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Feb 20
Exercise lessens heart problems in the elderly
Every minute of physical activity contributes to reducing risk of heart attack and coronary death in older adults with limited mobility, says a study.

"Reducing time spent being sedentary even by engaging in low-intensity activities could have important cardiovascular benefits for older adults with mobility limitations," said senior author of the study Thomas Buford from the University of Florida Institute on Aging in Gainesville, Florida.

For the study, the researchers measured movement with accelerometers in 1,170 people aged 74-84 at eight centers across the US who had physical limitations but could walk 400 metres.

Using factors such as age, cholesterol levels and blood pressure, the researchers calculated participants' predicted 10-year risk of heart attack or coronary death.

For every 25-30 minutes a participant was sedentary per day, his/her predicted risk was one percent higher.

Physical activity like slow walking or light housekeeping was linked to higher HDL or high-density lipoprotein ("good") cholesterol levels in people with no history of heart disease.

Participants on an average spent only an hour or less with physical activity such as moderate walking.

Generally, most physical activity recommendations suggest that adults should engage in higher intensity activities to improve or maintain health. But that level might not be realistic for sedentary older adults with limited mobility, researchers said.

"Encouraging individuals to just reduce the amount of time they spend being sedentary may have important cardiovascular benefits," Buford noted.

The study appeared in the Journal of the American Heart Association.

Feb 19
Unhealthy eating habits triumphing over healthy eating worldwide
Even though healthy eating habits have increased over the past two decades, consumption of unhealthy food had outpaced it in most world regions.

According to the first study to assess diet quality in 187 countries covering almost 4.5 billion adults, the diet patterns vary widely by national income, with high-income countries generally having better diets based on healthy foods (average score difference +2.5 points), but substantially poorer diets due to a higher intake of unhealthy foods compared with low-income countries (average score difference -33.0 points). On average, older people and women seem to consume better diets.

The highest scores for healthy foods were noted in several low-income countries (eg, Chad and Mali) and Mediterranean nations (eg, Turkey and Greece), possibly reflecting favourable aspects of the Mediterranean diet. In contrast, low scores for healthy foods were shown for some central European countries and republics of the former Soviet Union (eg, Uzbekistan, Turkmenistan, and Kyrgyzstan).

Of particular interest was that the large national differences in diet quality were not seen, or were far less apparent, when overall diet quality (including both healthy and unhealthy foods) was examined as previous studies have done.

Dr Imamura said that as per the projections, by 2020, non-communicable diseases would account for 75 percent of all deaths. Improving diet has a crucial role to play in reducing this burden. Policy actions in multiple domains are essential to help people achieve optimal diets to control the obesity epidemic and reduce non-communicable diseases in all regions of the world.

According to Dr Mozaffarian, there was an urgent need to focus on improving diet quality among poorer populations, as under-nutrition would be rapidly eclipsed by obesity and non-communicable diseases, as is already being seen in India, China, and other middle-income countries.

Carlo La Vecchia from the University of Milan in Italy and Lluis Serra-Majem from the University of Las Palmas de Gran Canaria in Spain said that the main focus of the paper remains the need to understand the agricultural, trade, and food industry, and health policy determinants to improve dietary patterns and nutrition in various areas, taking into account the traditional characteristics of diets worldwide.

The study is published in The Lancet Global Health journal.

Feb 18
600 million people will have diabetes by 2035: Report
A report looking at the prevalence of type-2 diabetes worldwide has warned that an estimated 600 million people will suffer from the disease by 2035.

The report, "Rising to the Challenge",was published at the World Innovation Summit for Health (WISH) which kicked off here Tuesday.

The report urges policymakers to address the serious, urgent and universal diabetes challenge.

According to the report, the cost of direct healthcare for diabetes and its complications was around 11 per cent of total healthcare costs worldwide in 2014, which is equivalent to USD 612 billion and is greater than the entire GDP of countries such as Nigeria or Sweden.

