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May 21
WHO Urges H1N1 Vaccine Producers To Give 10 Per Cent To Poor Countries
The World Health Organization (WHO) urged pharmaceutical companies to donate at least 10 per cent of their H1N1 pandemic swine flu vaccine to poor countries, or at least offer them lower prices, to ensure that they don't get left out as it is likely that demand will outstrip capacity to supply in the months ahead.

Six out of 30 major drug companies have agreed to do so. Their chiefs met with UN Secretary General Ban Ki-moon and WHO Director-General Dr Margaret Chan in Geneva where health ministers from nearly 200 member countries are currently attending the 62nd World Health Assembly.

Ban said there was still a need for vigilance over the H1N1 virus:

"We may be in a grace period with H1N1 but we are still in the danger zone," said Ban, as reported by the BBC.

By grace period Ban was referring to Chan's opening speech on Monday where she used the phrase "grace period" to refer to the fact that the virus has not yet reached developing countries, giving us time to help them prepare for it.

She said if and when the virus reaches developing countries they were likely to be more vulnerable and experience a higher proportion of serious cases and deaths than we have seen so far because their populations carried 80 per cent of the world's burden of chronic diseaeses such as HIV/AIDS, malaria and tuberculosis.

According to the WHO, there are now nearly 10,000 confirmed cases of new H1N1 swine flu in 40 countries, including 79 deaths, most of them in Mexico where the outbreak was first reported.

Many rich countries such as Britain, Canada, Denmark, France and Switzerland have already agreed contracts with drug companies to supply millions of doses of pandemic vaccines as they come off the production line.

However, Chan said the drug companies have given "very serious commitments" to helping developing countries when she met them on Tuesday.

Ban called for global solidarity in confronting the new H1N1 virus, and said it was important for the drug companies and governments to work together to lessen the impact.

Solidarity "must mean that all have access to drugs and vaccines," said Ban, according to a report by the Associated Press.

"Partnerships with the private sector are absolutely vital," he added.

But the manufacturers said it will take months to produce large quantities of the vaccine, and production cannot start before mid-July, which is weeks later than anticipated.

One of the reasons that the manufacturers will not be able to start making vaccine until mid-July is because the new H1N1 strain is proving very slow to grow in laboratories, said the WHO.

Eric Althoff, a spokesman for Novartis AG, a large Swiss drug company said:

"I don't think that all of the answers are there yet."

GlaxoSmithKline PLC, which is British based, said they would donate 50 million doses and offer more at discount prices.

According to the AP report, another drug company with much less capacity said they would share half their doses. The WHO did not say which company as the deal was still in negotiation.

And other smaller companies also said they would offer 10 per cent of their vaccine doses to the UN at lower prices.

There is also confusion about how many doses will be available and by when. Some experts say 5 billion doses should be ready within a year of starting full scale production, while others say that is too optimistic.

David Fedson, a vaccine expert who used to be a medical professor at the University of Virginia, said we need to be cautious about predictions, and just "go forward with production as quickly as possible".

Another area of debate is whether to dedicate all vaccine making capacity to the new H1N1 strain and not develop any seasonal flu vaccine for the coming season. Seasonal flu kills up to half a million people worldwide every year.

The United States has not reserved any swine flu vaccine capacity, and is working to enhance seasonal flu production capacity so that it can switch over to pandemic flu vaccine if necessary.

May 19
Genetic Factors Play Lead Role For Adolescent Crime Victims
Genes trump environment as the primary reason that some adolescents are more likely than others to be victimized by crime, according to groundbreaking research led by distinguished criminologist Kevin M. Beaver of The Florida State University.

The study is believed to be the first to probe the genetic basis of victimization.

"Victimization can appear to be a purely environmental phenomenon, in which people are randomly victimized for reasons that have nothing to do with their genes," said Beaver, an assistant professor in FSU's nationally top-10-ranked College of Criminology and Criminal Justice. "However, because we know that genetically influenced traits such as low self control affect delinquent behavior, and delinquents, particularly violent ones, tend to associate with antisocial peers, I had reasons to suspect that genetic factors could influence the odds of someone becoming a victim of crime, and these formed the basis of our study."

Beaver analyzed a sample of identical and same-sex fraternal twins drawn from a large, nationally representative sample of male and female adolescents interviewed in 1994 and 1995 for the National Longitudinal Study of Adolescent Health. "Add Health" interviewers had gathered data on participants that included details on family life, social life, romantic relationships, extracurricular activities, drug and alcohol use, and personal victimization.

