result, "it didn't translate into long-term depression or anxiety".

However, the results did show that:

"Persons with high levels of emotional distress before undergoing genetic testing were more likely to have emotional difficulties after disclosure," wrote the authors.

"The findings show if you do (disclose this genetic information) genetic counseling may be an important component to ensure that most people do not respond with significant distress," said Roberts.

Genetic counseling puts the test results in context and helps people understand the meaning and limits of the results, he added, citing the example of a person with a 55 per cent lifetime risk being reminded that this also meant there was a 45 per cent risk that they would not get the disease.

The study's results are timely because as more and more private firms offer genetic testing, it raises the question of whether people should know about genetic risks outside of a clinical context.

Roberts said some might argue that it is "paternalistic" to decide for others what they can and cannot know about their own genes.

He said that after the initial education session, only 20 per cent of the participants refused to go ahead with the test, which meant the majority wanted to know.

Jul 15
Linking Genes, Brain, And Behavior In Children
It comes as no surprise that some babies are more difficult to soothe than others but frustrated parents may be relieved to know that this is not necessarily an indication of their parenting skills. According to a new report in Psychological Science, a journal of the Association for Psychological Science, children's temperament may be due in part to a combination of a certain gene and a specific pattern of brain activity.

The pattern of brain activity in the frontal cortex of the brain has been associated with various types of temperament in children. For example, infants who have more activity in the left frontal cortex are characterized as temperamentally "easy" and are easily calmed down. Conversely, infants with greater activity in the right half of the frontal cortex are temperamentally "negative" and are easily distressed and more difficult to soothe.

In this study, Louis Schmidt from McMaster University and his colleagues investigated the interaction between brain activity and the DRD4 gene to see if it predicted children's temperament. In a number of previous studies, the longer version (or allele) of this gene had been linked to increased sensory responsiveness, risk-seeking behavior, and attention problems in children. In the present study, brain activity was measured in 9-month-old infants via electroencephalography (EEG) recordings. When the children were 48 months old, their mothers completed questionnaires regarding their behavior and DNA samples were taken from the children for analysis of the DRD4 gene.

The results reveal interesting relations among brain activity, behavior, and the DRD4 gene. Among children who exhibited more activity in the left frontal cortex at 9 months, those who had the long version of the DRD4 gene were more soothable at 48 months than those who possessed the shorter version of the gene. However, the children with the long version of the DRD4 gene who had more activity in the right frontal cortex were the least soothable and exhibited more attention problems compared to the other children.

These findings indicate that the long version of the DRD4 gene may act as a moderator of children's temperament. The authors note that the "results suggest that it is possible that the DRD4 long allele plays different roles (for better and for worse) in child temperament" depending on internal conditions (the environment inside their bodies) and conclude that the pattern of brain activity (that is, greater activation in left or right frontal cortex) may influence whether this gene is a protective factor or a risk factor for soothability and attention problems. The authors cautioned that there are likely other factors that interact with these two measures in predicting children's temperament.

Jul 15
Lowering Your Blood Pressure Can Be As Easy As Watching What You Eat
According to the National Institutes of Health (NIH), about two-thirds of people over the age of 65 have high blood pressure. What's more, they report that if you haven't had it by the time you reach age 55, there is a 90 percent chance you will end up with it during your lifetime. It is something that almost all of us will encounter in our lifetime. But the good news is that watching what you eat can go a long way toward helping you avoid high blood pressure and get the problem under control.

"Having high blood pressure is common and it can be quite dangerous," explains Enzo Febbraro, the co-owner and executive chef of D'Acqua Ristorante, located in Washington, D.C. "Making some simple changes to our diet can have a big impact on helping us avoid getting high blood pressure, or even lowering it if we already have it."

High blood pressure, or hypertension, is a consistent blood pressure of over 140/90 mmHg. Those with readings between 120/80 and 139/89 are considered to have prehypertension, and are likely to develop hypertension if changes are not made to avoid it. Our blood pressure normally rises and lowers throughout the day, but it's when it stays elevated that it becomes dangerous. According to the NIH, high blood pressure can lead to atherosclerosis, heart disease, kidney disease and even blindness.

