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Oct 12
Birth environment can trigger homosexuality
Claiming that genetic changes which happen after birth can determine whether a man is straight or gay, scientists have recently found out that homosexuality may be triggered by environmental factors during childhood.

Researchers revealed that the finding of the study is highly controversial because it suggests that some men are not born gay, but are turned homosexual by their surroundings and it also raises privacy concerns that medical records could reveal sexuality, reports the Telegraph.

Dr. Tuck Ngun said that he hopes this research helps them to understand themselves better and why they are the way they are.

During the research, the scientists found out that it was possible to tell whether a man was gay or straight by monitoring tiny changes in how his DNA functions after birth, a field known as epigenetics.

Epigenetic changes are known to be triggered by environmental factors such as chemical exposure, childhood abuse, diet, exercise and stress.

Talking about their research done on identical twins, researcher Tim Spector said that it has always been a mystery why identical twins who share all their genes can vary in homosexuality.

He added epigenetic differences are one obvious reason and this study provides evidence for this.

Oct 10
Genes can predict sexual orientation in men
In a first, scientists have developed a method that can almost accurately reveal the sexual orientation of men just by looking at some specific genes.

The team is now ready with a predictive model that can help people understand their sexual orientation better.

In trials, an algorithm using genetic information from just nine regions of the human genome predicted the sexual orientation of males with up to 70 percent accuracy.

"To our knowledge, this is the first example of a predictive model for sexual orientation based on molecular markers," said Tuck C Ngun, postdoctoral researcher at University of California-Los Angeles.

Beyond the genetic information contained in DNA, the researchers examined patterns of DNA methylation - a molecular modification to DNA that affects when and how strongly a gene is expressed - across the genome in pairs of identical male twins.

While identical twins have exactly the same genetic sequence, environmental factors lead to differences in how their DNA is methylated.

In all, the study involved 37 pairs of twins in which one twin was homosexual and the other was heterosexual, and 10 pairs in which both twins were homosexual.

"A challenge was that because we studied twins, their DNA methylation patterns were highly correlated," Dr Ngun explained.

Even after some initial analysis, the researchers were left with over 400,000 data points to sort through.

To sort through this data set, Dr. Ngun and his colleagues devised a machine learning algorithm called FuzzyForest.

They found that methylation patterns in nine small regions, scattered across the genome, could be used to predict study participants' sexual orientation with 70 percent accuracy.

Previous studies had identified broader regions of chromosomes that were involved in sexual orientation.

"We were able to define these areas down to the base pair level with our approach," Dr Ngun added.

Sexual attraction is such a fundamental part of life but it is not something we know a lot about at the genetic and molecular level, the authors noted.

They are currently testing the algorithm's accuracy in a more general population of men.

The findings were shared at the American Society of Human Genetics (ASHG) 2015 annual meeting in Baltimore this week.

Oct 09
Radiotherapy inaccessible to most people in low income nations
As many as 90 percent of the people in low income countries lack access to radiotherapy treatment, an inseparable part of cancer care, new research has found.

"Radiotherapy is a crucial and inseparable part of cancer care," said study co-author Timothy Hanna from Queen's University in Kingston, Canada.

"Globally, there is a major shortfall in access to radiotherapy. Our report found that expanding radiotherapy access in low and middle-income countries would not only save millions of lives, but also result in substantial economic benefits to nations," Hanna noted.

The researchers estimated that optimal radiotherapy access in low and middle-income countries by 2035 could save an estimated 26.9 million life years for patients who currently lack access to care.

Hanna and colleagues developed a method to measure the treatment benefits of guideline-based radiotherapy programmes.

They found that globally in 2012, with optimal radiotherapy access, more than 580,000 people would derive a survival benefit from radiotherapy.

By 2035, projections suggest substantial increases, with over 950,000 people deriving a survival benefit from global access to radiotherapy.

Improving access to radiotherapy in low and middle-income countries could be achieved by 2035 with an investment of $184 billion, the report projected.

