World's first medical networking and resource portal

News & Highlights
Please make use of the search function to browse preferred content
Medical News & Updates
Jan 27
Diabetes sugar 'can go too low'
Intense treatment to lower blood sugar in patients with diabetes could prove nearly as harmful as allowing glucose levels to remain high, a study says.

Cardiff researchers looked at nearly 50,000 patients with type 2 diabetes and found the lowest glucose levels linked to a heightened risk of death.

Significant differences in death rates between patients on insulin and those taking tablets are also flagged up.

But there could be various explanations for this, experts noted.

Patients taking insulin-based treatments have been urged not to stop taking their medication as a result of the Cardiff University study, which is published in The Lancet.

Changing treatments

Using data from GPs, the team identified 27,965 patients with type 2 diabetes whose treatment had been intensified to include two oral blood glucose lowering agents - metformin and sulphonylurea.

A further 20,005 patients who had been moved on to treatment which included insulin were added to the study.

Patients whose HbA1c levels - the proportion of red blood cells with glucose attached to them - were around 7.5%, ran the lowest risk of dying from any cause.

For both groups this risk went up by more than half if levels dropped to 6.4%, the lowest levels recorded. For those with the highest levels the risk of death increased by nearly 80%.

But the risks appeared to be particularly pronounced among those on the insulin-based regimen than those on the combined treatment.

Irrespective of whether their HbA1c levels were low or high, there were 2,834 deaths in the insulin-taking group between 1986 and 2008, nearly 50% more than in the combined group.

'Don't stop'

The authors acknowledged there could be various factors associated with this, such as these being older patients with more health problems, who perhaps had had diabetes for a longer period of time. They also make reference to a possible link between use of insulin and cancer progression that had been reported in a different study.

"Whether intensification of glucose control with insulin therapy alone further heightens risk of death in patients with diabetes needs further investigation and assessment of the overall risk balance," wrote lead author Dr Craig Currie.

"Low and high mean HbA1c values were associated with increased all-cause mortality and cardiac events. If confirmed, diabetes guidelines might need revision to include a minimum HbA1c value."

Dr Iain Frame, head of research at Diabetes UK, described the study as "potentially important" but stressed it had limitations.

"It is not clear what the causes of death were from the results reported. Furthermore, when it comes to the suggestion made in this research that insulin could increase the risk of death, we must consider important factors such as age, the duration of their diabetes and how the participants managed their condition.

"It is crucial to remember that blood glucose targets should always be agreed by the person with diabetes and their healthcare team according to individual needs and not according to a blanket set of rules."

While people would be able to manage their condition for a period with diet, exercise and even tablets, many would eventually have to move on to insulin, he noted.

Jan 27
Women need more sleep than men: Study
Women need more sleep than men - around 20 minutes of more sleep on an average - owing to their busy and multi-tasking brain, according to a new research by a British sleep expert.

"Women need 20 minutes more shut-eye than the average man. This is because women's brains are wired differently from men's and are more complex, so their sleep need is slightly greater," said Professor Jim Horne, director of the Sleep Research Centre at Loughborough University in UK.

Pointing out that one of the major functions of sleep is to allow the brain to recover and repair itself, Horne said, "During deep sleep, the cortex - part of the brain responsible for thought memory, language and so on - disengages from the senses and goes into recovery mode. The more a person uses his brain during the day, the more sleep he needs at night to recover, Horne said adding, "Women tend to multi-task - they do lots at once and are flexible - and so they use more of their actual brain than men do. Because of that, their sleep need is greater."

"A man who has a complex job that involves a lot of decision-making and lateral thinking may also need more sleep than the average male - though probably still not as much as a woman," he told.

Jan 25
Cells Critical to Childhood Leukemia Found
Cells that cause a common type of childhood leukaemia have been discovered by scientists at The Royal Melbourne Hospital and the University of Melbourne in Australia. Targeting of these cells may lead to improved treatments for this disease and help prevent relapse.

