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Jan 18
Diabetes gene points way to new treatments
One of the largest genetic studies ever undertaken has discovered nine new genes linked to type 2 diabetes, opening a door to new understanding and possible treatment.

Scientists from 174 research centres around the world, who studied the genes and blood glucose level of more than 120,000 volunteers, were able to identify a set of genes that control the body's response to glucose in the blood.

It is hoped the discovery could lead to new treatments for diabetes, which affects more than 220 million people worldwide. Ninety per cent of those have type 2 diabetes, also known as late-onset diabetes because it typically develops later in life.

It occurs when the tissues of the body become resistant to the effects of insulin, needed to regulate glucose. Sufferers may control the disease with diet and exercise but often have to take drugs and in more serious cases have to inject insulin.

Jim Wilson, a geneticist from Edinburgh University who heads the Scottish cohort study, said: "This is an incredibly important finding. The discovery of these new genes influencing blood-sugar levels is the first step on the important journey to developing new therapies for diabetes.

"It opens up a whole new area of research to find which proteins are 'druggable'. Genetics is like a can-opener: it allows us to get inside and understand what's going on."

The hope is that in five to ten years scientists will be able to pinpoint which individuals are genetically susceptible to developing type 2 diabetes, and that there will be a drug available which can prevent its onset. "What we have found may not contribute to personalised medicine becoming a reality today, but it will contribute to it happening tomorrow," Dr Wilson said.

The nine new genes include those that influence blood sugar levels and also the first gene influencing levels of insulin. A subset of the genes was associated with diabetes itself.

Dr Wilson said the biological pathways that the genes highlighted were those involved in the control of blood sugar and might point to novel drug targets for glycaemic control. The pathways included not only glucose transport and sensing and pancreatic cell development, but also circadian rhythms and fatty acid metabolism.

To find out which genes are involved in glucose control, the team studied the genes of 50,000 healthy volunteers, also measuring glucose. It then sought to replicate the findings in approximately 75,000 more people.

Jan 16
Non-invasive technique to remove fibroids
A new technique to remove uterine fibroids without surgery will soon be available in the city. Jaslok Hospital in south Mumbai is set to launch Magnetic Resonance (MR)-focused ultrasound system to remove them. The non-invasive procedure uses high intensity ultrasound waves to ablate tissue in combination with Magnetic Resonance Imaging (MRI) that guides, monitors and controls the treatment.

Uterine fibroids are non-cancerous tumours found in women aged between 30 and 40. "Submucosal fibroids develop just under the lining of the uterine cavity and causes heavy bleeding, infertility and even miscarriages. They need to be removed without harming other organs," said Dr Rishma Pai, obstetrician, gynaecologist and infertility specialist at Jaslok Hospital.

"This procedure will stop the fibroid to recur again in the same region and increases the chances of fertility."

"Ultrasound is a form of energy that can pass through skin, muscle, fat and other soft tissues. High intensity ultrasound waves focused on a small target raises the temperature and destroys the tissue. This procedure is called thermal ablation," said Dr W M Gedroye, consultant radiologist at St Mary's Hospital in London. Dr Gedroye has treated over 500 patients using this technology. "Success rate is about 80 per cent," he said.

Studies show that this procedure can even remove liver tumours. "Studies are under way in Japan to establish this procedure can successfully treat breast and prostrate cancer also," said Dr Gedroye.

Jan 15
Stress can cause cancer: Study
Stress kills, doctors often say. And, now a new study has claimed that it can cause cancer as it aids the growth of tumour cells.

Experts had suspected that stress was involved in the development of cancer, but had no biological evidence. Earlier studies failed to establish any link between the condition and the disease.

Now, an international team has found that it may not necessarily be the emotional stress, but could be physical stress or even the stress which occurs in people's bodies as they fight infection and this may lead to cancer.

The study has revealed mutant genes that are primed to turn cancerous can be made active by stress signals, British newspaper the Daily Express reported.

Lead researcher Prof Tian Xu from Yale University's School of Medicine said: "A lot of different conditions can trigger stress, signalling physical stress, emotional stress, infections, inflammation - all these things. Bad news for cancer."

For their study, the researchers focused on the activity of two mutant genes known to be involved in human cancers.

One, called RAS, has been involved in 30 per cent of cancers. The other, tumour-suppressing gene called "scribble", allows cancers to develop when it becomes defective. Neither can cause cancer on its own.

Jan 14
Extra pounds at birth reduce TB risk
New research at the University of Michigan suggests that every 1.1 pounds of birth weight reduces the possibility of developing tuberculosis later in life by almost 46percent in identical twins.

According to Eduardo Villamor, study author and associate professor at the U-M School of Public Health, tuberculosis risk came down by 87percent for each pound in males, whereas it was only about 16 percent for every 1.1 pounds of birth weight in girls.

