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Apr 04
Men who started smoking before age 11 likelier to have fatter sons
Researchers have revealed men, who started smoking regularly before the age of 11 had sons who, on average, had 5-10kg more body fat than their others by the time they were in their teens.

The researchers at the University of Bristol say this could indicate that exposure to tobacco smoke before the start of puberty may lead to metabolic changes in the next generation.

The effect, although present, was not seen to the same degree in daughters. Many other factors, including genetic factors and the father's weight, were taken into account but none could explain the change. In fact, the fathers who started smoking before 11 tended to have lower BMIs (body mass index) on average.

The effect was not seen in the sons of men who started smoking after the age of 11, suggesting that the period before the start of puberty is a particularly sensitive period for environmental exposures.

Of the 9,886 fathers enrolled in the study, 5,376 (54 per cent) were smokers at some time and, of these, 166 (3 per cent) reported smoking regularly before the age of 11.

When measured at age 13, 15 and 17, the sons of the men in the latter category had the highest BMIs at each time point compared with the sons of men who had started smoking later or who had never smoked. More precisely, these boys had markedly higher levels of fat mass (recorded using whole-body scans), ranging from an extra 5kg to 10kg between ages 13 and 17.

The research has been published in the European Journal of Human Genetics.

Apr 04
Circumcision benefits far outweigh its risks
In a new study, researchers have shown that the benefits of infant male circumcision exceed the risks by over 100 to 1.

Brian Morris, Professor Emeritus in the School of Medical Sciences at the University of Sydney and his colleagues in Florida and Minnesota found that over their lifetime half of uncircumcised males will contract an adverse medical condition caused by their foreskin.

The findings add considerable weight to the latest American Academy of Pediatrics policy that supports education and access for infant male circumcision.

Whereas circumcision rates have risen in white men to 91 percent, in black men to 76 percent, and in Hispanic men to 44 percent, the study authors found an alarming decrease in infants. To get the true figures they had to correct hospital discharge data for underreporting. This showed that circumcision had declined from a high of 83 percent in the 1960s to 77 percent today.

There seemed to be two major reasons for the fall - one is a result of demographic changes, with the rise in the Hispanic population. Hispanic families tend to be less familiar with the custom, making them less likely to circumcise their baby boys, while the other is the current absence of Medicaid coverage for the poor in 18 US states. In those states circumcision is 24 percent lower.

"The new findings now show that infant circumcision should be regarded as equivalent to childhood vaccination and that as such it would be unethical not to routinely offer parents circumcision for their baby boy. Delay puts the child's health at risk and will usually mean it will never happen," Professor Morris said.

In infancy the strongest immediate benefit is protection against urinary tract infections (UTIs) that can damage the kidney in half of babies who get a UTI. Morris and co-investigator Tom Wiswell, MD, Center for Neonatal Care, Orlando, showed last year that over the lifetime UTIs affect 1 in 3 uncircumcised males.

In a landmark systematic review, Morris, with John Krieger, MD, Department of Urology, University of Washington, Seattle, showed that there is no adverse effect of circumcision on sexual function, sensitivity, or pleasure. This helped dispel one myth perpetuated by opponents of the procedure.

The study has been published in Mayo Clinic Proceedings.

Apr 03
Indian American scientist finds why cholesterol worsens in winter
Cholesterol levels usually go up in colder months - a trend that may be driven by behavioural changes that occur with the changing seasons, new research by an Indian American researcher shows.

While previous studies have shown that heart attacks and heart-related deaths increase during the winter, researchers at Johns Hopkins' Ciccarone Center for the Prevention of Heart Disease were interested in finding out whether cholesterol parameters might follow a similar pattern.

They studied a massive data representing 2.8 million adults - the largest study so far to look at seasonal lipid trends in adults.

"We found that people tend to have worse cholesterol numbers on average during the colder months than in the warmer months - not by a very large amount, but the variation is significant," said Parag Joshi, a cardiology fellow at Johns Hopkins Hospital.

"The data instead validates a clear seasonal pattern and underscores the need to pay attention to behaviours that are critical to minimising cardiovascular risk," Joshi said.

"In the summer, we tend to get outside, we are more active and have healthier behaviours overall," Joshi added.