The team, led by Dr Matthew McCormack and Dr David Curtis of the Rotary Bone Marrow Research Laboratories and the University's Department of Medicine at The Royal Melbourne Hospital, made the discovery whilst studying mice prone to developing this leukaemia.

The results have been published online today by the prestigious international journal Science.

The team found that with irradiation treatment in animal models, over 99 per cent of cells in the thymus were killed, but these stem cell-like cells persisted and rapidly recovered. This suggests that these cells may survive therapy and be responsible for relapsed disease following treatment.

Currently, children with T-ALL are given extended therapy over two to three years in an attempt to stop a relapse. More targeted therapy on the thymus cells could reduce the length and toxicity of treatment and prevent relapse.

Dr McCormack, a leading international expert on childhood leukaemia, said: "The cellular origins of this leukaemia are not well understood. Our discovery that these cells are similar to normal stem cells explains why they are capable of surviving for long periods. It also explains why they are remarkably resistant to treatment."

Approximately 50 new cases of T-ALL are diagnosed every year in Australia, two thirds of these in children or adolescents. Adults also contract T-ALL, and the majority succumb to resistant or relapsed disease.

Dr Curtis, a Clinical Haematologist and head of the Leukaemia Research Program at The Royal Melbourne Hospital, said: "The identification of these cells provides an important target for the development and testing of new treatments for patients with T cell Acute Lymphoblastic Leukaemia."

The team will now focus on novel treatments capable of killing these cells, which may lead to clinical trials within the next five years

Jan 25
Blueberry Boosts Memory
Scientists have found evidence suggesting that blueberries may help improve memory in older adults because of its antioxidative phytochemicals, according to a new study published in the Journal of Agricultural and Food Chemistry.

Previous animal studies have suggested that eating blueberries may boost memory in older people, according to Robert Krikorian, author of the current study; he and colleagues from the University of Cincinnati worked in conjunction with several other organizations on the research.

Krikorian and colleagues tested the effect of blueberry juice on memory in a group of volunteers in their 70s with early memory decline. In the study, the study group drank 2 to 2.5 cups of blueberry juice while the control group drank a beverage every day for two months.

Those who drank blueberry juice experienced signficant improvement on learning and memory tests, according to the scientists.

"These preliminary memory findings are encouraging and suggest that consistent supplementation with blueberries may offer an approach to forestall or mitigate neurodegeneration," the authors wrote in the report.

Blueberries may also be helpful in encouraging weight loss and preventing type 1 diabetes according to previous studies.

Jan 23
Malnutrition higher in children born to child brides in India
London: Infants born to child brides in India have a higher risk of malnutrition than those born to older mothers, a new research has indicated.

The research found that 67 percent of babies born to child brides in India were malnourished, meaning they were either underweight or suffering from a wasted or stunted growth.

However, birth weight and childhood mortality are not significantly linked with the age of the mother, the research published on BMJ.com (British Medical Journal's website) said.

Despite significant economic growth in the past decade, India still has the highest number of under-five deaths in the world.

Almost half (44.5 percent) of 20-24 year olds in India are married before they are 18 and a quarter (22 percent) of the same age group have given birth before they are 18.

The researchers led by Associate Professor Anita Raj, from Boston University School of Public Health, investigated the relationship between early marriage and infant and children mortality-related infection in India.

They investigated into 19,000 children born to 13,500 women who had been married between the ages of 15 and 24.

The results show that the majority of babies (73 percent) were born to child brides.

The authors argue that "in view of previous evidence that child brides often are more controlled by husbands and in-laws, it may be that women married as minors are unable to advocate for adequate nutrition for their children."

Prof Raj said the findings "emphasise the value of delayed child bearing among adolescent wives."

They also reveal the need for targeted intervention efforts to support children born to mothers married as minors, who may be more vulnerable to nutritional deprivation than others in the family.

Jan 23
Over 52,500 poultry culled in West Bengal
Bird flu in West Bengal spread to two more localities in Murshidabad district, health authorities here said Friday after over 52,500 birds were culled in the affected areas.

'Two more epicenters surfaced in the Khargram block,' a health ministry official said.

