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Mar 25
Men who exercise more have better erectile and sexual function
Washington: A new study has examined that men who exercise more have better erectile and sexual function, regardless of race.

The study conducted at Cedars-Sinai Medical Center is the first to link the benefits of exercise in relation to improved erectile and sexual function in a racially diverse group of patients.

Nearly 300 study participants self-reported their activity levels, which researchers then categorized as sedentary, mildly active, moderately active or highly active. The subjects also self-reported their sexual function, including the ability to have erections, orgasms, the quality and frequency of erections and overall sexual function.

Results found that men who reported more frequent exercise, a total of 18 metabolic equivalents, or METS, per week, had higher sexual function scores, regardless of race. MET hours reflect both the total time of exercise and the intensity of exercise. A total of 18 METS can be achieved by combining exercises with different intensities, but is the equivalent of two hours of strenuous exercise, such as running or swimming, 3.5 hours of moderate exercise, or six hours of light exercise.

Stephen Freedland, MD, co-author on the study and director of the Center for Integrated Research in Cancer and Lifestyle in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, cautions that exercise should be tailored for each individual.

Freedland added that when it came to exercise, there was no one-size-fits-all approach, however, they were confident that even some degree of exercise, even if less intense, was better than no exercise at all.

The study is published in the Journal of Sexual Medicine.

Mar 24
Soaring antibiotic use in animals fuels "super bug" fears
Developing countries are pumping livestock full of antibiotics at such a startling rate that they are dramatically increasing the risk of creating drug-resistant "super bugs", scientists warned on Monday.

Antibiotic use in animals is expected to surge by two thirds globally between 2010 and 2030, while doubling in emerging giants like China, Brazil, India and Russia, according to a Princeton University study.

It warned that the practice is pushing us closer to a time when common infections could become a death sentence because they will no longer respond to drugs.

Consumption of meat, milk and eggs is growing fast in many developing and middle-income countries.

Urbanisation, increased wealth and changing diets mean industrial livestock producers are expanding rapidly.

They are relying on antibiotics to keep disease at bay in the short-term, said co-author Tim Robinson, a scientist with the International Livestock Research Institute (ILRI).

But the systematic use of low doses on livestock is creating "perfect conditions to grow resistant bacteria", he told the Thomson Reuters Foundation.

Bacteria like E. coli and salmonella are already becoming resistant to antibiotics, Robinson said, increasing fears that these diseases will endanger humans.

Passed from animals to people through food contamination, direct contact or the broader environment, antibiotic resistant bacteria will make it harder for doctors to treat basic infections or other ailments, he said.

The study by experts from Princeton, ILRI and the National Institutes of Health is the first to measure global antibiotic consumption by livestock.

Asia is the main region of concern as this is where demand for livestock products is growing dramatically while regulations governing antibiotic use in animals are either non-existent or not publicly available, scientists say.

China`s livestock industry alone could soon be consuming nearly one third of the world`s antibiotics.

The five countries with the largest projected increases in antibiotics consumption are Myanmar (205 percent), Nigeria (163 percent), Peru (160 percent) and Vietnam (157 percent).

Increasing food production for the estimated 805 million people who go to bed hungry every night will require a new approach that is less reliant on intensive, antibiotic-fuelled breeding, Robinson said.

"Poor livestock producers aren`t responsible for this problem, it`s the big firms rushing to meet demand in the growing cities," he added.

But the poor will be worst affected if resistant bacteria transfer to humans more often, he said, because they will be the least able to afford the bigger and more frequent doses of drugs required to fight infections.

Mar 19
Australian research brings malaria vaccine closer
A team of Australian researchers are a step closer to finding a vaccine to prevent malaria, after discovering patterns in the human immune system that help fight the disease in its early stages.

The team from the Burnet Institute in Melbourne collaborated with universities from Australia, Britain and Africa to develop the research over a 10-year period, Xinhua news agency reported.

The study, published in the medical journal Immunity, concluded that the human immune system can trigger a response that calls upon proteins in red blood cells, and the head of the Burnet Institute's biomedical research centre, James Beeson, said that this development could be used in creating a vaccine for the disease.

"The immune system needs to produce specific antibodies and they are proteins that the immune system produces that combat infections," he told the Australian Broadcasting Corporation (ABC) on Wednesday.

"Those antibodies recognise the malaria infection or parasites as we call them. Then they need to recruit these other proteins that are in the bloodstream, known as complement proteins.

"And then the two together -- the antibodies and the complement -- perform a double hit on the malaria infection and stop it from getting inside red blood cells, and therefore stopping the infection and the subsequent disease.

"We're hoping that this new knowledge opens up a new strategy to generate or develop highly effective vaccines."

Researchers have been seeking a vaccine for the disease for decades, but this natural development in the human immune system brings the chances of a vaccine that much closer.

