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Jul 23
Menopause raises heart disease risk in women
Post-menopausal women have significantly greater volumes of fat around their hearts - a risk factor for heart disease - than their pre-menopausal counterparts, new research shows.

"Cardiovascular disease is the leading cause of death in women, and it increases after age 50 - the average age when a woman is going through menopause," said lead author Samar El Khoudary, assistant professor at University of Pittsburgh Graduate School of Public Health in the US.

"By showing that menopause appears to be associated with a shift in fat deposits that leads to more fat around the heart, we have uncovered a new potential contributor to increased risk of cardiovascular disease in women," El Khoudary said.

The finding, published online in The Journal of Clinical Endocrinology & Metabolism, could guide potentially life-saving interventions.

Weight gain in women during and after menopause has long been attributed to ageing, rather than menopause itself.

In the new research, El Khoudary and her team evaluated clinical data, including blood samples and heart CT scans, on 456 women in the US.

The women averaged about 51 years of age and were not on hormone replacement therapy.

As concentrations of the sex hormone estradiol - the most potent estrogen - declined during menopause, greater volumes of cardiovascular fat were found.

The finding held even after the team took into account the effects of age, race, obesity, physical activity, smoking, alcohol consumption, medication use and chronic diseases.

"Developing prevention strategies to reduce cardiovascular fat in women at midlife may reduce their heart disease risk, especially knowing that the menopausal transition puts women at risk for excess fat around their hearts," El Khoudary said.

Jul 22
Arthritis drug beats untreatable eczema
Treatment with a drug approved for rheumatoid arthritis has led to dramatic improvement in six patients with moderate to severe eczema who had previously tried old therapies with no success, says a study.

The new study suggests that a change in the standard of care for eczema -- a skin condition for which there is no targeted therapy -- may be on the horizon, said the researchers.

Eczema (atopic dermatitis) is a chronic condition that causes severe itching and leaves the skin red and thickened. It can adversely affect sleep and also the quality of life. Standard treatments, such as steroid creams and oral medicines, commonly fail to relieve symptoms in patients with moderate to severe eczema.

In the study, the researchers from Yale School of Medicine in the US hypothesized that the drug tofacitinib citrate, would interrupt the immune response that causes eczema.

During treatment all six patients reported significant reduction in itch as well as improved sleep. The redness and thickening of the skin also diminished, showed the findings reported in the Journal of the American Academy of Dermatology.

"These individuals were not only very happy with the results, they also expressed a tremendous sense of relief at being comfortable in their skin for the first time in many years," said assistant professor of dermatology Brett King.

The researchers had previously shown that tofacitinib citrate regrows hair in patients with an autoimmune-related form of hair loss called as alopecia areata.

They also published findings reporting the successful treatment of a patient with vitiligo, which can leave widespread irregular white patches all over the body.

Jul 21
Benefits of chocolate milk vary according to workout intensities
Chocolate milk has it all whether it comes to proteins, carbs, sugar or the taste and is also trending with athletes, but a big question arises that is this dairy beverage perfect for everyone in replenishing the energy?

According to Slate, during high intensity workouts muscle proteins break down and glycogen levels deplete by 60-75 percent, however for muscle growth after workout, one need to replenish glycogen and protein that can easily be gained from chocolate milk.

Even trainers suggest their students to take 4 grams of carbohydrates to 1 gram of protein within 30 minutes after workout.

However, workout intensity and duration of workouts determines how much energy is used like high intensity workout such as running stairs, boxing, competitive soccer, where the max heart rate is 80-85 percent burn more calories, whereas low intensity workout such as Pilates, walking, hiking that makes the heart rate reaches to 60-65 percent and burns fewer calories.

Though a less intense workout requires less replenishing and less chocolate milk and instead of this one should go for Blueberries (rich in anti-oxidants and accelerates muscle recovery time), Organe juice (high in potassium and carbs and helps in restoring body fuel levels), Coconut Water (high in potassium and low sodium which is better for low intensity workout) and Water (key to post-workout recovery).

Jul 20
Exercise of five hours a week may cut breast cancer
Post-menopausal women, especially those who are obese, should exercise at least five hours a week to curb obesity and breast cancer risk, shows research.

Exercising 300 minutes per week is recommended for reducing total fat in post-menopausal women than the currently recommended 150 minutes, the researchers said.

"A possible association between physical activity and post-menopausal breast cancer risk is supported by more than 100 epidemiologic studies, with strong biologic rationale supporting fat loss as an important (though not the only) mediator of this association," the study said.

"Our findings of a dose-response effect of exercise on total fat mass and several other adiposity measures, including abdominal fat, especially in obese women, provide a basis for encouraging post-menopausal women to exercise at least 300 minutes/week, longer than the minimum recommended for cancer prevention," researchers said.

The results of the one-year clinical trial was published online in the journal JAMA Oncology.

According to the study, physical activity is an inexpensive, non-invasive strategy for disease prevention advocated by public health agencies around the world, with recommendations to be physically active at least 150 minutes per week at moderate intensity or 60 to 75 minutes per week at vigorous intensity for overall health.

