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Nov 21
Eating nuts tied to fewer cancer, heart disease deaths
People who eat a diet rich in nuts, including peanuts, are less likely to die from heart disease or cancer, new research suggests.

The more nuts consumed, the greater the apparent benefit, according to the report. It included data from nurses and other health professionals who have been tracked since the 1980s.

Heart disease and cancer - the biggest killers in the U.S. - are responsible for more than one million annual deaths nationwide.

The International Tree Nut Council Nutrition Research and Education Foundation helped pay for the new report, which was published in the New England Journal of Medicine.

The findings dovetail with other research suggesting regularly eating nuts may lower the risk of common health problems such as heart disease, colon cancer and type 2 diabetes.

"Nuts used to be demonized because they're high in fat. Now, 20 years later, they're recognized as a healthful food," Jeffrey Blumberg said.

He is from the USDA Human Nutrition Research Center on Aging at Tufts University in Boston and wasn't part of the study team.

"It's just like coffee and eggs used to be demonized," Blumberg said. "Eggs used to be a heart attack in a shell. Nuts are high in fat, but they're high in good fats."

The new study - the largest to look at deaths - suggests the health benefits of nuts may translate to a lower risk of premature death, researchers said.

The variety of nut, including peanuts, which are actually legumes, did not seem to make a difference, senior author Dr. Charles Fuchs said.

"The benefit really seems to span across nuts," Fuchs, from the Dana-Farber Cancer Institute in Boston, said.

The two databases used in the analysis included about 76,000 women who are part of the ongoing Nurses' Health Study and 42,000 men who are regularly evaluated as part of the Health Professionals Follow-up Study. The findings are based on questionnaires in which the volunteers periodically recalled their eating habits.

The researchers had to account for the fact that nut eaters tended to be healthier when it came to smoking, alcohol consumption, obesity, exercise habits and other elements of their diet, such as eating more fruits and vegetables.

Yet even when those factors were taken into account, they said, nut consumption seemed to be tied to a lower risk of early death.

During 30 years of the Nurses' Health Study, about 16,000 women died. About 11,000 men died over a 24-year period in the Health Professionals Follow-up Study.

Compared to people who never ate nuts, those who ate nuts once a week were 11 percent less likely to die during the studies and those who ate nuts every day were 20 percent less likely to die.

People who reported eating nuts at least five times per week were 29 percent less likely to die of heart disease, in particular, than those who avoided nuts. They were also 24 percent less likely to die of respiratory conditions like chronic obstructive pulmonary disease and 11 percent less likely to die of cancer.

Nuts were not linked to fewer deaths from stroke, neurodegenerative disease, infection or kidney disease. Nor were they tied to a lower risk of dying from diabetes, even though some research has suggested nuts may have a benefit in that disease.

Fuchs said his personal recommendation is that people eat an ounce of nuts each day, although smaller amounts still seem to make a difference.

The study also suggests people who eat a lot of nuts are less likely to put on weight.

It's possible that people who like nuts tend to have a thinner body type, "but even after adjusting for lifestyle choices, we definitely see that people who eat nuts tend to be thinner and are less likely to be obese," Fuchs said.

It's not clear whether salted or spiced nuts are less beneficial than raw ones, the researchers noted.

Fuchs and his colleagues also cautioned that the study can't prove nuts were responsible for the lower risk of death. "However," they said, "our data are consistent with a wealth of existing observational and clinical-trial data in supporting the health benefits of nut consumption for many chronic diseases."

Nov 21
Signs of 'sudden' cardiac death may come weeks before, study finds
Signs of approaching "sudden" cardiac arrest, an electrical malfunction that stops the heart, usually appear at least a month ahead of time, according to a study of middle-age men in Portland, Oregon.

"We're looking at how to identify the Tim Russerts and Jim Gandolfinis - middle aged men in their 50s who drop dead and we don't have enough information why," said Sumeet Chugh, senior author of the study and associate director for genomic cardiology at the Cedars-Sinai Heart Institute in Los Angeles.

Some 360,000 out-of-hospital cardiac arrests occur each year in the United States, largely involving middle-aged men, with only 9.5 percent surviving, according to the American Heart Association.

Patients can survive if they are given cardiopulmonary resuscitation (CPR) immediately and their hearts are jolted back into normal rhythm with a defibrillator.

Earlier clinical trials have focused only on symptoms or warnings signs within an hour of such attacks. But Chugh's study set out to determine whether signs and symptoms occurred as much as a month before sudden cardiac arrests.

Researchers went back and examined medical records of men 35 to 65 years old after they had out-of-hospital attacks. In addition, paramedics reaching the scene of fatal attacks asked family members what signs and symptoms the patient may have had in preceding weeks.

