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May 14
Mediterranean diet combined with olive oil, nuts can boost cognitive function
Consuming plant-based Mediterranean diet with virgin olive oil or mixed nuts can lead to improved cognitive function in older adults, suggests a new study.

Spanish researchers Emilio Ros, M.D., Ph.D., and Ciber Fisiopatologia along with colleagues compared a Mediterranean diet supplemented with olive oil or nuts with a low-fat control diet.

The randomized clinical trial included 447 cognitively healthy volunteers (223 were women; average age was nearly 67 years) who were at high cardiovascular risk and were enrolled in the Prevencion con Dieta Mediterranea nutrition intervention.

The authors measured cognitive change over time with a battery of neuropsychological tests and they constructed three cognitive composites for memory, frontal (attention and executive function) and global cognition. After a median of four years of the intervention, follow-up tests were available on 334 participants.

The results suggested that in an older population a Mediterranean diet supplemented with olive oil or nuts may counter-act age-related cognitive decline. The lack of effective treatments for cognitive decline and dementia points to the need of preventive strategies to delay the onset and/or minimize the effects of these devastating conditions. "The present results with the Mediterranean diet are encouraging but further investigation is warranted."

The study is published online by JAMA Internal Medicine.

May 13
MRI scans may predict breast cancer risk, study says
Magnetic resonance imaging (MRI) scans may predict a woman's future risk of developing breast cancer, found a new study published Tuesday in Radiology.

Researchers reviewed screening breast MR images from high-risk women 18 years or older with no history of breast cancer and specifically looked for associations between cancer risk and imaging features, including breast density and background parenchymal enhancement (BPE). In MR images, BPE occurs when areas of normal background breast tissue appear white or enhanced. Previous research has suggested a possible link between BPE and cancer risk.

In the study, women who displayed elevated amounts of BPE were nine times more likely to have a breast cancer diagnosis, compared to those with little to no BPE.

Previous studies linked dense breast tissue to an increased likelihood of breast cancer development. In this new study, mammographic density appeared to have no significant relationship to cancer risk.

"To date, it's been difficult to assess the future risk of breast cancer for women, so there is a strong desire in the oncology community to identify ways to better determine this risk," study co-author Dr, Habib Rahbar, a breast imaging expert at Seattle Cancer Care Alliance and assistant professor at the University of Washington, said in a press release. "While breast density is loosely associated with the risk of developing breast cancer, it is unclear whether it or other imaging features can improve upon current risk assessment methods."

Women are considered at high risk for breast cancer if they have a family history or genetic mutations associated with the disease. Contrast-enhanced MRI is currently in use as an imaging option to supplement mammography in this group. The American Cancer Society recommends women with a 20 percent or greater risk of developing breast cancer undergo annual screening breast MRIs, in addition to routine annual screening mammography.

Researchers say their study shows that BPE could help physicians better tailor screening and management strategies for individuals' breast cancer risk, such as drug therapy and the need for mastectomies.

"MRI could be used in a broader group of women to determine who most needs supplemental screening based on their BPE levels," Rahbar said in the news release. "This is important as we move into an era of more personalized medicine."

More research is needed with a larger group of patients, researchers noted, and they're planning additional study into the role of BPE as a biomarker for breast cancer risk. BPE may be related to areas of inflammation associated with early stages of the disease, according to the press release.

"Breast cancer needs a supportive environment to grow, and recent research suggests that areas of inflammation are particularly conducive for such growth," Rabhar said in the press release.

May 12
Cheap junk food expands waistlines in emerging economies: Researchers
Eating healthy is becoming an expensive luxury in emerging market countries, where vegetable prices have spiked while high fat, sugary junk foods have become cheaper, economists said on Monday.

Prices of fruit and vegetables rose by 91 percent from 1990 to 2012, while the costs of ultra-processed ready-to-eat meals dropped by up to 20 percent in Brazil, China, South Korea and Mexico, researchers wrote in the first study of its kind on emerging economies.

The price shifts are contributing to rising obesity in the developing world, mirroring the expanding waistlines in wealthy countries, said the 64-page study "The rising cost of a healthy diet" from the Overseas Development Institute, a U.K.-based think tank.

The prevalence of overweight adults in Brazil has doubled since 1980 as cheap crisps, sugary drinks and energy bars became more popular, the study said.

The prices of green vegetables have doubled over the past 20 years in China, as obesity has surged, said the study.

