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Aug 02
New approach for organ regeneration, tissue repair identified
Researchers including an Indian origin have identified an entirely new approach to enhance normal tissue growth.

Tissue regeneration is a process that is not fully understood, but previous research has demonstrated that endothelial cells lining the insides of small blood vessels play a key role in tissue growth. It is also known that these endothelial cells generate chemical messengers called epoxyeicosatrienoic acids (EETs), which stimulate blood vessel formation in response to tissue injury.

In this new research, first author Dipak Panigrahy, MD, an investigator in Beth Israel Deaconess Medical Center (BIDMC) Center for Vascular Biology Research, and his colleagues wanted to find out how EETs might participate in organ and tissue regeneration.

To find the answers, they created 7 different mouse models. The models focused on liver, kidney and lung regeneration; wound healing; corneal vascularization; and retinal vascularization.

Panigrahy, an Instructor in Pathology at Harvard Medical School. Administering synthetic EETs spurred tissue growth in the research models, said that the team used genetic and pharmacologic tools to manipulate EET levels in the animals to show that EETs play a critical role in accelerating tissue growth, providing the first in vivo demonstration that pharmacological modulation of EETs can affect organ regeneration.

The team also demonstrated that proteins called soluble epoxide hydrolase (sEH) inhibitors, known to elevate EET levels, promoted liver and lung regeneration. (sEH is the main metabolizing enzyme of EETs.)

Panigrahy asserted that their results offer a mechanistic rationale for evaluating sEH inhibitors as novel therapeutics for a number of human diseases such as hepatic insufficiency after liver damage and diseases characterized by immature lung development, such as bronchopulmonary dysplasia, adding that the use of topical sEH inhibitors on the skin might also be useful for the acceleration of wound healing.

The researchers suspected that EETs were stimulating tissue regeneration by way of blood vessel formation, specifically by producing vascular endothelial growth factor (VEGF) to promote vessel growth. As predicted, when the investigators depleted VEGF in the mice, EETs` effects on organ regeneration disappeared.

Mark Kieran, MD, PhD, of the Division of Pediatric Oncology at Dana-Farber/Boston Children`s Cancer and Blood Disorders Center, said that discovering EETs` role could be of critical importance to help control the repair of liver, lungs and kidneys.

Their findings have been published online in the Proceedings of the National Academy of Sciences (PNAS).

Aug 02
Many teens have permanent ringing in the ears
One in five high schoolers has permanent ringing in the ears, and few take measures to protect their ears from loud music, according to a new study.

Those numbers are surprisingly similar to results of a study of college-aged adults, said lead author Annick Gilles, a clinical audiologist at Antwerp University Hospital in Edegem, Belgium.

She and her coauthors had expected the numbers to be higher for college-aged people, who "go out a lot," she told Reuters Health.

Tinnitus, or ringing in the ears, caused by loud noise exposure is clearly linked to hearing damage, she said. People with permanent ringing in the ears may be able to hear the same volumes of sound as before the damage, but often have trouble separating speech sounds out of a mix of noises.
For the new study, almost 4,000 Flemish high school students completed a questionnaire about temporary and permanent ringing in the ears, also answering questions about their attitudes toward loud noises and hearing protection.

Three out of four kids experienced temporary tinnitus, and one in five heard ringing all the time. Only five percent of the kids said they used any kind of hearing protection against loud noise, such as ear plugs, according to results in the journal PLOS ONE.

"Tinnitus on its own can be very troublesome and have dramatic effects on individuals," said hearing researcher Dr. Josef Shargorodsky, a fellow at Johns Hopkins Medicine in Baltimore. "Many of the teens in this study likely also have associated hearing loss, which really exacerbates the problem."

About 20 percent of people with tinnitus find it bothersome enough to seek medical help, said Brian Fligor, a pediatric audiologist from Harvard Medical School in Boston.

"Bothersome tinnitus interferes with sleep, concentration, communication, and ability to relax," said Fligor, who was not involved with the study.

