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Aug 18
VS demands probe into unethical clinical trial
Opposition Leader V S Achuthanandan said that cases should be registered against those responsible for carrying out unethical clinical trials on patients in the state and demanded immediate investigation by a high-level police team into the issue.

He said that by subjecting patients to clinical trial without their prior permission, the private hospital authorities had treated them as guinea pigs. "Reports say that in the past five years, around one lakh patients were subjected to clinical trials. Also, a section of media had reported that around 300 medicines were tested on patients and hundreds of people died owing to clinical trials. If the allegations are found true, then murder charges should be pressed against those responsible," said Achuthanandan.

He also alleged that in the name of free medical camps, some of the private hospitals in the state were carrying out clinical trials on patients and this should also be brought under the ambit of probe.

"Strict rules should be enforced to conduct medical camps by private hospitals so that such incidents won't be repeated in future," he said.

Meanwhile, the State Government has decided to constitute an expert committee to look into charges of unethical clinical trials on patients.

Health Minister V S Sivakumar has asked the health secretary to set up the committee. On Thursday, the police had sealed Health and Research Centre (HRC), a private medical firm near the Medical College Hospital here after the media reports came out, which said that around 47 unethical clinical trials were conducted by the firm without mandatory sanction.

Aug 17
Overweight mothers put babies at risk
If you happen to be an overweight expectant mother, the chances are that you could be jeopardising the unborn baby's health for a lifetime, a new research has warned.



Women who were very fat during their pregnancy were 65 percent more likely to give birth to an extra large baby. The risk rose by more than two-and-a-half times for those who were considered to be obese, Daily Express reported.



The latest research was conducted to highlight the dangers to both mother and baby of a woman being overweight when she becomes pregnant.



The study of almost 10,000 mothers, who did not develop gestational diabetes, revealed that those who were overweight while expecting were 65 percent more likely to give birth to a large child.



Earlier studies had shown heavier women were more likely to miscarry healthy babies, develop blood clots and have a child more prone to obesity and a raft of health problems such as diabetes and heart problems.

Aug 17
Walnuts 'improve sperm health'
Eating around two handfuls of walnuts a day improves sperm health in young men, a study in the journal Biology of Reproduction suggests.

Sperm shape, movement and vitality improved in men who added walnuts to their diet over 12 weeks.

The fatty acids found in these nuts are thought to have helped sperm development. It is not known if this would help improve male fertility.

About one in six couples are infertile, with 40% of these due to a male factor.

Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield said: "It would be relatively easy to poke fun at studies like this, but there is increasing evidence to show that aspects of a man's diet can affect the number and quality of sperm produced by his testicles."

The researchers say the next step is to work with couples who are attending infertility clinics to determine if placing sub-fertile men, with poor semen quality, on a walnut diet results in better success conceiving.
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Walnuts provide a rich source of omega-3, which we suspect may have been responsible for the improvements we observed."

Catherine Carpenter UCLA Centre for Human Nutrition

It is thought that infertility in men may be a result of too few sperm being made, or that the sperm have poor swimming ability, size or shape.
Walnut supplement

This study involved 117 men between the ages of 21 and 35, who were divided into two groups. One group added 2.6 ounces (75 grams) of whole-shelled walnuts to their daily diet.

The other group continued their usual diet but avoided eating tree nuts. Both groups ate a typical Western-style diet.

Lead author, Prof Wendie Robbins from UCLA's Fielding School of Public Health said: "We found a significant improvement in sperm parameters in the group that consumed the walnuts.
Healthy sperm

"The men who ate no tree nuts saw no change."

Sperm quality improved in terms of concentration, vitality, movement, shape and chromosome abnormalities.

Dr Pacey said: "The study has been well executed and my only criticism would be that the men in the walnut-eating arm of the trial could have altered other aspects of their behaviour to give the results shown in the paper.

"A better trial would be to produce tablets of walnut extract that looked identical to a placebo so that the study was completely blind.

"In spite of this, the results of the study show a small but statistically significant improvement in sperm health."