"In the colder months, we tend to crawl into our caves, eat fat-laden comfort foods and get less exercise, so what we see is that LDL and non-HDL bad cholesterol markers are slightly worse," he added.

So you have a lipid signature of higher risk but it is driven by behaviours that occur with the changing seasons.

Researchers speculate the shorter days of winter - and limited time spent outside - also mean less sun exposure and, subsequently, lower concentrations of vitamin D, which has also been associated with the ratio of bad to good cholesterol.

More research is needed to further tease out what might be behind these seasonal variations, Joshi told the gathering at the American College of Cardiology's 63rd Annual Scientific Session recently.

Apr 03
New blood test could predict risk of sudden cardiac death
A researcher has found that a simple blood test can predict a person's risk for sudden cardiac death.

Samuel C. Dudley , M.D., Ph.D, chief of cardiology at the CVI, said that the primary prevention model for at-risk patients in the U.S. is to implant an ICD before a cardiac event happens. While it's better to be safe, this has led to widespread overuse of ICDs throughout the U.S. and abroad.

Samuel C. Dudley , M.D., Ph.D, chief of cardiology at the CVI, said that the primary prevention model for at-risk patients in the U.S. is to implant an ICD before a cardiac event happens. While it's better to be safe, this has led to widespread overuse of ICDs throughout the U.S. and abroad.

Dudley asserted that with this blood test, they can refine the need for such a device, and instead implant the cardiac defibrillators only in the most severe cases of sudden cardiac death risk.

The new blood test is in a pilot phase and will be validated in a large, multi-site trial led by Dudley and other researchers at Lifespan's CVI anticipated to start this fall.

The study has been published online in the Journal of the American College of Cardiology.

Apr 02
Self-healing engineered muscle grown in lab
In a major breakthrough in the field of medical research, biomedical engineers have grown self-healing muscle in the laboratory for the first time.

The strong, lab-grown muscle contracts powerfully and rapidly, integrates into mice quickly, and demonstrates the ability to heal itself both inside the laboratory and inside an animal.

The study conducted at Duke University tested the bioengineered muscle by literally watching it through a window on the back of living mouse. The novel technique allowed for real-time monitoring of the muscle's integration and maturation inside a living, walking animal.

Both the lab-grown muscle and experimental techniques are important steps toward growing viable muscle for studying diseases and treating injuries, Nenad Bursac, associate professor of biomedical engineering at Duke, said.

Through years of perfecting their techniques, a team led by Bursac and graduate student Mark Juhas discovered that preparing better muscle requires two things: well-developed contractile muscle fibers and a pool of muscle stem cells, known as satellite cells.

Every muscle has satellite cells on reserve, ready to activate upon injury and begin the regeneration process. The key to the team's success was successfully creating the microenvironments, called niches, where these stem cells await their call to duty.

The engineers are now beginning work to see if their biomimetic muscle can be used to repair actual muscle injuries and disease.

The study is published in the Proceedings of the National Academy of Sciences Early Edition.

Apr 02
Earl Grey tea could keep heart disease at bay
Here's a good news for Earl Grey tea lovers! Scientists say drinking Earl Grey tea daily could keep heart disease at bay.

According to researchers, Earl Grey or black tea contains an extract of a Mediterranean citrus fruit called bergamot, which was found to lower cholesterol as well as guard against a disease that causes more than a quarter of all deaths in the UK.

Bergamot also gives Earl Grey the distinct taste and smell that has traditionally made this tea quite popular.

The study, published in the Journal of Functional Foods, revealed that the fragrant bergamot extract contains enzymes known as HMGF (hydroxy methyl glutaryl flavonones), which can attack proteins in the body known to contribute to cardiovascular disease.

The scientists added that a dietary supplement of HMGF could be just as effective as statins in combating low-density proteins (LDL) or "bad" cholesterol.

While statins are wonder drugs used to control cholesterol, it may have side effects on patients.

Mar 29
How good sleep can help chronic pain sufferers
Researchers have suggested that chronic pain sufferers could be kept physically active by improving the quality of their sleep.

The study found that sleep was a worthy target for treating chronic pain and not only as an answer to pain-related insomnia.