Among 567 men who had "sudden" arrests, researchers determined 53 percent had symptoms beforehand. Among those with symptoms, 56 had chest pain, 13 percent had shortness of breath and 4 percent had dizziness, fainting or palpitations.

About 80 percent of symptoms happened between four weeks and one hour before the cardiac arrest, researchers said. And although most men had coronary artery disease, just half had been tested for it before their attacks.

"The findings were entirely unexpected," Chugh said. "We never thought more than half of these middle-aged men would have had warning signs so long before their cardiac arrests. Previously we thought most people don't have symptoms so we can't do anything about it."

Chugh said most people who have the same kinds of symptoms don't go on to have cardiac arrests.

"Even so, they should seek medical care," he said. "The message here is, if you have these signs or symptoms, please don't ignore them: seek healthcare."

Chugh said he and his colleagues are also attempting to identify people at risk by comparing biologies of those that have had sudden cardiac arrests with sample populations in Portland that have never had cardiac arrests.

The new findings, from the 11-year-old "Oregon Sudden Unexpected Death Study," were presented on Tuesday at the annual scientific sessions of the American Heart Association being held in Dallas.

The researchers are conducting similar studies among women. The ongoing study is being funded by the U.S. Centers for Disease Control and Prevention, AHA and the Doris Duke Charitable Foundation.

Nov 20
Women who get proper sleep have low body fat
A new study has found that women who go to sleep and woke up at same time every day had lower body fat.

Brigham Young University exercise science professor Bruce Bailey studied more than 300 women from two major Western US universities over the course of several weeks and found that those with the best sleeping habits had healthier weight.

The study found that getting less than 6.5 or more than 8.5 hours of sleep per night is associated with higher body fat and that quality of sleep is important for body composition.

Women in the study were first assessed for body composition, and then were given an activity tracker to record their movements during the day and their sleep patterns at night. Researchers tracked sleep patterns of the participants (ages 17-26) for one week.

The most surprising finding from the study, according to the researchers, was the link between bed time and wake time consistency and body weight.

Study participants who went to bed and woke up at, or around the same time each day had lower body fat. Those with more than 90 minutes of variation in sleep and wake time during the week had higher body fat than those with less than 60 minutes of variation.

Wake time was particularly linked to body fat: Those who woke up at the same time each morning had lower body fat. Staying up late and even sleeping in may be doing more harm than good, Bailey said.

Bailey related consistent sleep patterns to having good sleep hygiene. When sleep hygiene is altered, it can influence physical activity patterns, and affect some of the hormones related to food consumption contributing to excess body fat.

Bailey and his team also found there was a sweet spot for amount of sleep: Those who slept between 8 and 8.5 hours per night had the lowest body fat.

The study findings have been published online in the American Journal of Health Promotion.

Nov 20
Drinking more milk during teens does not lower future hip fracture risk in men
A new study has revealed that drinking more milk as a teenager apparently does not lower the risk of hip fracture as an older adult and instead appears to increase that risk for men.

Diane Feskanich , Sc.D., of Brigham and Women's Hospital and Harvard University, Boston, and colleagues examined the association between remembered teenage milk consumption and risk of hip fracture at older ages in a study of more than 96,000 men and women with a follow-up of more than 22 years.

During the follow-up, 1,226 hip fractures were reported by women and 490 by men.

The study indicated that teenage milk consumption (between the ages of 13-18 years) was associated with an increased risk of hip fractures in men, with each additional glass of milk per day as a teenager associated with a 9 percent higher risk. Teenage milk consumption was not associated with hip fractures in women.

"We did not see an increased risk of hip fracture with teenage milk consumption in women as we did in men. One explanation may be the competing benefit of an increase in bone mass with an adverse effect of greater height. Women are at higher risk for osteoporosis than men, hence the benefit of greater bone mass balanced the increased risk related to height," the authors commented.

Cheese intake during teenage years was not associated with the risk of hip fracture in either men or women.

The study is published in JAMA Pediatrics.

Nov 19
Afternoon caffeine associated with significant sleep disruptions, study shows
You may want to reconsider that late afternoon trip to Starbucks.

A new study from the Journal of Clinical Sleep Medicine shows that consuming caffeine even six hours before bedtime can still cause significant sleep disruptions.

In a study conducted at Wayne State University in Detroit, Mich., researchers studied the way that caffeine exposure affected the sleep habits of 12 healthy sleepers.

Participants were given three pills a day and instructed to take one pill six hours before bedtime, one pill three hours before bedtime and one pill right before they went to sleep. Each day, only one of the pills contained 400 mg of caffeine, which is equivalent to the amount of caffeine found in two to three cups of coffee.

Researchers then measured participants' sleep using both subjective analyses and in-home sleep monitors that tracked their brain activity.

