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Feb 26
Obesity epidemic in Europe fuelled by lack of exercise and high fat diet
Obesity epidemic is slowly taking over the world. The fast paced lifestyle and careless way of living has further pushed up this epidemic. The World Health Organisation (WHO) has warned that lack of physical activity and diets high in fats, salts and sugars has led to obesity and overweight is becoming "the new norm" throughout Europe.

Ahead of EU summit in Greece, the officials informed that up to 27 percent of Europe's 13-year-olds and 33 percent of 11-year-olds are overweight. Seeing the data, childhood obesity poses the gravest challenge.

As per reports, countries with the highest proportion of overweight 11-year-olds included Greece, with 33 percent, Portugal (32 percent), and Ireland and Spain, both with 30 percent.

The WHO's regional director for Europe, Zsuzsanna Jakab, said that Europeans' "perception of what is normal has shifted".Obesity is no longer seen as unnatural and overweight is now more common than unusual.

Lack of physical activity, listed by the WHO as the fourth leading cause of death globally, is now viewed as one of the major health threats affecting developed countries.

More than two thirds of people in UK over the age of 15 were insufficiently active, according to the WHO's latest data, from 2008.

According to international guidelines ,it is recommended that adults get 150 minutes moderate-intensity exercise per week, while children and adolescents should have an hour per day.

Feb 26
'Body shape index' more accurate predictor of mortality than 'body mass index'
Beware if you have excess belly fat as that might put you in danger.

A new study reveals that "body shape index" is a more accurate predictor of mortality than "body mass index" (BMI).

Nir Krakauer, an assistant professor of civil engineering in City College of New York's Grove School of Engineering, and his father, Jesse Krakauer, MD, developed a new method- A Body Shape Index (ABSI) in 2012- to determine the risk specifically associated with abdominal obesity.

Now, a follow-up study, published on February 20 by the online journal PLOS ONE, supports the father-son duo technique and confirmed that A Body Shape Index (ABSI) is a more effective predictor of mortality than body mass index, the most common measure used to define obesity.

The results tracked closely with the earlier study, which used data from the National Health and Nutrition Examination Survey (NHANES), conducted in the US between 1999 and 2004.

This provides stronger evidence that ABSI is a valid indicator of the risk of premature death across different populations.

The study also showed that unlike BMI, ABSI incorporates waist circumference into its calculations, which helps account for the increased health risks of carrying excess weight in the lower abdomen.

Also, because the data came from two surveys seven years apart, the researchers were able to assess the effect of change in ABSI on mortality.

The researchers found an increase in ABSI correlated with increased risk of death, and that the more recent ABSI measurement was a more reliable predictor.

Feb 25
Mixed evidence over Echinacea being useful treatment for colds
A new study has found that for people seeking a natural treatment for the common cold, some preparations containing the plant Echinacea work better than nothing, yet "evidence is weak".

The evidence review revealed no significant reductions in preventing illness, but didn't rule out "small preventive effects."

The six authors conducted reviews on this subject in 1998, 2006 and 2008 and wanted to do an update to include several new trials conducted since then.

"We've been doing this for so long and are very familiar with past research- which has been mixed from the very beginning," author Bruce Barrett , M.D., Ph.D. in the department of family medicine at the University of Wisconsin in Madison, said.

The research team reviewed 24 randomized controlled trials to determine whether Echinacea was a safe and effective cold prevention and treatment.

Trials included 4631 participants and 33 preparations, along with placebo. Echinacea products studied in these trials varied widely according to characteristics of three different plant species, the part of the plant used and method of manufacturing.

Barrett added that "it looks like taking Echinacea may reduce the incidence of colds. For those who take it as a treatment, some of the trials report real effects-but many do not. Bottom line: Echinacea may have small preventive or treatment effects, but the evidence is mixed."

The study was published in the journal Cochrane Library.

Feb 25
Mysterious polio-like disease reported in California
As many as 20 kids have been affected by a mysterious polio-like syndrome in California since 2012, leaving them with paralysed limbs.

The state public health officials and physicians have been investigating the illness since a doctor recommended a polio testing for a child with severe paralysis in 2012, reports The Los Angeles Times.

Dr Carol Glaser, leader of a California Department of Public Health team investigating the illnesses said that a virus may be behind the disease, which is occurring sporadically throughout the state.

Symptoms have ranged from restricted movement in one limb to severe weakness in both legs and arms, and sometimes a mild respiratory illness.

Glaser said two of the affected kids tested positive for enterovirus-68, a virus that is usually associated with respiratory illness but which has been linked to polio-like illnesses as well.