Despite the high estimated cost, the predicted net economic benefits reaped from the lives saved could reach between $278 billion and $365 billion, said the study published in the journal Lancet Oncology.

Oct 08
Why people with common genetic mutation may be more at diabetes risk
A new study has shed new light on why people who carry a common genetic mutation may be more at risk for developing type 2 diabetes.

By carefully studying healthy subjects, researchers from Brigham and Women's Hospital (BWH) and the University of Murcia, Spain, were able to chart the effect of melatonin supplements on blood sugar control. Their results suggest that taking melatonin close to mealtimes may put people with a common genetic variant more at risk.

The work is the first to show that a person's genetic profile could impact their ability to tolerate glucose when they take melatonin, said co-corresponding author Frank Scheer.

The results suggest that people may need to exert caution when taking melatonin close to meal times, especially in carriers of the risk variant, said co-corresponding author Marta Garaulet.

The data suggest that when subjects take melatonin, the genetic risk variant in MTNR1B causes a much greater change in glucose tolerance in carriers compared to non-carriers, even in people who are not obese and not diabetic, said Scheer.

Scheer added that the results suggest that it may be important to take genetics into account when thinking about timing of food consumption and melatonin administration.

The team notes that further, large-scale studies will be needed in vulnerable populations before clinical recommendations can be made.

The study is reported in Metabolism.

Oct 06
To eat less, consider smaller plates and packages
Adults consume more food when it comes in bigger packages or is served on larger plates, a review of past research has found.

The study team analyzed 58 studies with a combined 6,600 participants that examined how the size of things like cereal bowls and snack bags influences the number of calories people take in.

Combined, these brief experiments suggest that smaller containers, dishes and cutlery might help adults consume up to 16 percent fewer calories in the U.K. and 29 percent less in the U.S.

"It provides the most conclusive evidence to date that people consistently consume more food and drink when offered larger-sized portions, packages, or tableware than when offered smaller-sized versions," said lead study author Dr. Gareth Hollands, a behavioral health researcher at the University of Cambridge in the U.K.

The results, published in the Cochrane Database of Systematic Reviews, highlight the important role of environmental influences on food consumption and suggest that actions to limit exposure to larger serving sizes may be effective tools for getting people eat less, Hollands said by email.

Globally, 1.9 billion adults are overweight or obese, according to the World Health Organization. Obesity increases the risk of heart disease, diabetes, joint disorders and certain cancers.

The effect of smaller sizes for dishes and packages didn't vary by gender and was similar for normal-weight, overweight and obese people, the researchers found. Only children appeared unaffected by size when deciding how much food or drink to consume.

Most of the studies reviewed didn't follow people for long periods and researchers lacked data to assess whether sustained changes in container and plate sizes over time might contribute to weight loss or maintaining a healthy weight, the authors acknowledge. They also note that they lacked data on the impact of bottle, can or glass size on alcohol consumption.

Still, when it comes to plate size, reducing the diameter by even an inch or two can make a difference in calorie consumption, said Dr. David Sharp, a nutrition researcher at Kent State University School of Health Sciences in Ohio.

Ideally, adults should use 9-inch or 10-inch plates, and children should have 7.5-inch plates, Sharp, who wasn't involved in the study, said by email. But this isn't an easy message to convey in a culture with a "supersize" mentality, he said.

"Hunters try to kill the deer with the largest antlers, fishermen tell stories of their biggest catch, and we sensationalize even the act of dieting by hosting reality TV shows such as The Biggest Loser," Sharp said. "When we are bombarded with the appeal of getting things bigger or larger, it creates a bit of dissonance that the message for our most intimate choices such as our meals, our plates and our bodies runs opposite to our culture of plenty when considering long-term health and wellness."

While plate size may matter, downsizing dishes alone may not be enough to help people lose weight, sad Dr. Donald Hensrud, medical director of the Mayo Clinic Healthy Living Program in Rochester, Minnesota.