For the new study, Christine Friedenreich of Alberta Health Services, Canada, and colleagues compared 300 minutes of exercise per week with 150 minutes per week of moderate to vigorous aerobic exercise for its effect on body fat in 400 inactive post-menopausal women who were evenly split into the two exercise groups.

The women, who had body mass index (BMI) 22 to 40, were asked not to change their usual diet.

Any aerobic activity that raised the heart rate 65 percent to 75 percent of heart rate reserve was permitted, and most of the activities involved the elliptical trainer, walking, bicycling and running.

Average reductions in total body fat were larger in the 300-minute versus 150-minute group.

Abdominal fat, BMI, waist circumference and waist-to-hip ratio also decreased more in the 300-minute group, the findings showed.

Jul 17
Workout can help middle-aged men cut risk of osteoporosis
Middle aged men should exercise to reverse age related bone loss, cut risk of decrease osteoporosis, finds a new study.

University of Missouri researchers have found that certain types of weight-lifting and jumping exercises, when completed for at least six months, improve bone density in active, healthy, middle-aged men with low bone mass. These exercises may help prevent osteoporosis by facilitating bone growth.

Associate professor Pam Hinton said that their study was the first to show that exercise-based interventions work to increase bone density in middle-aged men with low bone mass who are otherwise healthy.Hinton said the study results did not indicate that all kinds of weight lifting will help improve bone mass; rather, targeted exercises made the training programs effective.

Throughout their training programs, participants rated pain and fatigue after completing their exercises. The participants reported minimal pain and fatigue, and these ratings decreased over the year. Hinton said individuals who want to use similar training programs to improve bone density should consider their current activity levels and exercise preferences as well as time and equipment constraints.

The study is published in Bone.

Jul 16
Brazilian researchers say modified butter can treat Alzheimer's
Patients suffering from the first stages of Alzheimer's can benefit from the consumption of butter, enriched with a special fatty acid extracted from milk, Brazilian researchers found.

Tests showed a diet rich in the modified butter increases the activity of an enzyme linked to memory and reduces damage caused by the disease to this function, said the University of Sao Paulo (USP) on its website.

The results of the project, authored by researchers from the Institute of Psychiatry at USP, were featured in the latest edition of the international scientific Journal of Neural Transmission.

According to the researchers, conjugated linoleic acid, an acid extracted from dairy fats, helps the body to increase activity of fosfolipase A2, an enzyme that acts on memory, in the brain, Spanish news agency Efe reported.

The enzyme acts directly on the fats that make up cell membranes, which, among other functions, helps in memory formation.

In healthy patients, these membranes are flexible and are renewed periodically but the carriers of Alzheimer's are rigid, hinder the release of fatty acids, and cannot be replaced at the same rate.

"We saw that the action of this enzyme is altered in Alzheimer's patients, so we began to analyse how we could alter the metabolism of A2 fosfolipase in these patients," explained the head of the Neurosciences Laboratory of the USP, Leda Talib, who coordinated the project.

Experiments with mice, which began five years ago, showed the treatment is effective in patients in early stages of the disease, but researchers are trying to determine whether it can also prevent the disease.

"When the symptoms begin to appear it is because the disease is already established. We do not know at what point it begins, but we will investigate to determine whether the treatment can also be preventive," she said.

Talib added there needs to be more experiments with mice to establish the collateral effects of the modified butter diet, before clinical trials on humans can begin.

"We need to establish whether this diet may cause damage to your health," she concluded.

Jul 15
Kidney stones don't cause osteoporosis in post-menopausal women
Post-menopausal women with kidney or bladder stones are not prone to osteoporosis, but they do have about a 15 percent increased risk of another painful stone, shows research.

Studying the data of approximately 150,000 post-menopausal women, the study found that despite the two conditions being clearly associated in men, the same did not hold true for women.

"We found that, unlike what has been reported in men, a woman having a kidney stone is not a risk factor for osteoporosis. However, having one urinary tract stone does put women at increased risk for a second stone," said Laura D. Carbone, chief of rheumatology section at the Medical College of Georgia at Georgia Regents University.

Carbone said in the study that appeared in the Journal of Bone and Mineral Research. However, women with a stone likely should work with their physician to reduce their increased risk of a subsequent stone.

Having a stone also was known to put people at risk for subsequent stones, but the new study helps clarify the risk. The incidence of urinary tract stones is on the rise generally, particularly in women, with a 70 percent increase in the last 15 years.

One link between the seemingly disparate conditions of stones and weak bones is an excess of calcium in the urine, which tends to be more common in men.

When sodium levels are high, from eating too much processed or fast food, more calcium is eliminated in the urine. Over activity of the parathyroid glands, which regulate levels of calcium in the blood, is associated with both urinary tract stones and fractures of the vertebra in the spine.

Jul 13
Brazilian researchers say modified butter can treat Alzheimer's
Patients suffering from the first stages of Alzheimer's can benefit from the consumption of butter, enriched with a special fatty acid extracted from milk, Brazilian researchers found.

