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Aug 14
Mouth bacteria change diet as per body health
In what could lead to better ways to prevent or even reverse the gum disease periodontitis and diabetes, researchers have found that bacteria inside your mouth drastically change how they act when you are sick.

"The main thing that they change when they go from health to disease is that they change their metabolism," said Marvin Whiteley, a professor at University of Texas, Austin.

In other words, a species of bacteria that ate fructose for example can switch to a different kind of sugar to feed on if one is ill.

Bacteria share nutrients and one species will even feed on another as they constantly interact.

"The thing that we found in this paper," said Whiteley, "is that this sharing, and how they interact with each other changes quite drastically in disease than it does in health".

For the study, the researchers used supercomputers at the Texas Advanced Computing Center (TACC).

The researchers chose 60 different species of bacteria to represent the total community. More than 160,000 genes were analysed, yielding 28 to 85 million reads of RNA snippets, including about 17 million mRNA reads for each sample.

"RNA, for those who know about computers, is kind of like the RAM (random access memory), the working memory of the cell," study co-author Keith Turner, a postdoctoral researcher in Whiteley's lab, explained.

The RNA sample acts like a memory image or 'core dump' to reveal the processes of the as-yet unknown bacterium it came from.

The study appeared in the journal mBio.

Aug 14
Too much salt is linked to 1.65 million deaths per year
People around the world eat twice as much salt as they should, and this behavior translates into 1.65 million heart-related deaths per year, researchers said Wednesday.

Excess salt can cause high blood pressure, which is leading factor in heart disease and stroke, according to the study in the New England Journal of Medicine.

Led by scientists at Harvard and Tufts University, the study combined data from 205 surveys of sodium intake in 66 countries around the world.

"These 1.65 million deaths represent nearly one in 10 of all deaths from cardiovascular causes worldwide," said lead researcher Dariush Mozaffarian, dean of the Friedman School of Nutrition Science and Policy at Tufts University.

"These new findings inform the need for strong policies to reduce dietary sodium in the United States and across the world."

The average level of global daily sodium intake in 2010 was 3.95 grams per day, nearly double the World Health Organization recommendation of two grams per day, the study found.Although salt intake was higher than it should be in all world regions, the numbers varied.

Regional averages ranged from 2.18 grams per day in sub-Saharan Africa to 5.51 grams per day in Central Asia.

Americans` average daily salt intake was 3.6 grams. The US government recommends limiting sodium to no more than 2,300 mg (2.3g) per day.

"The majority of Americans have acquired a taste for a sodium consumption by a high salt diet," said Kevin Marzo, chief of cardiology at Winthrop-University Hospital in Mineola, New York, who was not involved in the study.

"Health risks, particularly in its contribution to high blood pressure, may occur with the total daily consumption of more than a teaspoon of table salt."An accompanying editorial in the journal by doctor Suzanne Oparil at the University of Alabama at Birmingham urged caution in interpreting the results "given the numerous assumptions necessitated by the lack of high-quality data."

Other research published in the same issue of the New England Journal of Medicine showed evidence that both high and low levels of sodium were linked to greater risk of death and cardiovascular disease.

That further complicates the question of whether lower sodium diets might help or hurt public health, she said.

"These provocative findings beg for a randomized, controlled outcome trial to compare reduced sodium intake with usual diet," Oparil wrote.

"In the absence of such a trial, the results argue against reduction of dietary sodium as an isolated public health recommendation," said Oparil.

The Institute of Medicine has convened experts to weigh in on the matter, and they reported last year that most evidence shows high sodium boosts the risk of heart disease.

However, the IOM also said there is not enough research to say for sure that lowering sodium to the recommended intake range of 1.5-2.3 grams per day would lower the risk of heart disease in the general population.

Still, it probably wouldn`t hurt for most people to try and cut down on sodium, said David Friedman, chief of heart failure services at North Shore-LIJ`s Franklin Hospital in Valley Stream, New York.

"Based on the available data, reducing our collective sodium intake to the daily range between 1,500 to 2,000 milligrams per day is probably the sweet spot for just enough but not too much oral sodium intake in most adults with known heart disease or those who are trying to prevent further personal cardiovascular trouble," said Friedman, who was not involved in the study.

Valentin Fuster, physician-in-chief of The Mount Sinai Hospital in New York, said eliminating processed foods is a good way to improve health.

"Nearly 50 percent of daily sodium intake comes from consumption of bread, processed meats, pizza, soups, sandwiches, snacks, and cheese," he said.