"Improving disease management for people with diabetes to reduce complication rates, establish effective surveillance to identify and support those at risk of type 2 diabetes and deliver a range of interventions to help create an environment focused on prevention," the report said while proposing three clinical goals.

The expert report also said that type-2 diabetes currently affects about 350 million people worldwide. It said that 80 per cent of the world's diabetic population lives in countries where only 20 per cent of the global budget for healthcare is spent.

"Doing nothing is not an option, so it is vital that we share and learn from best practice examples from around the world and put interventions in place," said Stephen Colagiuri, Professor of Metabolic Health at University of Sydney, Australia, who led the team that published the report.

The report focuses on proposing actionable recommendations which enable policymakers to improve disease management, increase effective surveillance and implement prevention strategies, based on innovative approaches from around the world.

This is one of eight reports being presented at the WISH Summit 2015 where leading international health experts, leaders and policymakers are participating to discuss innovative solutions to some of the most pressing global health challenges.

Type-2 diabetes is a metabolic disorder where high levels of blood sugar occur and if left untreated, it can cause heart attacks, strokes, blindness and kidney failure.

Feb 17
Menopause plays no role in sleep difficulties
Menopause neither increases nor creates any difficulty in sleeping amongst women, says a University of Pennsylvania study.

According to the researchers, women in their late thirties and forties who have trouble sleeping are more than three times more likely to suffer sleep problems during menopause than women who have an easier time getting shut-eye.

Only 25 percent of women who had reported no earlier sleep problems developed moderate or severe insomnia or other sleep disturbances during a 16-year period around menopause. What's more, the researchers say that these sleep woes did not appear to be caused by menopause itself, which may quell common fears about symptoms associated with this phase of life. The study is among the first to document long-term sleep patterns in women in the years before, during and after menopause.

Lead author, Ellen W. Freeman, said that a small subgroup of women with only mild sleep disturbance prior to menopause also experienced worsening sleep disturbance during the transition, but their results show that for the majority of women, menopause does not further exacerbate existing sleep problems or cause new ones.

The study assessed annually the sleep patterns of 255 women participating in the Penn Ovarian Aging Study who reached natural menopause during a 16-year period (1996-2012). At enrollment, all women were aged 35 to 48 years and premenopausal, with 28 percent reporting moderate-to-severe sleep disturbances, which is similar to the prevalence of insomnia symptoms among adults, and 56 percent reporting no sleep disturbances at all. Over the 16 year period, 82 percent of the sample experienced moderate-to-severe issues with sleep, while only 7 percent had no poor sleep.

The study also found that hot flashes are strongly associated with poor sleep as expected, but a large proportion of poor sleep in menopausal women occurred without hot flashes. The finding, Freeman says, indicates that sleep difficulties in the transition to menopause in generally healthy women should not automatically be imputed to ovarian decline.

Freeman added that clinicians should be alert to the strong possibility that poor sleep in women approaching menopause is not simply caused by menopause or hot flashes.

Possible reasons for poor sleep instead may include health problems, anxiety, and stress, Freeman said.

The study is published in the journal Menopause.

Feb 16
HPV vaccine may prevent multiple cancer types
The human papilloma virus (HPV) vaccine, Cervarix, not only has the potential to prevent cervical cancer but also other HPV-caused common cancer types, shows a multinational clinical trial, involving nearly 20,000 young women.

That effectiveness endured for the study's entire follow-up, of up to four years, the researchers noted.

"The study confirms that targeting young adolescent girls before sexual debut for prophylactic HPV vaccination has a substantial impact on the incidence of high grade cervical abnormalities," said corresponding author Dan Apter, director, The Sexual Health Clinic, Family Federation of Finland, Helsinki.

The vaccine was extremely effective in young women who had never been infected with HPV.

It protected nearly all from HPV-16 and 18, and protected 50-100 percent against different grades of precancerous transformation of cervical cells caused by other strains of HPV.