Villamor, who worked with a team at the Karolinska Institute in Sweden and began the research at Harvard, also pointed out that low birth weight of babies is widespread problem in developing countries, but prevalent elsewhere too.

Although Villamor said it is too early to conclude that insufficient prenatal growth leads to clinical tuberculosis, it may be the case.

He added: "Prenatal exposure to environmental insults, including maternal malnutrition, could program what happens later on in terms of our immune responses to infection, possibly through programming of the immune system. This study is an example of that."

The study, "Evidence for an effect of fetal growth on the risk of tuberculosis," will be published in the Feb. 1 edition of the Journal Infectious Disease. (ANI)

Jan 13
Blood pressure drugs cut dementia risk
The blood pressure drugs that block the protein angiotensin could reduce the risk of developing Alzheimer's disease and other forms of dementia, according to the online British Medical Journal Wednesday.

In a study, scientists in U.S. found that older people taking a certain type of blood pressure medication known as angiotensin receptor blockers (ARBs) were significantly less likely to develop the brain-wasting illnesses.

"We think it (angiotensin) is one of the most important factors determining healthy blood vessels and also acts in the brain to help neurons to be a little more resilient," said Benjamin Wolozin, the senior author of a report on the findings.

Wolozin, also a professor of pharmacology and neurology Boston University School of Medicine, and his colleagues looked at the incidence of dementia in 800,000 mostly male patients in the U.S. from 2002 to 2006. They all had heart disease and were 65 or older.

The patients were divided into three groups. One of them was using ARBs, another was taking a different type of the blood pressure lowering drug, an angiotensin-converting enzyme (ACE) inhibitor called lisinopril, and a third was on other heart medications.

Among patients, those who took ARBs were nearly half as likely to be needing admission to a nursing home by the end, according to the study.

The team also found that ARBs have an added effect when combined with ACE inhibitors in patients who had already developed Alzheimer's or dementia. Those taking both drugs were less likely to die early or be admitted to nursing homes.

However, the study had its limitations. Colleen Maxwell and David Hogan of the University of Calgary, Canada, said the study did not factor in family history of dementia; was rather short in duration; and did not look at dementia among women.

There are 35 million people worldwide having a form of dementia such as Alzheimer's disease and the tally will almost double every 20 years -- to 66 million in 2030 and more than 115 million in 2050, Alzheimer's Disease International predicted.

Jan 13
Kids brain cancer can arise from stem cells
A new study has shed light on the role of stem cells in medulloblastomas, the most common type of children's brain tumor.

Researchers at Queen Mary, University of London, studied equivalent cells taken from mouse brains. Principal investigator Silvia Marino, Professor of Neuropathology at Queen Mary, University of London, and her team showed that medulloblastomas can grow from a type of brain stem cell and that these cancers are a distinct form of the disease which may require a completely different approach to treatment.

She said "This type of brain tumour can pose a great challenge to doctors. In some children, treatment works well but in others the cancer is aggressive and far harder to treat. As scientists we have been trying to understand how these cancers which look the same can behave so differently. This study is a major advance for us because it shows for the first time that some of these tumours develop from endogenous stem cells."

She added " This is important for two reasons. First, it could help us to tell which cancers will respond well to treatment and which will need a more aggressive therapy. Second, this new understanding could help us to find much-needed new drugs for the disease."

Jan 12
In puberty, fat builds mass
Girls suffering through the insecurities of puberty are often likely to yearn for the rail-thin bodies of supermodels plastered across the typical supermarket glossy.

But, as new research shows, puberty is a crucial time for a woman to love those curves.

In a study to be published in the Journal of Clinical Endocrinology and Metabolism, scientists found that fat mass helps build bone mass, particularly in girls.

Add brittle bones to the long list of physical and psychological damage caused by an eating disorder -- the research could have implications for "whether development of the female skeleton is preferentially affected by conditions such as anorexia nervosa associated with reduced fat mass," the study said.

Scientists aren't quite clear on why exactly a woman's fat content makes a difference. Some of that bone accrual is likely a response to the stress caused by the weight her skeleton is carrying; the study's authors also suggest a possible relationship with estrogen levels.

Whatever the underlying causes are, given the post-menopausal specter of osteoporosis, it's important to encourage a healthy body image.

Not only is skin-and-bones an unflattering look, it's bad for your bones in the long run.

Jan 12
Sunglasses can ease migraine pain
Suffering from migraine? Fret not, slip on a pair of a shades, for a new study has revealed that sunglasses can help in easing the debilitating pain from the condition, even at night.

Previous researches have found that even at night, light intensifies a migraine headache but failed to explain the exact reason behind the cause.

Now, a team, led by Prof Rami Burstein of Harvard Medical School, has found the reason why light makes migraine worse - by identifying a new visual pathway which underlies sensitivity to light during migraine in both blind individuals and in individuals with normal eyesight.