"In short, in a teenager it means they will fall way behind academically, might miss a lot of school, repeat grades, etc. This of course has huge implications for future college and employment opportunities," he told Reuters Health in an email.

Using the widespread cases of tinnitus among kids as a warning sign for future hearing loss could be a good strategy, said Dr. Roland Eavey, an ear, nose and throat specialist at Vanderbilt University in Nashville, Tennessee, who also didn`t participate in the research.

"Perhaps that might be like warning smokers to heed the cough before lung cancer is found," Eavey told Reuters Health.

"Hearing loss from noise used to be from external sources such as loud industry and the military," he said. "Nowadays the loud volume is from self-inflicted sources such as personal listening devices."

Gilles said there is treatment for noise trauma that results in hearing loss and tinnitus - including steroids or hyperbaric oxygen chambers - but after a few days, the damage cannot be reversed.

"It is always a very good idea to use hearing protection in noisy situations such as concerts, festivals (and) parties," Gilles said. "In addition, the use of personal listening devices should be more carefully controlled."

Many young people listen to music that is too loud for too long on headphones, she said.

"Parents should check that their kids are listening to music at reasonable volumes, and use hearing protection in loud environments," Shargorodsky, who wasn`t part of the study team, told Reuters Health.

Kids who say they hear ringing should be tested for hearing loss, since the two often go together, he added.

"There is no cure for tinnitus or hearing loss, but physicians can guide the families to help deal with the problems depending on the severity," he said.

Aug 01
Stress during pregnancy can drive offspring to obesity
Offsprings of expecting mothers, who experience stress during pregnancy, can become obese, if the children cope with stress passively, a new study has suggested.

The research shows that passively coping offspring of mothers stressed during their pregnancy were at risk to develop obesity and type 2 diabetes.

Previous research in rodents suggested that both prenatal stress exposure and passive stress coping style might predispose offspring to develop type 2 diabetes later in life.

Passive stress coping is typically seen in more introverted personality types whereas, proactive stress coping is typically seen in more extroverted personalities.

The research team at Johns Hopkins exposed pregnant rats to different stressors during the third week of their pregnancy.

The study found there was a difference in risk for diabetes and obesity in offspring from stressed mothers depending on the coping style of the offspring.

Stressed dams` offspring that had been characterized by a passive stress coping style, showed increased weight gain and developed impaired glucose tolerance, an early indicator of diabetes, whereas prenatally stressed offspring characterized by proactive stress coping did not.

Lead investigator Gretha Boersma said that the results might imply that in their efforts to prevent obesity and its associated disorders we need to advise pregnant women to reduce stress exposure during their pregnancy .

Boersma added that these data may lead to the identification of at-risk offspring by looking at their stress coping style and prenatal environment, and then tailoring a prevention strategy accordingly.

Aug 01
Researchers find gene linked to gestational diabetes
Research on the genetics of diabetes could help women get to know their risk of developing gestational diabetes before getting pregnant - and lead to measures being taken to protect the health of the offspring.

Gestational diabetes affects 18 percent of pregnancies but usually disappears when a pregnancy is over. Babies born to women with gestational diabetes are typically larger at birth, which can lead to complications during delivery.

They are at an increased risk of developing metabolic diseases, like diabetes, in childhood and adulthood.

Researchers found variants in two genes - HKDC1 and BACE2 - that were associated with measures of glucose and insulin levels of pregnant women but not associated with these measures in the rest of the population, including people with type 2 diabetes.

First author M. Geoffrey Hayes, an assistant professor of medicine-endocrinology at Northwestern University Feinberg School of Medicine and assistant professor of anthropology at Northwestern`s Weinberg College of Arts and Sciences, said that with additional study and verification of these and other risk genes, we could one day have genetic risk profiles to identify individuals at elevated risk for developing gestational diabetes.

The findings suggest that the roles of the gene HKDC1 in glucose metabolism and BACE2 in insulin secretion are more important during pregnancy versus the non-pregnant state - across all ethnicities studied.

