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Jan 21
Links between alcoholic liver disease, circadian clock revealed!
Researchers have revealed a putative role for the circadian clock in the liver in the development of alcohol-induced hepatic steatosis, or fatty liver disease.

The team from the University of Notre Dame and the Indiana University School of Medicine has shown that the development of liver steatosis produced by alcohol abuse is intertwined with disturbances of the normal operation of the 24-hour clock system located in the cells of the liver.

The study has suggested that either the circadian clock is important in the actual development of the liver disease or that the development of steatosis disrupts the normal pattern of the clock mechanism.

The researchers said that the mechanism by which chronic alcohol intake is thought to alter the control of fat metabolism in the liver is also a shared signal to the circadian clock mechanism, this being the ratio of production of reduced nicotinamide adenine dinucleotide, and may be a key to the shared disturbance to the two biological mechanisms of lipid metabolism and the circadian clock.

The study was published this week in the journal Nature: Scientific Reports.

Jan 21
Good night's sleep may lower prostate cancer risk
Sleeping well may prevent prostate cancer in men, a new study has claimed.

Men with higher levels of melatonin, a hormone involved in the sleep-wake cycle, had a 75 percent reduced risk for developing advanced prostate cancer compared with men who had lower levels of melatonin, researchers found.

Melatonin is produced exclusively at night in the dark and is an important output of the circadian rhythm.

"Sleep loss and other factors can influence the amount of melatonin secretion or block it altogether, and health problems associated with low melatonin, disrupted sleep, and/or disruption of the circadian rhythm are broad, including a potential risk factor for cancer," said Sarah C Markt, doctoral candidate in the Department of Epidemiology at Harvard School of Public Health in Boston.

"We found that men who had higher levels of melatonin had a 75 percent reduced risk for developing advanced prostate cancer compared with men who had lower levels of melatonin," Markt said.

"Our results require replication, but support the public health implication of the importance of maintaining a stable light-dark and sleep-wake cycle.

"Because melatonin levels are potentially modifiable, further studies of melatonin and prostate cancer risk and progression are warranted," added Markt.

To investigate the association between urine levels of the main breakdown product of melatonin, 6-sulfatoxymelatonin, and risk of prostate cancer, Markt and colleagues conducted a case-cohort study of 928 Icelandic men from the AGES-Reykjavik cohort between 2002 and 2009.

They collected first morning void urine samples at recruitment, and asked the participants to answer a questionnaire about sleep patterns.

The researchers found that one in seven men reported problems falling asleep, one in five men reported problems staying asleep, and almost one in three reported taking sleeping medications.

The median value of 6-sulfatoxymelatonin in the study participants was 17.14 nanogrammes per millilitre of urine.

Men who reported taking medications for sleep, problems falling asleep, and problems staying asleep had significantly lower 6-sulfatoxymelatonin levels compared with men without sleep problems, according to Markt.

Of the study participants, 111 men were diagnosed with prostate cancer, including 24 with advanced disease.

The researchers found that men whose 6-sulfatoxymelatonin levels were higher than the median value had a 75 per cent decreased risk for advanced prostate cancer.

A 31 per cent decreased risk for prostate cancer overall was observed as well, but this finding was not statistically significant.

The study was presented at a meeting of the American Association for Cancer Research.

Jan 20
How parents-to-be can prepare for childbirth
Pregnancy, the period between conception and childbirth, can be a testing time for parents-to-be, especially for expecting women, but with proper mental and physical preparation this trying time can turn into a beautiful experience for both of them.

Ferdinand Lamaze, a French obstetrician, encourages both parents to address their fears and emotions regarding childbirth so that they can work together as a team while dealing with the impending labour pains.

Lamaze insists that pregnant women should keep a check on their diet, consume adequate nutrition and let go of their worries and stress by having a positive attitude towards childbirth.

Women should also realise the importance of breastfeeding and what is the correct technique to nurse a baby, Lamaze added.

Lamaze offers classes to expecting parents on how to happily handle pregnancy and also prepares them for post-partum.

Jan 20
Healthy treats for breakfast
Cereals, toasts and sweet delights may seem unavoidable during breakfast time, but it is advisable to consume healthier food to begin your day with, says an expert.

According to Ilona Wesle, a nutritionist and co-founder of MyDetoxDiet.com, wheat must be avoided in the morning as it converts quickly to sugar and then fat, and that even without the added sugar in cereals and jams, reports femalefirst.co.uk.