Along with being physically active and maintaining a healthy weight, what you eat has a big impact on high blood pressure. Healthy eating can help you avoid getting it and if you already have it, can reduce it.

Keep these tips in mind when you eat, to help keep blood pressure under control:

- Eat healthy. You have heard it before, but it is important to eat healthy each day in order to keep a healthy body. Get plenty of fruits, vegetables, whole grains, and lean protein.

- Go low-fat. Look for no fat or low fat options of foods, such as when you buy dairy or dairy alternative products. Cut back on the amount of butter or margarine you use.

- Keep it whole. Try to eliminate or reduce the amount of processed foods that you eat, especially foods like frozen meals, lunch meats, bacon, and chips, which are all high in sodium.

- Dark chocolate. Research has found that eating moderate amounts of dark chocolate, not milk chocolate, can be beneficial to lowering blood pressure.

- Skip the salt. Avoid salting foods, instead opt for spices to give food more flavor.

- Make it gradual. Trying to make the changes overnight may be difficult. But if you stick with making gradual changes you will find success and improve your health.

- Limit alcohol. If you drink, you should consider cutting back to help improve your blood pressure. Also, try to avoid smoking or being around second-hand smoke, which can raise blood pressure.

"Changing the way we eat seems hard to do at first," adds Febbraro. "But if you make some small, gradual changes you are going to see results. And that is well worth the effort. This is a serious condition that we have to be mindful of and keep in check."

Jul 15
Obesity Threshold Is Lowered For People In India
The threshold for being overweight or obese has been lowered in India, as people of South Asian origin are more likely than white people to develop obesity-related conditions such as Type 2 diabetes and heart disease.

Indian health experts have also called for the threshold point to be lowered for all South Asian people across the world, including in the UK.

Global obesity measurements

Standards used around the world to tell when someone is overweight or obese are based on data from white people. These state that people with a body mass index (BMI) of 25 or more are overweight and obese if it goes above 30. BMI is calculated using weight and height.

In India those limits have been lowered to 23 for being overweight and 25 for being obese, to reflect the risks for their own population. They also have lower thresholds for waist circumference measurements.

The move has led to an extra 70 million people being re-classified as overweight or obese. This means that doctors in India are encouraged to intervene earlier, sometimes with drugs or surgery.

Jul 15
New Study: Men Diagnosed With Infertility Suffer Intense Negative Sexual, Personal And Social Strain
A new research study published in The Journal of Sexual Medicine and led by noted men's health researcher Dr. Paul Turek has a powerful conclusion: that men diagnosed with infertility suffer intense negative sexual, personal and social strains that might be considered typical for other medical illnesses, including cancer.

Traditionally viewed as a "silent disease" in men, the psychological toll infertility takes on men's health was previously not well known by medical researchers. Researchers at the University of California San Francisco, in collaboration with Dr. Turek, a nationally recognized urologist, male infertility specialist and founder of the renowned Turek Clinic in San Francisco, conducted the study.

"Since male infertility is such a common problem, it is important to understand the real impact it has on male health and relationships," Dr. Turek said. "This study makes clear, for the first time, that male infertility is a 'disease' like any other, silent or not, and can have a serious effect on the overall well-being of the individual, the couple, and the family."

The study shows that the diagnosis of infertility increases social strain in male partners of infertile couples. Male partners in couples with perceived, isolated male factor infertility have a lower sexual and personal quality of life compared to male partners of couples without perceived male factor infertility.

About one in eight couples - around 7.3 million Americans - has trouble conceiving. Half of those cases have male infertility issues - often easily treatable ones. Male infertility affects 10% to 15% of reproductive aged couples worldwide and is treatable in many cases.

The goal of the research was to measure the personal, social, sexual and marital impact of a diagnosis of male factor infertility among men in couples evaluated for infertility. Among the 357 men studied, no male factor was reported in 47%, isolated male factor was present in 12%, combined male and female factors were present in 16%, and unexplained infertility was present in 25% of couples. The research involved cross-sectional analysis of 357 men in infertile couples from eight academic and community-based fertility clinics.

