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Nov 09
A handful of walnuts secret to better sperm: Researchers
The simple way to boosting male fertility, a major problem across the world, could be gobbling a handful of walnuts, researchers say.

"The initial research we conducted regarding walnuts and male fertility found improvement in sperm parameters after adding walnuts to the diet and has set the stage for us to further explore the impacts of walnuts on male fertility and reproductive health," Professor Wendie Robbins, University of California, Los Angeles (UCLA) School of Nursing.

"New projects are underway that we hope to be able to share with you in the near future," she told PTI.

Infertility and subfertility affect a significant proportion of humanity and the burden in men is relatively unknown.

Infertility is defined as a "disease of the reproductive system" and results in disability.

Commenting on the study in 2012 by a team led by her, Robbins said that 75 grams of walnuts consumed daily improved sperm vitality, motility, and morphology (normal forms) in a group of healthy young men between 21-35 years of age.

These findings, published in the journal Biology of Reproduction, are of particular interest to the over 70 million couples worldwide who experience sub-fertility or infertility.

In fact, 30 to 50 per cent of these cases are attributed to the male partner, and in the US the prevalence of men seeking help for fertility is estimated at 3.3?4.7 million.

This research suggests that walnuts provide key nutrients that may be essential in male reproductive health.

According to Robbins, "the positive finding of walnuts on sperm may be a result of their unique nutrient profile."

Walnuts are the only nut that are an excellent source of alpha-linolenic acid (ALA) the plant-based omega-3 fatty acid.

The study also reported higher amounts of ALA provided by walnuts correlated with less frequent aneuploidy or abnormal cell sperm chromosome numbers which can result in genetic abnormalities such as Down syndrome, she said.

In addition to ALA, walnuts have high antioxidant content, along with numerous micronutrients that Robbins thinks may work together synergistically.

Food has been linked with human reproductive success but most of the emphasis has been on the maternal diet and very little focus has been given to the paternal diet, Carol Berg Sloan, Nutrition Consultant with the California Walnut Commission said.

She said the study by Robbins emphasises that a father's diet not only impacts fertility, but can also influence the health of the child and future generations.

The study by UCLA researchers included 117 healthy young men who routinely eat a Western-style diet. Approximately half consumed the 75 grammes of walnuts per day for 12 weeks, while the remaining half served as the control group.

After 12 weeks, compared to the control group, the walnut group experienced improvement in sperm vitality, motility, and morphology key components in male fertility, Robbins said.

Nov 06
Just one junk food snack may trigger metabolic disease
Overindulgence at the dinner table or at snack time may be enough to trigger signs of metabolic disease, a new study has warned.

In the study, just one high-calorie shake was enough to make people with metabolic disease worse, while in others, relatively short periods of overeating triggered the beginnings of metabolic disease.

"Acute effects of diet are mostly small, but may have large consequences in the long run," said Suzan Wopereis, a researcher from TNO, Microbiology and Systems Biology Group in Zeist, The Netherlands.

"Our novel approach allows detection of small

but relevant effects, thereby contributing to the urgently needed switch from disease-care to health-care, aiming for a life-long optimal health and disease prevention," said Wopereis.

To make this discovery, Wopereis and colleagues used two groups of male volunteers. The first group included 10 healthy male volunteers.

The second group included nine volunteers with metabolic syndrome and who had a combination of two or more risk factors for heart disease, such as unhealthy cholesterol levels, high blood pressure, high blood sugar, high blood lipids, and abdominal fat.

Both groups had blood samples taken, before and after consuming a high-fat milk-shake. In these blood samples, the researchers measured 61 biomarkers, such as cholesterol and blood sugar.

They found that biochemical processes related to sugar metabolism, fat metabolism and inflammation were abnormal in subjects with metabolic syndrome.

The 10 healthy male volunteers were also given a snack diet consisting of an additional 1300 kcal per day, in the form of sweets and savoury products such as candy bars, tarts, peanuts and crisps for four weeks.

The response of the same 61 biomarkers to the challenge test was evaluated. Signalling molecules such as hormones regulating the control of sugar and fat metabolism and inflammation were changed, resembling the very subtle start of negative health effects similar to that affecting those with metabolic disease.

The study was published in The FASEB Journal.

Nov 05
Standing six hours a day cuts obesity risk
Standing for at least one-quarter of the day is linked to to 32 percent reduced likelihood of obesity, new research has found.

While sedentary behaviour (such as watching TV and commuting time) has been linked to negative health effects, it is unclear whether more time spent standing has protective health benefits.