Earlier, the outbreak of the flu was reported in Hazrabati and Nagar villages in Murshidabad Jan 14 and in Faridpur village of Burwan block Jan 17.

'Containment measures have been initiated as per the contingency plan and culling of birds has started. So far 52,578 birds have been culled and 4,572 eggs have been destroyed,' the official added.

Officials also said that 301 poultry workers and veterinary surgeons involved in culling operations have been put on chemoprophylaxis.

The surveillance activities are going on.

Jan 22
Plasma 'could cut dentist pain'
People who live in fear of the dentist's drill could be in for a more comfortable future - as new plasma technology arrives.

"Plasma jets" could one day be used to clean out bacteria from tooth cavities, say researchers from Saarland University in Homburg, Germany.

Tests reported in the Journal of Medical Microbiology found the plasma destroyed bacteria in infected teeth.

They say plasma dentistry may be available within three to five years.

Matter can be either solid, liquid, a gas or a fourth type, plasma, which is actually the most common in the universe.

While there are many natural forms of plasma, including the contents of our sun and lightning, modern technology relies heavily on plasma technology - for example in fluorescent lighting and the manufacture of semiconductors.

Artificial plasmas can be created when energy is added to a gas, perhaps using an electrical field or a laser.

The resulting matter can behave differently when it comes into contact with other particles.

While many artificially-created plasmas are extremely hot - for example, the flame on an arc welder - advances in recent years have allowed the creation of much cooler plasmas.

This, in turn, has opened the possibility of using them on the human body, where they could offer a very precise way of targeting tiny areas.

In this case, the properties of the plasma are harmful to bacteria, without affecting the surrounding tissue.

Normally, a dentist's drill is used to clean out bacteria from a cavity, before the filling is inserted.

The German team used a plasma jet to do the same job and found that it was able to do this quickly and efficiently, even where the bacteria were arranged in resistant "biofilms" on the dentine - the main part of the tooth under the enamel.

'Uncomfortable'

Dr Stefan Rupf, who led the study, said the low temperature killed the microbes while preserving the tooth.

He said:"Drilling is a very uncomfortable and sometimes painful experience. Cold plasma, in contrast, is a completely contact-free method that is highly effective.

"Presently, there is huge progress being made in the field of plasma medicine and a clinical treatment for dental cavities can be expected within 3 to 5 years."

Professor Bill Graham, a physicist from Queen's University Belfast, said that plasma medicine had the potential to pick out tiny targets, perhaps even single cells.

He said that "plasma scalpels" were already being used in sports medicine to treat collagen problems, and there was great interest in the technology for use in burns patients.

He said: "Obviously, as with any new treatment, we need to check that it can be used safely, but there is no evidence at the moment that there are any problems."

Jan 21
Common chemical linked to thyroid
A "ubiquitous" chemical widely used in the manufacture of non-stick frying pans is linked to thyroid disease, researchers say.

A study involving almost 4,000 people in the United States found people that those with the highest levels of man-made perfluorooctanoic acid - also known as PFOA - in their blood were twice as likely to be diagnosed with thyroid disease or taking medication compared with those with the lowest levels.

PFOA is widely used in industry because it excels at repelling heat, water, grease and stains, and traces of the chemical are found in water, air and soil throughout the world.

But the researchers from the University of Exeter, who carried out the latest study, stressed that further research was needed to establish whether the chemical was a direct cause of illness in humans.

Previous studies in animals have suggested that high exposure to the chemical can affect the action of the thyroid gland, located in the neck, which is responsible for controlling the body's rate of metabolism through the release of hormones.

Tamara Galloway, Professor of Ecotoxicology at Exeter, said that it was likely that the chemical could be ingested or inhaled from the air or as a component of household dust, and might stay in the bloodstream for about five days.

Her team analysed an American database of 3,966 adults aged 20 and older, because no figures for blood levels of PFOA is available in Britain. Of these, 163 women and 46 men reported having current thyroid disease and were taking medication.