Surprisingly, the researchers discovered that caffeine consumption appeared to cause significant sleep disruptions, regardless of when it was consumed during the day.

"We expected to see a time-sleep effect. We expected to see it at all time points, but we thought it would be more pronounced the closer to bedtime," study author Thomas Roth, founder of the Sleep Disorders and Research Center at the Henry Ford Hospital in Detroit, told FoxNews.com. "(But) it was pretty comparable at all time points."

In fact, consuming caffeine six hours before bedtime was associated with a one-hour reduction in total sleep time, the researchers reported.

"One hour of loss sleep - that's huge." Roth said. "The average sleeping pill you take will increase sleep for 30 minutes. This decreases sleep for about an hour. If you did this on a chronic basis, you'd become pretty sleep deprived."

Though researchers didn't examine why caffeine has such a pronounced effect on sleep, Roth suspects it has something to do with the way caffeine effects adenosine - a neurotransmitter that builds up in the brain during waking hours and decreases with sleep.

"Adenosine is what builds up in your brain to increase sleep pressure and (caffeine) may be negating that," Roth said.

Overall, Roth said that chronic sleep deprivation can cause a number of ill health effects, including cognitive impairment during the day and negative mood.

Though heavy caffeine drinkers may be more immune to the stimulant's effects, people who drink a moderate amount of coffee should avoid it later in the day.

Nov 19
Childhood cancer survivors face heart risks soon after treatment
Children who survive cancer treatment face increased heart health risk and should take measures soon after life-saving therapy to reduce the risk of serious problems later in life, according to research presented at a major medical meeting.

The five-year survival rate from childhood cancer has soared from 58 percent in 1975 to 1977, to 83 percent in the period from 2003 to 2009.

While earlier research had shown that childhood cancer survivors face heart disease and other potentially serious health problems decades after treatment, a new study found that chemotherapy takes a toll on artery health while survivors are still children, leaving them vulnerable to premature atherosclerosis and heart disease.

"We may need to start the clock earlier monitoring these children," said Donald Dengel, lead author of the study presented on Sunday at the American Heart Association scientific meeting in Dallas.

"Healthcare providers who are managing chemotherapy-treated childhood cancer survivors need to monitor cardiovascular risk factors immediately following completion of their patients' cancer therapy," said Dengel, a professor at the University of Minnesota.

Researchers used measures of the brachial and carotid arteries to test artery stiffness, thickness and function of 319 Americans ages 9 to 18 who had survived leukemia or other cancers, and compared the findings to 208 siblings not diagnosed with cancer.

Signs of premature heart disease, demonstrated by a decline in artery function, was more prevalent among those children and teenagers who had survived cancer, researchers found.

Childhood leukemia survivors had a 9 percent decrease in arterial health after completing chemotherapy compared with the non-cancer group.

"Given the increased risk, children who survive cancer should make lifestyle changes to lower their cardiovascular risk," Dengel said.

Such changes would include a heart-healthy diet and regular exercise.

However, more studies would be needed to assess whether blood vessel health can be improved by lifestyle changes in these survivors as has been shown in studies of childhood obesity. It may be that damage caused by chemotherapy cannot be reversed, Dengel said.

"I really don't think it's the cancer per se, it's the treatment" that is causing the problems, Dengel added.

A pilot study has begun in which childhood cancer survivors will be given cholesterol lowering statins after puberty to see if that can reduce the risk of future heart problems.

"It may serve them better to be more aggressive," Dengel said.

The study did have limitations, researchers noted.

Because of differences in cancer treatments, they were unable to attribute changes in arterial health to any particular chemotherapy.

In addition, most of the children in the study were white, so the findings were not necessarily applicable to other racial or ethnic groups.

Children in the study, which was funded by the National Institutes of Health and other research groups, had survived at least five years since their initial cancer diagnosis, researchers said.

They said it was the first such study to look at heart health of childhood cancer survivors while they were still children.

Nov 18
Malaria may be evolving around natural defence
Scientists have discovered recent genetic mutations in a malaria parasite and have found a duplication of a gene known to enable the parasite to infect red blood cells and two possible additional components to a more complex red cell invasion mechanism.

To learn the functions of the mutations, and whether the parasite is evolving around a natural defence, Peter A. Zimmerman, professor of international health, biology and genetics at the Case Western Reserve School of Medicine, and David Serre, a scientific staff member of the Genomic Medicine Institute at Lerner and assistant professor of genomics at Case Western Reserve, have received a 3.5 million dollars grant from the National Institute of Allergy and Infectious Disease at the National Institutes of Health. They will begin their field study in early 2014.

Researchers have long thought that P. vivax infects a person one way: a protein on the parasite, called the Duffy binding protein, latches onto a Duffy receptor on the surface of the person's red blood cell and works itself through the membrane.