The data convinced Beaver that genetic factors explained a surprisingly significant 40 to 45 percent of the variance in adolescent victimization among the twins, while non-shared environments (those environments that are not the same between siblings) explained the remaining variance. But among adolescents who were victimized repeatedly, the effect of genetic factors accounted for a whopping 64 percent of the variance.

"It stands to reason that, if genetics are part of the reason why some young people are victimized in the first place, and genetics don't change, there's a good chance these individuals will experience repeat victimization," Beaver said.

Findings from the study are described in a paper to be published in a July 2009 special issue of the journal Youth Violence and Juvenile Justice dealing with biosocial criminology. Beaver served as lead author of the paper, "The Biosocial Underpinnings to Adolescent Victimization," ­which currently can be accessed on the journal's Web site. His co-authors are criminology graduate students Brian Boutwell and J.C. Barnes of Florida State and Jonathon A. Cooper of Arizona State University.

"It is possible that we detected this genetic effect on victimization because it is operating indirectly through behaviors," Beaver said. "The same genetic factors that promote antisocial behavior may also promote victimization, because adolescents who engage in acts of delinquency tend to have delinquent peers who are more likely to victimize them. In turn, these victims are more likely to be repeatedly victimized, and to victimize others."

Thus, write Beaver and his colleagues, victims of crime are not always innocent bystanders targeted at random, but instead, sometimes actively participate in the construction of their victimization experiences.

May 19
Simple, Inexpensive Blood Test Could Speed Diagnosis Of Muscular Dystrophy In Boys
Boys show signs of Duchenne Muscular Dystrophy (DMD) for 2 ½ years before they obtain a diagnosis and disease-specific treatment, about the same length of delay children have endured for the past 20 years despite advances in genetic testing and treatment. A simple and inexpensive blood test for any boy with symptoms and signs of motor delays and abnormalities could speed up the process while pilot studies on newborn screening are conducted.

Recent University of Rochester Medical Center research published in the Journal of Pediatrics shows that boys who are eventually diagnosed with DMD show signs of the disease for more than a year before families bring it to the attention of a health care provider. It takes another year before these children are screened with a serum CK test - a simple and inexpensive blood test for creatine kinase, an enzyme that leaks out of damaged muscle.

"The CK test is an easily available and cheap test," said Emma Ciafaloni, M.D., associate professor of Neurology at the University of Rochester Medical Center and author of the paper. "If they get the test and the diagnosis earlier, they can start treatment earlier and access the best care in the appropriate clinics and the best available services in their school. Early diagnosis will avoid unnecessary and costly tests and numerous unnecessary referrals to the wrong specialists. Parents and maternal relatives can also seek genetic counseling before they plan to have more children."

DMD, the most common muscular dystrophy in children is a particularly devastating form of the disease that affects 1 in 3,500 boys. It is an X-linked recessive genetic disease with onset of symptoms in boys between 2 and 6 years old. It progresses rapidly, rendering patients wheelchair bound by 10 or 11 years old. Most patients die in their mid-late 20s.

The Centers for Disease Control and Prevention-funded study analyzed medical records of 453 boys born since 1982 with DMD or Becker Muscular Dystrophy in the Muscular Dystrophy Surveillance, Tracking and Research Network (MD STARnet). Of those, 156 boys had no known family history of muscular dystrophy. The first signs of the disease in those boys were seen at an average of 2 ½ years old, but the average age when families brought the signs to the attention of a health care provider was 3 ½ years old. The average age for children to receive the CK test or to see a neurologist was more than 4 ½ years old.

May 19
Tongue And Pharyngeal Exercises May Benefit Patients With Mild To Moderate OSA
Practicing certain tongue and pharyngeal exercises may reduce symptoms of mild to moderate obstructive sleep apnea (OSA), according to new research being published in the second issue for May of the American Journal of Respiratory and Critical Care Medicine.

Although CPAP is the gold standard treatment for severe OSA, the vast majority of subjects from epidemiological studies have mild or moderate OSA. The compliance to CPAP among mild to moderate OSA is variable, and there are only a few forms of alternative treatments for this large number of subjects and patients.