These benefits may be down to the fatty acids in the nuts.

Co-author Catherine Carpenter, from the UCLA Centre for Human Nutrition said: "Walnuts provide a particularly rich source of a-linolenic acid, a natural plant source of omega-3, which we suspect may have been responsible for the improvements we observed."

The walnuts for the study were supplied by the California Walnut Commission and the study was funded by the UCLA Fielding School of Public Health's Centre for Occupational and Environmental Health.

Aug 16
Olive oil can protect bones: Study
A diet enriched with olive oil can help preserve bone strength, a new study has claimed.

Researchers from Hospital Dr Josep Trueta in Girona, Spain found that consumption of a Mediterranean diet enriched with olive oil for two years is associated with increased bone formation markers, suggesting a protective effect on bone.

"The intake of olive oil has been related to the prevention of osteoporosis in experimental and in vitro models," Jose Manuel Fernandez-Real, lead author of the study said.

"This is the first randomised study which demonstrates that olive oil preserves bone, at least as inferred by circulating bone markers, in humans," Jose said in a statement.

The participants in this study were 127 community-dwelling men aged 55 to 80 years randomly selected from one of the Prevencion con Dieta Mediterranea (PREDIMED) study centres who had at least two years of follow-up.

Participants were randomly assigned to three intervention groups: Mediterranean diet with mixed nuts, Mediterranean diet with virgin olive oil, and a low-fat diet.

Biochemical measurements of osteocalcin, glucose, total cholesterol, HDL-cholesterol and triglycerides were performed at baseline and after two year follow-up on fasting blood samples.

Researchers found that only consumption of the Mediterranean diet with olive oil was associated with a significant increase in the concentrations of total osteocalcin and other bone formation markers.

There were also no significant changes in serum calcium in subjects taking olive oil whereas serum calcium decreased significantly in the other two groups.

The study will be published in the Endocrine Society`s Journal of Clinical Endocrinology and Metabolism (JCEM).

Aug 16
Haryana bans gutkha, Gujarat to impose ban from Sept 11
The Haryana government has prohibited manufacture, storage, sale and distribution of gutkha and paan masala containing tobacco or nicotine as ingredients. The ban came into effect from Wednesday. The order has been issued in public health interest for one year, Commissioner of Food Safety, Haryana, Rakesh Gupta said here.

The Food Safety and Standards Act, 2006, enacted by the Centre, prohibits the sale and manufacture of products which are injurious to health, Gupta said. He said under the Act, any person who manufactures for sale, stores, sells, distributes or imports any food which is unsafe, shall be punished.

Meanwhile, speaking at Junagadh in Gujarat,

Chief Minister Narendra Modi said gutkha will be banned in the state from September 11.

"I have to save the youths of Gujarat from the dreaded evil of cancer and that's why a decision to impose a complete ban on gutkha has been taken," Modi said in his Independence Day speech.

The comprehensive ban on sale, stocking, production and distribution of the product shall come into effect from September 11, he said

Aug 14
India witnesses sharp decline in HIV cases
India Tuesday announced that the country had witnessed a sharp decline in the number of new HIV cases -- a 56 percent drop -- in the past 10 years.

"HIV infections have declined by 56 percent during the last decade from 2.7 lakh in 2000 to 1.2 lakh in 2009 in our country," Indian Health and Family Welfare Minister Ghulam Nabi Azad said in the national capital.

"This has been possible due to political support at the highest levels to the various interventions under National AIDS Control Programme, including Parliamentarians and elected leaders at the state and local levels and cooperation received from NGOs, civil society, etc." the minister said while addressing an international HIV vaccine symposium.

Expressing similar sentiments, Minister of Science and Technology and Earth Sciences Ashwani Kumar said that the government believes that the new HIV infections could be significantly reduced if effective prevention programs are expanded and reach those at greatest risk of HIV infection.

In fact, HIV -- which causes AIDS -- was detected in India nearly 25 years back.

