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Feb 19
How this gene variant influences what we eat
Hate the taste of broccoli? Do you perceive honey as too sweet? According to a new study, a common gene variant should be blamed for our food choices.

The McGill-led research team has recently discovered that for girls who are carriers of a particular gene variant (DRD4 VNTR with 7 repeats), the crucial element that influences a child's fat intake is not the gene variant itself.

Instead, it is the interplay between the gene and girls' early socio-economic environment that may determine whether they have increased fat intake OR healthier than average eating compared to their peers from the same class background. The DRD4 repeat 7 is found in approximately 20 per cent of the population and is known to be associated with obesity, especially in women.

Lead researcher Laurette Dube said that they found that among girls raised in poorer families, those with DRD4 repeat 7 had a higher fat intake than other girls from the same socio-economic background, but they also found that girls with exactly the same gene variant who came from wealthier families, compared to these with the same economic conditions, had a lower fat intake.

Dube noted that this suggests that it's not the gene acting by itself, but rather how the gene makes an individual more sensitive to environmental conditions that determines "for better or worse" a child's preference for fat and consequent obesity as the years pass by.

Interestingly, the researchers found this effect to be true only in the girls that they tested. They speculate that this may be because, from an evolutionary standpoint, it may have been more important for girls to be able to gain weight easily to adapt to adverse conditions in order to reproduce.

Another possibility they advance is that at age four, it may simply be too early to see these effects in boys since boys and girls gain weight at different stages at this age, and may also have different behavioural responses to hunger and feelings of satiety.

These results underscore the importance of moving beyond a 'one-size-fits-all' approach to childhood obesity prevention, said Dube, adding "we need to move towards targeted approaches that focus on populations that are particularly vulnerable to both genetic and environmental factors: those who are biologically more vulnerable under adverse environments are those likely to be more responsive to improvements in their conditions."

The study appears in JAMA Pediatrics.

Feb 18
Whooping cough vaccine offers short-term protection
A new study has found that the effectiveness of routine Tdap booster wanes in adolescents.

Kaiser Permanente's Vaccine Study Center found that the vaccine provides moderate protection against whooping cough during the first year after vaccination, but its effectiveness wanes to less than 9 percent after four years among teenagers who have received only a newer form of the whooping cough vaccine (acellular pertussis vaccine) as infants and children.

The study explored Tdap effectiveness among adolescents during outbreaks of whooping cough in Northern California in 2010 and 2014. Despite Tdap coverage of more than 90 percent in adolescents, they had the highest incidence of pertussis of any age group in 2014. Routine vaccination at ages 11 to 12 did not prevent the epidemic.

This study demonstrates that despite high rates of Tdap vaccination, the growing number of adolescents who have received only the newer acellular pertussis vaccines continue to be at higher risk of contracting whooping cough and sustaining epidemics, said lead author Nicola Klein.

Klein added that because Tdap provides reasonable short-term protection, it may contain whooping cough more effectively if it is administered to adolescents in anticipation of a local outbreak rather than on a routine basis at age 11 or 12.

Klein noted that the strategy of routinely vaccinating adolescents to prevent future disease did not prevent the 2014 epidemic, arguably because the protection afforded by a dose of Tdap was too short-lived. While awaiting development of new vaccines that will provide longer-lasting protection against pertussis, we should consider alternate Tdap immunization strategies for adolescents.

These findings are published in Pediatrics.

Feb 16
Transcendental meditation lowers BP, heart and mortality risks
Since the Nobel Prize-winning discovery of the enzyme telomerase in 1984, identifying other biological molecules that lengthen or shorten the protective caps on the ends of chromosomes has been slow going.

A new Maharishi University of Management study found that the Transcendental Meditation technique and lifestyle changes both appear to stimulate genes that produce telomerase, an enzyme that's associated with reduced blood pressure, cardiovascular disease and mortality.

Specifically, these approaches were found to activate two genes that code for telomerase, which adds molecules to the ends of chromosomes, or telomeres, protecting them from deteriorating.