Malaria is one of the world's biggest killers. In Africa alone, more than 600,000 people die of this each year, and Beeson said the research was a huge step towards eliminating the disease worldwide.

"Despite recent advances in malaria control and prevention globally, it remains a huge burden and a vaccine is desperately needed," he said in a statement.

Beeson said that a "double blow" knockout punch was required to kill the disease, as malaria can adapt to fight off drugs used to treat it.

He said the results were encouraging, but there was much work still to be done.

"There are still a number of questions to address before we can develop a highly effective vaccine," he said.

Mar 18
Emotions can dictate how you eat
A new book has observed that emotions can dictate how you eat and also demonstrates what kind of eater one is.

Hypnotherapist Marisa Peer in her new book suggests that there are different kinds of eaters like one can be an emotional eater or a habitual eater or a destructive eater or an angry eater, the Daily Express reported.

Emotional eaters find temporary relief from loneliness, boredom and sadness when they fill their stomachs with refined carbohydrates. The feeling of fullness from eating soft, sweet foods such as cake and ice cream leads to a temporary feeling of satisfaction and calmness.

Habitual eaters will eat whenever they are given the opportunity, without being aware of whether they are actually hungry.

Destructive eaters often feel uncomfortable if they are not in control of their own eating, whereas, angry eaters like crunchy or chewy foods because they find chewing hard helpful when they are feeling tense or wound up.

Mar 17
Energy drinks raise resting blood pressure
Energy drinks may increase the risk of cardiac events, warns a new study.

Healthy young adults who don't consume caffeine regularly experienced a greater rise in resting blood pressure after consumption of a commercially available energy drink - compared to a placebo drink, researchers found.

We know that energy drink consumption is widespread and rising among young people. "We and others have previously shown that energy drinks increase blood pressure," said lead study author Anna Svatikova from the Mayo Clinic.

"Now we are seeing that for those not used to caffeine, the concern may be even greater," Svatikova added.

In the study, researchers alternately gave a can of a commercially available energy drink or a placebo drink to 25 healthy young adults, age 19 to 40, and assessed changes in heart rate and blood pressure.

Blood pressure and heart rate were recorded before and 30 minutes after energy drink/placebo drink consumption, and were also compared between caffeine-naive participants (those consuming less than 160 mg of caffeine per day) and regular caffeine users.

Participants experienced a marked rise in blood pressure after consuming the energy drink as compared to the placebo.

The effect was most dramatic in people who did not typically consume much caffeine, researchers found.

Overall, the blood pressure increase was more than doubled in caffeine naive adults after consuming the energy drink versus placebo, they found.

Consumers should use caution when using energy drinks because they may increase the risk of cardiovascular problems, even among young people," Svatikova said.

The study is scheduled to be presented at the American College of Cardiology's 64th Annual Scientific Session in San Diego on March 14.

Mar 13
Eating at 'right' time key to healthy heart
A new study has revealed that eating at the right time is as important as what the person is eating in order to maintain a healthy heart.

Researchers at San Diego State University and the Salk Institute for Biological Studies found that by limiting the time span during which fruit flies could eat, they could prevent aging-and diet-related heart problems.

The researchers also discovered that genes responsible for the body's circadian rhythm are integral to this process, but they're not yet sure how.

Previous research has found that people who tend to eat later in the day and into the night have a higher chance of developing heart disease than people who cut off their food consumption earlier.

The researchers also sequenced the RNA of the flies at various points in the experiment to find which of their genes had changed as a result of time-restricted feeding.

They identified three genetic pathways that appear to be involved: the TCP-1 ring complex chaperonin, which helps proteins fold; mitochondrial electron transport chain complexes (mETC); and a suite of genes responsible for the body's circadian rhythm.

Girish Melkani, a biologist at SDSU whose research focuses on cardiovascular physiology was optimistic that the results could one day translate into cardiac- and obesity-related health benefits for humans.

The study is published in Science.

Mar 12
High vitamin D levels may lead to stroke
Too high levels of vitamin D in the blood may increase your risk of dying from a stroke, warns a study.

In terms of public health, a lack of vitamin D has long been a focal point and several studies have shown that too low levels can prove detrimental to our health.

The new study, therefore, suggests that the level of vitamin D in our blood should neither be too high nor to low.

"If your vitamin D level is below 50 or over 100 nanomol per litre, there is a greater connection to deaths," said Peter Schwarz, professor at the University of Copenhagen in Denmark.

The researchers studied the level of vitamin D in 247,574 people and analysed their mortality rate over a seven-year period. In that time 16,645 patients had died.

"We have looked at what caused the death of patients, and when numbers are above 100, it appears that there is an increased risk of dying from a stroke or a coronary," Schwarz added.

"In other words, levels of vitamin D should not be too low, but neither should they be too high. Levels should be somewhere in between 50 and 100 nanomol per litre, and our study indicates that 70 is the most preferable level," Schwartz explained.