Here are a few tasty ideas which will satiate your tummy as well as taste buds:

Bircher muesli: Take rolled oats with sliced apple and pear (or whatever fruit, nuts and raisins take your fancy). Then soak it all in some agave syrup or apple juice overnight in a bowl. Eat with soya yoghurt the next morning. Delicious as a snack any time of day, and full of good fibre and protein.

Eggs: You can choose to get some proper protein with a boiled egg and toasted rye bread soldiers; scrambled eggs with a bit of spinach and cayenne pepper; or a poached egg on smoked salmon. It makes for great brain food for the day ahead, and it is easy to make.

Yoghurt: Just get your hands on a simple probiotic yogurt with nuts and berries. Try it with goji berries and flaxseed. Soak the flaxseeds in water overnight - the combination with probiotic yogurt is great for soothing tummy troubles. This can also make a healthy pudding that you can have after lunch.

Green juice: Grab a cold pressed green juice before heading out of home. Oxygenating and full of chlorophyll, pressed juices retain the goodness of their ingredients by savouring the nectar straight from the pulp. Pressing - rather than chopping or blending - doesn't degrade the fruit or vegetable and avoids over heating it and zapping away minerals. Try courgette, broccoli, lemon, apple and fennel for a zesty morning kick.

Jan 18
Microparticles may reduce heart attack damage
Microparticles - small vesicles circulating in the blood - if injected into the blood stream within 24 hours of the heart attack, may reduce the muscle damage to a great extent.

After a heart attack, much of the damage to the heart muscle is caused by inflammatory cells that rush to the scene of the oxygen-starved tissue.

When biodegradable microparticles were injected after a heart attack, the size of the heart lesion was reduced by 50 percent and the heart could pump significantly more blood, said a path-breaking research.

"The inflammatory damage is reduced to a great extent when microparticles are injected into the blood stream immediately," according to researchers from Feinberg School of Medicine, Northwestern University and University of Sydney in Australia.

"This is the first therapy that specifically targets a key driver of the damage that occurs after a heart attack," said Daniel Getts, a visiting scholar in microbiology-immunology at Northwestern University.

"There is no other therapy on the horizon that can do this. It has the potential to transform the way heart attacks and cardiovascular disease are treated," said the study published in the journal Science Translational Medicine.

The microparticles work by binding to the damaging cells - inflammatory monocytes - and diverting them to a fatal detour. Instead of racing to the heart, the cells head to the spleen and die, said the study.

"This discovery opens new pathways to treat several different diseases," said Getts.

Jan 18
More evidence lumpectomy for early breast cancer is safe
A new review of a decade's worth of U.S. cancer statistics finds that women who got breast-conserving surgery and radiation to treat early-stage cancer were less likely to die from breast cancer during the next 10 years than those who had their breasts removed.

Researchers found that 94 percent of women who had lumpectomy and radiation between 1998 and 2008 had not died of breast cancer after 10 years, compared to about 90 percent of the women who had mastectomy, with or without radiation.

"We can see what's happening in modern-day practice," Dr. Shailesh Agarwal said. "Patients who are undergoing breast conservation therapy - versus patients who are undergoing mastectomy - are having better survival."

Agarwal, an associate professor of plastic and reconstructive surgery at the University of Utah School of Medicine in Salt Lake City, is the study's lead author.

His team's report, published in the journal JAMA Surgery, is not the first to point out that women who have lumpectomy and radiation for breast cancer appear to live longer than others.

But research looking into whether women who have breast-conserving therapy have a higher risk of their cancer returning or spreading has yielded mixed results.

In January 2013, a study published in the journal Cancer found that Californian women who had lumpectomy were also more likely to survive longer than those who had their breasts removed.

But older randomized controlled trials, considered the "gold standard" of medical research, have found that survival is about equal between women who undergo lumpectomy with radiation and those who have their breasts removed.

For the new study, the researchers used data on more than 130,000 U.S. women between the ages of 18 and 80 years old who were treated for early-stage breast cancer. That meant the tumor size was less than 4 centimeters and three or fewer lymph nodes showed signs of cancer cells having spread.

Overall, about 70 percent of the women underwent lumpectomy with radiation, about 27 percent had mastectomy and about 3 percent had mastectomy with radiation.