Aug 13
Synthetic sperm protein to treat male infertility
In a new hope for couples affected by infertility, researchers have come up with a method for treating male infertility using a synthetic version of the sperm-originated protein known as PAWP.

This protein is sufficient and required to initiate the fertilisation process, showed the finding that promises to diagnose and treat cases of male factor infertility where a patient's sperm is unable to initiate or induce activation of the egg to form an early embryo.

"PAWP is able to induce embryo development in human eggs in a fashion similar to the natural triggering of embryo development by the sperm cell during fertilisation," said Richard Oko from Queen's University in Canada.

"Based on our findings, we envision that physicians will be able to improve their diagnosis and treatment of infertility, a problem that affects 10-15 percent of couples worldwide," Oko added.

The results of this study highlight the potential clinical applications of sperm PAWP as a predictor of infertility treatment.

Since most human infertility treatments are now done by injecting a single sperm directly into an egg, supplementation of human sperm with PAWP protein may potentially be used to improve the success rate of infertility treatments in the future.

"The results of our study set the stage for further investigation of PAWP protein as a molecular marker for diagnosis and as a factor for improvement of infertility treatments," Oko added.

The study was published in the FASEB Journal.

Aug 13
Salt can kill cancer cells: Study
The next weapon to effectively fight cancer could be salt as researchers have found that an influx of salt into a cell triggers its death.

The finding could lead to new anti-cancer drugs, said the researchers who created a molecule that can cause cancer cells to self-destruct by carrying sodium and chloride ions into the cells.

"This work shows how chloride transporters can work with sodium channels in cell membranes to cause an influx of salt into a cell," said study co-author professor Philip Gale from the University of Southampton in Britain.

"We found we can trigger cell death with salt," Gale added.

Cells in the human body work hard to maintain a stable concentration of ions inside their cell membranes.

Disruption of this delicate balance can trigger cells to go through apoptosis, known as programmed cell death, a mechanism the body uses to rid itself of damaged or dangerous cells.

Unfortunately, when a cell becomes cancerous, it changes the way it transports ions across its cell membrane in a way that blocks apoptosis.

The new synthetic ion transporter works by essentially surrounding the chloride ion in an organic blanket, allowing the ion to dissolve in the cell's membrane, which is composed largely of lipids, or fats.

The researchers found that the chloride transporter tends to use the sodium channels that naturally occur in the cell's membrane, bringing sodium ions along for the ride.

"We have shown that this mechanism of chloride influx into the cell by a synthetic transporter does indeed trigger apoptosis," said co-author of the study Jonathan Sessler from the University of Texas at Austin.

The study appeared in the journal Nature Chemistry.

Aug 12
Germ killer in cosmetics may affect newborn's size
Expecting mothers may take note that exposure to some common germ killers used in cosmetics can lead to reproductive problem and may even affect the size of your newborn, a study shows.

"We looked at the exposure of pregnant women and their foetuses to triclosan and triclocarban - two of the most commonly used germ killers in soaps and other everyday products," said Benny Pycke, a research scientist at Arizona State University (ASU) in the US.

"We found triclosan in all of the urine samples from the pregnant women that we screened. We also detected it in about half of the umbilical cord blood samples we took, which means it transfers to foetuses. Triclocarban was also found in many of the samples," Pycke claimed.

The problem with this, Pycke explained, is that there is a growing body of evidence showing that the compounds can lead to developmental and reproductive problems in animals and potentially in humans.

Also, some research suggests that the additives could contribute to antibiotic resistance, a growing public health problem.

The compounds are used in more than 2,000 everyday products marketed as antimicrobial, including toothpastes, soaps, detergents, carpets, paints, school supplies and toys, the researchers noted.

The study also yielded a link between women with higher levels of another ubiquitous antimicrobial, butyl paraben, which is commonly used in cosmetics and shorter newborn lengths, said Laura Geer from State University of New York.

Aug 12
Gene key to blood vessel formation discovered
In what could add to our knowledge of how early life develops and also lead to better treatment of heart diseases and cancer, scientists have discovered a gene that plays a vital role in blood vessel formation.

"Blood vessel networks are not already pre-constructed but emerge rather like a river system. Vessels do not develop until the blood is already flowing and they are created in response to the amount of flow," explained professor David Beech from University of Leeds in Britain.

The gene called Piezo1 provides the instructions for sensors that tell the body that blood is flowing correctly and gives the signal to form new vessel structures, the findings showed.

