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Dec 13
Diabetes drug may help Alzheimers patients
In a new study, medical researchers have discovered that a drug intended for diabetes appears to restore memory in Alzheimer's brain cells.

Jack Jhamandas, principal investigator from the University of Alberta, with the team took brain tissue from animal models with Alzheimer's disease and tested the tissue in the lab, looking specifically at the cells' memory capacity.


When brain cells are shocked by a barrage of electrical impulses, the cells "remember" the experience and this is a typical way to test or measure memory in the lab setting.

Amyloid protein, which is found in abnormally large amounts in the memory and cognition parts of the brains of Alzheimer's patients, diminishes memory. A sister protein, known as amylin, which comes from the pancreas of diabetic patients, has the same impact on memory cells.

Jhamandas and his team demonstrated last year that a diabetes drug that never made it to market, known as AC253, could block the toxic effects of amyloid protein that lead to brain cell death.

In the lab, Jhamandas and his teammates, which included Ryoichi Kimura, a visiting scientist from Japan, tested the memory of normal brain cells and those with Alzheimer's-both from animal models. When the drug AC253 was given to brain cells with Alzheimer's and the shock memory tests were redone, memory was restored to levels similar to those in normal cells.

"This is very important because it tells us that drugs like this might be able to restore memory, even after Alzheimer's disease may have set in," Jhamandas said.

His team is continuing their research in this area and wants to see if the drug, when given before symptoms appear, can "stop the impairment of behaviour and cognition altogether in animals destined to develop Alzheimer's," says Jhamandas. Their continued research tests will take a least a year to complete.

He noted that it is difficult for AC253 to cross the brain barrier, so research teams in pharmaceutical companies would need to design a similar drug that is easier to penetrate brain cells. Jhamandas says if the tests are successful, he thinks clinical trials could start within about five years, but he stressed that further testing needs to be done before such trials can occur.

The study has been published in The Journal of Neuroscience.

Dec 13
Five easy tips to gain weight
It is a common phenomenon that we hear that people talk about losing weight and making special New Year resolutions to ooze out that extra fatty layer from their waists, but what about those who want to gain weight and add on a few extra kilos to get that perfect chubby look?

Let me tell you, if you want to learn the art of gaining weight, you don't just have to eat, eat and eat, but eat the right food and yes enough of them.

Read on to know the best tips to gain weight this season.


Increase calorie intake

Yes, you heart it right. You need to eat more than your usual calorie intake as this is the simplest way to gain those extra kilos. Eat a lot of protein rich food like beans, pulses etcetera. Then, add dairy products like eggs, fish, and meat to your platter. You can also gorge on starchy food like potato as they help in gaining weight early. But, remember to add only those many calories that are required and not too much that it converts into fat. Another important advice is try to stick to a time routine for consuming meals and you will see the difference yourself.

Snacking in between meals

It should be kept in mind especially for a person who wants to gain weight that he/she should never skip meals. Try eating every 2-3 hours. This will ensure that a consistent level is maintained and your body gets the necessary supplements without a break. You can divide your food into say 3 main meals with 3 in between small meals. One can try a handful of dry fruits, energy bars, granola, chikki and laddoo for snacks.

Say no to junk food

They are very tempting and finger licking good, but eating junk is not the answer to your weight gain query as they contain large amount of calories, bad fats and off course very little nutrition. So, a burger or a pizza or finger chips are a strict no as eating too much fast foods help weight gain through fat, not through healthy lean muscle. Also, as a healthy advice avoid consuming processed food.

Eat a balanced diet

In your quest to gain weight, one should remember to eat a balanced diet and include a variety of nutrients like proteins, starch, vitamins, minerals etcetera so that the body is not used to eating just certain foods. Also, while choosing a balanced meal, one should avoid eating foods that contain bad fats like Dalda, red meat, margarine etcetera as they are bad for the health of your heart and will only leave you more worried.