To investigate further, a research team led by Kerem Shuval from American Cancer Society examined reported standing habits in relation to objectively measured obesity and metabolic risk among more than 7,000 adults between 2010 and 2015.

Specifically, the association between standing time and obesity was determined through three measures: body mass index (BMI), body fat percentage, and waist circumference.

The association between standing and metabolic risk was assessed via metabolic syndrome, a clustering of risk factors that increase the risk for heart disease, stroke, and diabetes.

The study found that among men, standing a quarter of the time was linked to a 32 percent reduced likelihood of obesity (body fat percentage).

Standing half the time was associated with a 59 percent reduced likelihood of obesity. But standing more than three-quarters of the time was not associated with a lower risk of obesity.

In women, standing a quarter, half, and three quarters of the time was associated with 35 percent, 47 percent, and 57 percent respective reductions in the likelihood of abdominal obesity (waist circumference).

No relationship between standing and metabolic syndrome was found among women or men.

The study appeared in the journal Mayo Clinic Proceedings.

Nov 04
Pet dogs cut asthma risk in kids
A new study has revealed that children who grew up with pet dogs have about 15 percent less asthma than children without dogs.

In the study, a total of more than one million children were included, and two dog ownership registers.

Researcher Tove Fall of the Uppsala University said that their results confirmed the farming effect, and they also saw that children who grew up with dogs had about 15 percent less asthma than children without dogs.

Fall said that because they had access to such a large and detailed data set, they could account for confounding factors such as asthma in parents, area of residence and socioeconomic status.

In Sweden, dog ownership registration is mandatory in Sweden since 2001. These scientists studied whether having a parent registered as a dog-owner or animal farmer was associated with later diagnosis or medication for childhood asthma.

Senior author Catarina Almqvist Malmros of the Karolinska Institute said that their results also indicated that children who grow up with dogs have reduced risks of asthma later in life.

Malmros said their results were generalisable to the Swedish population, and probably also to other European populations with similar culture regarding pet ownership and farming.

The study is published in the Journal JAMA Pediatrics.

Nov 03
Diet lacking soluble fibre can lead to weight gain
A diet missing soluble fibre promotes inflammation in the intestines and poor gut health, leading to weight gain, suggests new research.

Moreover, incorporating soluble fibre back into the diet can restore gut health, the research conducted in mice showed.

Foods rich in soluble fibre include oatmeal, nuts, beans, apples, and blueberries.

"If our observations were to prove applicable to humans, it would suggest that encouraging consumption of foods with high soluble fibre content may be a means to combat the epidemic of metabolic disease," the researchers said.

The research team at Georgia State University examined the effects of diets varying in amounts of soluble and insoluble fibres, protein and fat on the structure of the intestines, fat accumulation and weight gain in mice.

The researchers found that mice on a diet lacking soluble fibre gained weight and had more fat compared with mice on a diet including soluble fibre.

The intestines of mice on the soluble fibre-deficient diet were also shorter and had thinner walls. These structural changes were observed as soon as two days after starting the diet.

Introducing soluble fibre into the diet restored gut structure.

Supplementing with soluble fibre insulin restored the intestinal structure in mice on the soluble fibre-deficient diet.

Mice that received cellulose, an insoluble fibre, however, did not show improvements.

The data suggest a difference in health benefits between soluble and insoluble dietary fibres, the researchers stated.

The study was published in the journal American Journal of Physiology.

Nov 02
Chronic fatigue linked to abnormal brain connectivity at rest
A recent study has associated chronic fatigue with abnormal brain connectivity at rest.

Patients with chronic fatigue have decreased signaling and communication between specific brain regions when the brain is at rest, and less effective connectivity between these regions strongly correlates with greater fatigue.

Charles Gay, Roland Staud, and colleagues, University of Florida college of Medicine, Gainesville, studied the association between fatigue and altered resting-state connectivity in patients with myalgicencephalomyelitis/chronic fatigue syndrome using functional magnetic resonance imaging.

The researchers used two methods: comparing data on resting-state brain networks; and analyzing cerebral blood flow in selected brain regions.

The study is published in Brain Connectivity.

Oct 31
Ovarian cancer pill can help men
A new research has revealed that an ovarian cancer pill for women might provide a highly effective treatment for up to a third of men with advanced prostate cancer. The ovarian cancer, 'Olaparib,' is the first drug which was used to tackle inherited cancer mutations.

Researchers at Institute of Cancer Research found it could also halt tumour growth in many men with treatment-resistant prostate cancer, The Independent reports.

The study included 49 men and one third responded to the drug.

According to the results, cancers stopped growing, numbers of circulating tumour cells in the blood fell, and clinically positive results were obtained from scans.