Tests showed a diet rich in the modified butter increases the activity of an enzyme linked to memory and reduces damage caused by the disease to this function, said the University of Sao Paulo (USP) on its website.

The results of the project, authored by researchers from the Institute of Psychiatry at USP, were featured in the latest edition of the international scientific Journal of Neural Transmission.

According to the researchers, conjugated linoleic acid, an acid extracted from dairy fats, helps the body to increase activity of fosfolipase A2, an enzyme that acts on memory, in the brain, Spanish news agency Efe reported.

The enzyme acts directly on the fats that make up cell membranes, which, among other functions, helps in memory formation.

In healthy patients, these membranes are flexible and are renewed periodically but the carriers of Alzheimer's are rigid, hinder the release of fatty acids, and cannot be replaced at the same rate.

"We saw that the action of this enzyme is altered in Alzheimer's patients, so we began to analyse how we could alter the metabolism of A2 fosfolipase in these patients," explained the head of the Neurosciences Laboratory of the USP, Leda Talib, who coordinated the project.

Experiments with mice, which began five years ago, showed the treatment is effective in patients in early stages of the disease, but researchers are trying to determine whether it can also prevent the disease.

"When the symptoms begin to appear it is because the disease is already established. We do not know at what point it begins, but we will investigate to determine whether the treatment can also be preventive," she said.

Talib added there needs to be more experiments with mice to establish the collateral effects of the modified butter diet, before clinical trials on humans can begin.

"We need to establish whether this diet may cause damage to your health," she concluded.

Jul 11
Anxiety-related spectrum disorder identified
Observing higher prevalence of certain physical illnesses among people suffering from panic disorder, US researchers has proposed the existence of a spectrum syndrome comprising a core anxiety disorder and four related domains.

The study published in the Journal of Neuropsychiatry and Clinical Neurosciences points to a link between mental and physical health.

When mental and physical illnesses co-occur, patients' accounts of physical illness are sometimes arbitrarily discredited or dismissed by physicians. The naming of the new disorder may help many patients receive proper diagnosis.

"Patients who have certain somatic disorders - illnesses for which there is no detectable medical cause and which physicians may consider to be imagined by the patient - may instead have a genetic propensity to develop a series of real, related illnesses," said one of the researchers Jeremy Coplan, professor of psychiatry at SUNY Downstate Medical Centre in the US.

"Panic disorder itself may be a predictor for a number of physical conditions previously considered unrelated to mental conditions, and for which there may be no or few biological markers," Coplan said.

The researchers found correlation between panic disorder, bipolar disorder, and physical illness, with significantly higher prevalence of certain physical illnesses among patients with panic disorder when compared to the general population.

To describe the new spectrum disorder, the researchers have coined the term ALPIM, where "A" stands for anxiety disorder (mostly panic disorder); "L" for ligamentous laxity (joint hypermobility syndrome, scoliosis, double-jointedness, mitral valve prolapse, easy bruising); "Pa for pain (fibromyalgia, migraine and chronic daily headache, irritable bowel syndrome, prostatitis/cystitis); "I" for immune disorders (hypothyroidism, asthma, nasal allergies, chronic fatigue syndrome); and "M" for mood disorders.

Two thirds of patients in the study with mood disorder had diagnosable bipolar disorder and most of those patients had lost response to antidepressants.

"Our argument is that delineations in medicine can be arbitrary and that some disorders that are viewed as multiple disparate and independent conditions may best be viewed as a single spectrum disorder with a common genetic etiology."

Jul 09
Eating fruits, veggies can lower risk of heart disease: Study
High vitamin C concentrations in the blood from the intake of fruit and vegetables are associated with a reduced risk of cardiovascular disease and early death, a new large-scale study has found.

Researchers from the University of Copenhagen and Herlev and Gentofte Hospital in Denmark studied data from 100,000 Danes and their intake of fruit and vegetables as well as their DNA.

"We can see that those with the highest intake of fruit and vegetables have a 15 per cent lower risk of developing cardiovascular disease and a 20 per cent lower risk of early death compared with those who very rarely eat fruit and vegetables," said Camilla Kobylecki, a medical doctor and PhD student at the Department of Clinical Biochemistry, Herlev and Gentofte Hospital.

"At the same time, we can see that the reduced risk is related to high vitamin C concentrations in the blood from the fruit and vegetables," Kobylecki said.

Vitamin C is a potent antioxidant which protects cells and biological molecules from the damage which causes many diseases, including cardiovascular disease.

The human body is not able to produce vitamin C, which means that we must get the vitamin from our diet.

"Eating a lot of fruit and vegetables is a natural way of increasing vitamin C blood levels, which in the long term may contribute to reducing the risk of cardiovascular disease and early death," said Borge Nordestgaard, a clinical professor at the Faculty of Health and Medical Sciences, University of Copenhagen, and a consultant at Herlev and Gentofte Hospital.

"You can get vitamin C supplements, but it is a good idea to get your vitamin C by eating a healthy diet, which will at the same time help you to develop a healthier lifestyle in the long term, for the general benefit of your health," said Nordestgaard.

The study has just been published in the American Journal of Clinical Nutrition.

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