Researchers used DNA and phenotype data of more than 4,000 participants of four different ancestry backgrounds (Hispanic, Thai, Afro-Caribbean and European) from the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study.

This study`s findings could one day help pinpoint quantitative genetic traits that predict which women may develop gestational diabetes.

William L. Lowe, Jr. , M.D., professor of medicine-endocrinology at Feinberg and senior author of the study, said that by knowing your risk when going into a pregnancy or early on during pregnancy, you might be screened for evidence of high glucose levels test sooner rather than later and begin preventive measures to protect the health of your offspring.

The findings have been published in Diabetes, a journal of the American Diabetes Association.

Jul 31
Excessive cell phone use linked to cancer, genetic mutations
Excessive use of mobile phone can lead to oxidative stress in cells that is linked to cellular and genetic mutations which cause development of tumours, says a study.

Oxidative stress is a process that damages all aspects of a human cell, including DNA, through the development of toxic peroxide and free radicals.

Dr. Yaniv Hamzany of Tel Aviv University`s Sackler Faculty of Medicine and the Otolaryngology Head and Neck Surgery Department at the Rabin Medical Center looked for clues in the saliva of cell phone users to further explore the relationship between cancer rates and cell phone use.
Since the cell phone is placed close to the salivary gland when in use, he and his fellow researchers, including departmental colleagues Profs. Raphael Feinmesser and Thomas Shpitzer and Dr. Gideon Bahar and Prof. Rafi Nagler and Dr. Moshe Gavish of the Technion in Haifa, hypothesised that salivary content could reveal whether there was a connection to developing cancer, reports Science Daily.

Comparing heavy mobile phone users to non-users, they found that the saliva of heavy users showed indications of higher oxidative stress. More importantly, it is considered a major risk factor for cancer.

The findings have been reported in the journal Antioxidants and Redox Signaling.

Jul 31
Prolonged breastfeeding linked to kids` intelligence
Scientists have linked breastfeeding with better receptive language at 3 years of age and verbal and nonverbal intelligence at age 7 years.

Evidence supports the relationship between breastfeeding and health benefits in infancy, but the extent to which breastfeeding leads to better cognitive development is less certain, according to the study background.

Mandy B. Belfort, M.D., M.P.H., of Boston Children`s Hospital, and colleagues examined the relationships of breastfeeding duration and exclusivity with child cognition at ages 3 and 7 years.

They also studied the extent to which maternal fish intake during lactation affected associations of infant feeding and later cognition. Researchers used assessment tests to measure cognition.

The study said that longer breastfeeding duration was associated with higher Peabody Picture Vocabulary Test score at age 3 years (0.21; 95 percent CI, 0.03-0.38 points per month breastfed) and with higher intelligence on the Kaufman Brief Intelligence Test at age 7 years (0.35; 0.16-0.53 verbal points per month breastfed; and 0.29; 0.05-0.54 nonverbal points per month breastfed). However, the study also noted that breastfeeding duration was not associated with Wide Range Assessment of Memory and Learning scores.

The authors said that in summary, our results support a causal relationship of breastfeeding in infancy with receptive language at age 3 and with verbal and nonverbal IQ at school age.

These findings support national and international recommendations to promote exclusive breastfeeding through age 6 months and continuation of breastfeeding through at least age 1 year.

The study has been published in JAMA Pediatrics.

Jul 30
New device uses precision to pinpoint best time to conceive
A new fertility monitor has been developed which can help pinpoint accurately the exact days of the month a woman is most likely to conceive.

The slim, walnut-sized device, which is worn like a patch underneath the armpit, takes body temperature measurements up to 20,000 times a day.

Dr. Jacques Moritz, director of gynecology at St. Luke`s-Roosevelt Hospital, said that DuoFertility is a very fancy thermometer that has human feedback linked to it, the New York Daily News reported.

After wearing it for 3-4 days, the temperature data can be uploaded to a computer, along with other observations regarding menstrual cycle, sleep habits and moods, and then it can be sent to a lab at Cambridge University in England.