Jul 15
Australia swine flu passes 10,000, prefers 'young'
Australia's swine flu cases have topped 10,000 with officials in the worst-hit Asia-Pacific country reporting two deaths and warned the virus "preferred young people."

Health Minister Nicola Roxon said the national tally was now 10,387, more than 10 percent of the global total confirmed by the World Health Organization with 123 people in hospital.

South Australia and Queensland states reported two deaths of people with the disease, taking the national flu-linked toll to 22. A(H1N1) however has not yet been confirmed as the cause of any of the deaths.

Roxon said the number of cases would climb as the southern hemisphere winter progresses. She said the real caseload was likely much higher as mild infections were not being tested.

"The numbers are expected to peak in August ... the pandemic strain of flu is becoming the predominant flu strain in Australia this winter," the minister told reporters.

She said those hit hardest mostly had pre-existing medical conditions, but warned that health authorities were now worried about a growing number of serious cases in young people.

"We do see that there are some people who are young and otherwise healthy who have the rapidly deteriorating disease ... it's obviously concerning," she said.

Roxon said patients' average age was 19, adding that doctors and health workers had been told to watch for young people with trouble breathing because their condition could quickly become life-threatening.

"We flagged early on that we were concerned that this was not the same as other flus, that it seemed to be a disease that preferred young people," she said.

Another high-risk group is the impoverished Aborigines, who account for 698 cases or almost seven percent of cases even though they make up only 2.5 percent of the population.

"This is not a surprise given our awareness that those particularly at risk are those with chronic diseases and that many indigenous Australians have those," Roxon said.

Australia has ordered 21 million doses of a forthcoming vaccine, enough to immunise the entire population if necessary, as concern grows over the pandemic which the WHO has described as "unstoppable."

Roxon said Australian pharmaceutical firm CSL would begin human trials of a swine flu vaccine next week and, if successful, it should be available in October.

She also rejected a report that computer modelling had shown the virus could kill up to 10,000 in New South Wales state alone over a two-month period if the mass immunisation is not carried out.

"We've seen some fairly ambitious, if not ludicrous, claims being made that it could be 10,000 or 20,000 or 30,000 in particular states," she said, adding that the death rate was not as high as initially feared.

Roxon said the government's own modelling projected 6,000 deaths under a worst-case scenario but the steps being taken to contain the disease meant it would be far lower.

"That's the modelling if no action was taken, of course we are taking a lot of action and we believe that can be significantly reduced," she said.

According to the UN's World Health Organization (WHO), 94,512 cases of A(H1N1) influenza have been reported, causing 429 deaths.

News of the figures from Australia comes as Japan's health ministry said the number of cases to hit the east Asian nation topped 3,000, up more than 1,000 from last week.

The tally of A(H1N1) virus infections in Japan reached 3,122 by early Wednesday but most of the people who were infected have already recovered, it said. Japan has yet to report any deaths from the virus.

The virus was first reported in Japan in early May and quickly spread through high schools in western cities before infecting the wider population.

Jul 13
CPR Mattress: An Innovation That Can Save Lives
Students from Michigan Technological University have designed and developed a breakthrough in medical care that could save lives in a heartbeat.

They devised a mattress that facilitates faster and more effective cardiopulmonary resuscitation (CPR), and they're working to put it on the open market.

The invention addresses a longstanding and critical problem: A standard hospital mattress, with six or more inches of foam, is pliable and cushiony. Pushing down to administer CPR is like pushing on a big sponge the force goes into the mattress and not the body lying on it.

A team of Michigan Tech students came up with a simple solution: Push a button, suck the air out of the foam, and make it firm. Some tubing, a little motor, and a vacuum pump work the magic. It takes just ten seconds to work.

The measure of their success? With a standard mattress, only 43 percent of the CPR load winds up reaching the heart; with a board underneath the mattress, that rises to 52 percent; and with the Michigan Tech students' design, it leaps to 81 percent.

Another team of Michigan Tech students has founded a company and is working to get this mattress into hospitals, especially in emergency rooms. The students expect to have a patent by September 2009. They are talking with a number of companies that have experience bringing medical products to market.

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