Study lead-author Dr Nicole Tang said engaging in physical activity is a key treatment process in pain management. Very often, clinicians would prescribe exercise classes, physiotherapy, walking and cycling programmes as part of the treatment, but who would like to engage in these activities when they feel like a zombie?

Dr Tang and study co-author Dr Adam Sanborn examined the day-to-day association between night-time sleep and daytime physical activity in chronic pain patients.

Tang said that many of the patients struggled to stay physically active after the onset of pain and we found that chronic pain patients spontaneously engaged in more physical activity following a better night of sleep.

She said that the research points to sleep as not only an answer to pain-related insomnia but also as a novel method to keep sufferers physically active, opening a new avenue for improving the quality of life of chronic pain sufferers .

The study saw chronic pain patients wear an accelerometer that measured motor activity to monitor their physical activity round the clock for a week in their usual sleeping and living environment. Additionally, they gave ratings of their sleep quality, pain intensity and mood using a mobile electronic diary every morning on waking.

Researchers used the time-specific data to determine, for individual patients, whether the quality of their sleep had an impact on how physically active they were the following day.

Multilevel models for each of the predictors were fit, and the only reliable predictor of physical activity was sleep quality.

A comparison between multilevel models demonstrated that sleep was a better predictor of physical activity than morning ratings of pain intensity or mood.

The study has been published in journal PLOS ONE.

Mar 29
Married people have healthier hearts
Married people have something to smile about! According to a research, it has been claimed that married people, regardless of age, sex, or even cardiovascular risk factors, had significantly less chances of having any kind of cardiovascular disease than those who were single, divorced or widowed.

Married people carry a 5 percent lower risk of having any cardiovascular disease than being single.

But the study holds some bad news for the widowed and divorced people because they aremore likely to suffer from any kind of cardiovascular disease, including peripheral artery disease, cerebrovascular disease, abdominal aortic aneurysm, and coronary artery disease.

The research also found that younger married people, those under age 50, had a 12 percent lower odd of disease than younger single people.

Older couples, between the ages of 51 and 60, had 7 percent reduced risk, while those above 60 had approximately 4 percent lower odds of disease

For risk factors of cardiovascular disease, smoking was highest among divorced people (at 31 percent) and lowest in widowed people (at 22 percent); and obesity was most common in single and divorced people (at 31 percent and 30 percent, respectively). Hypertension, diabetes and being sedentary were most common in widowed people (at 77 percent, 13 percent, and 41 percent respectively.)

Mar 28
When relaxation can trigger migraine headaches
Allowing stress to build up is so dangerous that even relaxation following heightened stress can act as a trigger for migraine attacks, a new research indicates.

"This study demonstrates a striking association between reduction in perceived stress and the occurrence of migraine headaches," said Richard B Lipton, director, Montefiore Headache Center in New York.

To examine what triggers headaches, the researchers conducted a three-month electronic daily diary study which captured 2,011 diary records and 110 eligible migraine attacks in 17 participants.

The study compared levels of stress and reduction in stress as predictors of headache.

"Results were strongest during the first six hours where decline in stress was associated with a nearly five-fold increased risk of migraine onset," Lipton added.

The hormone cortisol, which rises during times of stress and reduces pain, may contribute to the triggering of headache during periods of relaxation.

"This study highlights the importance of stress management and healthy lifestyle habits for people who live with migraine," said Dawn C Buse, director of behavioural medicine at Montefiore Headache Center.

People should attempt to relax during periods of stress rather than allowing a major build up to occur, Buse added.

This could include exercising or attending a yoga class or may be as simple as taking a walk or focusing on one's breath for a few minutes, said the study that appeared in the journal Neurology.

Mar 28
WHO officially declares India polio-free
Indians have another reason to smile as the World Health Organisation (WHO) on Thursday officially declared India as a polio-free nation.

For the record, India has not reported any new case of polio for three consecutive years now.

Union Health Minister Ghulam Nabi Azad said, "This (southeast Asia) is the fourth region to be certified polio-free. The distant dream of polio eradication in the region is now a reality."

Azad said that resources were never allowed to be a problem for the campaign against polio. "It was an unbelievable operation. It is a significant step towards global eradication of polio."

Apart from India, the other countries which were given polio-free certificates were Bangladesh, Bhutan, North Korea, Thailand, Indonesia, the Maldives and Myanmar.

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