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Aug 11
Stem cells drive human creativity: Scientists
Scientists claim to have discovered a new type of stem cells responsible for creative thinking and memories in humans.

Researchers at The Scripps Research Institute identified a stem cell population that may give birth to neurons which play a key role in abstract thought and creativity.

The finding also paves the way for production of these neurons in culture, a first step towards developing better treatments for cognitive disorders like schizophrenia and autism.

The cells were found in embryonic mice, where they formed the upper layers of the brain's cerebral cortex. In humans, the same brain region allows abstract thinking, planning for the future and solving problems. Previously it was thought that all cortical neurons - upper and lower layers - arose from the same stem cells, called radial glial cells (RGCs).

The new research shows that the upper layer neurons develop from a distinct population of diverse stem cells. "Advanced functions like consciousness, thought and creativity require quite a lot of different neuronal cell types and a central question has been how all this diversity is produced in the cortex," Dr Santos Franco, member of the US team from the Scripps Research Institute said.

"Our study shows this diversity already exists in the progenitor cells." said Franco. In mammals, the cerebral cortex is built in onion-like layers of varying thickness.

The thinner inside layers host neurons that connect to the brain stem and spinal cord to regulate essential functions such as breathing and movement.

The larger upper layers, close to the brain's outer surface, contain neurons that integrate information from the senses and connect across the two halves of the brain.

Higher thinking functions are seated in the upper layers, which in evolutionary terms are the "newest" parts of the brain.

"The cerebral cortex is the seat of higher brain function, where information gets integrated and where we form memories and consciousness," said the study's senior author Ulrich Mueller. The new research is published in the journal 'Science'.

Aug 10
Dentist to Pay Compensation over Not Checking Blood Sugar Level before Surgery
A city dentist will have to pay Rs. one Lakh as compensation to a patient, following a district consumer forum orders. The dentist prompted medical complications for the patient by operating him, without taking into account his blood sugar levels.

The patient had lodged a complaint of the dentist stating that the doctor didn't check his blood sugar level prior to the surgery; as a result the operated area developed pus, which has led to a severe infection in his throat that can be mended only by operation that would cost Rs. 70,000.

However, Dr. Vaneet Kakar emphasized that he performed the operation only after his patient Fateh Singh confirmed him that his sugar level was normal.

Still North District Consumer Disputes Redressal Forum asserted that they found Dr. Kakar to be negligent as if after being informed that the patient is diabetic, he believed in his words and did not check his sugar levels.

The forum pointed out that once the patient informed the doctor of his condition, he should have asked him to go for a blood sugar test before carrying out the root canal treatment.

"Contributory negligence on the part of patient is no defense though it is a circumstance which can be taken into account in determining the quantum of compensation", the forum said.

Aug 10
Where are the brains?
That the law is an ass is almost a truism. But few understand that the law is often turned into an ass by its literal interpretation. This is exactly what is preventing the country's first international kidney swap transplant from taking place in Mumbai's Hinduja hospital and BSES MG hospital.

The matter is simple. Two women, one from Rajasthan and the other from Kenya, are in a position to save the life of a member of the other's family by donating a kidney. Both families are keen on the swap and doctors are ready to perform the operation. The hitch: the stubborn Rajasthan government, whose transplantation committee, which needs to give the go-ahead for the operation, is refusing to do so citing the Transplantation of Human Organs Act, 1994. The act prohibits the transplantation of a vital organ from an Indian national in a foreign patient.

The act was passed to prevent the then rampant sale of kidneys by poor Indians to wealthy foreigners for money. It obviously does not matter to Rajasthan government officials that in the case in question, there is no exchange of money involved and no exploitation of a poor Indian by a wealthy foreigner. If anything, there is a happy ending in store for both families.

The Universal Declaration of Human Rights, which has been accepted by all countries, including India, clearly says the law cannot supersede life. Laws are made by human beings for the betterment of society and cannot become impediments to someone's right to life. The sooner the obstinate government officials understand this basic concept and clear the operation, the better it is for everyone, including the families involved.

Aug 09
Telling lies bad for health
Honesty is the best policy after all! Researchers have found that telling fewer lies can improve your physical and mental health.

A study found that people experienced about four fewer mental health complaints such as feeling tense or sad by telling three fewer lies in a 10-week period.

They also had three fewer physical problems - including sore throats and headaches, the Daily Mail reported on Wednesday.

A total of 110 people, their age ranging from 18 to 71, took part in the study conducted by the University of Notre Dame researchers.

About half the participants were instructed to stop telling lies during the study. The other half served as a control group that received no special instructions about lying.

