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Jul 27
Blame bad night`s sleep on full Moon
Can`t sleep? Blame it on the Moon!

Scientists have found evidence that human sleep patterns are timed to the phases of the Moon, and that people sleep 20 minutes less on average during a full Moon.

Many people complain about poor sleep around the full Moon and the study offers some of the first convincing scientific evidence to suggest that this really is true.

The findings add to evidence that humans - despite the comforts of our civilised world - still respond to the geophysical rhythms of the moon, driven by a circa-lunar clock.

"The lunar cycle seems to influence human sleep, even when one does not `see` the Moon and is not aware of the actual Moon phase," said Christian Cajochen of the Psychiatric Hospital of the University of Basel.

In the new study, the researchers studied 33 volunteers in two age groups in the lab while they slept. Their brain patterns were monitored while sleeping, along with eye movements and hormone secretions.

The data show that around the full Moon, brain activity related to deep sleep dropped by 30 per cent. People also took five minutes longer to fall asleep, and they slept for twenty minutes less time overall.

Study participants felt as though their sleep was poorer when the Moon was full, and they showed diminished levels of melatonin, a hormone known to regulate sleep and wake cycles.

"This is the first reliable evidence that a lunar rhythm can modulate sleep structure in humans when measured under the highly controlled conditions of a circadian laboratory study protocol without time cues," the researchers said.

Cajochen said that this circalunar rhythm might be a relic from a past in which the Moon could have synchronised human behaviours for reproductive or other purposes, much as it does in other animals.

Today, the Moon`s hold over us is usually masked by the influence of electrical lighting and other aspects of modern life, researchers said.

They said it would be interesting to look more deeply into the anatomical location of the circalunar clock and its molecular and neuronal underpinnings. It could turn out that the Moon has power over other aspects of our behaviour as well, such as our cognitive performance and our moods.

The study was published in Current Biology.

Jul 27
Omega fatty acid diet could alleviate dry eye symptoms
Daily dietary supplementation with a unique combination of omega fatty acids for six months could improve optical irritation symptoms and halt the progression of inflammation that characterizes moderate to severe dry eye, a new study has found.

The multicenter, double-blind, randomized, placebo-controlled clinical trial conducted at Baylor College of Medicine and Virginia Eye Consultants evaluated 38 post-menopausal women with tear dysfunction in both eyes.

Participants randomly received a proprietary blend of omega fatty acids, antioxidants and other nutrients (HydroEye), or a placebo every day.

Patients were assessed at baseline, four, 12 and 24-week intervals using a variety of disease parameters including Ocular Surface Disease Index (OSDI) symptom severity questionnaire, topographical indices (SAI and SRI), inflammatory biomarkers (HLA-DR and CD11c), Schirmer tear flow measurement, tear breakup time (TBUT), and conjunctival fluorescein and lissamine green staining.

HydroEye was found to improve ocular irritation symptoms, suppress ocular surface inflammation, and maintain corneal surface smoothness.

The study is published online in the journal Cornea.

Jul 26
Indian researchers find faster way to detect sepsis in newborn
Indian researchers have devised a method that can immensely reduce the detection time of sepsis, one of the most common problems in newborn in India, thus reducing usage antibiotics usage.

Researchers at the Sir Ganga Ram Hospital`s department of haematology have devised the method which will bring down the sepsis detection timing from 24-72 hours to just two hours.

"Neonatal sepsis poses a major problem in India with septicemia and pneumonia accounting for 52 percent deaths in home-cared rural born neonates," said Manorama Bhargava, lead author of the study and haematology department chairperson.

"Early detection is challenging as clinical signs are subjective, and requires 1-3 days," she said.

The method is based on a study done on 92 infants and it was published in the International Journal of Hematology.

According to doctors, the new method will help in preventing extra usage of antibiotics and the diagnosis cost remains the same.

Jul 26
Widest study highlights risks from MERS virus
The broadest probe yet into the deadly MERS virus which erupted in Saudi Arabia last year says older patients, men, and people with underlying medical conditions are those particularly at risk.

Saudi and British scientists, reporting in The Lancet on Friday, looked at symptoms and disease progression among 47 people, 36 of them men, admitted to Saudi hospitals with Middle East Respiratory Syndrome (MERS).

The vast majority of the patients had fever, coughing and shortness of breath, and a minority experienced diarrhoea, vomiting and other gastrointestinal symptoms.