"The policy implications are clear," Steve Wiggins, an agricultural economist and lead author of the study, told the Thomson Reuters Foundation.

"Governments should start using taxes and subsidies to nudge people towards a healthier diet."

Of the four countries studied, Mexico has the most serious problems with junk food consumption. Roughly two-thirds of its population is obese or overweight, a figure roughly equivalent to the U.K., Wiggins said.

In response to obesity and an "epidemic" of type 2 diabetes, Mexico has imposed a tax on sugary drinks, Wiggins said.

The economists who wrote the study said they are unable to explain why fruit and vegetable prices are rising.

Processed food is getting cheaper because industrial conglomerates have become more efficient in taking cheap ingredients and turning them into food that is "tasty but high in fat, energy, sugar and salt", Wiggins said.

May 11
Ebola may persist in survivors' eyeballs for months: Study
Washington: The Ebola virus can persist within the eyeballs for months after a patient recovers from the deadly disease, researchers have found.

A report released this week by the US journal New England Journal of Medicine described a case in which Ebola was present in the eye`s aqueous humor 10 weeks after the virus was cleared from the patient`s blood, Xinhua reported

Aqueous humor is the clear fluid in the front of the eye, between the lens and the cornea.

Despite the presence of Ebola in the eye, the researchers were quick to note that samples from the patient`s tears and conjunctiva, the surface of the eye and eyelids, tested negative for the virus.

It, therefore, indicated that casual contact with Ebola survivors carried no risk.

The patient, identified by US media as 43-year-old Ian Crozier, was diagnosed with Ebola in September, while working in an Ebola treatment unit in Sierra Leone as a doctor for the World Health Organization (WHO).

He was then transported to the US and treated at Emory University Hospital`s serious communicable disease unit for 40 days, including 12 days of mechanical ventilation and 24 days of renal replacement therapy.

After his blood and urine tested negative for the virus, Crozier was discharged home.

A semen sample obtained on the day of discharge, however, tested positive, so he was advised to abstain from sex or to use condoms for at least three months, according to the report.

Shortly after discharge, Crozier found he had new symptoms, including low back pain.

Two months later, he returned to the same hospital with an inflammation called uveitis and increased pressure in his left eye. The resulting swelling led to reduced vision, and, surprisingly, eye colour changed from blue to green.

The doctors obtained an aqueous humor sample, which tested positive for the Ebola virus.

"It felt almost personal that the virus could be in my eye without me knowing it," Crozier told the New York Times.

Several studies of prior outbreaks have shown that Ebola infections often manifest in the eyes, and can impact vision and cause blindness long after a systemic infection has cleared.

Lead author Steven Yeh, an ophthalmologist at the Emory Eye Center, believed that surveillance for the development of eye disease in the post-Ebola period is needed.

"The presence of viable Ebola virus in the eye could mean that other Ebola survivors may also be at risk for the development of uveitis," he said in a statement.

Uveitis is inflammation of the uvea, the middle layer of the eye between the retina and the sclera (white of the eye). It can lead to vision loss.

The findings also pointed to a need for infection control precautions when Ebola survivors underwent invasive procedures involving the eyes, the researchers said.

As for Crozier, he experienced visual recovery following therapy for uveitis. His eye colour also returned to normal, but why it changed colour is still a mystery.

May 09
Epilepsy drug could help treat Alzheimer's disease
A new epilepsy drug holds promise as a treatment for Alzheimer's disease, scientists have found.

The study by the University of British Columbia reinforces the theory that brain hyperexcitability plays an important role in Alzheimer's disease, and that anticonvulsant drugs - drugs that prevent or reduce the severity of seizures - represent a promising treatment that deserve further human studies.

In previous studies, several groups have tested the effects of the widely used anticonvulsant drug levetiracetam in both rodent models as well as two clinical trials in patients with early signs of Alzheimer's disease.

The findings suggest it may slow some of the symptoms of the disease, including memory loss.

In the new research, Dr Haakon Nygaard, the Fipke Professor in Alzheimer's Research in UBC's Faculty of Medicine, tested the effects of brivaracetam, an anticonvulsant drug still in clinical development for epilepsy, and closely related to levetiracetam.

Since it is 10 times more potent than levetiracetam, it can be used at lower dosages. Nygaard and his colleagues found that it completely reversed memory loss in a rodent model of Alzheimer's disease.

While the drug appears effective, the researchers are unclear how it works to reverse memory loss. Nygaard points out that the current study represents very preliminary data with respect to treating patients with Alzheimer's disease.