Results showed the link between less lying and better health was significantly stronger for participants in the no-lie group.

They experienced four fewer mental health complaints and three fewer physical problems - after telling three fewer lies.

Aug 09
'Martian landscape looks like Earth'
The raw images sent back by Mars rover Curiosity has revealed that the crater where it landed looks remarkably Earth-like, scientists said.

"The first impression that you get is how Earth-like this seems looking at that landscape," said chief scientist John Grotzinger of the California Institute of Technology.

It provided the best view so far of its destination since touching down Sunday night after nailing an intricate choreography. During the last few seconds, a rocket-powered spacecraft hovered as cables lowered Curiosity to the ground.

In the latest photos, Curiosity looked out toward the northern horizon. Nearby were scour marks in the surface blasted by thrusters, which kicked up a swirl of dust. There were concerns that Curiosity got dusty, but scientists said that was not the case.

"We do see a thin coating of dust, but nothing too bad," said Justin Maki, imaging scientist at NASA's Jet Propulsion Laboratory, which manages the USD 2.5 billion mission.

Scientists were giddy about the scour marks because they exposed bedrock below information that should help scientists better understand the landing site.

Since landing, Curiosity has zipped home a stream of low-resolution pictures taken by tiny cameras under the chassis and a camera at the end of its robotic arm, which remained stowed. It also sent back a low-quality video glimpsing the last 2 1/2 minutes of its descent.

The rover successfully raised its mast packed with high-resolution and navigation cameras. With the mast up, it can begin its shutterbug days in force including taking a 360-degree color view of its surroundings as early as today.

Grotzinger said he was struck by the Martian landscape, which appeared diverse. There seemed to be harder material underneath the gravelly surface, he said.

"It kind of makes you feel at home," he said. "We're looking at a place that feels really comfortable."

Mars, of course, is very different from Earth. It's a frigid desert constantly bombarded by radiation. There are geological signs that it was a warmer and wetter place once upon a time. One of the mission's goals is to figure out how Mars transformed.

Aug 08
Teens who don't have sex still at risk for HPV
Even girls who have not had sexual intercourse are at risk for infection with human papillomavirus (HPV), a new study shows.

In the study, which involved teen girls and young women, 11.6 percent of those who had never had sexual intercourse were infected with at least one strain of HPV.

HPV is a sexually transmitted disease that is most commonly passed between people during vaginal or anal intercourse. But it can also be transmitted through genital-to-genital, or hand-to-genital contact, which is how the participants in the study likely got the virus, the researchers said. Out of the more than 40 sexually transmitted HPV strains, more than a dozen have been identified as cancer-causing, according to the National Cancer Institute.

HPV infections are usually transient, but can cause cervical cancer in some people if the infection lingers for long periods.

The findings support the recommendation to administer the HPV vaccine to girls ages 11 and 12, before many become sexually active, the researchers said. Doctors and parents should not delay HPV vaccination because a teen is not sexually active, they said.

"Even before kids have intercourse,they're being exposed to HPV," said study researcher Lea Widdice, an assistant professor of pediatrics at Cincinnati Children's Hospital. "Vaccination at 11 to 12 years old is not too early," Widdice said.

Because the study was conducted in just one community of mainly African American young women, further research is needed to see if the findings apply to the general population. A high percentage of the participants in the study had become sexually active or had sexual contact, and the prevalence of HPV may be lower in a group with different sexual behaviors, experts say.

One of Widdice's teammates receives funding from Merck, the company that manufactures the HPV vaccine Gardasil.

Widdice and colleagues analyzed information from 259 girls ages 13 to 21 who visited a clinic in Cincinnati and got their first HPV vaccination between 2008 and 2010. The majority of participants (78 percent) were African American, and 75 percent reported having public health insurance.

Participants were asked whether they had ever had sexual intercourse, or whether they had ever had sexual contact without intercourse. A swab was used to collected cell samples from the vagina and cervix (either by doctors or the participants themselves), and the samples were tested for HPV.

One hundred ninety participants (73 percent) were sexually experienced, and many had had multiple sexual partners; the average number of sexual partners was about six. Among sexually active participants, 133 (70 percent) tested positive for HPV.

Of the 69 participants who had not had sex, eight tested positive for HPV, two of whom had HPV-16, a high-risk type of HPV. (Most cervical cancers are caused by HPV-16 or HPV-18.)

Eduardo Franco, a cancer epidemiologist at McGill University, in Montreal, said the percentage of girls in the study who tested positive for HPV and had not had sex was higher than he would have expected. But this may be because many of the girls in the group had had some type of sexual exposure, said Franco, who was not involved in the study.