The women were followed for up to four years post-vaccination.

The vaccine was distinctly more effective among those aged 15-17 than those aged 18-25, underscoring the value of vaccinating young adolescents, Apter added.

The lower efficacy in the oldest age group may result from a larger proportion of women in that age group having had persistent infections at the time of vaccination, he said.

The study is the final report from the Papilloma Trial Against Cancer in Young Adults (PATRICIA), a multinational clinical trial, encompassing 14 countries in Europe, the Asia-Pacific region, North America, and Latin America, and it confirms previous reports in this trial.

The study appeared in the journal Clinical and Vaccine Immunology.

Feb 13
Coming soon, juicy steaks made of plants
Now, foodies might be in for a treat as one might be able to gorge on juicy steaks made of plants.

A new research has shed light on meat-like foods produced by plants suggesting that many people crave requires a lot of animals raised on huge, unsustainable amounts of plant protein.

The research conducted by American Chemical Society is trying to focus that plant protein should be consumed by humans itself instead of giving so much of it to animals as feed.

Melody M. Bomgardner, a senior editor at C and EN, notes that they need protein, which their bodies break down into essential amino acids, to maintain good health.

Low-carb diets and research showing the benefits of protein have boosted the trendiness of this macronutrient and as a result, on average Americans consume more protein than they need and raising livestock, the major source of dietary protein in the U.S., puts a tremendous strain on water resources and arable land.

Americans are increasingly turning to plants for protein out of concern that red meat can lead to heart disease and obesity. Food manufacturers are paying attention. They have quickly responded with a growing range of protein-packed soy, pea and algae products but to win over more steak lovers, scientists are still working toward the ultimate goal: plant protein that looks, feels and tastes like meat.

The study is published in journal Chemical and Engineering News (C and EN).

Feb 12
Here's why antibiotics can have unwanted side effects
A new study has revealed that antibiotics have an impact, which is broader and more complex than previously known, on the microorganisms that live in an animal's gut.

The research at Oregon State University helps explain in much more detail why antibiotics can have unwanted side effects, especially in disrupting the natural and beneficial microbiota of the gastrointestinal system, and also suggests that powerful, long-term antibiotic use can have even more far-reaching effects.

Scientists now suspect that antibiotic use, and especially overuse, can have unwanted effects on everything from the immune system to glucose metabolism, food absorption, obesity, stress and behavior.

The issues are rising in importance, since 40 percent of all adults and 70 percent of all children take one or more antibiotics every year, not to mention their use in billions of food animals. Although when used properly antibiotics can help treat life-threatening bacterial infections, more than 10 percent of people who receive the medications can suffer from adverse side effects.

Researcher Andrey Morgun said that prior to this most people thought antibiotics only depleted microbiota and diminished several important immune functions that take place in the gut, which actually is only about one-third of the picture.

Morgun added that they also kill intestinal epithelium and destruction of the intestinal epithelium is important because this is the site of nutrient absorption, part of our immune system and it has other biological functions that play a role in human health.

The research also found that antibiotics and antibiotic-resistant microbes caused significant changes in mitochondrial function, which in turn can lead to more epithelial cell death.

Morgun concluded that when the host microbe communication system gets out of balance it can lead to a chain of seemingly unrelated problems.

The work is published online in the journal Gut.

Feb 11
Now simple blood test to detect risk of dementia
Now you can test the possibility of developing dementia with a prick of a needle.

As opposed to cardiovascular diseases, where the level of cholesterol in our blood indicates the risk of cardiac arrest, there are no such trustworthy markers in our blood in terms of diagnosing the risk of dementia setting in. However, Scientists at Rigshopitalet, Herlev Hospital and the University of Copenhagen have now identified a new biomarker, measurable in a simple blood test, which will help predict the onset of dementia.

Assistant clinical and research professor Ruth Frikke-Schmidt, said that the blood test would help provide a more precise risk evaluation of a citizen's risk of developing dementia later in life.