Though more than 2 million people are affected by the virus, India is said to be one of the few countries which has actually made significant reductions in HIV infections. The country's HIV- AIDS prevention model has been even lauded by United Nations Secretary General Ban-Ki Moon.

Aug 14
Depression may up risk of peripheral artery disease
A study of more than one thousand men and women with heart disease has found depression to be associated with an increased risk of peripheral artery disease (PAD).

PAD is a circulatory problem in which narrowed arteries reduce blood flow to the limbs usually the legs and feet resulting in pain, reduced mobility and, in extreme cases, gangrene and amputation.


Marlene Grenon, MD, CM, a vascular surgeon at San Francisco VA Medical Center and the University of California (SFVAMC) and an assistant professor of Surgery at UCSF, led the analysis of data from 1,024 participants in the Heart and Soul Study, a prospective study of men and women with coronary artery disease who were followed for an average of approximately seven years.

"We discovered that there was an association between depression and PAD at baseline, and also found that the patients who were depressed at the beginning of the study had a higher likelihood of developing PAD during follow-up at seven years," said Grenon.

The researchers found that some of the risk for PAD was partly explained by modifiable risk factors such as smoking and reduced physical activity.

"We still don't know which comes first. Is it that patients with PAD become depressed because their mobility is impaired, or that people who are depressed engage in unhealthy behaviours such as smoking and lack of exercise, and are thus more at risk of developing PAD? Or might it be a vicious cycle, where one leads to the other? " said Grenon.

Further research is needed to tease out cause and effect, she said.

The study authors suggest that whatever the initial cause, lifestyle modifications such as being more physically active, eating better, quitting smoking and managing stress more effectively might reduce the risk for the association, as well as potentially address symptoms of both PAD and depression.

The study was published last month in the Journal of the American Heart Association.

Aug 13
New technology to detect resistant TB bacteria developed
Scientists have developed a new technique to detect tuberculosis bacteria which survive the treatment, paving the way for effectively treating TB bacilli resistant to antibodies.

Researchers from the Antwerp Institute of Tropical Medicine have created a simple technique of Fluorescein diacetate staining, which only stains living tuberculosis bacilli (and not dead ones) which can immediately tell if resistant bacilli survived after treatment.

Tuberculosis bacilli have become resistant against major antibiotics. According to World Health Organization (WHO) estimates, only 11 per cent of multiresistant cases were discovered in 2009.

Checking smears under the microscope still is the recommended technique for TB screening, but it cannot differentiate between living and dead bacilli.

It is therefore not clear whether you are looking at the cadavers of a successful treatment, or at resistant survivors. Only if the numbers after a long wait still don't fall, you know you are dealing with a resistant strain. But all that time the patient has remained contagious, the researchers said in a statement.

Armand Van Deun and colleagues in Bangladesh gave a new application to a forgotten technique: vital staining with fluorescein diacetate (FDA). It only stains living TB bacilli, so one immediately sees those bacilli escaping treatment.

The scientists improved the detection of the luminous bacilli by replacing the classical fluorescence microscope with its LED counterpart.

This simple test allows, also in resource-limited labs, to detect a high number of resistant TB bacilli that otherwise would have been discovered too late or not at all.

The study was published in the International Journal of Tuberculosis and Lung Disease.

Aug 13
Scientists find the stem cells that drive our creativity
A newly-discovered type of stem cell could be the key to higher thinking in humans, research suggests.

Scientists have identified a family of stem cells that may give birth to neurons responsible for abstract thought and creativity.

The cells were found in embryonic mice, where they formed the upper layers of the brain's cerebral cortex.

In humans, the same brain region allows abstract thinking, planning for the future and solving problems.

Previously it was thought that all cortical neurons - upper and lower layers - arose from the same stem cells, called radial glial cells (RGCs).

The new research shows that the upper layer neurons develop from a distinct population of diverse stem cells.

Dr Santos Franco, a member of the US team from the Scripps Research Institute in La Jolla, California, said: 'Advanced functions like consciousness, thought and creativity require quite a lot of different neuronal cell types and a central question has been how all this diversity is produced in the cortex.