"It was commonly thought among doctors that strengthening and toning oropharyngeal muscles would have no benefit to the patient during sleep, but a recent study showed that didgeridoo playing helped decrease snoring and OSA," said Geraldo Lorenzi-Filho, M.D., Ph.D. "This was a change of paradigm, and indicated that not everything you do during the day is lost during sleep."

Dr. Lorenzi-Filho and colleagues investigated the effects of exercises on the symptoms of OSA in the first randomized, controlled study to do so. They recruited a group of 31 recently-diagnosed patients, who were evaluated for OSA severity using polysomnography. Snoring frequency and intensity, daytime sleepiness and sleep quality were assessed using self-reports and validated questionnaires. The subjects were the randomized to two groups - the exercise group and the control group. Each of the 16 individuals in the exercise group underwent a daily and weekly regimen of tongue and pharyngeal exercises. The 15 individuals in the control group underwent a sham treatment regimen involving deep breathing and nasal lavage with a saline solution.

After three months, there were no significant changes to OSA symptoms in the control group. However, the treatment group showed significant improvements in lowest oxygen saturation levels in blood, subjective sleepiness, snoring symptoms and quality of sleep scores.

Additionally, while there were no changes in abdominal circumference in either group, neck circumference decreased significantly in the treatment group with no concomitant changes in body mass index.

"These data suggest that the exercises were able to promote remodeling of the upper airways," Said Dr. Lorenzi-Filho.

Overall, the treatment groups showed a 40 percent decrease in OSA severity. Ten of the 16 patients in the treatment group who had originally been classified as having moderate OSA based on their apnea-hypopnea index (AHI) score were reclassified as having either mild (eight) or no OSA (two). "This was nearly two thirds of the treatment group, whereas none of the control group were reclassified with a milder disease," said Dr. Lorenzi-Filho. "This indicates to us that these exercises have significant potential to improve symptoms in sufferers of OSA."

"The muscles of the upper airways are extremely complex and the mechanisms leading to OSA are far from being well understood," said Dr. Lorenzi-Filho. "A strong muscle may be working on the wrong direction and not necessarily helping to open the airways. The overall set of exercises we tested target the correct physiology of the upper airway and should promote remodeling of the upper airways."

This was the first rigorous study of the subject, and the evidence supports that certain exercises do, in fact, aid in remodeling the upper airways in such a way as to reduce OSA symptoms.

May 19
Local Breast Surgeon And Radiation Oncologists Offer New Device That Tracks Radiation
A new sensor device allowing doctors to receive data on the precise amount of radiation being delivered to tumors and surrounding tissue is now being offered at Maury regional Medical Cancer Center. Maury Regional Medical Center is the first in Tennessee to use the technology called DVS® (Dose Verification System) for breast cancer patients undergoing radiation treatment.

John P. W. Brown, M.D., surgeon, inserts a device that is as small as the length of a dime and can be inserted inside the patient's tumor bed in less than 15 minutes. After each radiation treatment, the DVS® provides the radiation oncologists (Dr. Michael Sattasiri and Dr. Joel Kochanski) with a measurement of the actual amount of radiation hitting the target where the malignant tumor was removed. This allows Dr. Sattasiri and Dr. Kochanski to make any necessary adjustments to the prescribed dose during the radiation therapy treatment course, making it more precise. The DVS® sensor wirelessly transmits data to the physician immediately following each radiation treatment.

Increasing cancer cure rates and decreasing complications associated with radiation therapy are the goals physicians strive for when treating their patients. DVS® is the first wireless, implantable radiation sensor available in the United States to assist physicians in obtaining these goals. The sensor provides data on the precise amount of radiation being delivered to the tumor and surrounding normal tissue.

"Patients with breast cancer are well educated and often spend considerable amounts of time researching new treatment options to help them in their battle with cancer. They also place tremendous value on being treated with the most up to date technologies. We are excited to be the first facility in Tennessee to offer this technology to patients with breast cancer," says John Brown, M.D., breast surgeon at Maury Regional Medical Center. "Traditional radiation therapies rely on knowing the exact location of the tumor, but provide no guidance on quantifying the actual dose being delivered to the tumor. DVS® provides an unprecedented level of precision to physicians and added reassurance to breast and prostate cancer patients," he adds.