"The obesity epidemic is a result of a number of different and complex influences," Hensrud, who wasn't involved in the study, said by email. "Recommending smaller plates is just one piece of a very large puzzle."

Oct 05
High-fructose diet hampers recovery from brain injury
A diet high in processed foods which are often sweetened with high-fructose corn syrup may impair the brains' ability to heal after serious head injury, warn researchers.

"We found that processed fructose inflicts surprisingly harmful effects on the brain's ability to repair itself after a head trauma," said Fernando Gomez-Pinilla, professor at David Geffen School of Medicine at University of California, Los Angeles, US.

Fructose also occurs naturally in fruit, which contains antioxidants, fiber and other nutrients that prevent the same damage.

In the study, laboratory rats were fed standard rat chow and trained for five days to solve a maze.

Then they were randomly assigned to a group that was fed plain water or a group that was fed fructose-infused water for six weeks.

The fructose was crystallised from corn in a dose simulating a human diet high in foods and drinks sweetened with high-fructose corn syrup.

A week later, the rats were anesthetised and underwent a brief pulse of fluid to the head to reproduce aspects of human traumatic brain injury (TBI).

After an additional six weeks, the researchers retested all the rats' ability to recall the route and escape the maze.

The scientists discovered that the animals on the fructose diet took 30 percent longer to find the exit compared to those who drank plain water.

The team also found that fructose altered a wealth of biological processes in the animals' brains after trauma.

The sweetener interfered with the ability of neurons to communicate with each other, rewire connections after injury, record memories and produce enough energy to fuel basic functions.

Sources of fructose in diet include honey, cane sugar (sucrose) and high-fructose corn syrup, an inexpensive liquid sweetener.

Made from cornstarch, the liquid syrup is widely added as a sweetener and preservative to processed foods, including soft drinks, condiments, applesauce and baby food.

The study was published in the Journal of Cerebral Blood Flow and Metabolism.

Oct 03
Exercise improves fertility in women
Exercise and weight loss improves ovulation in women who have polycystic ovary syndrome (PCOS), a common hormone disorder that often causes infertility, a new study says.

"The findings confirm what we have long suspected - that exercise and a healthy diet can improve fertility in women who have PCOS," said one of the study authors, Richard Legro, a professor at Penn State College of Medicine in Pennsylvania.

Polycystic ovary syndrome is the most common cause of female infertility. The condition occurs when a woman's body produces slightly higher than normal amounts of testosterone and other androgens, sex hormones associated with male traits.

The resulting hormone imbalance can cause irregular or absent menstrual periods, weight gain, acne, excess hair on the face and body, or thinning hair on the scalp.

Women with PCOS often take birth control pills to regulate the menstrual cycle and reduce the level of androgens in the body as past research has indicated that pretreatment with a short-term course of birth control pills can raise pregnancy rates among women with PCOS.

The latest study examined the differences in pregnancy outcomes among 149 women with PCOS who either took birth control pills, underwent lifestyle modification or a combination of the two interventions for a four-month period.

The participants were between the ages of 18 and 40.

The researchers found that women who participated in the lifestyle modification intervention and took birth control pills were more likely to ovulate than women who were assigned to take birth control pills.

"The research indicates preconception weight loss and exercise improve women's reproductive and metabolic health," Legro said.

The study was published in the Journal of Clinical Endocrinology & Metabolism.

Sep 30
A 10-minute walk break can reverse vascular dysfunction
By breaking up desk time with a short 10-minute walk, you can offset the harm that prolonged sitting causes to vascular health, suggests new research.

"Our study found that when you sit for six straight hours, or the majority of an eight-hour work day, blood flow to your legs is greatly reduced," said lead author of the study Jaume Padilla, assistant professor of nutrition and exercise physiology at University of Missouri School of Medicine in the US.

"We also found that just 10 minutes of walking after sitting for an extended time reversed the detrimental consequences," Padilla noted.

During the study, the researchers compared the vascular function of 11 healthy young men before and after a period of prolonged sitting.