P. vivax does not grow well in the laboratory, so to try to understand how the parasite lives and operates; the researchers gathered samples from malaria patients and focused on its genome.

They found a duplication of the Duffy binding protein in half of 189 P. vivax infection samples taken in Madagascar. Other researchers' prior efforts to sequence the P. vivax genome missed the duplication but all indications are it's a recent change, Serre said.

The researchers suspect the mutation is spreading from Madagascar through travellers. They found the duplication in less than 10 percent of samples from Cambodia and Sudan.

"Binding proteins and receptors are locks and keys," Zimmerman said. "If the parasite has one key and there's one lock, you may be able to block that. But if it has more keys and there are more locks, there are multiple ways in."

The researchers say the duplication may be a cause of the growing infections among Duffy negative people, but it's too early to tell.

The study is scheduled to be published in the journal PLoS Neglected Tropical Disease.

Nov 18
India is world's coronary, diabetic capital, says expert
India has earned the dubious distinction of becoming the world's capital of coronary heart disease and diabetes, says a wellness expert.

Conducting a fitness workshop for journalists at Mumbai Press Club here, leading wellness expert Namita Jain said that several studies exposed the health hazards faced by stress-ridden Indian society.

She was speaking on the occasion of 'World Diabetes Day' observed recently.

According to the World Congress of Cardiology, it is estimated that by 2020, heart diseases will be the cause of over 40 per cent deaths in India as compared to 24 per cent in 1990.

"World Health Organisation (WHO) estimates that nearly 200 million people all over the world suffer from diabetes and this number is likely to double in the coming years. In India, there are nearly 50 million diabetics," Jain said.

The enormity can be gauged from a recent report that states many heart patients are below the age of 30. In a study of 350 heart attack patients conducted by a team of doctors, around 9.5 per cent of cases were below 40 years of age and 3 per cent below 30, she said.

According to the November 2009 issue of Harvard Men's Health Watch, as many as 10 per cent of all heart attacks in men occur before the age of 45.

Smoking was invariably a common factor in almost all the young patients. Apart from Smoking, sedentary lifestyle, obesity, stress, high-blood pressure, high cholesterol levels, diabetes, increasing age, family history are some other factors that increase chances of heart ailments.

Jain also touched upon a common problem experienced by many people - indigestion and acidity. This is due to bad eating and dietary habits, especially when we copy the West in their eating patterns, whereas we in India have the most complete and wholesome meal - like Thali.

"Digest what you eat, eat slowly, chew well, drink water, and watch what you eat will help in somewhat alienating the problem. Your diet should consist of cereals, fruits / vegetables, proteins and fats", she added.

Nov 16
CDC importing meningitis vaccine to fight Princeton outbreak
Federal health officials have agreed to import a meningitis vaccine approved in Europe and Australia but not the U.S. as officials at Princeton University consider measures to stop the spread of the disease on the Ivy League campus.

The Food and Drug Administration this week approved importing Bexsero for possible use on Princeton's campus, said Barbara Reynolds, a spokeswoman for the Centers for Disease Control and Prevention. Princeton officials confirmed the school's seventh case of meningitis in 2013 this week and a spokesman said trustees will discuss the issue this weekend.

No vaccine for use against the type B meningococcal bacteria which caused the cases at Princeton is available in the U.S., Reynolds said, adding that the decision to receive the vaccine would be optional if Princeton and CDC officials agree to offer it to students.

Bacterial meningitis can cause swelling of the membranes covering the brain and spinal cord. The disease is fairly rare in the United States. Those who get it develop symptoms quickly and can die in a couple of days. Survivors can suffer mental disabilities, hearing loss and paralysis.

The bacteria are spread by coughing, sneezing and kissing, and most cases occur in previously healthy children and young adults. The disease can easily spread in crowded conditions, like dorm rooms. All students living in dorms are required by state law to have a licensed meningitis vaccine, but it does not protect against type B.

The school is telling students to wash their hands, cover their coughs and not to share items such as drinking glasses and eating utensils.

Nov 16
Baby illnesses tied to parents nixing vitamin K shots
Health officials are reporting four Tennessee cases of a rare infant illness that have been linked to parents refusing a routine shot for newborns.

The four Nashville-area infants suffered brain or stomach bleeding earlier this year. Their parents had declined vitamin K shots, which have routinely been given to newborns since 1961. The shots improve blood clotting and prevent internal bleeding. All four children were treated with vitamin K and survived.

On Thursday, the Centers for Disease Control and Prevention said the illnesses were the first tied to parents opting out of the shots; reports of vitamin K deficiency are rare. The CDC said the parents cited a belief that the shots weren't necessary or cause leukemia. Officials say neither is true.

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