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May 05
Cuba to start clinical trials of pneumonia
Cuba will begin this year clinical trials of a new pneumonia vaccine developed by the island nation`s biotech industry, the official daily Granma said.


The vaccine was developed by scientists at Havana`s Finlay Institute and the Center for Biomolecular Chemistry, Finlay Director Concepcion Campa was quoted as saying by Granma.

Campa is participating in the 16th International Seminar of the Caribbean Medical Association, which began Wednesday in Havana and gathered 200 specialists from various countries.

Campa gave a lecture on the impact on national public health of the more than 10 vaccines manufactured on the island, reported Xinhua.

She headed the scientific team that created the "first and only effective vaccine in the world against meningococcal group B" (vaccine VA-MENGOC-BC), according to the Cuban medical authorities.

Among the vaccines Cuba produces are one against hepatitis "B", the first therapeutic vaccine to prevent lung cancer, and a pentavalent against diphtheria, whooping cough, tetanus, hepatitis "B" and the bacterium Haemophilus influenzae type B.

Cuba`s biotech industry represents one of the country`s main revenue sources, marketing about 38 medications in 40 countries.

According to official data, in 2008, the industry registered profits exceeding $350 million, representing some 10 percent of the country`s total annual exports.

May 05
Cancer drugs to cost less, Cipla slashes price
After the Indian government recently lifted a patent license, Indian pharma major, Cipla, has announced a massive reduction of up to 76 per cent in its cancer drug prices.

Following the move, the price of Cipla's generic kidney cancer drug, Sorafenib, will be available at Rs 6,840 a month from the earlier Rs 27,950.

The lung cancer drug Gestinib price has been cut down by 60 per cent to just over Rs 4000, instead of earlier Rs 10,200.

Temozolamide, a very effective brain tumour treatment drug has come down to Rs 5000 from the original Rs 20,250.

"It is a wonderful move, because lots of patients were not able to buy these drugs, but now they will be able to afford," said Dr Sanjay Sharma, Onco Surgeon, SL Raheja Hospital, Mumbai.

For 58-year-old Mumbai resident Popat Yadav, an advance stage liver cancer patient and factory worker, cancer care has meant a whopping burden of Rs 50,000 a month in treatment.

"It is good that medicine prices have come down, but they should come down further. Middle Class people still can't afford so much," said his daughter Jyoti Yadav.

Meanwhile, Cipla has said "This initiative of price reduction is a humanitarian approach by Cipla to support cancer patients".

However, experts see this as a competitive pricing issue, as in March, the government lifted the patenting license and allowed domestic drug maker Natco Pharma to manufacture and sell the generic version of Bayer's patent-protected cancer medicine, Nexavar.

"It's a ripple effect - there can be further deduction in terms of prices if the demand is high," said Pharma expert Vikas Dandekar.

Notably, according to the World Health Organisation, more than 2.5 million Indians are diagnosed with some form of cancer every year.

May 04
Acid in energy and sports drinks 'rots teeth after just FIVE days'
Sugar may get a bad rap from the dentist, but energy drinks could also be a great danger to your smile.

A new study published in the journal of the Academy of General Dentistry (AGD) found that after just five days of guzzling down energy or sports drinks, like Red Bull or Gatorade, a tooth's enamel suffers extensive damage.

With more and more teens sipping energy drinks instead of soda, the researchers sought to sound the alarm against the consumption of these drinks, which are the equivalent of 'bathing teeth in acid.'

Nearly 30 to 50 per cent of U.S. teens regularly enjoy their energy or sports drink of choice, with 62 per cent of them washing down at least one per day.

'Young adults consume these drinks assuming that they will improve their sports performance and energy levels and that they are "better" for them than soda,' said Poonam Jain, BDS, MS, MPH, lead author of the study.

'Most of these patients are shocked to learn that these drinks are essentially bathing their teeth with acid.'

For the study, researchers examined 13 sports drinks and nine energy drinks.

Acidity levels vary among the different brands, so they immersed samples of human tooth enamel in each beverage for just 15 minutes, followed by an immersion in artificial saliva for two hours.

That cycle was then repeated four or five times a day for five days, in order to replicate the average person's exposure to the drinks.