Developed by Sicel Technologies, Inc., the DVS® sensors are implanted during a minimally invasive procedure and gather data on the amount of radiation being delivered to the tumor and normal tissue. Wireless technology transmits the radiation dose information to a hand-held monitor during each of the daily treatments, enabling doctors to verify that the patient is receiving the prescribed dose. If a dose deviation is detected, the treatment plan can be modified and corrected for each individual patient. Accurate delivery of the appropriate dose of radiation is critical for tumor control and cure.

"Maury Regional Medical Center is committed to bringing patients innovative new technologies that can have a positive effect on their end results. We provide many options to our patients and are now screening breast cancer patients to receive this breakthrough technology," says Dr. Brown, who inserted the first DVS® sensor at Maury Regional Medical Center.

May 16
India gets its first swine flu patient: A 23-year-old Hyderabadi
New Delhi: A 23-year-old man, who arrived at Hyderabad airport from the US, has been found to be infected with influenza A (H1N1). This is the first case of swine flu in India, the health ministry said Saturday.

The passenger travelled by Emirates Airline from New York to Hyderabad via Dubai. He reached India Wednesday morning and was quarantined after he was found to be suffering from fever.

"He was shifted to the identified isolation facility under strict infection control. His samples have tested positive for influenza A (H1N1)," a health ministry statement issued here said.

The person, who has not been identified, was being treated with anti-influenza drugs Oseltamivir and Afebrile.

All the passengers who came in contact with the infected person are also being monitored.

"The office of the concerned airlines has been contacted to provide the list of passengers who travelled with him in close proximity. Information of such passengers would be provided to the WHO (World Health Organisation) and respective countries through the external affairs ministry," it said.

The passengers are being advised to remain under home quarantine for a period of seven days and monitor themselves for symptoms like fever, cough and difficulty in breathing.

They are also being asked to provide their contact details to Indian authorities

May 16
New Tool Could Help Predict Dementia In Older People
Scientists have developed a new 'risk index' that helps predict which individuals over the age of 65 may go on to develop dementia.

The index is made up of a number of tests of different characteristics, which are put together to predict an older person's risk of developing dementia.

'This new risk index is a very useful tool that could help boost dementia research into treatments and prevention. However, it is very unlikely to be routinely available to older people in the UK because some of the tests are very expensive to carry out.

One million people will develop dementia in the next ten years. Scientists investigating ways to prevent this devastating condition could use this tool to select people who are at a high risk. This would produce stronger results, reduce the number of participants needed in clinical trials and reduce the cost of research.

May 16
SANE Australia Announces Book Of The Year Award
SANE Australia is pleased to announce the 2009 SANE Book of the Year is Back From The Brink Too: Supporting Your Loved One In Overcoming Depression by Graeme Cowan.

The SANE Book of the Year Award recognises outstanding Australian non-fiction titles which promote understanding of mental illness and its effect in the community. Previous winners include Anne Deveson AO for Tell Me I'm Here and Craig Hamilton for Broken Open.

Drawing on Australian and overseas research, as well as the author's own experience, Back from the Brink Too offers a step-by-step approach to the support family and friends of people with depression need, and provides guidance on how carers can look after their own mental and physical health too.

SANE Australia Executive Director Barbara Hocking says family members of people with mental illness play an enormous role in providing care and support for people living with depression, as well as other forms of mental illness.

'Not only does Back >From The Brink Too provide much-needed practical guidance for family carers and raise awareness of the key role they play in helping to manage mental illness, but it also works to reduce the isolation many families experience,' Ms Hocking said.

'We are delighted to present the SANE Book of the Year Award to Mr Cowan for his contribution to helping the community better understand the experience of mental illness and its impact on families and friends'

Graeme Cowan says of the Award, 'I am honoured and humbled that SANE Australia has recognised my book. Only after recovering from my own depression did I come to understand the tremendous toll that my illness caused my family. I would like to dedicate this award to my loved ones and the two million other Australians that support those living with depression and anxiety.'

May 16
Unraveling The Roots Of Dyslexia
By peering into the brains of people with dyslexia compared to normal readers, a study published online on March 12th in Current Biology, a Cell Press publication, has shed new light on the roots of the learning disability, which affects four to ten percent of the population. The findings support the notion that the reading and spelling deficit - characterized by an inability to break words down into the separate sounds that comprise them - stems in part from a failure to properly integrate letters with their speech sounds.

