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Aug 08
Scientists find bacteria that prevents type 1 diabetes
Scientists have found that a set of bacteria in our body, known as microbiota, can also protect us against the development of type 1 diabetes.

A research team comprising of Inserm, Paris Descartes University and the CNRS through collaboration with teams from China and Sweden, and coordinated by Julien Diana is focusing on a category of antimicrobial peptides, i.e. cathelicidins.

Apart from their protective function, these peptides have also exhibited immunoregulatory abilities against several autoimmune diseases. As such, scientists hypothesise that cathelicidins may be involved in the control of type 1 diabetes, an autoimmune disease where certain cells in the immune system attack beta cells in the pancreas which secrete insulin.

To combat pathogens, the immune system has developed various mechanisms to detect, defend against and even destroy micro-organisms that are harmful to the body. This includes antimicrobial peptides and natural proteins that destroy pathogenic bacteria by disrupting their cellular membrane. Not only are they produced by immune cells, they are also produced by cells whose functions are not immune-related. Injecting cathelicidins inhibit the development of pancreatic inflammation and, as such, suppressed the development of autoimmune disease in mice, states Julien Diana.

Since the production of cathelicidins is controlled by short-chain fatty acids produced by gut bacteria, scientists are studying the possibility that this may be the cause of the cathelicidin deficiency associated with diabetes.

By transferring part of the gut bacteria from healthy mice to diabetic mice, they are re-establishing a normal level of cathelicidin. Meanwhile, the transfer of micro-organisms reduces the occurrence of diabetes.

The research is published in the Immunity journal.

Aug 07
Asian pears could ward off hangovers
Heading out for a booze-fuelled night out? Drink pear juice to avoid a hangover!

Drinking Asian pear juice before consuming alcohol can prevent hangover symptoms, scientists have found.

Researchers at Australia's Commonwealth Scientific and Industrial Research Organisation (CSIRO) led by Professor Manny Noakes found that drinking the juice of Asian pear, also known as Korean pear, can prevent hangovers as well as lower blood alcohol levels.

Researchers measured hangover severity in study subjects using a 14-item hangover symptom scale.

They found that those given 220 ml of Asian pear juice reported reduced overall hangover symptoms compared to those in the placebo group, with the most pronounced improvement reported in the area of "trouble concentrating."

The hangover was only avoided if the pear juice was consumed before the alcohol, 'Gizmag' reported.

While the study involved pear juice, the researchers believe consuming whole pears would produce similar effects.

Further research is needed to determine whether the hangover-preventing capabilities extend to other pear varieties as the studies have so far only involved the Asian pear, which is known to have a number of compositional differences to Western pear varieties.

While the mechanism responsible for Asian pear's protective effects against a hangover is not completely understood, the researchers said that factors in Asian pears have an effect on key enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which accelerate the metabolism of alcohol and inhibit its absorption in the body.

Specifically, blood acetaldehyde levels, which is the toxic metabolic thought to be responsible for hangover symptoms, were reduced after consuming pear juice.

Noakes noted that the research was only a preliminary scoping study but the team plans to deliver a comprehensive review of the scientific literature regarding pears, pear components and relevant health measures in the future.

Aug 04
Scientists successfully breed symbiotic bacteria in mosquitoes to control dengue fever
In a breakthrough, Chinese scientists have successfully bred a symbiotic bacteria in mosquitoes to inhibit the spread of dengue fever in south China's Guangdong Province.

The scientists from Sun Yat-sen University in Guangzhou City inject Wolbachia into Aedes albopictus, a kind of mosquito originating in South Asia and often spread dengue viruses.

Wolbachia is a genus of bacteria that only live inside insect cells and can inhibit dengue viruses in mosquitoes.

"Dengue viruses normally need to replicate in mosquitoes. But the symbiotic bacteria can prevent the replication of the viruses. So the viruses are controlled in the mosquitoes," said Xi Zhiyong, medical professor at Sun Yat-sen University.

Earlier this year in March, the research team has launched a pilot program in the city and released mosquitoes carrying with Wolbachia into nature.

The scientists have planned to release a large number of male mosquitoes carrying Wolbachia into nature and reduce mosquito population in order to control the spread of dengue viruses.

"All mosquito eggs cannot hatch due to our control in some areas. In other areas, at least half of the eggs cannot hatch," said Xi.

According to Xi, mosquitoes with Wolbachia will not harm people because the bacteria cannot survive in human bodies.

Dengue is a viral disease of the tropics, transmitted by mosquitoes, and causing sudden fever and acute pains in the joints. Since dengue fever is caused by a virus, there is no specific medicine or antibiotic to treat it.