That having too much vitamin D in our blood can be bad for our health has never been proven before, and it may have great influence on our future intake of nutritional supplements.

The study appeared in the Journal of Endocrinology and Metabolism.

Mar 11
Here's how 'blood group O' protects against malaria
We all know that malaria parasites evade the human immune system while living in human red blood cells. A good news is that according to a new study, blood type O provides protection against malaria.

The study suggests that a protein secreted by parasites called RIFIN, plays an important role in providing protection against malaria in people who have blood group O.

A team of Scandinavian scientists explains the mechanisms behind the protection that blood type O provides and suggests that the selective pressure imposed by malaria may contribute to the variable global distribution of ABO blood groups in the human population.

It has long been known that people with blood type O are protected against severe malaria, while those with other types, such as A, often fall into a coma and die. Unpacking the mechanisms behind this has been one of the main goals of malaria research.

Scientists led from Karolinska Institutet in Sweden have now identified a new and important piece of the puzzle by describing the key part played by the RIFIN protein.

Using data from different kinds of experiment on cell cultures and animals, they show how the Plasmodium falciparum parasite secretes RIFIN, and how the protein makes its way to the surface of the blood cell, where it acts like glue. The team also demonstrates how it bonds strongly with the surface of type A blood cells, but only weakly to type O.

Principal investigator Mats Wahlgren describes the finding as conceptually simple, however, since RIFIN is found in many different variants, it has taken the research team a lot of time to isolate exactly which variant is responsible for this mechanism.

Wahlgren said that their study ties together previous findings, adding they can explain the mechanism behind the protection that blood group O provides against severe malaria, which can, in turn, explain why the blood type is so common in the areas where malaria is common.

Wahlgren added that in Nigeria, for instance, more than half of the population belongs to blood group O, which protects against malaria.

The study was published in Nature Medicine.

Mar 10
Genetically modified soybean oil equally 'unhealthy'
If you thought that genetically modified (GM) soybean oil is any better than the normal soybean oil, you might be disappointed.

A study on mice by an Indian American researcher shows that genetically modified (GM) soybean oil is as unhealthy as conventional soybean oil. The study found that GM soybean oil too induces obesity, diabetes and fatty liver.

"The GM soybean oil has zero grams trans fat and more of the monounsaturated fats that are considered heart healthy," said lead researcher Poonamjot Deol of the University of California-Riverside.

"But it had not been tested for long term metabolic effects until our current study," Deol noted.

GM soybean oil, however, does not cause insulin resistance - the inability to efficiently use the hormone insulin.

The researchers compared the effects of both oils in experiments done in the lab on mice. Four groups of mice, each group comprising 12 mice, were given different diets for 24 weeks.

The control group received a low-fat diet (5 percent of daily calories from fat), while the other groups received a diet with 40 percent of daily calories from fat.

The fourth group had 41 percent of the saturated fat replaced with the GM soybean oil.

The mice fed a diet with either of the soybean oils had worse fatty liver, glucose intolerance and obesity than the group that got all their fat from coconut oil.

But the mice whose diet included the GM soybean oil had less fat tissue than the animals that ingested regular soybean oil.

"These results indicate that linoleic acid may contribute to insulin resistance and adiposity but that another as yet unidentified component of the soybean oil affects the liver and overall weight gain," Deol pointed out.

The study was presented at Endocrine Society's 97th annual meeting in San Diego.

Mar 09
Onion extract lowers high blood sugar, cholesterol
Combined with the antidiabetic drug metformin, an onion extract can help lower high blood glucose (sugar) and total cholesterol levels among diabetics, says a study.

The onion extract used for the experiment in rats was a crude preparation from onion bulb.

"We need to investigate the mechanism by which onion brought about the blood glucose reduction," said lead investigator Anthony Ojieh from the Delta State University in Abraka, Nigeria.

"We do not yet have an explanation," Ojieh noted.

To rats with medically induced diabetes, the researchers gave metformin and varying doses of onion extract -- 200, 400 and 600 milligrams per kilograms of body weight daily (mg/kg/day) -- to see if it would enhance the drug's effects.

Two doses of onion extract, 400 and 600 mg/kg/day, strongly reduced fasting blood sugar levels in diabetic rats by 50 percent and 35 percent, respectively, compared with "baseline" levels at the start of the study before the rodents received onion extract, Ojieh reported.

It reportedly lowered the total cholesterol level in diabetic rats, with the two larger doses again having the greatest effects.

Onion extract led to an increase in average weight among nondiabetic rats but not diabetic rats.

"Onion is not high in calories. However, it seems to increase the metabolic rate and, with that, to increase the appetite, leading to an increase in feeding," Ojieh said.

The findings were presented at ENDO 2015, the annual meeting of the Endocrine Society in San Diego, California.

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