The finding that telomerase gene expression is increased and that this is associated with a reduction in blood pressure in a high-risk population, suggests that this may be a mechanism by which stress reduction improves cardiovascular health, said coauthor Robert Schneider.

The new study examined what was happening at the level of DNA, showing that the Transcendental Meditation technique increases telomerase gene expression and suggesting that this may contribute to the cardiovascular and aging benefits.

Coauthor Otelio Randall of Howard University College of Medicine concluded this pilot study in African Americans suggests stress reduction and lifestyle modifications may reduce blood pressure with an increase in telomerase.

The study appears in PLOS ONE.

Feb 15
An egg a day doesn't risk your heart
Due to their cholesterol content, their reputation has been perceived as "bad" for quite some time, but now eggs are back in the game with a new study revealing that they don't increase the risk of heart attack.

The University of Eastern Finland study shows that a relatively high intake of dietary cholesterol or eating one egg every day is not associated with an elevated risk of incident coronary heart disease.

Furthermore, no association was found among those with the APOE4 phenotype, which affects cholesterol metabolism and is common among the Finnish population.

In the majority of population, dietary cholesterol affects serum cholesterol levels only a little, and few studies have linked the intake of dietary cholesterol to an elevated risk of cardiovascular diseases. Globally, many nutrition recommendations no longer set limitations to the intake of dietary cholesterol.

The study did not establish a link between dietary cholesterol or eating eggs with thickening of the common carotid artery walls, either.

The findings suggest that a high-cholesterol diet or frequent consumption of eggs do not increase the risk of cardiovascular diseases even in persons who are genetically predisposed to a greater effect of dietary cholesterol on serum cholesterol levels.

The findings are published in the American Journal of Clinical Nutrition.

Feb 13
Head-down yoga postures fatal for glaucoma patients: Study
For people suffering from glaucoma, certain yoga positions - especially head-down postures - and other exercises like push-ups and lifting heavy weights may be dangerous, a team of US researchers has warned.

Glaucoma patients may experience increased eye pressure as the result of performing several different head-down positions while practicing yoga, claimed the researchers from New York Eye and Ear Infirmary of Mount Sinai (NYEE).

Four inverted yoga positions - facing dog, standing forward bend, plow and legs up the wall - were key to the research.

"While we encourage our patients to live active and healthy lifestyles, certain types of activities, including pushups and lifting heavy weights, should be avoided by glaucoma patients," said Robert Ritch, senior study author and Director, Glaucoma Research, NYEE.

Damage to the optic nerve occurs in glaucoma patients when fluid pressure inside the eye rises. Elevated intraocular pressure (IOP) is the most common known risk factor.

Certain yoga postures and exercises increase "the risk of increasing IOP and possibly damaging the optic nerve," Ritch noted.

In previous research, studies and case reports had tested only the headstand position which showed a marked two-fold rise in IOP.

In the new study, researchers asked healthy participants with no eye-related disease and glaucoma patients to perform four inverted yoga positions.

Both normal and glaucoma study participants showed a rise in IOP in all four yoga positions, with the greatest increase of pressure occurring during downward facing dog.

When the measurements were taken after the participants returned to a seated position and again after waiting for 10 minutes, the pressure in most cases remained slightly elevated from the baseline.

"As we know that any elevated IOP is the most important known risk factor for development and progression of nerve damage to the eye, the rise in IOP after assuming the yoga poses is of concern for glaucoma patients and their treating physicians," explained study first author Jessica Jasien at NYEE.

"In addition, glaucoma patients should share with their yoga instructors their disease to allow for modifications during the practice of yoga," Jasien added.

The research team emphasises the importance of educating glaucoma patients on all of the risks and benefits of relating to physical exercise and their overall vision health.

"The new study will help clinicians advise their patients on the potential risk associated with various yoga positions and other exercises that involve inverted poses," the authors concluded in a paper published in the journal PLOS ONE.

Feb 12
Focus on quality, not quantity, of food to stay slim
Have you come across a few people who never seem to worry about weight and yet manage to stay slim? One secret that works behind their seeming effortlessness may actually be a sharp focus on the quality of food that they eat, suggests new research.