After five years, about 97 percent of women who had lumpectomy with radiation had not died of breast cancer. That compared to about 94 percent of women who had mastectomy and about 90 percent of women who had mastectomy and radiation.

After 10 years, about 94 percent of women who had lumpectomy with radiation had not died of breast cancer. That compared to about 90 percent of women who had mastectomy and about 83 percent of women who had mastectomy and radiation.

The researchers acknowledge in their report that they can't explain why people who have breast conservation therapy are less likely to die of breast cancer, compared to those who have their breasts removed.

It could be, they write, that there are differences in the other therapies they received, such as chemotherapy, or the aggressiveness of a woman's tumor, that were not reflected in the data.

There could also be differences between the women who chose one therapy over another, including unrelated health problems, lifestyle, family history and other variables.

When researchers compared women with similarly-sized tumors and similar lymph node involvement, for example, race appeared to play a role in survival, with African American women nearly twice as likely to die from the cancer.

Women who had mastectomy and radiation were also typically younger with more advanced breast cancer, which may partially explain why they were most likely to die of breast cancer over 10 years, Agarwal and his colleagues write.

But when women with similar tumors and other variables were compared, overall, the women who had lumpectomy with radiation still had a lower chance of dying than those who had mastectomy.

Dr. Shelley Hwang, who led the 2013 study, said the new study validates her team's findings.

"I think it's really going to help women make decisions about which one to choose and show women that lumpectomy is not a less and worse treatment," she said.

Hwang was not involved in the new study but is chief of breast surgery at Duke University Hospital in Durham, North Carolina.

She emphasized that the findings only apply to people who have early-stage breast cancer without other complications.

"This is not for the special cases of women who have a (genetic) mutation or that sort of thing," Hwang said.

Agarwal said that it's also important for women to have frank discussions with their doctors about treatments.

"Despite this being a large database study and a large number of patients, breast cancer treatment is highly individualized," he said.

"I think the main thing is to have good discussion with your breast surgeon and even the multi-disciplinary (treatment) team so that you have the best chance of getting the optimal treatment."

Jan 17
Artificial bone marrow development brings leukemia treatment closer to reality
Researchers have developed a prototype of artificial bone marrow that may be used to reproduce hematopoietic stem cells.

The porous structure developed by the scientists of KIT, the Max Planck Institute for Intelligent Systems, Stuttgart, and Tubingen University, possesses essential properties of natural bone marrow and can be used for the reproduction of stem cells at the laboratory.

This might facilitate the treatment of leukemia in a few years.

Blood cells, such as erythrocytes or immune cells, are continuously replaced by new ones supplied by hematopoietic stem cells located in a specialized niche of the bone marrow.

Hematopoietic stem cells can be used for the treatment of blood diseases, such as leukemia. The affected cells of the patient are replaced by healthy hematopoietic stem cells of an eligible donor.

However, not every leukemia patient can be treated in this way, as the number of appropriate transplants is not sufficient. This problem might be solved by the reproduction of hematopoietic stem cells.

The stem cell niche is a complex microscopic environment having specific properties. The relevant areas in the bone are highly porous and similar to a sponge.

This three-dimensional environment does not only accommodate bone cells and hematopoietic stem cells but also various other cell types with which signal substances are exchanged. Moreover, the space among the cells has a matrix that ensures certain stability and provides the cells with points to anchor. In the stem cell niche, the cells are also supplied with nutrients and oxygen.

The newly developed artificial bone marrow that possesses major properties of natural bone marrow can now be used by the scientists to study the interactions between materials and stem cells in detail at the laboratory.

The study was published in the Biomaterials journal.

Jan 17
Hot tubs and spas linked to winter disease outbreaks
A new study suggests that disease outbreaks tied to swimming happen even in the winter, and that occurs often after people go in hot tubs or spas.

Between 2009 and 2010, there were 81 outbreaks and 1,326 cases of illness in the United States linked to recreational water exposure (in pools, lakes, hot tubs, etc.), according to information reported from 28 states and Puerto Rico.

Eighteen of these outbreaks (22 percent) were linked with hot tubs or spas, and about 40 percent of the outbreaks occurred in February or March, according to the report from the Centers for Disease Control and Prevention. Many of the winter outbreaks occurred in hotels.