Dr. Keith Van Haren, a paediatric neurologist at Stanford University's Lucile Packard Children's Hospital who has worked with Glaser's team, will present the cases of five of the children at the American Academy of Neurology's upcoming annual meeting in Philadelphia.

He said all five patients had paralysis in one or more arms or legs that reached its full severity within two days. None had recovered limb function after six months.

"We know definitively that it isn't polio," Van Haren added, noting that all had been vaccinated against that disease.

While the infection remains rare, doctors say they do not expect an epidemic of the polio-like virus.

Polio is a highly infectious disease caused by a virus, mainly affecting children under the age of five. It invades the nervous system and can cause total paralysis in a matter of hours.

Feb 24
Women more prone to heart attacks than men
Women are more prone to heart attacks than men, says a new study.

The research led by Dr. Janine Austin Clayton, Director of the Office of Research on Women's Health at the National Institutes of Health, revealed that there are significant differences between men's and women's hearts and both experience varying heart attack symptoms.

The hallmark chest pain is more likely to be felt by men, whereas women may experience less obvious symptoms like trouble sleeping, nausea, indigestion, fatigue and jaw pain.

The study showed that men and women have substantive, clinically important differences in their bodies in all of health, from how their organs are structured to how they function.

One major difference is how the blood vessels of women with heart disease look compared to those of men.

Coronary heart disease is caused by plaque- made by cholesterol, fat and other substances- building up in the arteries that supply oxygen-rich blood to the heart muscle.

Clayton explained that in women, this buildup lines the walls of the blood vessels evenly- like the inside of a straw getting more narrow because the wall is thickening.

However, in men, this plaque buildup can be more concentrated in one area, as if a section of the straw is pinched.

The study was published in the journal of the American Medical Association.

Feb 24
Healthy liver cells created in lab
In a path-breaking research, scientists have discovered a way to transform skin cells into mature, fully functioning liver cells that flourish on their own.

The technique could serve as an alternative for liver-failure patients who do not require full-organ replacement or who do not have access to a transplant owing to limited donor organ availability.

Researchers at Gladstone Institutes and University of California, San Francisco (UCSF) revealed a new cellular reprogramming method that transforms human skin cells into liver cells that are virtually indistinguishable from the cells that make up liver tissue.

"Earlier studies tried to reprogramme skin cells back into a stem cell-like state in order to then grow liver cells. However, generating these pluripotent stem cells, or iPS cells, and then transforming them into liver cells was not always resulting in complete transformation," explained Sheng Ding, senior investigator at Gladstone Institutes.

"So we thought that, rather than taking these skin cells all the way back to a stem cell-like state, perhaps we could take them to an intermediate phase," he added.

Instead of taking the skin cells back to the beginning, the scientists took them only part way, creating endoderm-like cells.

Endoderm cells are cells that eventually mature into many of the body`s major organs - including the liver.

This step allowed them to generate a large reservoir of cells that could more readily be coaxed into becoming liver cells.

Next, the researchers discovered a set of genes and compounds that can transform these cells into functioning liver cells.

After just a few weeks, the team began to notice a transformation.

"The cells began to take on the shape of liver cells and even started to perform regular liver-cell functions," said Milad Rezvani from University of California.

They transplanted these early-stage liver cells into the livers of mice.

Two months post-transplantation, the team noticed a boost in human liver protein levels in the mice.

Nine months later, cell growth had shown no signs of slowing down.

These results offer new hope for the millions of people suffering from, or at risk of developing, liver failure.

At present, the only option is a costly liver transplant.

The power of regenerative medicine already allows scientists to transform skin cells into cells that closely resemble heart cells, pancreas cells and even neurons, concluded the study that appeared in the journal Nature.

Feb 21
Kids living near fast food outlets more likely to be obese
Parents, note! Your neighbourhood may determine whether your kids are overweight, a new study has found.

Children living in areas surrounded by fast food outlets are more likely to be overweight or obese, according to researchers from the University of East Anglia (UEA) in UK and their colleagues.

The research looked at weight data from more than a million children in UK and compared it with the availability of unhealthy food from outlets including fish and chip shops, burger bars, pizza places, and sweet shops.

They found that older children in particular are more likely to be overweight when living in close proximity to a high density of unhealthy eating outlets.

"We found that the more unhealthy food outlets there are in a neighbourhood, the greater the number of overweight and obese children," said Professor Andy Jones, from UEA's Norwich Medical School, who led the research.

"The results were more pronounced in secondary school children who have more spending power to choose their own food. But the association was reversed in areas with more healthy food options available," Jones said.

"If we can use these findings to influence planning decisions and help create a more healthy food environment, we may be able to help reverse this trend for future generations," study co-author Andreea Cetateanu, from UEA's school of Environmental Sciences, said.