Aug 03
Spinach can curb food craving in men
A compound found in spinach can slow down fat digestion, leading to reduced hunger and food craving especially in men, a study says.

A concentrated extract of thylakoids encourage the release of satiety hormones, which is very beneficial in controlling hunger.

"The reduction in hunger and the desire for salty food that we saw might make thylakoids particularly useful for people with high blood pressure and associated weight problems," said study co-author Frank. L. Greenway from the Pennington Biomedical Research Center in Louisiana.

The researchers examined the effect of consuming a single dose of concentrated extract of thylakoids from spinach on satiety, food intake, lipids, and glucose compared to a placebo.

Sixty people (30 men and 30 women) classified as overweight or obese consumed either the spinach extract or a placebo in random order at least a week apart.

The results showed that the spinach extract containing thylakoids increased satiety over a two-hour period compared to a placebo.

There were no differences in plasma lipids and energy intake at dinner but men showed a trend toward decreased energy intake.

"Thylakoid consumption may influence gender-specific food craving," the authors said.

A previous study had found that in women, a reduced urge for sweets was significant after a single dose of the spinach extract and the reduced urge for sweets was sustained throughout the study.

The article was published in the Journal of the American College of Nutrition.

Aug 01
Exercise and diet control can prevent gestational diabetes
A combination of physical activity and diet control can help prevent gestational diabetes mellitus (GDM) in women who are at high risk of developing the disorder, says a new study.

Gestational diabetes and maternal obesity may increase the offsprings' predisposition to obesity and impaired glucose regulation.

"A simple and individualised lifestyle intervention reduced the incidence of gestational diabetes by 39 percent in high-risk pregnant women," said one of the researchers Saila Koivusalo from Helsinki University Hospital in Finland.

In the study, a total of 293 women with a history of GDM or a pre-pregnancy body mass index of less tha 30 kg/m2 were enrolled at less than 20 weeks of gestation.

They were randomly allocated to an intervention group or a control group.

The participants in the intervention group received individualised counselling on diet, physical activity and weight control from trained nurses and a dietician.

The control group received standard ante-natal care.

Intervention reduced the incidence of gestational diabetes by 39 percent in high-risk pregnant women, the findings showed.

Gestational weight gain was lower in the intervention group, and women in the intervention group also increased their leisure time physical activity more and improved their dietary quality compared with the women in the control group.

The findings appeared in the journal Diabetes Care.

Jul 31
Increasing coffee intake bad for your brain
London: While drinking your daily cup of coffee can help you stay sharp, modifying your habit by increasing coffee consumption over time may increase risk of mild cognitive impairment (MCI), early symptoms of Alzheimer's disease (AD) and dementia, says new research.

"These findings from the Italian Longitudinal Study on Ageing suggested that cognitively normal older individuals who never or rarely consumed coffee and those who increased their coffee consumption habits had a higher risk of developing MCI," said one of the researchers Francesco Panza from the University of Bari Aldo Moro, Bari, Italy.

"Therefore, moderate and regular coffee consumption may have neuroprotective effects also against MCI - confirming previous studies on the long-term protective effects of coffee, tea, or caffeine consumption and plasma levels of caffeine against cognitive decline and dementia," Panza noted.

The study involved 1,445 individuals aged 65-84 years.

An interesting finding in this study was that cognitively normal older individuals who modified their habits by increasing with time their amount of coffee consumption ( more than a cup of coffee/day) had about two times higher rate of MCI compared to those with reduced habits (less than a cup of coffee/day).

They also had about one and a half time higher rate of MCI in comparison with those with constant habits (neither more nor less than one cup of coffee/day).

Moreover, those who habitually consumed a moderate amount of coffee (one or two cups of coffee/day) had a reduced rate of the incidence of MCI than those who habitually never or rarely consumed coffee.

These findings were published in the Journal of Alzheimer's Disease.

Jul 30
Google Glass may improve social skills in autistic people
A new technology uses Google Glass to help those with autism make eye contact, engage in conversations and more easily read social situations.

Ned Sahin, a Boston entrepreneur and scientist, has developed a new technology that aims to change the way those with autism see the world.

"The Brain Power system adds enhancements to the Google Glass or other wearable (technology) and then a suite of software," Sahin said.

The software was designed to help those with autism make eye contact, engage in conversations and more easily read social situations.

"It coaches eye contact directly, rewarding points to the child or adult with autism. Then, when they look at someone in the eye, their little computer screen shows the emotions the other person is feeling," Sahin said.