"The adults with dyslexia in the study had enough reading experience to match letters and their speech sounds correctly," said Vera Blau of the University of Maastricht, The Netherlands "Still, the results show that the way their brain integrates letters and speech sounds is very different from normal readers. It's quite astonishing."

The researchers examined activity in the brains of dyslexic and normal adult readers by using functional magnetic resonance imaging (fMRI) as they were presented with letters, speech sounds, or a matching or non-matching combination of the two. While undergoing that task, dyslexic adults showed lower activation of a brain region known as the superior temporal cortex than the more typical readers did.

The findings point to a neural deficit in letter-speech sound integration as a fundamental mechanism that might distinguish poor from good readers, Blau said. Such a difficulty in integrating the most basic units of written and spoken language could offer a promising link between well-documented difficulties in processing the sounds of language (phonology) and the actual reading problem itself, she added.

Her team, led by Leo Blomert at the University of Maastricht, is currently conducting further studies in children as they are learning to read to help identify whether the difficulty to integrate letters with speech sounds begins in early school years and whether it comes before or after deficits in processing the sounds of language.

In addition to enhancing scientists' fundamental understanding of the disability, the new results might also have some ultimate implications for therapy. "Our findings may offer a way to validate intervention strategies and narrow down the best training approaches," Blau said. Indeed, in a new series of studies, the group is investigating whether training strategies focused on phonological skills as well as letter-sound associations improve reading skills by changing activity levels in the brain of dyslexic readers.

May 16
More Support Needed For Families Adopting From Foster Care
A new University of Illinois study of families adopting from foster care revealed significant declines in professional services and social support over the first three years of adoptive family life, even though parents indicated that they need continued assistance.

"Children who have been in foster care can have a host of medical issues and a history of multiple placements so parenting them can be a challenging task for adoptive parents," said Laurie Kramer, a U of I associate dean and professor of applied family studies.

If these children are to thrive, their families need continued access to an array of professionals, including therapists, school staff, adoption specialists, and trained child-care providers who have experience working with children who have social, emotional, and developmental challenges. These experts can teach parents how to help a child who's been in a neglectful or abusive home environment, she said.

"Families who adopt from foster care also need informal support networks, such as family, friends, and clergy. Peer support from other foster and adoptive parents who have experienced the challenges of parenting a previously traumatized child is also important," said Doris M. Houston, co-author of the study and an assistant professor in the School of Social Work/Center for Adoption Studies at Illinois State University.

The three-year longitudinal study assessed the social, emotional, and behavioral outcomes of 34 families who were adopting a child out of foster care over a three-year period.

"We started working with 49 families when they began parenting their child. And we wanted to know how these parents were doing three years down the road. Nine of the adoptions hadn't been finalized, and we thought that was telling," said Houston.

Parents in the 34 families who followed through with the planned adoption and retained custody of their adoptive child were asked to complete a questionnaire that assessed current child well-being, the quality of family life, and the family's use of supportive services. Parents who no longer had custody of the child they adopted or had planned to adopt were asked to participate in an interview to shed light on the factors that contributed to the disruption.

"Families were more likely to be able to follow through and maintain the adoption when they had more contact with adoption agency staff during the pre-adoption period," said Kramer.

Part of the reason was that caseworkers were able to relay information about the child's history that parents needed to parent the child effectively, she said.

But the survey also showed that contact with all types of support had significantly decreased over the first three years of adoptive family life, she said.

That loss of contact with adoption professionals hadn't occurred because the parents believed they no longer needed it. "Even though their needs may be different now, our data show that parents would still like more support from adoption caseworkers and other specialists as they raise the children they've adopted from foster care," she said.

Houston emphasized that continued contact can be beneficial even if the child doesn't have complicated issues. "Adoption professionals can help prepare parents for the developmental stages that adopted children may go through as they come to terms with separation and loss," she said.

"And, if families do need more help, professionals can link them with community resources. They can help families decide if there's a need for adoption-specific counseling services so they can address concerns before they reach a point of crisis," she added.

Why the decline in post-adoption services? "Adoption professionals are skilled at helping adoptive families face the initial challenges they encounter - helping families get the legal assistance they need, doing the case study, and shepherding them through the adoption process, but they may not have the resources to maintain an investment with these families down the road," said Houston.

She noted that infant adoptions have historically been shrouded in secrecy, and adoptive families often try to handle problems independently to avoid being singled out or appearing dysfunctional.

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