"The gene gives instructions to a protein which forms channels that open in response to mechanical strain from blood flow, allowing tiny electrical charges to enter cells and trigger the changes needed for new vessels to be built," Beech noted.

The research team is planning to study the effects of manipulating the gene on cancers, which require a blood supply to grow, as well as in heart diseases such as atherosclerosis, where plaques form in parts of blood vessels with disturbed blood flow.

"This work provides fundamental understanding of how complex life begins and opens new possibilities for treatment of health problems such as cardiovascular disease and cancer, where changes in blood flow are common and often unwanted," Beech added.

Aug 11
Now, breathe to spot fake drugs
Checking whether a drug you are buying is real may become a lot easier as researchers have developed labels that reveal a hidden image when you breathe on them.

"You can verify that you have the real product with just a breath of air," said Nicholas Kotov, a professor of chemical engineering at University of Michigan in the US.

The researchers found a way to print tiny features 500 times smaller than human hair onto labels through nanotechnology, the image becomes visible when someone blows on it.

Tiny pillars on the surface hide the images printed which reappear when the pillars trap moisture.

The material they have developed is a special blend of polyurethane and adhesive and can stick to plastics, fabric, paper and metal.

"We use a moulding process," Terry Shyu, a doctoral student in chemical engineering at the University of Michigan said, noting that this inexpensive manufacturing technique is also used to make plastic cups.

The technique currently costs a dollar per square inch.

The study appeared in the journal Advanced Materials.

Aug 11
Cure for deadly Ebola virus comes closer to reality
World Health Organisation (WHO) has revealed that the trials of preventative vaccine for the Ebola virus may commence in September, 2014 and might be available by 2015.

Jean-Marie Okwo Bele, the WHO's head of vaccines and immunization said that they were targeting September for the start of clinical trials, first in the United States and certainly in African countries, given that that was where they had the cases, News24 reported.

Bele asserted that they could already have results by the end of the year if they will start the trials from next month.

CurrentlY, there was no available cure or vaccine for Ebola, a virus that caused severe fever and unstoppable bleeding.

Aug 09
Hand-held device can detect deadly skin cancer
A new hand-held device that uses lasers and sound waves may change the way doctors treat and diagnose the deadly skin cancer melanoma, says new research.

The instrument can be used directly on a patient and accurately measure how deep a melanoma tumour extends into the skin, providing valuable information for treatment, diagnosis or prognosis.

The technique relies on the photoacoustic effect in which light is converted into vibrations.

In the case of the new device, a laser beam shines into the skin at the site of a tumour.

Melanin, the skin pigment that's also in tumours, absorbs the light whose energy is transferred into high-frequency acoustic waves.

Unlike light, acoustic waves do not scatter as much when traveling through skin.

Tumour cells will produce more melanin than the surrounding healthy skin cells, and as a result, the acoustic waves can be used to map the entire tumour with high resolution.

The device has a detector that can then turn the acoustic signal into a three-dimensional image on a screen.

"Being able to measure the depth of the tumour in vivo enables doctors to determine prognoses more accurately a" potentially at the time of initial evaluation a" and plan treatments and surgeries accordingly," said dermatologist Lynn Cornelius from Washington University in St Louis.

The latest version is not only hand-held but it also delivers light around and below the tumour, which generates a bright image of the tumour's bottom and an accurate measurement of its depth, researchers added.

The paper was published in the journal Optics Letters.

Aug 09
US on high alert over Ebola outbreak
US Thursday has put on high alert the Centers for Disease Control and Prevention (CDC) Thursday against Ebola outbreak, which has killed many hundred people in West Africa.

"I have activated the CDC emergency operation centre at level one for this outbreak. This is our highest level of response," CDC director Tom Frieden told a congressional hearing

"It doesn't mean that there's an increased risk to Americans, but it does mean that we are taking an extensive effort to do everything we can to stop the outbreaks," Xinhua quoted Frieden as saying.

Calling it "a crisis" and "unprecedented," he said at the current trend there will have been more cases in this outbreak than in all previous recognised outbreaks of Ebola put together" within another few weeks.

And the best way to protect everyone worldwide is to stop the outbreak at the source in today's interconnected world, Frieden said.

"That is the only way to get control," he said. "I am confident that if we do what works, we will stop this one. But it won't be quick and it won't be easy. It requires meticulous attention to detail, because if you leave behind even a single burning ember, it's like a forest fire. It flares back up."

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