Stay hydrated

Drink plenty of water, milk, fresh juices and energy drinks to ensure you are properly hydrated. As a healthy advice drink at least 8-10 glasses of water each day. But, remember not to drink water before meal and in between the meal as it may decrease your calorie intake.

Dec 12
Scientists create dissolvable condom to protect against HIV
Researchers have developed a female condom which they claim can protect against pregnancy and sexually transmitted diseases such as HIV by dissolving inside the body and releasing chemicals.

Besides blocking the sperm, the condom could time-release a potent mix of anti-HIV drugs and hormonal contraceptives, the `Daily Mail` reported.

Experts claim the `discreet protection` can safeguard people from HIV and unwanted pregnancy by `melting` inside the body.

Researchers at the University of Washington (UW) developed the condom from tiny microfibres through a method called `electrospinning`.

The cloth-like fibres can be woven from medicine into extremely thin `webs`. They are then designed to dissolve after use, either within minutes or over several days.

The team was given USD 1 million to develop the technology, which uses an electric field to charge fluid through air to create the very fine, nanometre-sized fibres.

"Our dream is to create a product women can use to protect themselves from HIV infection and unintended pregnancy," Kim Woodrow, a UW assistant professor of bioengineering, said.

"We have the drugs to do that. It`s really about delivering them in a way that makes them more potent, and allows a woman to want to use it," Woodrow said.

"This method allows controlled release of multiple compounds. We were able to tune the fibres to have different release properties," co-author Cameron Ball said.

One of the fabrics dissolves within minutes, offering users immediate protection, while another fabric dissolves gradually over a few days, providing an alternative to the birth-control pill, to provide contraception and protect against Human immunodeficiency virus (HIV).
While the researchers agree the technology is more discrete, they admit that people may have some doubts.
"At the time of sex, are people going to actually use it? That`s where having multiple options really comes into play," Krogstad told the University of Washington.

Dec 12
Now, sensors to detect cancers early
Researchers are developing a cutting-edge sensor that will help detect and diagnose cancers early, potentially saving many more lives.

The new technology is the vision of doctoral researcher Emma Carland from the Swinburne University of Technology.

Inspired by her experience helping sick children in intensive care at The Royal Children`s Hospital in Melbourne, Carland decided to use her biomedical engineering skills to give people a better chance against illnesses.

"I maintained and tested life-support medical equipment such as drug pumps and respirators, and saw how the kids rely on these tools in their day-to-day struggle for life," Carland said.

"This was a powerful motivation for me to embark on this research."

Her work is based on an optical-fibre touch sensor as fine as a human hair built by her supervisors, Paul Stoddart and Scott Wade, last year to prevent injuring delicate ear tissues during cochlear implant insertion, according to an university statement.

The sensor is built into an optical fibre - a technology that has revolutionised communications - that sends light between its two ends.

Due to its tiny size and fast transmission of signals, optical fibres are often used in medicine, including endoscopies and keyhole surgeries.
"A tumour is stiffer than cells from a healthy area," Carland said.

"So, the difference between the sensor`s signals tells you how stiff the tissue is - a diseased tissue, being firmer, will push back at the sensor with more force, resulting in a larger difference."

The long, thin and flexible structure of the fibre sensor will also allow it to be inserted into endoscopes that explore small tissue regions, such as ear, nose, throat cavities and the colon.

Dec 11
New drug halves transplant`s deadly side-effect
A new drug halves the risk of serious and often deadly side-effect of lifesaving bone marrow transplant treatments, according to a new finding.

The study combined vorinostat with standard drugs given after transplant, bringing down the percentage of patients developing graft-versus-host disease (GVHD) to 21, compared to 42 percent of patients who did with standard medications alone.

"GVHD is the most serious complication from transplant that limits our ability to offer it more broadly. Current prevention strategies have remained mostly unchanged over the past 20 years," says study co-author Sung Choi, assistant professor of paediatrics at the University of Michigan Medical School.