The damage was startling.

Energy drinks cause twice as much damage to teeth as sports drinks and the beverages begin attacking enamel in less than a week - just five days.

Damage to tooth enamel is irreversible and makes teeth prone to cavities and decay.

'Teens regularly come into my office with these types of symptoms, but they don't know why,' says AGD spokesperson Jennifer Bone, DDS.

'They don't realize that something as seemingly harmless as a sports or energy drink can do a lot of damage to their teeth.'

The only way to prevent the damage is to cut down on energy and sports drink consumption, or brush your teeth after every beverage, Ms Bone said.

The American Beverage Association shot down the study's allegations, saying that the circumstances of the study were unrealistic.

'People do not keep any kind of liquid in their mouths for 15 minute intervals over five day periods,' the statement read.

'The findings of this paper simply cannot be applied to real life situations.'

Blame for tooth decay, they argue, falls solely on the shoulders of an individual's dental hygiene, heavier, diet and genetic make-up.

May 04
How black pepper helps keep fat under check
Researchers have offered a long-sought explanation for the beneficial fat-fighting effects of black pepper.

The research pinpoints piperine - the pungent-tasting substance that gives black pepper its characteristic taste, concluding that piperine also can block the formation of new fat cells.

Soo-Jong Um, Ji-Cheon Jeong and colleagues describe previous studies indicating that piperine reduces fat levels in the bloodstream and has other beneficial health effects.

Black pepper and the black pepper plant, they noted, have been used for centuries in traditional Eastern medicine to treat gastrointestinal distress, pain, inflammation and other disorders.

Despite that long medicinal history, scientists know little about how piperine works on the innermost molecular level. The scientists set out to get that information about piperine's anti-fat effects.

Their laboratory studies and computer models found that piperine interferes with the activity of genes that control the formation of new fat cells.

In doing so, piperine may also set off a metabolic chain reaction that helps keep fat in check in other ways.

The group suggests that the finding may lead to wider use of piperine or black-pepper extracts in fighting obesity and related diseases.

May 03
Living with asthma isnt a chore, say doctors
Living with asthma isn't something people ought to dread, said government doctors at a programme held to boost awareness on the respiratory condition. Hosted jointly by the Rajiv Gandhi Government General Hospital and the Government Tuberculosis Research Centre in Chetpet on Monday, the event was held ahead on World Asthma Day, generally observed on the first Tuesday of May. Besides offering a free screening and consultation camp on May Day, the doctors also held a public awareness meet to educate people on ways to spot signs of asthma - whether for themselves or for their children. With the kind of treatment options, drugs and inhalers available today, being an asthmatic isn't really something people need to worry about, they reinforced.

Besides the treatment, they also urged the public to live in a way that prevented the condition from developing - uncluttered living, dust-free spaces to sleep in, as much greenery as possible would definitely boost the chances of your family being asthma-free.

May 03
Energy drinks start to destroy teenagers' teeth after only five days
Teenagers' love of energy drinks is taking a terrible toll on their teeth, scientists have warned.

A study published in the Academy of General Dentistry charted an alarming increase in the consumption of both energy and sports drinks among young adults in the U.S. who use them to help get through the day.

But they said the habit is causing irreversible damage to teeth as the high acidity levels in the drinks erode tooth enamel, the glossy outer layer of the tooth

In some cases it can take as little as five days for the eroding effect to begin.

'Young adults consume these drinks assuming that they will improve their sports performance and energy levels and that they are 'better' for them than soda,' said lead author Dr Poonam Jain, from Southern Illinois University.

'Most of these patients are shocked to learn that these drinks are essentially bathing their teeth with acid.'

Researchers examined the acidity levels in 13 sports drinks and nine energy drinks. They found that the acidity levels can vary between brands of beverages and flavors of the same brand.

To test the effect of the acidity levels, the researchers immersed samples of human tooth enamel in each beverage for 15 minutes, followed by immersion in artificial saliva for two hours. This cycle was repeated four times a day for five days, and the samples were stored in fresh artificial saliva at all other times.

'This type of testing simulates the same exposure that a large proportion of American teens and young adults are subjecting their teeth to on a regular basis when they drink one of these beverages every few hours,' said Dr Jain.

