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Mar 03
Overeating may be caused by lack of sleep: Study
Do you often find yourself overeating without any specific reason? Turns out that it might be caused by lack of sleep.

A new study has said that sleep deprivation might be the reason behind you feeling munchy most of the time.

This is because, sleep deprivation may boost levels of a chemical that makes eating more pleasurable, which leads to overeating and poor food choices.

According to a report in The Hawk, this chemical signal is endocannabinoid 2-arachidonoylglycerol (2-AG). Blood levels of 2-AG are typically low overnight. They slowly rise during the day, peaking in the early afternoon, researchers said.

The Hawk further reported that this increase in circulating endocannabinoid levels, "could be a mechanism by which recurrent sleep restriction results in excessive food intake, particularly in the form of snacks, despite minimal increases in energy need," researchers said.

The study was published in the journal SLEEP.

Mar 02
Forever young? Scientists claim breakthrough in anti-ageing treatment!
In a breakthrough discovery, scientists claimed to have found the key to preventing skin ageing.

For the first time, researchers found that the activity of a key metabolic enzyme in human skin cells declines with age.

"Our study shows, for the first time, in human skin that with increasing age there is a specific decrease in the activity of a key metabolic enzyme found in the batteries of the skin cells," said lead researcher Mark Birch-Machin, professor at Newcastle University in England.

"This enzyme is the hinge between the two important ways of making energy in our cells and a decrease in its activity contributes to decreased bio-energy in ageing skin," Birch-Machin noted.

Researchers believe the findings could lead to a new range of anti-ageing creams that actually work.

"Our research means that we now have a specific biomarker, or a target, for developing and screening anti-ageing treatments and cosmetic creams that may counter this decline in bio-energy," Birch-Machin pointed out.

"There is now a possibility of finding anti-ageing treatments which can be tailored to differently aged and differently pigmented skin, and with the additional possibility to address the ageing process elsewhere in our bodies," Birch-Machin noted.

The researchers believe that the findings may also lead to a greater understanding of how other organs in the body age, which could pave the way for drug developments in a number of age-related diseases, including cancer.

For the study, complex II activity was measured in 27 donors, from aged six to 72 years. Samples were taken from a sun-protected area of skin to determine if there was a difference in activity with increasing age.

They found that the activity of mitochondrial complex II significantly decreases in older skin.

The study has been published online in the Journal of Investigative Dermatology.

Mar 01
Closer the grocery store, healthier are your food choices
Your proximity to a grocery store can actually change the way you eat, according to a recent study.

Living close to a supermarket is something you may associate with an unhealthy lifestyle, but the research has turned this thinking on its head, finding those who live close to the store make healthier food choices.

The foods on the first list are more exclusive in social media feeds of people living in northeastern food deserts, a term used by the United States Department of Agriculture (USDA) to describe communities with limited access to grocery stores. The second list is more exclusive to non-food deserts.

The Georgia Institute of Technology study identified the food choices and nutritional profiles of people living in both types of communities throughout America. It included three million geo-tagged posts on the social media platform where food is king: Instagram.

The researchers found that food posted (and eaten) by people in food deserts is 5 to 17 percent higher in fat, cholesterol and sugars compared to those shared in non-food deserts areas.

Munmun De Choudhury, who led the study, said that the USDA identifies food deserts based on the availability of fresh food. Instagram literally gave them a picture of what people are actually eating in these communities, allowing them to study them in a new way.

"Fruits and vegetables are the biggest difference," De Choudhury said. "Forty-eight percent of posts from people in non-food deserts mention them. It's only 33 percent in food deserts."

Another observation made by the researchers was, irrespective of food availability, people in the US tend to eat the food their region is most known for - steak and coffee in the west, smoked salmon and cheesecake in the east, and okra and biscuits in the south.

The study has been presented at the ACM Conference on Computer-Supported Cooperative Work and Social Computing (CSCW).

Feb 27
Ebola survivors face long-term health problems
Majority of the people who survive Ebola virus disease are at risk of long-term health problems, say researchers.

According to a new study, most Ebola survivors were found to be suffering from neurological issues six months after infection.

Researchers examined 82 Ebola survivors in Liberia and found that most of them continued to have severe neurological problems, including headaches, memory loss, depressed moods and muscle pain.

The study, by the US National Institute of Neurological Disorders and Stroke in Bethesda, however, found that patients were 'suicidal' or having 'hallucinations' in rare cases.

About two thirds of the survivors, which had an average age of 35, had body weakness, while half of the patients suffered headaches and memory loss. Two people were suicidal and one suffered hallucinations.

"While an end to the outbreak has been declared, these survivors are still struggling with long-term problems," said Lauren Bowen, the study's author.

"It is important for us to know how this virus may continue to affect the brain long term," Bowen added.

