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Feb 06
Every hour of sitting may up diabetes risk: Study
Every extra hour a day spent sitting could increase the risk of developing diabetes by about a fifth, new study has warned.

The study by Julianne van der Berg of Maastricht University in the Netherlands and colleagues investigated cross-sectional associations of total duration and patterns of sedentary behaviour with glucose metabolism status and the metabolic syndrome.

Each extra hour of daily sedentary time (for example spent sitting at a computer) was associated with a 22 per cent increased risk of developing type 2 diabetes, researchers said.

The study participants used a thigh-worn accelerometer, which classifies sedentary behaviour using data on posture, as this has shown to be an accurate means of assessing sedentary behaviour.

The study included 2,497 participants (mean age 60 years, 52 per cent men) who were asked to wear their accelerometer 24 hours per day for 8 consecutive days.

Researchers calculated the daily amount of sedentary time, daily number of sedentary breaks, number of prolonged sedentary periods (of 30 minutes or more), and the average duration of these sedentary periods.

To determine diabetes status, participants underwent an oral glucose tolerance test.

Overall, 1,395 (56 per cent) participants had a normal glucose metabolism, 388 (15 per cent) had an impaired glucose metabolism and 714 (29 per cent) had type 2 diabetes.

Participants with type 2 diabetes spent the most time sedentary, up to 26 more minutes per day in comparison with participants with an impaired or normal glucose metabolism.

The increased risk of diabetes per additional hour of sedentary time was 22 per cent.

No significant associations were seen for the number of sedentary breaks, the number of prolonged sedentary periods or average duration of these sedentary periods with diabetes status.

The study is the largest in which this type of posture-identifying accelerometry has been used to objectively measure total duration and patterns of sedentary behaviour in a cohort of people with type 2 diabetes, impaired glucose tolerance, and normal glucose metabolism, researchers said.

"An extra hour of sedentary time was associated with a 22 per cent increased odds for type 2 diabetes," they said.

The study was published in the journal Diabetologia.

Feb 05
Epilepsy drug brings hope for multiple sclerosis patients
A commonly-used epilepsy drug has brought hope for multiple sclerosis sufferers as it may help prevent nerve damage.

The University College London study found that the drug phenytoin slowed the progress of optic neuritis, a symptom leading to blurred vision, and scientists believe it could have a similar protective effect throughout the brain.

Currently there are no neuroprotective drugs available for MS sufferers, whose nerve fibres are attacked by their own immune system.

In the study, 86 people with acute optic neuritis were either given phenytoin or an inactive placebo "dummy drug" for three months and at the end of the trial, the group who received the genuine drug had on average 30 percent less damage to the nerve fibre layer at the back of the eye.

Lead researcher Dr Raj Kapoor said that these are promising results and if the findings are confirmed by larger, Phase III trials, could lead to a new treatment that protects nerves from the damage caused both in optic neuritis and throughout the central nervous system in other attacks of MS.

The findings are reported in the journal The Lancet Neurology.

Feb 04
Anxiety, sleeping pills don't put you at increased dementia risk
A new study has suggested that taking drugs for anxiety and sleep problems is not associated with an increased dementia.

These results from the University of Washington (UW) and Group Health in Seattle do not support a direct (causal) association between benzodiazepine (widely used drugs to treat anxiety and insomnia) use and dementia, say the researchers.

However, the researchers suggest that healthcare providers should avoid benzodiazepines in older adults to prevent important adverse health outcomes.

Benzodiazepines are widely prescribed among older adults to manage sleep, anxiety and depressive disorders. Some studies have suggested that benzodiazepine use could be associated with an increased risk of dementia, but results are conflicting.

The study involved 3,434 participants at Group Health aged 65 and older without dementia at study entry, who were followed for an average of seven years.

During follow-up, 797 participants developed dementia, of whom 637 developed Alzheimer's disease.

The team found no association between the highest level of benzodiazepine use (the median level of use in this group was equivalent to about one year of daily use) and dementia or cognitive decline.

Contrary to expectations, they found a small increased risk for dementia in people with low (up to one month) or moderate (one to four months) use.

The study appears in The BMJ.

Feb 03
Blood pressure drug may treat Alzheimer's disease
A drug used to treat high blood pressure has been found to reduce cell damage often linked to Alzheimer's disease, reports a new study.

The researchers explored the effect of the US Food and Drug Administration (FDA) approved drug candesartan for the early treatment of Alzheimer's disease.

"Our findings make sense in many ways. Hypertension reduces blood flow throughout the body and brain and is a risk factor of Alzheimer's disease," said the study's senior author Juan Saavedra from Georgetown University Medical Center (GUMC) in Washington, DC.