The glasses can help make someone relax by playing soft music and even has a solution to the fear of "wandering", 'wbir.Com' reported.

"Mom can speak to her child through the device and actually see what he is seeing," Sahin explained.

"We activate the camera so it becomes a remote version of her eyes," he said.

Clinical trials for the new technology will begin later this year at Harvard Medical School.

Jul 27
Exercise, healthy food prevent knee pain in adults with diabetes
As per a new study by medical researchers, regular exercise and healthy food habits may reduce the short-term onset of knee pain for overweight adults with type 2 diabetes.

Daniel White, Assistant Professor at the University of Delaware, wrote an article which was a key study for 2015 at the Osteoarthritis Society's international meeting.

The study compared subjects receiving intensive lifestyle intervention (ILI) to a group receiving standard diabetes support and education (DSE) to measure knee pain at the end of one year and four years.

White and his colleagues conducted a secondary analysis of the Action for Health in Diabetes study, a randomised intervention of trial adults aged 45 to 76 years who were obese and had Type 2 diabetes mellitus. The Action for Health in Diabetes study began in 2001.

White said that the analysis involved a group of 2,889 subjects, who reported no knee pain at baseline, but were at high risk due to obesity.

The primary method of achieving weight loss was caloric intake restrictions, based on guidelines from the American Diabetes Association. The diet limits total calories from fat to 30 percent while mandating at least 10 percent of calories to be obtained from protein.

Moderate-intensity walking encouraged as a primary type of physical activity for most of the participants.

White said the study concluded that an intensive program of diet and exercise had a small but statistically significant protective effect against the development of knee pain in the short-term among overweight adults with diabetes.

The story is published in Arthritis Care and Research.

Jul 25
Prawns can protect us from parasitic disease: Study
Freshwater prawns can help prevent the spread of schistosomiasis, a potentially deadly parasitic disease that can cause anaemia, stunted growth, infertility, liver failure, bladder cancer and lasting cognitive impairment, says a new study.

"Where drugs, alone, fail to control schistosomiasis due to rapid reinfection, prawns may offer a complementary strategy for controlling the disease," the study said.

The prawns prey on parasite-infected snails, while providing a source of marketable protein-rich food. Because prawns cannot support schistosomiasis' complex life cycle, they do not transmit the disease themselves, the findings showed.

"The results of our study open the pathway to a novel approach for the control of schistosomiasis," said study co-author Giulio De Leo, a biology professor at Hopkins Marine Station of Stanford University in the US.

Worldwide, nearly 800 million people are at risk of getting schistosomiasis. The study, published in the journal Proceedings of the National Academy of Science, tracked parasite-infected snails and people in villages in Senegal, West Africa.

In one village, the international research team and Senegalese partner Biomedical Research Center Espoir pour la Sante stocked a river access point with prawns.

Over the course of 18 months, they found 80 percent fewer infected snails and a 50 percent lower disease burden (the mean number of parasite eggs in a person's urine) in people living in the prawn-stocked village.

"They can synergize with local efforts in the developing world to fight parasitic disease and to foster new aquaculture-based industries," lead author Susanne Sokolow from Stanford's Hopkins Marine Station said.

Currently, the only treatment for the disease is the drug praziquantel. Insufficient global supplies, cost and other factors limit that drug's effectiveness.

Even if it were widely and cheaply available, praziquantel would be an incomplete solution for people who enter river water to bathe and clean clothing, among other reasons, and get reinfected frequently through contact with schistosome-contaminated waters, the study said.

Jul 24
Class of diabetes drugs may also help with Parkinson's disease
Scientists have found a link between a class of drugs used to treat diabetes and protection against Parkinson's disease (PD).

The study conducted by Dr. Ruth Brauer, of the London School of Hygiene & Tropical Medicine, found a lower incidence of PD among people using a glitazone drug (either rosiglitazone or pioglitazone) to treat diabetes when compared to people who had used different treatments for diabetes.

These findings are consistent with animal and in vitro studies which suggested that glitazones and other drugs that target peroxisome proliferation-activated receptor gamma may have neuroprotective effects.

It is important to note that these results may not apply to people without diabetes and do not indicate whether glitazones can slow PD progression.

Further, it is possible that unknown patient characteristics associated with glitazone use might also be linked to PD, contributing to the appearance of a direct causal connection. In addition, glitazones have been associated with serious side effects.

However, the authors are hopeful that these findings may pave the way towards other treatments that target the same pathway.

The study is published in PLOS Medicine. (ANI)

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