It's not clear whether the HPV infections seen in this study were found in the vagina or in the cervix, Franco said. HPV infections in the cervix are more risky in terms of their cancer-causing ability, but would be less likely in those who have not had sexual intercourse, Franco said.

The vaccines currently available prevent both vaginal and cervical strains, though they must be given before the infection emerges. That said, women who have an HPV infection in the vagina would still be protected against the cervical kind if they then get the HPV vaccine, Franco said.

(Gardasil protects four strains of HPV, while the vaccine Cervarix, manufactured by GlaxoSmithKline, protects against two strains.)

Widdice and her colleagues detail their results in the August issue of the journal Archives of Pediatric & Adolescent Medicine.

Aug 08
Weight training 'reduces diabetes risk'
Weight training helps to prevent type 2 diabetes in men, research suggests.

Researchers found regular weights reduced the risk by up to a third, in the study of more than 32,000 men published in the Archives of Internal Medicine journal.

It is already well known that regular exercise can prevent the disease.

But the report is considered important as weights provides an alternative to aerobic exercises such as running for people who are not so mobile.

Researchers from Harvard School of Public Health in the US and the University of Southern Denmark followed the men over an 18-year period, during which time nearly 2,300 developed the condition.
'Difficulty'

They found 30 minutes of weights a day, five times a week could reduce the risk of diabetes by 34%.

But they also reported that even less regular exercise - up to an hour a week - had an impact, cutting the risk by 12%.

Nonetheless, aerobic exercise was still found to be slightly better with regular activity halving the risk.

The two combined had the greatest effect, reducing it by up to 59%, the study found.

Lead author Anders Grontved said: "Many people have difficulty engaging in or adhering to aerobic exericse.

"These new results suggest that weight training, to a large extent, can serve as an alternative."

It is not clear if the same results would be found with women.

Aug 07
Are they bad for cholesterol and how many can I have?: Unscrambling the truth about eggs
Once demonised as bad for the heart, eggs have been repositioned as a health food in recent years as researchers have found that not only are they good for hearts, but can even help you to lose weight.

But last week Canadian researchers published findings that could crack eggs' nutritious reputation.

In the study of 1,200 subjects with an average age of 61, it was suggested that build-up of carotid plaque, a waxy substance that clogs blood vessels and is linked to cardiovascular disease, was greater in people who ate at least two eggs per week.

The researchers specifically blamed egg yolks for this effect.

Britons eat nearly 30 million eggs a day. Should we curtail our egg habit to protect our hearts?

A few years ago, Bruce Griffin, professor of nutritional metabolism at the University of Surrey, analysed 30 egg studies carried out over 30 years and found eggs 'have no clinically significant impact' on cholesterol levels.

In fact, a study in the American Journal of Clinical Nutrition found eggs helped to maintain healthy blood pressure levels, says Helen Bond.

And last year, scientists at the University of Alberta discovered egg yolks contain two important amino acids, tryptophan and tyrosine, and that two raw egg yolks have almost twice as many antioxidants as an apple.

Frying or boiling reduced antioxidant levels by about half.

Thanks to changes in chicken feed, eggs today are healthier than those produced 30 years ago.

Modern eggs contain 70 per cent more vitamin D and double the amount of selenium.

Levels of these are low in the UK diet, and linked to an increased risk of cancer, cardiovascular disease and infertility. Each egg yolk also provides 13 essential nutrients.

The Department of Health now says we can eat as many eggs as we like, as long as they form part of a healthy, balanced diet. There is no upper limit, says Bond, unless you have inherited high cholesterol.

Of the Canadian study, she says that carotid plaque rises anyway with age after 40.

And the researchers didn't take into account lifestyle factors such as exercise and diet.

In the Department of Health analysis it was found that eggs contain around 20 per cent less fat, 13 per cent fewer calories and 10 per cent less cholesterol than 30 years ago.

In one study, overweight women had eggs or a bagel for breakfast. The egg eaters consumed fewer calories in the following 24 hours.

'Scientists put the positive effects down to the satiating effects of egg protein,' says Bond.

Aug 07
Nose for happiness: Doctors discover NASAL SPRAY that can stop couples having heated arguments
Scientists might be a bit sniffy about this latest research, but a nasal spray containing a hormone can help bring happiness to warring couples living together.

A study has shown that breathing in a compound containing oxytocin makes women calmer and friendlier and men more sensitive and positive during arguments.

Dubbed the 'cuddle drug', oxytocin is naturally made in the body and is involved in sex, sexual attraction, trust and confidence.