But a total of 16 per cent of women with the highest blood levels of the chemical (above 5.7ng/ml) reported having thyroid disease or were taking related medication, compared to 8 per cent of those with the lowest levels. the trend was similar in men, but not said to be statistically significant because of the low numbers of individuals involved.

"Our results highlight a real need for further research into the human health effects of low-level exposures to environmental chemicals like PFOA that are ubiquitous in the environment and in people's homes. We need to know what they are doing," Professor Galloway said.

But Diane Benford, Head of Toxicology of Food, Food Standards Agency, commented: "This type of study investigates associations and cannot establish causality. It is important to look at the consistency of the data with the results of other studies, and with what is known about the toxicity of PFOA and PFOS, which differ.

"Studies of workers with higher exposure to these compounds have not shown consistent evidence of increased risk of thyroid disease, which would be expected if effects are occurring in the general population. More research is needed to establish whether this association is causal."

Ashley Grossman, Professor of Neuroendocrinology, at Queen Mary, University of London, said that it was also unknown how PFOA might affect the thyroid gland.

"Thyroid disease is often caused by the body's own immune system attacking the thyroid gland so perhaps this chemical is having some effect on the immune system, rather than directly on the thyroid," he said.

"We'd need to do a lot more research to verify this link and to understand how the two are linked. In the meantime, it's important to remember that thyroid disease can be successfully treated."

Jan 20
H1N1 vaccine trails start in India
Even as questions are raised about the efficacy of the H1N1 vaccine, India has given leading French pharmaceutical company Sanofi Pasteur permission to start trials from Wednesday. While the trials will take about three weeks, the single dose vaccine
will be available from the second week of February.

"The vaccines which we will have in India are safe and effective. Those having adverse effects are adjuvant, while all our vaccines are non-adjuvant," Drug Controller General of India (DCGI) Dr Surinder Singh told The Indian Express. The Sanofi Pasteur vaccine trials will be conducted on over 100 subjects in Chandigarh, Pune and Delhi.

Meanwhile, the domestically developed H1N1 vaccine will be available in the second half of April for about Rs 80 per dose, said the DCGI. "There are about 145 types of Influenza. While there are influenza vaccines available abroad, in India we do not have any. This will be the domestic vaccine for influenza," said Union Health minister Ghulam Nabi Azad.

As of now four Indian companies have got permission to conduct clinical trials for developing H1N1 vaccine with Zydus Cadila already starting human trials in January. While the Serum Institute has got approval for an intra-nasal vaccine earlier this month, Panacea and Bharat Biotech are yet to begin trials.

Jan 19
Genes may play a role in breast cancer
Breast cancer screening may not be appropriate for all women, warned the experts from the University of Michigan. A genetic mutation that plays a significant role in increasing a woman's risk of developing breast cancer and ovarian cancer has been discovered.

Breast cancer, estimated to increase by 3 percent per annum up to 2015 in India, result from genetic abnormalities. However, only five to ten percent of the cases are due to inherited genetic factors, mostly due to abnormalities in two genes, BRCA1 and BRCA2. These two genes may be inherited from either of the parents and may pose a higher lifetime risk of developing breast and ovarian cancer, more likely to develop at an earlier stage.

Lifetime risk of breast cancer in these women jumps from 12.5 percent in the general population to approximately 60 percent in women with BRCA mutations. It should also be kept in mind that occurance of most of breast and ovarian cancers are random and may not be due to BRCA gene inheritence.

According to Dr Sofia Merajver, director of the Breast and Ovarian Risk Evaluation Program at the University of Michigan Comprehensive Cancer Centre, it is important that the right women seek out genetic testing for breast and ovarian cancer.

Though it is a simple blood test, the interpretation of the results may be complicated. Doctors recommend genetic testing for those with family history of cancer cases and diagnoses through several generations, older family members (above 50) diagnosed with cancer, family member with cases of multiple cancers like breast and ovarian and also male breast cancer, or other cancers like colon, stomach or prostrate cancers.

Undergoing genetic tests can help assess the risk factor of the person diagnosed with cancer.

Browse Archive