The findings indicated that blood flow in the popliteal -- an artery in the lower leg -- was greatly reduced after sitting at a desk for six hours.

Researchers then had the participants take a short walk, and found that 10 minutes of self-paced walking could restore the impaired vascular function and improve blood flow.

"When you have decreased blood flow, the friction of the flowing blood on the artery wall, called shear stress, is also reduced," Padilla said.

"Moderate levels of shear stress are good for arterial health, whereas low levels of shear stress appear to be detrimental and reduce the ability of the artery to dilate. Dilation is a sign of vascular health. The more the artery can dilate and respond to stimuli, the healthier it is," Padilla noted.

The findings appeared in the journal Experimental Physiology.

Sep 29
Losing sense of smell linked with earlier death
People who have problems with their sense of smell may be at increased risk for dying sooner than those who don't have trouble smelling, a new study suggests.

Researchers analyzed information from more than 1,100 adults in New York City whose average age was 80. The participants took a "scratch and sniff" test in which they attempted to identify 40 common odors. People who scored less than 18 points out of 40 were said to have anosmia, or an inability to smell.

The study found that the people with scores in the low range (zero to 20 points) were nearly four times more likely to die over a four-year period than those with scores in the high range (31 to 40 points). About 45 percent of participants with scores in the low range died during the study period, compared with 18 percent of those with scores in the high range. [7 Ways the Mind and Body Change with Age]

The results held even after the researchers took into account factors that could affect people's risk of death, such as age, alcohol use, head injury, smoking or having dementia.

Therisk of death "increased progressively with worse performance in the smell identification test and was highest in those with the worst smelling ability," study co-author Dr. Davangere Devanand, a professor of psychiatry and neurology at Columbia University, said in a statement.

The results agree with those of a study published last year, which also found a link between smell loss and an increased risk of dying in older adults.

People tend to perform worse on smell tests as they age, and impairments in sense of smell have been linked with Alzheimer's and Parkinson's disease. But the new study suggests that dementia and other medical conditions, by themselves, are not enough to explain the link between problems with smell and increased risk of death.

The researchers noted that a loss of sense of smell could put people at risk for certain hazards, such as ingestion of spoiled food or an inability to smell a natural gas leak or a fire.

A loss of a person's sense of smell may also mean that the cells in the individual's body are not able to regenerate as well as they used to (since the cells responsible for smell detection regenerate throughout life). This could put a person at higher risk of death from other causes.

There remains a need for larger studies looking at whether other factors may explain the link, the researchers said. More work is also needed to determine if the same link can be found in younger populations, the researcher said.

The study is published in the journal Annals of Neurology.

Sep 28
Alcohol, drug addicts far likelier to smoke
A team of researchers has revealed that around the world, those who are treated for addiction are far more likely to smoke.

People in addiction treatment programs around the world use tobacco at two to three times the rate of people who are not being treated for addiction, according to a review of research studies from 20 countries other than the United States.

UC San Francisco's Joseph R. Guydish said that when people come into treatment for drugs and alcohol, they are not treating another addiction that has a significant chance of eventually killing them, which is tobacco use, adding that at a public health level, this means that the addiction treatment efforts should address smoking and tobacco use better than they do now.

Every person who enters substance abuse treatment ought to have their tobacco use evaluated and treated, noted Guydish, adding that if they don't want to be treated and quit right away, they should have some education to help them think more about quitting.

Guydish observed that "there are data from a number of studies which strongly suggest that you can improve substance treatment outcomes by addressing smoking among the patients in treatment. That's what we should be doing."

The World Health Organization (WHO) has created a policy package called MPOWER, noted Guydish, which is designed to assist countries in implementing anti-smoking initiatives.

"We would recommend that WHO pay attention to this finding and use it to extend their MPOWER strategies," said Guydish. "Anyone who is interested in smoking reduction internationally could use this information at the policy level."

The study is published in the journal Addiction.

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