"These results are encouraging because they imply that instead of putting restrictions on one's diet and avoiding favourite foods, weight gain could be prevented early on by learning to listen to inner cues and putting emphasis on the quality instead of the quantity of food," said lead researcher Anna-Leena Vuorinen from the University of Tempere in Finland.

You know that one friend who never worries about weight and seems to stay effortlessly slim? That friend, and others like him might unknowingly possess secrets to helping those who struggle with their weight.

The findings are based on Global Healthy Weight Registry that surveyed adults who have successfully maintained a healthy body weight throughout their lives.

The registry was created by Cornell Food and Brand Lab of Cornell University in the US.

Those who voluntarily signed up for the registry answered a series of questions about diet, exercise and daily routines.

The researchers then divided the respondents into two groups. Group one, the mindlessly slim, consisted of 112 adults who reported that they did not maintain strict diets.

The other group consisted of those who dieted regularly, thought about food frequently and were highly conscious of what they ate.

After comparing the responses from each group, the researchers found that mindlessly slim individuals were more likely to use strategies that differ from traditional recommendations for weight loss or maintenance.

These strategies include eating high-quality foods, cooking at home and listening to inner cues in order to stay slim.

Also they did not indicate feeling as guilty as the other group about overeating.

Furthermore, mindlessly slim people were more likely to have an enjoyment-based, internally informed approach to food and eating, the study found.

The findings were presented recently at the annual scientific meeting of The Obesity Society in Los Angeles, US.

Feb 11
Radiation from X-rays, CT scans doesn't cause cancer
A new study has debunked the widespread belief that radiations from X-rays and CT scans can cause cancer.

Scientists said that it is time to hurl away an unproven, decades-old theoretical model that has led many people, including doctors to believe otherwise.

Scientists used a model known as linear no-threshold (LNT) to estimate cancer risks from low-dose radiation such as medical imaging.

But, risk estimates based on this model are only theoretical and, as yet, have never been conclusively demonstrated by empirical evidence, they said.

The use of LNT model drives unfounded fears and excessive expenditures on putative but unneeded and wasteful safety measures, according to James Welsh, a professor at the Loyola University Chicago Stritch School of Medicine in US.

The LNT model dissuades many physicians from using appropriate imaging techniques and "discourages many in the public from getting proper and needed imaging, all in the name of avoiding any radiation exposure," Welsh and colleagues wrote in the study published in the American Journal of Clinical Oncology.

The said that the LNT model assumes there is no safe dose of radiation, no matter how small. However, the human body has evolved the ability to repair damage from low-dose radiation that naturally occurs in the environment.

They said that studies of atomic bomb survivors and other epidemiological studies of human populations have never conclusively demonstrated that low-dose radiation exposure can cause cancer.

Any claim that low-dose radiation from medical imaging procedures is known to cause cancer "should be vigorously challenged, because it serves to alarm and perhaps harm, rather than educate," they said.

The researchers suggested that the LNT model "should finally and decisively be abandoned."

The researchers reexamined the original studies, dating back more than 70 years, which led to adoption of the LNT model.

Feb 10
Honey can destroy harmful fungus, save lives
Researchers from Britain have identified the effect of honey used since ancient times for the treatment of several diseases, on pathogenic fungi that can cause devastating infections in vulnerable people.

Researchers from the University of Manchester in Britain discovered a powerful link between Surgihoney -- a medicinal type of honey and the destruction of Fusarium -- a fungus that can cause blindness or even death.

The researchers used different concentrations of Surgihoney, a biologically engineered honey that produces chemically reactive molecules containing oxygen, to test how effective it could be in destroying the fungus Fusarium, which is found on plants and in soil.

Even the lowest concentrations had a significant effect in breaking down the cell wall of the fungus, demonstrating its potential as a future treatment for patients, the study revealed.

Chronic infections, such as those found in long-lasting wounds comprise about 60-80 percent of infectious diseases in humans and the way fungi invades wounds is associated with the use of broad-spectrum antibiotics.