Such characteristics are shared with MERS` coronavirus cousin, Severe Acute Respiratory Syndrome (SARS), which triggered a global health scare a decade ago, they wrote. The two viruses also have the same incubation period.

But, according to the investigators, there are important differences between the two viruses.

Unlike SARS, MERS is likelier to cause a fast-track progression to respiratory failure, taking five days less than SARS.

In addition, SARS affected people were relatively healthy and young, whereas MERS seems to target older patients and those with a chronic medical condition.

Out of the 47 cases, 45 were already being treated for diabetes, high blood pressure, heart or kidney disease and other disorders, according to the new study.

Statistically, MERS also appears to be deadlier. Twenty-eight out of the 47 patients died, a case-fatality rate of 60 percent, compared with only 1-2 percent for SARS.

"This high mortality rate with MERS is probably spurious due to the fact that we are only picking up severe cases and missing a significant number of milder or asymptomatic cases," cautioned Professor Ziad Memish, Saudi Arabia`s deputy health minister, who led the research.

The kingdom accounts for 38 of the 45 fatalities recorded in nine countries, and 67 of the total 90 cases. Other cases have been recorded in Jordan, Qatar and the United Arab Emirates, Tunisia, Britain, France and Italy.

Key aspects of the virus, notably how it spreads and whether it has a "reservoir" among wild animals, remain unclear.

Jul 23
More than 30 mn girls at risk of Female Genital Mutilation over next decade: Unicef
The Unicef has reportedly found that there are more than 30 million girls who are `at risk` of being subject to Female Genital Mutilation (FGM) over the next decade.

FGM, a ritual cutting of girls` genitals is practised by some African, Middle Eastern and Asian communities in the belief it protects a woman`s virginity and more than 125 million girls and women alive today underwent this procedure which is now opposed by a majority of countries where it was practiced.

According to the report, Unicef survey found that support for FGM from both men and women has seen a decline and the organization wants action to end the practice completely.

Unicef deputy executive director Geeta Rao Gupta said that FGM `is a violation of a girl`s rights to health, well-being and self-determination and added that legislation is not enough to end the practice.

The study found that FGM remains almost universal in Somalia, Guinea, Djibouti and Egypt and there was little discernible decline in Chad, Gambia, Mali, Senegal, Sudan or Yemen.

However, it was seen that most girls and women and a significant number of boys and men, opposed the practice.

Rao Gupta said that the challenge now is to let girls and women, boys and men speak out loudly and clearly and announce they want this harmful practice abandoned.

The report added that the consequences of FGM include severe bleeding, problems in urinating, infections, infertility and increased risk of newborn deaths in childbirth.

Jul 23
Skipping breakfast can give you heart attack
Men who regularly skip breakfast are at a 27 percent higher risk of heart attack or death from coronary heart disease than those who don`t.

Researchers analyzed food frequency questionnaire data and tracked health outcomes for 16 years (1992-2008) on 26,902 male health professionals ages 45-82.

The study suggested that men who reported not eating breakfast were younger than those who did, and were more likely to be smokers, employed full time, unmarried, less physically active and drank more alcohol.

It was also found that men who reported eating late at night- eating after going to bed- had a 55 percent higher coronary heart disease risk than those who didn`t. But researchers were less convinced this was a major public health concern because few men in the study reported this behaviour.

During the study, 1,572 of the men had first-time cardiac events.

"Skipping breakfast may lead to one or more risk factors, including obesity, high blood pressure, high cholesterol and diabetes, which may in turn lead to a heart attack over time," Leah E. Cahill, Ph.D., study lead author and Postdoctoral Research Fellow in the Department of Nutrition at Harvard School of Public Health in Boston, Mass said.

Men who reported eating breakfast ate on average one more time per day than those who skipped breakfast, implying that those who abstained from breakfast were not eating additional make-up meals later in the day.

Although there was some overlap between those who skipped breakfast and those who ate late at night, 76 percent of late-night eaters also ate breakfast, researchers said.

According to researchers, while the current study group was composed of men who were of 97 percent white European descent, the results should also apply to women and other ethnic groups, but this should be tested in additional studies.

The study was published in the American Heart Association journal Circulation.

Jul 22
33% of throat cancer cases linked to Human Papillomavirus
One third of people suffering from throat cancer are infected with a form of the Human Papillomavirus (HPV), a study has suggested.

More than 100 types of HPV are there and there are two HPV strains that are likelier to cause cancer - HPV-16 and HPV-18.