'Our study shows this diversity already exists in the progenitor cells.'

In mammals, the cerebral cortex is built in onion-like layers of varying thickness.

The thinner inside layers host neurons that connect to the brain stem and spinal cord to regulate essential functions such as breathing and movement.

The larger upper layers, close to the brain's outer surface, contain neurons that integrate information from the senses and connect across the two halves of the brain.

Higher thinking functions are seated in the upper layers, which in evolutionary terms are the "newest" parts of the brain.

The new research is reported today in the journal Science.

Growing the stem cells in the laboratory could pave the way to better treatments for brain disorders such as schizophrenia and autism.

Aug 11
Red meat could raise risk of cancer 'due to high levels of iron'
Scientists claim high levels of iron may be one reason why eating red meat raises the risk of bowel cancer.

Iron may switch on the disease process via a faulty gene in the gut which would normally resist the disease.

Red meat contains large amounts of iron and is also known to increase the likelihood of bowel cancer.

The discovery could lead to new treatments that can 'mop up' iron in the bowel in people who develop cells affected by the defective gene.

In studies of mice, researchers found that susceptibility to bowel cancer was strongly influenced both by iron and a gene called APC.

When the APC gene was faulty, mice with a high iron intake were two to three times more likely to develop the disease.

Mice fed a low iron diet remained cancer free even if the gene was defective, but when it functioned normally, high iron levels did no harm.

Lead scientist Professor Owen Sansom, deputy director of the Cancer Research UK Institute in Glasgow, said 'We've made a huge step in understanding how bowel cancer develops.

'The APC gene is faulty in around eight out of 10 bowel cancers but until now we haven't known how this causes the disease.

'It's clear that iron is playing a critical role in controlling the development of bowel cancer in people with a faulty APC gene.

'And, intriguingly, our study shows that even very high levels of iron in the diet don't cause cancer by itself, but rely on the APC gene.'

Each year, more than 41,000 people in the UK are diagnosed with bowel cancer and around 16,000 die from the disease.

Previously, researchers have estimated that red meat contributes to around 17,000 cases of bowel cancer a year.

But this estimate was based on two different dietary factors thought to play a part in promoting bowel cancer because a substance called haem, which gives red meat its colour, can damage the lining of the colon, while burning meat produces cancer-causing compounds.

The latest laboratory study proposes another mechanism that, if confirmed in people, might help explain why people's risk of bowel cancer increases with age.

Over time, cells in the bowel would be increasingly likely to develop APC gene faults and thus react to iron in the diet.

Researchers say that when the APC gene doesn't work, iron is allowed to build up in the cells lining the gut.

This activates a genetic cancer 'switch' called wnt that causes cells to multiply out of control.

But consumption of iron also aids the growth of cells with defective APC over time, says the study published in the journal Cell reports.

In mice fed a diet with no iron, cells with a faulty APC gene were killed off and bowel cancer did not develop.

Mice with a fully functioning APC gene did not grow tumours even when fed high amounts of iron in their diet. In these animals, the wnt signalling pathway remained switched 'off'.

Co-author Dr Chris Tselepis, a Cancer Research UK scientist at the University of Birmingham, said 'Our results also suggest that iron could be raising the risk of bowel cancer by increasing the number of cells in the bowel with APC faults.

'The more of these cells in the bowel, the greater the chance that one of these will become a starting point for cancer.

'We're now planning to develop treatments that reduce the amount of iron in the bowel and so could lower the risk of developing bowel cancer.

'We hope to start using these in trials in the next few years in people who are at a greater risk.'

Dr Julie Sharp, senior science information manager at Cancer Research UK, said 'Bowel cancer is the third most common cancer in the UK.

'These findings suggest a potentially effective way of reducing the chances of bowel cancer developing in people who are at high risk.

'Finding ways of 'mopping up' the iron that is in the bowel could have a real impact on the number of people who develop the disease.'

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