"Now we have many different research groups using antiepileptic drugs that engage the same target, and all point to a therapeutic effect in both Alzheimer's disease models, and patients with the disease," he said.

"Both of these drugs are likely to be tested in larger clinical trials in Alzheimer's disease over the next five to 10 years," Nygaard said.

"Larger clinical studies in human subjects will be needed before we can determine whether anticonvulsant therapy will be part of our future therapeutic arsenal against Alzheimer's," he added.

May 08
'Coffee waste' could lead to new nutritious foods
The antioxidant effects of coffee by-products are 500 times greater than those found in vitamin C and could be employed to create functional foods with significant health benefits, a new research has found.

Coffee silverskin (the epidermis of the coffee bean) is usually removed during processing, after the beans have been dried, while the coffee grounds are normally directly discarded.

It has traditionally been assumed that these by-products - coffee grounds and coffee silverskin -- have few practical uses and applications. So they end up in landfills causing considerable knock-on effect on the environment.

The new research demonstrates the powerful antioxidant and antimicrobial properties of the coffee grounds and silverskin, which are highly rich in fibre and phenols.

"They also contain high levels of melanoidins, which are produced during the roasting process and give coffee its brown colour," said lead researcher Jose Angel Rufian Henares, professor at University of Granada in Spain.

"The biological properties of these melanoidins could be harnessed for a range of practical applications, such as preventing harmful pathogens from growing in food products," Rufian Henares said.

However, he also added, "If we are to harness the beneficial prebiotic effects of the coffee by-products, first of all we need to remove the melanoidins, since they interfere with such beneficial prebiotic properties."

The researchers concluded that processed coffee by-products could potentially be recycled as sources of new food ingredients.

This would also greatly diminish the environmental impact of discarded coffee by-products.

The study was published in the academic journal Food Science and Technology.

May 07
Diabetes accelerates brain ageing, reveals new study
A new study has indicated that brains of people with type 1 diabetes show signs of accelerated ageing that correlate with slower information processing.

The study conducted at University of Pittsburgh Schools indicate that clinicians should consider screening middle-aged patients with type 1 diabetes for cognitive difficulties.

Senior author Caterina Rosano, MD, MPH, associate professor in Pitt Public Health's Department of Epidemiology, said that severity of cognitive complications and cerebral small vessel disease which can starve the brain of oxygen is much more intense than they expected, but it can be measured in a clinical setting. Rosano continued that further study in younger patients is needed, but it stands to reason that early detection and intervention such as controlling cardiometabolic factors and tighter glycemic control, which help prevent microvascular complications also could reduce or delay these cognitive complications.

The people with type 1 diabetes were all participants in the Pittsburgh Epidemiology of Diabetes Complications Study.

The MRIs showed that 33% of the people with type 1 diabetes had moderate to severe levels of white matter hyperintensities (markers of damage to the brain's white matter, present in normal aging and neurological disorders) compared with 7% of their non-diabetic counterparts.

On three cognitive tests that measure abilities such as information-processing speed, manual dexterity and verbal intelligence, the people with type 1 diabetes averaged lower scores than those without the condition. Among only the participants with type 1 diabetes, those with greater volumes of white matter hyperintensities averaged lower cognitive scores than those with smaller volumes, though the difference was less pronounced.

Lead author Karen A Nunley, Ph D , postdoctoral fellow in Pitt Public Health's neuroepidemiology program said that people with type 1 diabetes were living longer than ever before, and the incidence of type 1 diabetes was increasing annually.

The research will be published in the May 19 issue of the journal Neurology.

May 06
Sleepwalking may run in family: Study
Children are seven times more likely to sleepwalk if both their parents have a history of sleepwalking, according to a new study.

More than 60 per cent of children developed sleepwalking when both their parents were sleepwalkers in a study among kids born in the Canadian province of Quebec, researchers said.

The study also found that children with one parent who was a sleepwalker had three times the odds of becoming a sleepwalker compared with children whose parents did not sleepwalk.

Sleepwalking is a common childhood sleep disorder that usually disappears during adolescence. Sleep terrors are another early childhood sleep disorder often characterised by a scream, intense fear and a prolonged period of inconsolability.

The two disorders (also known as parasomnias) share many of the same characteristics and arise mainly from slow-wave sleep, according to the study.