GVHD is characterized by the transplanted stem cells producing immune cells that attack the recipient`s body. The new immune cells treat the patient`s normal cells as foreign invaders and begin to damage the patient`s organs, according to a Michigan statement.

Vorinostat is currently approved by the US Food and Drug Administration to treat certain types of cancer. But Michgian researchers, led by senior study author Pavan Reddy, found in lab studies that the drug had anti-inflammatory effects as well.

Participants were older adults undergoing a reduced-intensity bone marrow transplant with cells donated from a relative. They received standard drug used post transplant to prevent GVHD. They also received vorinostat as a pill.
Researchers found vorinostat was safe and tolerable with manageable side-effects. Besides, rates of patient death and cancer relapse among the study participants were similar to historical averages. The results mirror those found in the laboratory using mice.

These findings were presented on Sunday at the 54th Annual Meeting of the American Society of Hematology.

Dec 11
Brain Scans reveal why some people make sound choices
Researchers, after analyzing brain scans, have figured out why some people have better insight into their choices than others.

We`re constantly evaluating our options and making decisions based on available information. For example, investment bankers have to be confident that they`re making the right choice when deciding where to put their clients` money.

Researchers at the Wellcome Trust Centre for Neuroimaging at University College London, led by professor Ray Dolan, have pinpointed specific brain areas that compute both the value of the choices we have and our confidence in those choices, giving us the ability to know what we want.

The team used functional magnetic resonance imaging (fMRI) to measure activity in the brains of hungry volunteers while they made choices between food items that they would later eat, the journal Nature Neuroscience reports.

To determine the subjective value of the snack options, the participants were asked to indicate how much they would be willing to pay for each snack. Then they were asked to report how confident they were about making the right choices, according to a University College statement.

It has previously been shown that a region at the front of the brain, the ventromedial prefrontal cortex, is important for working out the value of decision options.

The new findings reveal that the level of activity in this area is also linked to the level of confidence participants placed on choosing the best option.
Steve Fleming, Wellcome postdoctoral fellow, now based at New York University, says: "We found that people`s confidence varied from decision to decision. While we knew where to look for signals of value computation, it was very interesting to also observe neural signals of confidence in the same brain region."

Dec 10
Every human has 400 flaws on an average in their DNA
Every humans has 400 flaws on an average in their DNA, geneticists say.

According to the UK researchers, most are "silent" mutations and do not affect health although they can cause problems when passed to future generations, while are linked to conditions like cancer or heart disease that appear in later life.

The evidence comes from the 1,000 Genomes project, which is mapping normal human genetic differences, from tiny changes in DNA to major mutations.

In the study, 1,000 seemingly healthy people from Europe, the Americas and East Asia had their entire genetic sequences decoded, to look at what makes people different from each other, and to help in the search for genetic links to diseases.

"All of our genomes contain flaws; some of us will carry deleterious variants but will not be at risk of acquiring the associated disease for one reason or another," the BBC quoted Dr Chris Tyler-Smith, lead researcher from the Wellcome Trust Sanger Institute as saying.

The new research compared the genomes of 179 participants, who were healthy at the time their DNA was sampled, with a database of human mutations developed at Cardiff University.

It revealed that a normal healthy person has on average about 400 potentially damaging DNA variations, and two DNA changes known to be associated with disease.

"Ordinary people carry disease-causing mutations without them having any obvious effect," Tyler-Smith said.

"In a population there will be variants that have consequences for their own health," he added.

The research gives an insight into the "flaws that make us all different, sometimes with different expertise and different abilities, but also different predispositions in diseases," Prof David Cooper of Cardiff University, the other lead researcher of the study, said.

"Not all human genomes have perfect sequences," he said.
"The human genome is packed with pervasive, architectural flaws," Cooper added.

The study has been published in The American Journal of Human Genetics.