It is released into the blood during labour - triggering the production of breast milk - and floods the brain during breastfeeding, helping mother and baby bond.

The research, reported in the journal Social Cognitive and Affective Neuroscience, looked at how the hormone affects stress and the autonomic nervous system during disagreements between couples.

When there is an argument, there is an increased heart rate and higher blood pressure.

Forty-seven couples, aged 20 to 50, were involved in the experiment at Zurich University. They were either married or had cohabited for at least a year.

They chose a topic which caused conflict in their relationship before having five puffs of oxytocin or a placebo spray. After 45 minutes they were left alone in a room and filmed discussing the contentious issue.

Researchers monitored the participants, taking saliva swabs to check for compounds showing how the nervous system was working.

The findings revealed that compared to those who took the placebo, women who sniffed oxytocin were more friendly, less demanding while men were more positive and more likely to engage.

There was a drop in nervous system activity for women while in men it went up.

According to the researchers, women tend to show demanding behaviour more frequently and men tend to withdraw. 'In out study, oxytocin might have driven quiescence in women and social salience and approach behaviour in men,' the journal reported.

Nottingham University professor Kavita Vedhara believes the study has shown that oxytocin reduces women's 'emotional and physiological arousal following verbal conflict' while the opposite happens to men.

Scientists have previously found that a man's libido was improved when he sniffed a spray containing oxytocin.

Research at the University of California reported that a married man who sniffed the spray twice a day saw a considerable improvement in his sexual performance.

His libido went from 'weak to strong' while arousal levels went from 'difficult to easy.'

In an unusual scientific experiment, couples who sprayed themselves with a compound containing the hormone oxytocin before they discussed contentious issues then behaved more positively.

Women were less emotionally aroused and men more aroused after using the spray. According to researchers, the women who took part in the tests were more friendly, less demanding and less anxious, while men were more aware of social cues, more positive, and more likely to engage.

Oxytocin is produced mainly in the hypothalamus region of the brain. It had been studied in women because it is released during labour to dilate the cervix, boost contractions and to trigger the release of milk in the breasts.

In the new study, reported in the journal Social Cognitive and Affective Neuroscience, researchers looked at its effects on stress and the activity of the autonomic nervous system during disagreements between couples.

This part of the nervous system automatically regulates organs of the body, and research has shown it is more active during conflict between couples, leading to increased heart rate and blood pressure.

Forty-seven couples, aged 20 to 50, who were married or had been cohabiting for at least a year, took part in the study at the University of Zurich. Couples chose a topic to discuss about which they continually disagreed, and then self-administered five puffs of either the oxytocin or a placebo spray.

Forty-five minutes later, each couple was left alone in a room and filmed while they talked about the subject that usually rubbed them up the wrong way.

At various times during the experiments, the researchers took saliva swabs to check for compounds that show how the nervous system is working.

The results showed that, compared to those who had sniffed the placebo, women who had the oxytocin spray experienced a drop in nervous system activity, whereas in the men it went up. The men displayed increased positive behaviour; the women became more friendly.

In general, the researchers say, women tend to show demanding behaviour more frequently, while men tend to withdraw: 'In our study, oxytocin might have driven quiescence in women and social salience and approach behaviour in men.''

Kavita Vedhara, professor of health psychology at Nottingham University, said the findings were very interesting: 'We are much clearer about the biological role of oxytocin in women, but these data suggest it could have significant effects in men.

What they have shown is that oxytocin appears to reduce women's emotional and physiological arousal following verbal conflict, but that the drug has the opposite effect on men, increasing both their emotional and physiological arousal.

It is not clear if the increased emotion in men was always positive, but it was certainly associated with more positive behaviours during the conflict situation.'

The researchers now want to look further into the possible benefits of oxytocin on warring couples.

'It is possible that the effect simply produced short-term changes in how couples interact with each other,' said Professor Vedhara.

'This might help to take the heat out of an argument. But whether it helps to resolve the issues that lead to the arguments is not clear.'

Aug 06
'E-cigs a risk' fear may see law move
Figures show TWO MILLION Brits have tried them and 650,000 use them regularly. But Health Minister Simon Burns said some e-cigs had been "found to pose a potential danger".

They contain nicotine-infused water inhaled as a vapour. A consultation has found support for having them controlled by the Medicines and Healthcare Regulatory Authority.

The MHRA said: "It's illegal to sell e-cigarettes as a 'quit smoking' aid unless they're licensed as a medicine."

Shadow health minister Diane Abbott said e-cigs' potential to help the UK's ten million smokers quit is being "held back by a lack of scientific research" into them.

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