The findings were published online in the journal Alzheimer's Research and Therapy.

Using neuronal cultures, the researchers explored the action of candesartan on the neurotoxic effects of exposure to excessive glutamate, a demonstrated injury factor in the early stages of Alzheimer's disease.

The scientists found that candesartan prevented glutamate-induced neuronal death.

They conducted in-depth gene analyses of the laboratory results, demonstrating that candesartan prevented neuronal inflammation and many other pathological processes, including alterations in amyloid metabolism, a hallmark of Alzheimer's disease.

"We hypothesise that candesartan, or other members of the ARB (Angiotensin receptor blockers) group, may not only slow progression of Alzheimer's but also prevent or delay its development," Saavedra noted.

Angiotensin receptor blockers form a class of medications used to treat high blood pressure.

Feb 01
Same genes influence health, thinking skills
Is there any link between low levels of mental functioning and poor health? A study shows that the same genes which influence people's health also shape how effectively they think.

The scientists found that genes associated with diseases, including Alzheimer's, schizophrenia and autism, also have an impact on some cognitive functions.

"In addition to there being shared genetic influences between cognitive skills and some physical and mental health states, the study also found that cognitive skills share genetic influences with brain size, body shape and educational attainments," said lead research professor Ian Deary from the University of Edinburgh.

The study, published in Molecular Psychiatry, was led by the University of Edinburgh that analysed data from around 100,000 people held in the UK Biobank.

To test the findings, researchers gathered data from previous genetic studies of other mental and physical health factors -- such as Alzheimer's disease, schizophrenia and autism.

To come to the conclusion, the national resource of health data helped researchers discover why some people develop particular diseases and others do not.

The researchers compared each person's mental test data with their genome-organism's complete set of DNA and found that some traits linked to disease and thinking skills shared the same genetic influences.

"The study supports an existing theory which says that those with better overall health are likely to have higher levels of intelligence," said another researcher, Saskia Hagenaars.

Jan 29
Green leafy vegetable intake lessens risk of glaucoma
A recent study says that leafy vegetables such as lettuce, spinach and kale and nitrate-rich vegetables are associated with lowering the risk of primary open-angle glaucoma by 20 to 30 percent.

Glaucoma is a condition which can affect sight, usually due to build up of pressure within the eye because fluid cannot drain away.

This new study found people who ate a nitrate-rich diet had lower levels of primary open-angle glaucoma (POAG), a rare condition which involves chronic or acute sudden painful build-up of pressure in the eye.

The researchers followed up participants biennially in the prospective cohorts of the Nurses' Health Study (63,893 women; 1984-2012) and the Health Professionals Follow-up Study (41,094 men; 1986-2012). Eligible participants were 40 years or older, were free of POAG, and reported eye examinations. Information on diet was updated with questionnaires.

During follow-up, 1,483 incident cases of POAG were identified. Participants were divided into quintiles (one of five groups) of dietary nitrate intake (quintile 5, approximately 240 mg/d; quintile 1, approximately 80 mg/d). The researchers found that greater intake of dietary nitrate and green leafy vegetables was associated with a 20 percent to 30 percent lower POAG risk; the association was particularly strong (40 percent-50 percent lower risk) for POAG with early paracentral visual field loss (a subtype of POAG linked to dysfunction in blood flow autoregulation).

The study has been published in JAMA Ophthalmology.

Jan 28
Early puberty may put women at diabetes risk
Women who began having menstrual cycles at a younger age are at a greater risk of developing gestational diabetes that can cause babies to develop Type-2 diabetes, reveals a study.

The study focuses specifically at menarche -- beginning of puberty and myriad hormonal changes in the body -- and gestational diabetes -- that begins or is first recognised during pregnancy, the researchers said.

Early menarche is also associated with higher levels of estrogen in adulthood, and other hormone imbalances are associated with an increased risk of gestational diabetes, the study said.

When menarche began at age 11 compared to age 14, women had a 39 percent higher risk of developing gestational diabetes, the study showed.

"This new finding could mean that doctors will begin asking women when they had their first period to determine their risk of developing gestational diabetes," said lead author Liwei Chen, assistant professor at the Clemson University in South Carolina, US.

Those affected may represent a high-risk population and should be targeted for prevention programs, the researchers warned.

Gestational diabetes affects up to seven percent of pregnant women. An increased risk, although lower, also occurred when menarche began at 12 and 13, the findings, published in the journal Diabetes Care, revealed.

Good weight control before pregnancy might help to reduce the gestational diabetes risk among those women, the researchers suggested.