The blood marker used to track the progress of prostate cancer also plunged by up to 96 percent.

Lead researcher Johann de Bonosaid said that their trial marked a significant step forward in the treatment of prostate cancer.

Bono said that it also proved the principle that they could detect prostate cancers with specific targetable mutations using genomic sequencing to deliver more precise cancer care by matching treatment to those men most likely to benefit.

Oct 30
Common heartburn drugs may damage your kidney
Increased use of certain medications commonly used to treat heartburn and acid reflux may have damaging effects on the kidneys, say researchers, including one of Indian-origin.

The researchers looked at the effects of the drugs called proton pump inhibitors (PPIs) on chronic kidney disease (CKD).

In one study, Pradeep Arora from State University of New York and his team found that among 24,149 patients who developed CKD between 2001 and 2008 (out of a total of 71,516 patients), 25.7 percent were treated with PPIs.

PPI use was linked with a 10 percent increased risk of CKD and a 76 percent increased risk of dying prematurely.

"As a large number of patients are being treated with PPIs, health care providers need to be better educated about the potential side effects of these drugs, such as CKD," Arora pointed out.

In another study, Benjamin Lazarus from Johns Hopkins University and his colleagues followed 10,482 adults with normal kidney function from 1996 to 2011.

They found that PPI users were between 20 percent and 50 percent more likely to develop CKD than non-PPI users, even after accounting for baseline differences between users and non-users.

This discovery was replicated in a second study, in which over 240,000 patients were followed from 1997 to 2014.

"In both studies, people who used a different class of medications to suppress stomach acid, known as H2-blockers, did not have a higher risk of developing kidney disease," Lazarus pointed out.

"If we know the potential adverse effects of PPI medications we can design better interventions to reduce overuse," Lazarus noted.

The findings will be presented at ASN (American Society of Nephrology) Kidney Week 2015 to be held at San Diego Convention Centre from November 3-8.

Oct 29
Shampoo ingredient can increase breast cancer risk
Even at low levels, a class of preservatives widely-used in consumer products like shampoos, cosmetics, body lotions, and sunscreens can contribute to development of breast cancer, suggests new research.

The estrogen-mimicking chemicals called parabens also have implications for other diseases that are influenced by estrogens, the study noted.

These chemicals are considered estrogenic because they activate the same estrogen receptor as the natural hormone estradiol.

Studies have linked exposure to estradiol and related estrogens with an increased risk of breast cancer, as well as reproductive problems.

As a result, the use of parabens in consumer products increasingly has become a public health concern.

"Although parabens are known to mimic the growth effects of estrogens on breast cancer cells, some consider their effect too weak to cause harm," said lead investigator Dale Leitman, a gynecologist and molecular biologist at University California, Berkeley in the US.

"But this might not be true when parabens are combined with other agents that regulate cell growth," Leitman noted.

However, existing chemical safety tests, which measure the effects of chemicals on human cells, look only at parabens in isolation and fail to take into account that parabens could interact with other types of signaling molecules in the cells to increase breast cancer risk.

To better reflect what goes on in real life, the researchers looked at breast cancer cells expressing two types of receptors: estrogen receptors and HER2, or human epidermal growth factor receptor 2.

The study demonstrated that parabens may be more potent at lower doses than previous studies have suggested, which may spur scientists and regulators to rethink the potential impacts of parabens on the development of breast cancer.

The findings were published online in the journal Environmental Health Perspectives.

Oct 28
Vegetative patients show glimmers of awareness
Despite being unable to move, some patients in a vegetative state retain awareness, according to a recent study.

New insight into a vital cerebral pathway has explained how some patients in a vegetative state are aware despite appearing to be unconscious and being behaviourally unresponsive.

The findings identify structural damage between the thalamus and primary motor cortex as the obstacle between covert awareness and intentional movement.

The University of Birmingham researchers hope that their study, the first to understand the phenomenon, will pave the way for the development of restorative therapies for thousands of patients.

Researcher Davinia Fernandez-Espejo explained that a number of patients who appear to be in a vegetative state are actually aware of themselves and their surroundings, able to comprehend the world around them, create memories and imagine events as with any other person.

Fernandez-Espejo noted that before they take the crucial step of developing targeted therapies to help these patients, they needed to identify the reason for the dissociation between their retained awareness and their inability to respond with intentional movement.

The ultimate aim is to use this information in targeted therapies that can drastically improve the quality of life of patients, Fernandez-Espejo added.

Though it may be a number of years before an effective therapy is developed, the team believes that a significant milestone has been reached with the discovery.

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