The researchers found that damage to enamel was evident after only five days of exposure to sports or energy drinks, although energy drinks showed a significantly greater potential to damage teeth than sports drinks.

In fact, the authors found that energy drinks caused twice as much damage to teeth as sports drinks.

With a reported 30 to 50 per cent of U.S. teens consuming energy drinks, and as many as 62 per cent drinking at least one sports drink per day, it is important to educate parents and young adults about the downside of these drinks.

Damage caused to tooth enamel is irreversible, and without the protection of enamel, teeth become overly sensitive, prone to cavities, and more likely to decay.

'Teens regularly come into my office with these types of symptoms, but they don't know why,' said Academy of General Dentistry spokesman Jennifer Bone.

'We review their diet and snacking habits and then we discuss their consumption of these beverages. They don't realize that something as seemingly harmless as a sports or energy drink can do a lot of damage to their teeth.'

Dr Bone recommends that her patients minimise their intake of sports and energy drinks. She also advises them to chew sugar-free gum or rinse the mouth with water following consumption of the drinks.

'Both tactics increase saliva flow, which naturally helps to return the acidity levels in the mouth to normal,' she says.

Also, patients should wait at least an hour to brush their teeth after consuming sports and energy drinks. Otherwise, says Dr Bone, they will be spreading acid onto the tooth surfaces, increasing the erosive action.

May 02
Blood test 'could detect breast cancer years in advance'
A blood test that can detect breast cancer decades before the disease develops could be available in five years, scientists have announced.

The test could help doctors to identify women at high risk of the disease allowing them to take preventive medicines and switch to healthier lifestyles.

Researchers have identified a 'genetic switch', carried by one in five women, that doubles their risk of developing breast cancer.

Experts described the breakthrough by scientists at Imperial College London as "exciting" and said signs of the disease could be detected "many decades in advance".

Dr James Flanagan, who led the new research, said the test could be available in five to ten years.

The 'genetic switch' is influenced by lifestyle factors such as alcohol, smoking, pollution, and hormones including HRT.

Carrying the genetic alterations increase a woman's lifetime risk of developing breast cancer from one in eight in the general population to one in four.

These tiny genetic changes could be detected in blood samples years before symptoms of breast cancer developed.

Scientists analysed blood samples from 1,380 women of various ages, 640 of whom went on to develop breast cancer.

On average, the blood tests were carried out three years before diagnosis. In some cases they pre-dated the discovery of breast cancer by up to 11 years.

The results were especially clear in blood samples from women under the age of 60.

Around 49,000 people are diagnosed with breast cancer each year and almost 12,000 die annually in Britain.

The changes are also associated with lymphoma and leukaemia meaning the test could have implications in other cancers.

A strong association was found between molecular changes in a white blood cell gene called ATM and breast cancer risk.

Dr Flanagan said: 'We are working towards prevention. If we can identify women at high risk of cancer we can work towards preventing it and could reduce the incidence of breast cancer quite dramatically.

"We have found one marker, we need to work towards finding them all and then we will have a more useful test."

The findings are published in the journal Cancer Research.

Baroness Delyth Morgan, chief executive of Breast Cancer Campaign, said: "Dr Flanagan's research into epigenetics is so exciting because it suggests that there is every possibility the risk of developing breast cancer could be decided many decades in advance.

"By piecing together how this happens, we can look at ways of preventing the disease and detecting it earlier to give people the best possible chance of survival."

Last month researchers announced that they had discovered that breast cancer was not a single disease but there were fact ten distinct genetic types.

This means that treatment can be tailored to the genetic profile of the specific type meaning drugs will work better, with fewer side effects.

May 02
'Light weights just as good for muscle building'
Lifting less weight more times is just as good at building muscle as doing it with heavy weights, says a new finding.

"We found that loads that were quite heavy and comparatively light were equally effective at inducing muscle growth and promoting strength," says Cam Mitchell, the study's co-author and a doctoral candidate in kinesiology at McMaster's University in Ontario, Canada.

The research suggests that the key to muscle gain is working to the point of fatigue and challenges the widely held belief that training with heavy weights is best for muscle growth, the Journal of Applied Physiology reports.