More than 28,600 people were infected with Ebola in West Africa during the outbreak, out of which 11,300 succumbed to the disease.

Researchers said they hope to find out more about possible continued long-term brain health problems for the more than 17,000 Ebola survivor.

The study will be presented to the American Academy of Neurology annual meeting in Vancouver in April.

Feb 26
High intensity exercise may be bad for your heart!
Just as too much of anything is bad, extreme strenuous workouts such as high intensity training could be bad for the heart, warns a new study.

According to researchers, high levels of intense exercise may be cardiotoxic and promote permanent structural changes in the heart.

The research, published in the Canadian Journal of Cardiology, is based on studies that looked into the relationship between exercise and heart problems.

There is already fairly compelling evidence supporting the association between long-term sports practice and increased prevalence of atrial fibrillation -- abnormal heart rhythm characterised by rapid and irregular beating.

"Much of the discussion regarding the relative risks and benefits of long-term endurance sports training is hijacked by definitive media-grabbing statements, which has fuelled an environment in which one may be criticized for even questioning the benefits of exercise," explained study author Andre La Gerche from the Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

"This paper discusses the often questionable, incomplete, and controversial science behind the emerging concern that high levels of intense exercise may be associated with some adverse health effects," La Gerche noted.

"The answers regarding the healthfulness of 'extreme' exercise are not complete and there are valid questions being raised," La Gerche said.

"Given that this is a concern that affects such a large proportion of society, it is something that deserves investment. The lack of large prospective studies of persons engaged in high-volume and high-intensity exercise represents the biggest deficiency in the literature to date, and, although such work presents a logistical and financial challenge, many questions will remain controversies until such data emege," La Gerche observed.

Researchers argue that before a definitive link between exercise and heart can be made, much more research needs to be carried out.

Feb 25
Shape-shifting nanoparticles to deliver drugs
Scientists have designed a set of shape-shifting nanoparticles attached to strands of DNA that can deliver drugs directly to cancer cells, while minimising side effects such as hair loss and skin damage.

Many cancer drugs target fast-growing cells. Injected into a patient, they swirl around in the bloodstream acting on fast-growing cells wherever they find them.

That includes tumours, but unfortunately also hair follicles, the lining of your digestive system, and your skin.

Professor Warren Chan from the University of Toronto has spent the last decade figuring out how to deliver chemotherapy drugs into tumours - and nowhere else.

No two tumours are identical. Early-stage breast cancer may react differently to a given treatment than pancreatic cancer, or even breast cancer at a more advanced stage, researchers said.

Which particles can get inside which tumours depends on multiple factors such as the particle's size, shape and surface chemistry.

Researchers studied how these factors dictate the delivery of small molecules and nanotechnologies to tumours, and have now designed a targeted molecular delivery system that uses modular nanoparticles whose shape, size and chemistry can be altered by the presence of specific DNA sequences.

"We're making shape-changing nanoparticles. They're a series of building blocks, kind of like a LEGO set," said Chan.

The component pieces can be built into many shapes, with binding sites exposed or hidden. They are designed to respond to biological molecules by changing shape, like a key fitting into a lock.

These shape-shifters are made of tiny chunks of metal with strands of DNA attached to them. Chan envisions that the nanoparticles will float around harmlessly in the blood stream, until a DNA strand binds to a sequence of DNA known to be a marker for cancer.

When this happens, the particle changes shape, then carries out its function - it can target the cancer cells, expose a drug molecule to the cancerous cell, or tag the cancerous cells with a signal molecule.

The research was published in the journals PNAS and Science.

Feb 24
Half the world's people to become myopic by 2050, says study
Nearly five billion people, that is about half the world's population, are poised to become myopic or short-sighted by the end of 2050, indicates a study.

Also called nearsightedness, myopia is a vision condition in which people can see clearly the objects that are close to eyes but objects far away appear to be blurred to the sight.

Acting like a silent epidemic, myopia is all set to become the leading cause of permanent blindness globally

With up to one billion people at an increased risk of blindness, myopia is all set to become the leading cause of permanent blindness globally.

Further, with the findings suggesting that the US will have 260 million myopes by 2050, up from the 90 million in 2000, and Canada will see 66 million high myopes by 2050, up from the 11 million in 2000, the vision loss from high myopia is expected to increase seven-fold from 2000 to 2050.

The rapid increase in the prevalence of myopia globally is attributed to "environmental factors, lifestyle changes resulting from a combination of decreased time outdoors and increased near work activities, among other factors", said the researchers.

Parents need to ensure that the children's eyes are regularly checked, improve time outdoors and moderate time on near based activities, including electronic devices.

Also, comprehensive eye care services is needed to check the rapid increase in high myopes, along with the development of treatments to control the progression of myopia and prevent people from becoming highly myopic, the researchers suggested in the study published in the journal Ophthalmology revealed.