Chronic infections, such as those found in long-lasting wounds, in which fungi invades, comprise about 60-80 percent of infectious diseases in humans.

Biofilms -- thin layers of micro organisms, which group together -- contribute to the severity and delayed healing of such chronic wounds, the researchers said.

"Through my research I wanted to show the potential for honey as a healing agent to break through these biofilms and in doing so increase the process of healing. What I found amazing is that honey actually works better than some antifungals," Zain Habib Alhindi, research student at the Manchester University said in an official statement.

The study opens door for further work on the application of honey for many fungal infections and allows scientists to adopt different options for treating a range of superficial infections, researchers concluded.

Feb 09
Now, sunscreen that gives you instant Vitamin D
US researchers have found a new sunscreen that guarantees no loss of vitamin D, rather allows the body to produce the essential vitamin, a deficiency or insufficiency of which causes major health problems in both adults and children.

Researchers from Boston University in the US developed Solar D, through a process in which the ingredients of a sunscreen are altered in such a way that it does not impact its sun protection factor (SPF), but does allow the body to produce vitamin D.

"Solar D was designed with compounds with differing filter compositions to maximise vitamin D production while maintaining its sun protection for reducing erythema or burning of the skin," said Michael F. Holick, professor at Boston University.

Sun exposure has been the major source of vitamin D for most children and adults worldwide.

However, the increased risk of skin cancer led to the widespread usage of sunscreens.

As a result, an SPF of 30 when properly applied reduces the capacity of the skin to produce vitamin D by almost 98 percent, the researchers said.

There are several chemical compounds that are typically used in a sunscreen that efficiently absorbed varying wavelengths of UVB radiation, the researchers explained in the study published in the journal PLOS ONE.

After removing certain ingredients the researchers compared Solar D, which has an SPF of 30, to a popular commercial sunscreen with the same SPF, and found Solar D allowed for up to 50 percent more production of vitamin D in-vitro.

Feb 08
Meditation lowers pain, anxiety in breast cancer biopsy
Meditation eases anxiety, fatigue and pain for women undergoing breast cancer biopsies, new research says.

Researchers from the Duke Cancer Institute in Durham, US found that during such period even music is effective, but only to a lesser extent.

Meditation also helps lower pain during biopsy, the study said.

"Listening to guided meditation resulted in significantly lower biopsy pain during imaging-guided breast biopsy, and both meditation and music reduced patient anxiety and fatigue," said Mary Scott Soo, associate professor at Duke Cancer Institute.

There are medical approaches to ease anxiety by providing anti-anxiety drugs but they may sedate the patients, the researchers noted, adding that meditation is simple and inexpensive, and can be seen as a good alternative.

Anxiety and potential pain can also have a negative impact on patient care undergoing image-guided needle biopsies for diagnosing breast cancer, which are otherwise efficient and successful, the researchers indicated.

Patients who experience pain and anxiety may move during the procedure, which can reduce the effectiveness of biopsy, or they may not adhere to follow-up screening and testing, the researchers revealed in the study published online in the Journal of the American College of Radiology.

The researchers enrolled 121 women undergoing breast cancer diagnosis at Duke and randomly assigned them to receive one of three approaches as they underwent stereotactic and ultrasound-guided biopsy: a recorded meditation, music, or standard care with a technologist offering casual conversation and support.

The meditation was a guided "loving/kindness" script that focused on building positive emotions such as compassion towards oneself and others and releasing negative emotions.

Patients in the music group listened to their choice of instrumental jazz, classical piano, harp and flute, nature sounds or world music. Standard-care patients received supportive and comforting dialogue with the radiologist or technologist.

Immediately before and after biopsy, participants completed questionnaires measuring nervousness and anxiety, ranking biopsy pain between a low of zero to a high of 10, and assessing feelings of weakness and fatigue.

Patients in the meditation and music groups reported significantly greater reductions in anxiety and fatigue after biopsy than those receiving standard care. The standard-care patients reported increased fatigue after biopsy, the researchers concluded.

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