One of the most common illnesses linked with hot tub/spa outbreaks is infection with the bacterium Pseudomonas aeruginosa.

Healthy people can develop Pseudomonas aeruginosa infections, including ear infections or skin rashes, after exposure to hot tubs that have not been properly chlorinated, according to the CDC.

Called "hot-tub rash," the infection often appears in the shape of the bathing suit a person is wearing, because the suit holds the contaminated water, Michele Hlavsa, an epidemiologist at the CDC's Waterborne Disease Prevention Branch, said.

Because of the high temperature in hot tubs, it can be hard to keep the level of disinfectant as high as it needs to be, Hlavsa told Live Science.

The report is published in the CDC's Morbidity and Mortality Weekly Report.

Jan 16
Stem cell breakthrough explains how breast cancer spreads
Breast cancer stem cells exist in two different states and each state plays a role in how cancer spreads, a new study has revealed.

Study's senior author Max S. Wicha from University of Michigan Comprehensive Cancer Center said the lethal part of cancer is its metastasis so understanding how metastasis occurs is critical.

"We have evidence that cancer stem cells are responsible for metastasis - they are the seeds that mediate cancer's spread. Now we've discovered how the stem cells do this," Wicha said.

First, on the outside of the tumour, a type of stem cell exists in a state called the (EMT) state. These stem cells appear dormant but are very invasive and able to get into the bloodstream, where they travel to distant parts of the body.

Once there, the stem cells transition to a second state that displays the opposite characteristics, called the mesenchymal-epithelial transition state (MET). These cells are capable of growing and making copies of themselves, producing new tumours.

The study looked specifically at breast cancer stem cells but the researchers believe the findings likely have implications for other cancer types as well.

The study was published in the journal of Stem Cell Reports.

Jan 16
Chilly winter can affect the eyes too
Blurred vision, scratching and burning sensation and irritation in the eye - these are not minor irritants in your daily routine but might be the pointers to a condition called the dry-eye syndrome which plagues many people during an extreme winter.

According to doctors, even though a person's entire body might be covered up as a protection against the chilly winter winds, there is one part that is always exposed: the eyes.

The surface of the eye is covered with a thin layer of liquid known as the tear film, which is essential for its health. A dry-eye condition caused by cold winds evaporates the tears, which could partially affect vision and cause constant eye pain.

"Occurrence of dry-eye syndrome is very common during the winter season because of the cold, dry outdoor air and dry indoor heat," Sanjay Dhawan, director of ophthalmology at Fortis Hospital, said.

Dhawan said when there is insufficient lubrication in the eye, the conjunctiva (the white part of the eye) becomes much less moist than normal.

He said this causes severe pain, discomfort and inflammation of the conjunctiva and cornea of the eye, due to inadequate tear secretion.

It is a common problem faced by both men and women above 50.

"Sometimes it becomes severe as this abnormality may result in disruption of the ocular (eye) surface, causing difficulty in vision," Dhawan said.

The other symptoms of the eye problem include a persistent watery discharge and irritation if one is using contact lenses.

"If menopause occurs at an early age, then the chances of developing dry-eye syndrome during the winter gets increased even among middle-aged women," Dhawan said, adding that at an initial stage, it may seem like a minor irritation but can become potentially serious.

According to Kinshuk Biswas, opthalmologist at Gurgaon's Columbia Asia Hospital, the condition could also be a result of constant use of a computer.

"Dry-eye syndrome is caused by the low humidity factor during winter which leads to evaporation of the lubricant in the eyes. Another contributing factor for this condition is the use of a computer and continuously looking at the screen for long," Biswas said.

To prevent this condition, one should use eye drops (as prescribed by a doctor) three-four times a day.

One could also close the eyes for half-a-minute while sitting in front of the computer screen to bring moisture back to the eyes, Biswas said.

Listing out the preventive steps, Dhawan said patients should wear sunglasses to protect the eyes from the cold wind, while artificial tears - also known as tear substitutes - should be applied at least four times a day.

If the condition aggravates, use lubricating ointment at bedtime and run a humidifier to put moisture back into the air.

Also, lay a warm, damp washcloth across your eyelids for a couple of minutes, drink extra fluids and use a hot- or cold-air humidifier, Dhawan said.

According to the American Association of Ophthalmology, approximately 3.2 million women and 1.7 million men over the age of 50 suffer from chronic dry eyes.

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