The study followed more than 27,000 women enrolled in the Nurses' Health Study II.

Jan 27
Texting at night is bad for teens' sleep, studies
A recent US study has found that teenagers who continue to text on their phones after turning off the lights for bedtime have poorer sleep and poorer grades than those who text with the lights on.

The new study, by Rutgers University, is the first of its kind to find an association specifically between nighttime texting and the sleep quality and school performance of American teens.

Led by Xue Ming, professor of neuroscience and neurology at Rutgers New Jersey Medical School, the team surveyed students at three diferent New Jersey area high schools.

A total of 1,537 surveys were completed and analyzed by the team to look at the length of text messages sent by respondents, whether messages were sent before or after the lights were turned off and the participants' school grades.

Results showed that students who stopped texting when the lights went out, or who texted for less than 30 minutes after the lights went out, slept for longer, felt less sleepy during the day, and performed better academically than those who continued to text for longer than 30 minutes.

When comparing boys to girls however, the study found that although girls text more and felt sleepier during the day than boys, they still outperformed then in school studies, which Ming believes is due to girls texting primarily before and not after turning off the light.

Ming explained that the negative effect on sleep once the lights go out is due to the effects of the "blue light" emitted from smartphones and tablets being intensified in the dark. This blue light delays the release of melatonin, the hormone that makes you feel sleepy and which is normally released around 9pm, meaning instead of going to bed and dropping off, you stay awake for longer. This blue light can also affect the release of melatonin even if it is emitted from the phone when eyelids are closed.

The delay in melatonin release could also be a factor in poorer school performance. "If a person keeps getting text messages with alerts and light emission, that also can disrupt his circadian rhythm", explained Ming, "Rapid Eye Movement sleep is the period during sleep most important to learning, memory consolidation and social adjustment in adolescents. When falling asleep is delayed but rising time is not, REM sleep will be cut short, which can affect learning and memory."

Ming suggested that not only should schools recognize the importance of sleep for teens and find a way to incorporate education on sleep into the school curriculum, but also noted that a later school start time could be beneficial.

The results of the study were published in the Journal of Child Neurology.

Jan 25
Weekend binges as bad as regular junk food
Sydney: If you are strict with your diet during the week and eat junk over the weekend, then maybe you are undoing all the good work done during the week.

Yo-yoing between eating well during the week and bingeing on junk food over the weekend is likely to be just as bad for your gut health as a consistent diet of junk, a new study warned.

The human gut consists of up to 100 trillion microbial cells that influence metabolism, nutrition and immune function. Disruption to the gut microbiota has been linked with gastrointestinal conditions such as inflammatory bowel disease and obesity.

"The study was the first to compare how continuous or intermittent exposure to an unhealthy diet can impact the composition of the gut microbiota," said lead author Margaret Morris from the University of New South Wales in Australia in the journal Molecular Nutrition and Food Research.

"The findings indicate that intermittent exposure to junk food three days a week is sufficient to extensively shift the gut microbiota towards the pattern seen in obese rats consuming the diet continuously," Morris added.

"A reduction in the diversity of the gut's microbiota and a loss of some of the beneficial biota is clearly not a good thing for health," Morris stated.

The study examined the impact of yo-yo dieting on the gut microbiota of rats.

The research team compared the abundance of microbiota in rats given continuous access to either a healthy diet or junk food with a group cycled between the two diets, healthy for four days and junk for three, over 16 weeks.

The study revealed that rats on the cycled diet were 18 percent heavier than those on the healthy diet, while leptin and insulin levels in cycled rats were in between rats fed junk or healthy food.

The microbiota of cycled rats was almost indistinguishable from rats fed a constant diet of junk, with both groups' microbiota significantly different from those in the rats fed a healthy diet, the researchers found.

Jan 23
How Aged Garlic Extract can protect your heart
Aged Garlic Extract can stop heart disease from progressing and in some cases, even reverse artery plaque accumulation, according to a new study.

The research, conducted at LA BioMed, found a reduction in the amount of low-attenuation plaque, or "soft plaque," in the arteries of patients with metabolic syndrome who took Aged Garlic Extract. Metabolic syndrome is characterized by obesity, hypertension and other cardiac risk factors.

This study is another demonstration of the benefits of this supplement in reducing the accumulation of soft plaque and preventing the formation of new plaque in the arteries, which can cause heart disease, said lead researcher Matthew J. Budoff.

Budoff noted that they have completed four randomized studies and they have led them to conclude that Aged Garlic Extract can help slow the progression of atherosclerosis and reverse the early stages of heart disease.

The study is scheduled for publication in the Journal of Nutrition.

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