Jacques Montplaisir, of the Hopital du Sacre-Coeur de Montreal, looked at the prevalence of sleepwalking and sleep terrors during childhood; any link between early sleep terrors and sleepwalking later in childhood; and the degree of association between parental history of sleepwalking and the presence of sleepwalking and sleep terrors in children.

Montplaisir and team analysed sleep data from a group of 1,940 children born in Quebec in 1997 and 1998 and studied in 1999 to 2011.

The authors found an overall childhood prevalence of sleep terrors (ages one and a half to 13 years) of 56.2 per cent. There was a high prevalence of sleep terrors (34.4 per cent) at one and a half years of age but that prevalence decreased to 5.3 per cent at age 13.

The overall childhood prevalence of sleepwalking (ages two and a half to 13 years) was 29.1 per cent. Sleepwalking was relatively infrequent during the preschool years but the prevalence increased steadily to 13.4 per cent by age 10 years.

Study results showed that children who had sleep terrors during early childhood were more likely to develop sleepwalking later in childhood at age 5 years or older than children who did not experience sleep terrors in early childhood (34.4 per cent vs 21.7 per cent).

Children's odds of sleepwalking increased based on the sleepwalking history of their parents.

Children with one parent who was a sleepwalker had three times the odds of becoming a sleepwalker compared with children whose parents did not sleepwalk; and children whose parents both had a history of sleepwalking had seven times the odds of becoming a sleepwalker, according to the results.

"These findings point to a strong genetic influence on sleepwalking and, to a lesser degree, sleep terrors. This effect may occur through polymorphisms in the genes involved in slow-wave sleep generation or sleep depth," researchers said.

May 05
Exercise key to healthy brain among the ageing
Physical activities such as walking helps older adults lessen age-related decline in brain structure, says a new research.

The researchers found the relationship between fitness and brain structure only in older adults, but not younger adults.

"We found that higher levels of cardiorespiratory fitness were associated with enhanced brain structure in older adults," explained study author Scott Hayes, assistant professor of psychiatry at Boston University School of Medicine.

"We found that physical activities that enhance cardio-respiratory fitness, such as walking, are inexpensive, accessible and could potentially improve quality of life by delaying cognitive decline and prolonging independent function," he noted.

Cardio-respiratory fitness refers to the ability of the circulatory and respiratory systems to supply oxygen to skeletal muscles during sustained physical activities.

For the study, the researchers compared younger adults (age 18-31) to older adults (age 55-82). All participants had magnetic resonance imaging (MRIs) taken of their brains and their cardiorespiratory (heart and lung) fitness was measured while they exercised on a treadmill.

The researchers found cardio-respiratory fitness was positively linked to the structural integrity of white matter fiber bundles in the brain in the older adults, while no such association was observed in younger adults.

"We hope this study provides additional motivation for older adults to increase their levels of physical activity, which positively impacts health, mood, cognition and the brain," Hayes said.

The findings appeared online in the journal Annals of Clinical and Translational Neurology.

May 04
Asthma may be easier to control than previously believed
If you suffer from asthma then you know that controlling the condition is the key to ensuring good quality of life. Now, scientists have come up with a bunch of tips and to help you do just that.

Allergist James Sublett, MD, at the American College of Allergy, Asthma and Immunology (ACAAI), said that patients were prone to hospitalization because they weren't aware of simple measures that can asthma under control. He added that sufferers are also not aware that uncontrolled asthma is dangerous and far costlier.

ACAAI has put together this list of facts to help you understand how you can not only achieve better outcomes with your asthma, but also start breathing easier.

Asthma sufferers may not realize that getting their symptoms under control can improve their overall health. Controlled asthma means:

No or fewer asthma symptoms even at night or after exercise.

Prevention of all or most asthma attacks.

Participation in all activities, including exercise.

No emergency room visits or hospital stays.

Less need for quick-relief medicines.

Minimize side effects from asthma medications.

Immunotherapy (allergy shots) can reduce sensitivity to the allergens that trigger asthma attacks and significantly reduce the severity of the disease. It might even prevent the development of asthma in some children with seasonal allergies.

Asthma is a complex condition, and exists in a variety of forms, including allergic asthma, exercise-induced asthma and work-related asthma. Each type can have different symptoms and triggers, and each requires a different approach to diagnosis and treatment. Similarly, each patient also has a different set of symptoms and triggers, which sets off an asthma attack.

According to the newly updated ACAAI Asthma Management and the Allergist: Better Outcomes at Lower Cost, asthma care provided by allergists is associated with better patient outcomes across a range of important markers.

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