The blood test would enable an earlier and more focused prevention effort, thus prolonging the onset of the illness and raising the individual's quality of life, she added. Researchers hope that with time, this new blood test will be applicable in clinical practice.

In the study, researchers show that a low level of the biomarker, the so-called apolipoprotein E, in our blood, increases the risk of developing dementia in the future. This was revealed in comprehensive studies of the general public, the Herlev-Oesterbro Study and the Oesterbro Study, involving 76,000 people.

The study is published in th internationally acclaimed journal, the Annals of Neurology.

Feb 10
How to stop common cold, HIV virus in their tracks found
Scientists have cracked the code used by a major group of viruses to spread infections such as the common cold, HIV, hepatitis C and polio in the human body, a finding that could lead to new drugs to combat the diseases.

Until now, scientists had not noticed the code, which had been hidden in plain sight in the sequence of the ribonucleic acid (RNA) that makes up this type of viral genome.

Researchers from the University of Leeds and University of York unlocked its meaning and demonstrated that jamming the code can disrupt virus assembly. Stopping a virus assembling can stop it functioning and therefore prevent disease.

"If you think of this as molecular warfare, these are the encrypted signals that allow a virus to deploy itself effectively," said Peter Stockley, Professor of Biological Chemistry in the Leeds' Faculty of Biological Sciences.

"Now, for this whole class of viruses, we have found the 'Enigma machine' - the coding system that was hiding these signals from us. We have shown that not only can we read these messages but we can jam them and stop the virus' deployment," said Stockley, who led the study.

Single-stranded RNA viruses are the simplest type of virus and were probably one of the earliest to evolve. However, they are still among the most potent and damaging of infectious pathogens, researchers said.

Rhinovirus (which causes the common cold) accounts for more infections every year than all other infectious agents put together (about 1 billion cases), while emergent infections such as chikungunya and tick-borne encephalitis are from the same ancient family.

Other single-stranded RNA viruses include the hepatitis C virus, HIV and the winter vomiting bug norovirus.

The group used single-molecule fluorescence spectroscopy to watch the codes being used by the satellite tobacco necrosis virus, a single stranded RNA plant virus.

"We have understood for decades that the RNA carries the genetic messages that create viral proteins, but we didn't know that, hidden within the stream of letters we use to denote the genetic information, is a second code governing virus assembly," said Dr Roman Tuma, Reader in Biophysics at Leeds.

The research was published in the journal PNAS.

Feb 09
Drinking green tea better than taking supplements
If you are planning to take supplements based on green tea extracts as a measure to lose weight, think again. Researchers have warned that the supplements could result in harmful side effects including liver toxicity.

Drinking green tea, instead of taking the supplements, could help you enjoy the benefits associated with the beverage while avoiding the risk of liver toxicity, they pointed out.

Also, drinking green tea in the weeks before taking supplements likely reduces risk of side effects, the findings showed.

"Drinking green tea rather than taking supplements will allow you to realise the benefits and avoid the risk of liver toxicity," explained Josh Lambert, associate professor of food science at College of Agricultural Sciences, Pennsylvania State University.

Tea is rich in catechins, polyphenols that are natural antioxidants. A number of animal studies have shown the preventive effects of green tea polyphenols against obesity.

For the new study, the researchers gave mice high doses of the green tea polyphenol epigallocatechin-3-gallate (EGCG).

The dosage was equivalent to the amount of the polyphenol found in some dietary supplements taken by humans.

Dietary pretreatment with the green tea polyphenol protects mice from liver toxicity caused by subsequent high oral doses of the same compound, the findings showed.

"We believe this study indicates that those who are chronic green tea consumers would be less sensitive to potential liver toxicity from green-tea-based dietary supplements," Lambert noted.

He, however, added that the beneficial effects that people have reported as being associated with green tea are the result of dietary consumption rather than the use of supplements.

The study appeared in the journal Food and Chemical Toxicology.

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