HPV-16 is believed to be responsible for about 60 percent of cervical cancers, 80 percent of cancers in the anus and 60 percent of oral cancers.

The new study observed HPV`s link with cancer of the back of the throat - oropharyngeal cancer .


In the study, the researchers looked at blood test results collected from people who took part in a huge prospective study into lifestyle and cancer, who were healthy at the beginning.

They compared blood test results of 135 people, who went on to develop throat cancer, and for 1,599 people free of cancer.

The University of Oxford team found 35 percent of those with throat cancer had the antibodies, compared with fewer than 1 percent of those who were cancer-free, the BBC reported.

The study has been published in the Journal of Clinical Oncology.

Jul 22
Soon, drugs to starve cancer to death
Scientists believe that cancer could be cured by starving tumours to death.

The key may be a newly identified protein, eEF2K, which helps cancer cells to thrive but can be shut off without causing ill effects.

A team of researchers at the University of Southampton is now experimenting with various drugs to block the work of this protein.

Professor Chris Proud, from the university, said that cancer cells grow and divide much more rapidly than normal cells, meaning they have a much higher demand for and are often starved of, nutrients and oxygen.

A cellular component, eEF2K, plays a critical role in allowing cancer cells to survive nutrient starvation, while normal, healthy cells do not usually require eEF2K in order to survive.

Therefore, by blocking the function of eEF2K, we should be able to kill cancer cells, without harming normal, healthy cells in the process.

Hopes are that the treatment will be available within five years.

Jul 19
Fish oil compound could help relieve chronic pain
A new study revealed that a derivative of DHA (docosahexaenoic acid), a main ingredient of over-the-counter fish oil supplements, can soothe and prevent neuropathic pain caused by injuries to the sensory system.

The research, by Duke University, focused on a compound called neuroprotectin D1=protectin D1 (NPD1=PD1), a bioactive lipid produced by cells in response to external stimuli.

NPD1=PD1 is present in human white blood cells, and was first identified based on its ability to resolve abdominal and brain inflammation.

"These compounds are derived from omega-3 fatty acids found in fish oil, but are 1,000 times more potent than their precursors in reducing inflammation," Ru-Rong Ji, professor of anesthesiology and neurobiology at Duke University Medical Center and principal investigator of the study, said.

The team used laboratory mouse models of nerve injuries to simulate pain symptoms commonly associated with post-surgical nerve trauma.

They treated these animals with chemically-synthesized NPD1=PD1, either through local administration or injection, to investigate whether the lipid compound could relieve these symptoms.

Their findings revealed that NPD1=PD1 not only alleviated the pain, but also reduced nerve swelling following the injuries.

Its analgesic effect stems from the compound`s ability to inhibit the production of cytokines and chemokines, which are small signaling molecules that attract inflammatory macrophages to the nerve cells.

By preventing cytokine and chemokine production, the compound protected nerve cells from further damage. NPD1=PD1 also reduced neuron firing so the injured animals felt less pain.

Ji believes that the new discovery has clinical potential.

"Chronic pain resulting from major medical procedures such as amputation, chest and breast surgery is a serious problem," he said.

Current treatment options for neuropathic pain include gabapentin and various opioids, which may lead to addiction and destruction of the sensory nerves.

On the other hand, NPD1=PD1 can relieve neuropathic pain at very low doses and, more importantly, mice receiving the treatment did not show signs of physical dependence or enhanced tolerance toward the lipid compound.

The research is published online in the Annals of Neurology.

Jul 19
Poor sleep in pregnancy could lead to complications
Scientists have shown that inadequate sleep during pregnancy can lead to complications and hinder normal immune processes, says a study.

Women with depression are more likely than non-depressed women to suffer from disturbed sleep and adverse pregnancy outcomes.

Scientists at the University of Pittsburgh School of Medicine conducted the research and the study was published in the journal "Psychosomatic Medicine".

"Our results highlight the importance of identifying sleep problems in early pregnancy, especially in women experiencing depression, since sleep is a modifiable behaviour," said Michele Okun, Ph.D., assistant professor of psychiatry at Pitt`s School of Medicine and lead author of the report. "The earlier that sleep problems are identified, the sooner physicians can work with pregnant women to implement solutions."

There is a dynamic relationship between sleep and immunity, and this study is the first to examine this relationship during pregnancy as opposed to postpartum," added Dr. Okun.

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