"We also need to ensure our children receive a regular eye examination from an optometrist or ophthalmologist, preferably each year, so that preventative strategies can be employed if they are at risk," said Kovin Naidoo, a professor at the University of New South Wales in Australia.

Feb 23
Period pain as bad as heart attack: But do we really care?
Almost every woman experiences menstrual cramps from time to time. Men don't get it, yet, doctors have ignore it thinking that pain is something to tolerate as normal.

But, now a new research has suggested that period pain can be as "bad as having a heart attack".

A recent article by Olivia Goldhill at Quartz reveals that the mechanisms behind menstrual cramps are poorly understood and for some unknown reasons, the topic remains under-researched, the Independent reported.

John Guillebaud, professor of reproductive health at University College London, said menstrual cramping can be as "bad as having a heart attack".

Guillebaud believes that the dismissive attitude toward menstrual cramps exists in both male and female physicians. He said that on the one hand, men don't suffer the pain and underestimate how much it is or can be in some women and on the other hand, some women doctors can be a bit unsympathetic because either they don't get it themselves or if they do get it they think, "Well I can live with it, so can my patient."

Dysmenorrhea, the scientific term for painful periods, has no definitive medical origin, with one of its causes being endometriosis, wherein tissue normally lining the uterus is found on the pelvis, fallopian tubes or ovaries.

Untreated endometriosis can cause infertility. Richard Legro from Penn State College of Medicine said that the "million dollar question" is why some women suffer more from period pain than others.

According to the American Academy of Family Physicians, period pain affects the lives of around one in five women.

Feb 22
Daily meditation can slow ageing too
For those who do meditation regularly, here is another good news. Researchers report that apart from reducing blood pressure and heart disease risk, Transcendental Meditation technique and lifestyle changes can slow cellular death too.

The new study examined what was happening at the level of DNA, showing that the Transcendental Meditation technique increases telomerase gene expression which may contribute to the cardiovascular and aging benefits.

Specifically, this was found to activate two genes that code for telomerase -- which adds molecules to the ends of chromosomes or telomeres -- protecting them from deteriorating.

"The finding that telomerase gene expression is increased with a reduction in blood pressure in a high-risk population suggests that this may be a mechanism by which stress reduction improves cardiovascular health," said Robert Schneider, from Iowa-based Maharishi University of Management (MUM).

Earlier research on the Transcendental Meditation technique found lower rates of high blood pressure, heart attack, stroke and early death.

For this trial, the participants included 48 men and women with high blood pressure who were recruited and studied at Howard University Medical Center.

Half were assigned to a group that learned the Transcendental Meditation technique and received a basic health education course.

The other half were assigned to a group that focused on achieving significant lifestyle modifications such as weight reduction, reducing salt intake, engaging in regular physical activity and moderating alcohol.

After 16 weeks, both groups showed significant increases in telomerase gene expression and reductions in blood pressure.

"These findings are very encouraging for prevention. They show that both the Transcendental Meditation technique and active lifestyle modification can contribute to heart health," said Schneider, director of the Institute for Natural Medicine and Prevention at MUM.

"The result is valuable new information, relevant both to cardiovascular disease and to the molecular mechanisms involved in Transcendental Meditation," noted John Fagan, professor of molecular biology in a paper published in the journal PLOS ONE.

Feb 20
High emotional intelligence may make young women manipulative
If you feel your girlfriend often manipulates her way to win the situation, partly blame evolution for such behaviour and seek proper guidance. According to a recent study, young women with high emotional intelligence (EI) are more likely to use manipulative behaviours, resulting in a greater engagement in delinquency.

"I would hypothesise that it's partly due to evolution. In some circumstances, young women may have come to see social survival as more important than social niceties so manipulation may have been an adaptive behaviour which has continued through to the present day," explained lead researcher Alison Bacon from University of Plymouth in Britain.

The research team wanted to assess why young women with high levels of EI are more likely to engage in anti-social behaviour than young men.

For this, 125 young women participated and completed three key measures of EI -- Machiavellianism, the managing emotions of others scale (MEOS) and self-reported delinquent behaviour.

The participants in the study answered standard questions on how they adapt their behaviour depending on, or to affect, the emotions of others.

High EI women also presented higher levels of Machiavellian tactics and delinquency -- both in literal delinquent behaviours and in relationships such as social exclusion or coercion.

"The study was conducted on a group of students and is not suggesting for a second that all young women with high emotional intelligence have these behavioural tendencies," the authors noted in a paper published in the Journal of Forensic Psychiatry and Psychology.

The results, however, suggest that high EI may enable manipulative relational behaviours in some women which, in turn, support delinquency aimed at fulfilment of social or material goals, Bacon noted.

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