"Public health policies to reduce obesity in children should incorporate strategies to prevent high concentrations of fast food and other unhealthy food outlets.

"But there is no quick fix - and any interventions for tackling childhood obesity and creating environments that are more supportive for both physical activity and better dietary choices must be part of the bigger picture looking at the whole obesity system," Cetateanu said.

The research team used data from the National Child Measurement Programme which records the height and weight of one million children at the majority of state schools in England annually.

Feb 21
How dark chocolate and red wine are good for your heart
A new study has revealed red wine and dark chocolate not only taste great, but also have heart-healthy components.

Red wine contains resveratrol, which has been found to lower blood sugar and LDL or "bad" cholesterol. It also is a source of catechins, which can help improve HDL or "good" cholesterol and polyphenols, which may prevent the formation of toxic plaque that leads to Alzheimer's disease.

Dark chocolate with a cocoa content of 70 percent or higher is rich in flavonoids, which help prevent the buildup of plaque in the arteries. It also boosts the immune system and contains cancer-fighting enzymes.

According to Loyola University Health System preventive heart specialist Sara Sirna , other items that top the list of heart-healthy foods include nuts, fish, flaxseeds, oatmeal, black or kidney beans, walnuts and almonds and berries.

Feb 20
Tumour 'monorail' may spell doom for cancer cells
Indian-origin scientists have successfully developed a radical new technique that may kill brain tumours by hijacking them into toxic pits or areas of the body that are safer to operate on.

One factor that makes glioblastoma cancers so difficult to treat is that malignant cells from the tumours spread throughout the brain by following nerve fibres and blood vessels to invade new locations.

Now, researchers have learned to hijack this migratory mechanism, turning it against the cancer by using a film of nanofibres thinner than human hair to lure tumour cells away.

Instead of invading new areas, the migrating cells latch onto the specially-designed nanofibres and follow them to a location - potentially outside the brain - where they can be captured and killed.

Using this technique, researchers can partially move tumours from inoperable locations to more accessible ones.

Though it would not eliminate the cancer, the new technique reduced the size of brain tumours in animal models, suggesting that this form of brain cancer might one day be treated more like a chronic disease, researchers said.

"We have designed a polymer thin film nanofibre that mimics the structure of nerves and blood vessels that brain tumour cells normally use to invade other parts of the brain," said Ravi Bellamkonda, lead investigator and chair of the Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

"The cancer cells normally latch onto these natural structures and ride them like a monorail to other parts of the brain. By providing an attractive alternative fibre, we can efficiently move the tumours along a different path to a destination that we choose," said Bellamkonda.

Treating the Glioblastoma multiforme cancer, also known as GBM, is difficult because the aggressive and invasive cancer often develops in parts of the brain where surgeons are reluctant to operate.

Even if the primary tumour can be removed, however, it has often spread to other locations before being diagnosed.

"The signalling pathways we were trying to activate to repair the spinal cord were the same pathways researchers would like to inactivate for glioblastomas," said first author of the study, Anjana Jain, an assistant professor in the Department of Biomedical Engineering at Worcester Polytechnic Institute in Massachusetts.

Tumour cells typically invade healthy tissue by secreting enzymes that allow the invasion to take place, Jain said. That activity requires a significant amount of energy from the cancer cells.

"Our idea was to give the tumour cells a path of least resistance, one that resembles the natural structures in the brain, but is attractive because it does not require the cancer cells to expend any more energy," she said.

Details of the technique were reported in the journal Nature Materials.

Feb 20
Loneliness ups older adult's chances of premature death by 14%
A new study has revealed that feeling extreme loneliness can increase an older person's chances of premature death by 14 percent.

The study by John Cacioppo, professor of psychology at the University of Chicago, and his colleagues shows that the impact of loneliness on premature death is nearly as strong as the impact of disadvantaged socioeconomic status, which they found increases the chances of dying early by 19 percent.

A 2010 meta-analysis showed that loneliness has twice the impact on early death as does obesity, he said.

The researchers looked at dramatic differences in the rate of decline in physical and mental health as people age.

Cacioppo and colleagues have examined the role of satisfying relationships on older people to develop their resilience, the ability to bounce back after adversity and grow from stresses in life.

The consequences to health are dramatic, as feeling isolated from others can disrupt sleep, elevate blood pressure, increase morning rises in the stress hormone cortisol, alter gene expression in immune cells, and increase depression and lower overall subjective well-being.

Cacioppo, one of the nation's leading experts on loneliness, said older people can avoid the consequences of loneliness by staying in touch with former co-workers, taking part in family traditions, and sharing good times with family and friends - all of which gives older adults a chance to connect others about whom they care and who care about them.

The study was presented at the American Association for the Advancement of Science Annual meeting in Chicago.

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