Within days, the lab email assessments of a woman`s fertility patterns - including the exact days the couple should try to conceive .


Cambridge Temperature Concepts is the company behind DuoFertility

Jul 30
Walking in the woods can help relieve stress
Taking a stroll in the woods can help manage stress levels, lessen BP and help fight heart ailments, a new study has revealed.

One of the experiments, conducted by the researchers at the University of Essex, discovered that just looking at images of forests helped to reduce strains.

Dr. Valerie Gladwell led a team of scientists that carried out experiments on volunteers while measuring their stress levels.

The participants in the research were asked to walk in specified "green environments" at lunchtime slept better that night.

After eight weeks, the volunteers had lower blood pressure and perceived stress.

Gladwell said that her team`s research has shown that `green environments` can be an effective stress-buster.

She asserted that if they can encourage more people to enjoy the great outdoors it may help increase their levels of physical activity and, therefore, could also be a powerful tool to help fight cardiovascular disease.

Jul 29
Heart disease number one killer of Indians
Heart disease has emerged as the number one killer among Indians, a new survey has revealed.

According to a recent study by the Registrar General of India ( RGI) and the Indian Council of Medical Research (ICMR), about 25 percent of deaths in the age group of 25- 69 years occur because of heart diseases.

If all age groups are included, heart diseases account for about 19 percent of all deaths.

It is the leading cause of death among males as well as females and in all regions of India, the study found.

India, with more than 1.2 billion people, is estimated to account for 60 percent of heart disease patients worldwide.

According to the World Health Organization, heart related disorders will kill almost 20 million people by 2015, and they are exceptionally prevalent in the Indian sub-continent.

Half of all heart attacks in this population occur under the age of 50 years and 25 percent under the age of 40.

It is estimated that India will have over 1.6 million strokes per year by 2015, resulting in disabilities on one third of them. The need is urgent.
It is in this context that the American Association of Physicians of Indian Origin (AAPI) has launched educational "Networks" of renowned thought leaders in the areas of Cardiology, Diabetes, and Stroke to foster high quality medical education of physicians of Asian Indian origin in the US.

Jul 29
DNA mutation breakthrough could help treat TB, cancer
A new method has been developed by researchers that has the capability of looking at a specific segment of DNA and point out a single mutation, which could help diagnose and treat diseases like cancer and tuberculosis.

These small changes can be the root of a disease or the reason some infectious diseases resist certain antibiotics.

Lead author Georg Seelig, a University of Washington assistant professor of electrical engineering and of computer science and engineering said that the team has really improved on previous approaches because their solution doesn`t require any complicated reactions or added enzymes, it just uses DNA.

He said that this means that the method is robust to changes in temperature and other environmental variables, making it well-suited for diagnostic applications in low-resource settings.

Seelig, along with David Zhang of Rice University and Sherry Chen, a UW doctoral student in electrical engineering, designed probes that can pick out mutations in a single base pair in a target stretch of DNA.

The probes allow researchers to look in much more detail for variations in long sequences - up to 200 base pairs - while current methods can detect mutations in stretches of up to only 20.

Zhang, an assistant professor of bioengineering at Rice University, said that in terms of specificity, our research suggests that we can do quadratically better, meaning that whatever the best level of specificity, our best will be that number squared.

The testing probes are designed to bind with a sequence of DNA that is suspected of having a mutation. The researchers do this by creating a complimentary sequence of DNA to the double-helix strand in question.

Then, they allow molecules containing both sequences to mix in a test tube in salt water, where they naturally will match up to one another if the base pairs are intact. Unlike previous technologies, the probe molecule checks both strands of the target double helix for mutations rather than just one, which explains the increased specificity.

The probe is engineered to emit a fluorescent glow if there`s a perfect match between it and the target. If it doesn`t illuminate, that means the strands didn`t match and there was in fact a mutation in the target strand of DNA.

The findings have been published online in the journal Nature Chemistry.

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