"Many older adults can have joint problems which would prevent them training with heavy loads," says Mitchell. "This study shows that they have the option of training with lighter and less intimidating loads and can still receive the benefits."

For the study, a series of experiments were conducted on healthy and young male volunteers to measure how their leg muscles reacted to different forms of resistance training over a period of 10 weeks, according to a McMaster's statement.

The researchers first determined the maximum weight each subject could lift one time in a knee extension. Each subject was assigned to a different training program for each leg.

In all, three different programmes were used in combinations that required the volunteers to complete sets of as many repetitions as possible with their assigned loads -- typically eight to 12 times per set at the heaviest weights and 25-30 times at the lowest weights.

May 01
'Heart shrinking' trial to combat heart failure to begin
A trial using electricity to shrink the hearts of patients with heart failure is about to start in Liverpool.

It will involve electrically stimulating one of the nerves leading to the heart, which it is hoped could shrink the heart and improve life expectancy.

The technique is being trialled in humans after it was shown to keep rats and dogs alive for longer.

This first patient at Liverpool will be operated on in the next few days.

The heart pumps blood around the body, and when it fails to do this properly people can become tired and out of breath far more quickly. For some patients it feels like running a marathon when they are only sitting in an armchair.

Heart failure affects around 900,000 people in the UK and can be the result of high blood pressure, dead heart muscle after a heart attack, or a genetic condition.
Bigger and bigger

As the heart loses its ability to pump, it fills with too much blood and becomes stretched over time. The more the heart enlarges, the worse the symptoms.

Surgeons at Liverpool Heart and Chest Hospital and The Royal Liverpool University Hospital hope to reverse the damage.

They will fit a device - similar to a pacemaker - to the vagus nerve which runs to the heart. Surgeons said the electrical stimulation should "protect the heart" from the effects of the hormone adrenaline.

Adrenaline makes the heart pump harder and faster; this is one of the body's responses to heart failure - but doctors say it becomes toxic over time and damages the heart further.

The idea is that by shielding the heart, it will stop enlarging and begin to shrink.

Dr Jay Wright, a consultant cardiologist at Liverpool Heart and Chest Hospital, told the BBC: "We're hoping it will shrink the heart, but it might not be to normal size."

He said shrinkage "would lead to improvement in symptoms - we know that the bigger the heart the worse the symptoms".

Nearly 100 patients will take part in the trial at 30 hospitals around the world.

Carl Jordan, who used to be a paramedic, will be operated on this week. He has had several heart attacks which have damaged his heart, causing it to become enlarged.

He said: "Being the first person to have this device implanted in Liverpool was a huge decision.

"My quality of life at the moment is not great, because of the restrictions my condition has imposed on me, especially the breathing problem, as some days this is quite severe and getting worse.

"Another factor is I have a young family who, although I am the one with the illness, they too are living with it and see every day what it can do to me, so hopefully it will improve my quality of life as well as the lives of others."

The Bristol Heart Institute is hoping to impant the device into five to 10 patients over the next year.

Dr Angus Nightingale, a consultant cardiologist at Bristol, said: "Stimulating the vagus nerve is commonly used to treat epilepsy and depression, but may have other significant benefits.

"The stimulation should alter the balance of the system and improve cardiac function."

May 01
WHO calls for early treatment to stop HIV from spreading
Any HIV infected person should be given immediate treatment to reduce the risk of transmission of the virus to his/her partner, suggests World Health Organization.

The recommendation is part of a global crackdown on the spread of HIV.

Last year, a clinical trial found that giving antiretroviral drugs to an infected partner earlier reduces the risk of transmission by 96%.

The new strategy is part of a drive to stop HIV spreading, even if it means treating people whose immune systems are not yet depleted to the levels that usually require therapy.

"This is the first time people would get treatment not necessarily for their own benefit, but to protect their partners," New Scientist quoted Bernhard Schwartlander, director of evidence, innovation and policy at UNAIDS in Geneva, Switzerland, as saying.

Andrew Ball of the WHO's HIV/AIDS department added. "The big question is to what extent reducing the viral load in a community impacts the HIV epidemic overall."

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