In fact, migraine pain are believed to develop when the matter surrounding the brain and central nervous system becomes irritated and 85 per cent of sufferers become sensitive to light.

Prof Burstein said they should do anything to avoid light during an episode. "Patients may wear sunglasses, even at night. The dimmest of light can make migraine pain worse," the British media quoted him as saying.

In their study, the researchers showed that light increased the effects of migraines by recruiting two groups of people who suffered regular severe headaches.

Jan 11
Brain imaging may help diagnose autism
A new research suggests that brain imaging technique may aid in early diagnosis of autism, a disorder of neural development.

Findings of the study suggest that autistic children process language and sound a fraction of second slower than the unaffected kids. However, brain imaging can detect the condition in early infancy.

The researchers
are hopeful that if successful, the discovery "may be refined into the first imaging biomarker for autism."

Autism is a neurological disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. These signs begin before a child is three-years-old.

Details of the study
To come up with these findings, researchers carried out a study on 25 children with autism spectrum disorders (ASDs) with an average age of 10 years and on 17 other children in the same age group who were in the initial stages of developing the neurological disorder.

For the study, researchers used an imaging technique called Magnetoencephalography (MEG), which uses magnetic fields in the brain to detect delayed brain response.

The children wore helmets through which they were made to listen to a series of recorded beeps, vowels, and sentences.

As the children responded to the different sounds, the non-invasive detectors in the MEG machine kept tracking the magnetic fields in their brains.

Children with ASD showed delayed responses
On analysing the brain scans of the children, it was found that those with ASD showed an average delay of 11 milliseconds (about 1/100 of a second) in their brain response to the varied sounds compared to other children who were treated as controls.

On the other hand, within the ASD group, similar delays were recorded in the brain responses, regardless of the fact whether or not these children had language impairments.

Dr Timothy Roberts, the lead researcher at Children's Hospital in Philadelphia, said, "An 11-millisecond delay is brief, but it means, for instance, that a child with ASD, on hearing the word 'elephant' is still processing the 'el' sound while other children have moved on," he said.

"The delays may cascade as a conversation progresses, and the child may lag behind typically developing peers."

Results of the study may have important implications in finding potential treatments of the disorder, the researchers stated.

It may also enable diagnosis of different types of ASDs such as classic autism and Asperger's syndrome in individual patients, they said.

The study appears in the journal Autism Research.

Jan 11
Shorter People More Likely To Develop Lung Disease - Poverty, The Culprit
Shorter people more are more likely to develop lung disease, says a new study. And they could hail from poorer backgrounds.

University of Nottingham researchers say those with Chronic Obstructive Pulmonary Disease (COPD) were 1.12cm shorter on average.

In the Journal of Epidemiology and Community Health, they write this lack of height may be a "marker" that people have come from a poorer background.

A number of historical studies have suggested that early life deprivation increases the risk of developing COPD in adult life, but whether this is still true now that living conditions have improved is not known, they point out.

So they set out to quantify the current association between adult height (a maker of socioeconomic status in early life) and COPD, and to determine how this varies by age.

They examined data on 1,204,110 people (aged over 35yrs old) from The Health Improvement Network - a general practice database and concluded, "The risk of developing COPD is still strongly associated with adult height. This association is strongest in the youngest age category suggesting that early life experience will remain an important risk factor for COPD for some time to come and possibly that COPD related to early life deprivation is more severe and tends to present at a younger age."

The smallest height difference was in the over 90s where the average difference was only 0.51cm.

They say this could be because many of the older generation who suffered from the disease actually died from it in recent years.

People with COPD have permanent scarring to the lung tissue caused mostly be smoking.

It is estimated that 3.7 million people in the UK have the disease, but only 900,000 are currently diagnosed.

The researchers
think that people who came from poorer backgrounds were more likely to have had mothers who smoked, had poor nutrition during their early years affecting general growth and lung development, and were more likely to live in smoking households and smoke themselves.

Richard Hubbard, professor of respiratory epidemiology at the University of Nottingham, who co-authored the study said: "There's a double whammy associated with deprivation.

"Poorer nutrition in the 'womb' and when growing up as a child can affect general growth and lung development.

"This is combined with an increased likelihood to live with families and peers who smoke - influencing the chance of taking up and sticking with the habit.

"We know that smoking is the principal cause of COPD and all of these factors combined could increase the risk even more."

Professor Mike Morgan, chairman of the British Thoracic Society, said: "We need to make it easier for people from disadvantaged backgrounds to make positive life choices and improvements to their health - whether it be eating well or stopping smoking.

"GPs and primary care professionals could also look out for height alongside smoking status and other chronic lung disease symptoms, to ensure that the disease is caught early."

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