Dec 10
Second-hand smoke can harm kids mental health
It is a known fact that active maternal smoking during pregnancy has negative effects on child health, such as attention deficit and hyperactivity disorder (ADHD).



However, a new research has suggested that second hand smoke, or environmental tobacco smoke (ETS), may be just as harmful.



In one of the first studies of its kind, researchers from the University of Pennsylvania School of Nursing examined data from 646 mother-child pairs in China, where more than 70 percent of men smoke, and concluded that 25 percent children of whose mothers were exposed to smoke exhibited behavior problems compared to 16 percent of children of unexposed mothers.

"Such findings could inform public health efforts to reduce public smoking and underscores the need for including ETS avoidance as a potential component of prenatal care among pregnant women," lead-author Jianghong-Liu, PhD, RN, FAAN, associate professor at Penn Nursing, said.

Using the Child Behavior Checklist (CBCL), a widely used, 99-item scale for assessing behavioral and emotional problems in children, researchers determined children of mothers with ETS exposure had 10 percent more prevalence of externalizing behavior problems than children of unexposed mothers.

The results took factors like parental education, occupation, psychological problems and marriage status into account.

Externalizing behavior problems included attention problems and aggression.
Children of passive smoking mothers demonstrated worse performance on tests of speech and language skills, intelligence, and behavioral outcomes (conduct disorders).

The study is published online in the journal NeuroToxicology.

Dec 08
Can beer fight against cold-causing virus?
There may be a new, alternative treatment for people suffering from winter colds large amounts of beer.

A study cited by Sapporo Breweries, Japanese breweries headquartered in Tokyo, found that a key ingredient in beer can help fend off symptoms of wintertime illnesses, as well as certain serious sicknesses in children, the Agence France-Presse (AFP) reported.

According to researchers at Sapporo Medical University, the compound humulone is effective in fighting against respiratory syncytial virus (RSV) which can cause pneumonia and bronchitis in infants and children, as well as cold-like symptoms in adults. Humulone is found in hops, an ingredient used in beer to give it a bitter taste.

However, the research comes with a catch. The amount of humulone in beer is so small that a person would have to drink 30 cans, each consisting of 12 ounces, in order to get its protective effect.

Dec 08
AIDS can cause blindness
Doctors say HIV infection when left undiagnosed and untreated for a long time, can trigger off a dormant virus called cytomegalovirus (CMV), which can lead to blindness.

Cytomegalovirus is the most common cause of blindness in people who have HIV.

Dr Linda Visser, the academic head of the Department of Ophthalmology at the University of KwaZulu-Natal, has been treating eye conditions in HIV-positive people since 1999.

She says Aids-related cytomegalovirus retinitis affects the retina, the neural tissue of the eye. If the tissue is damaged, it cannot be re-generated. However, if the part of the retina that is responsible for vision is not affected, the condition can be treated.

"They get necrosis of the retina, which is the white area. And the macular is the centre of the retina and once your macular has become necrotic, you cannot see. There's nothing one can do to bring it back. Luckily, not in all patients will the centre of the retina be involved. Sometimes it's on the periphery. Then, we can treat it," News24 quoted her as saying.

According to Dr Visser, about 75 percent of HIV-infected people will experience some form of eye problem, while about 10 percent will go totally blind in one or both eyes.

She said blindness in immune-compromised people, such as HIV-patients, is most commonly caused by a viral infection called cytomegalovirus, which normally thrives on a weakened immune system.

"It is actually only seen in patients who are in immune-compromised. We never see it in immune-competent patients. And because in our set-up, HIV is the most common cause for immune suppression, we see it probably 95 percent or even more in HIV-positive patients. But I have seen it in patients who have had transplants and I have seen it in patients with leukaemia and other cancers," she said.
She stated that in HIV-infected people, the infection manifests when they've left their condition for too long without having it treated and their CD 4 counts have fallen to dangerous levels.

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