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Jun 22
Eating grapes, berries daily can prevent weight gain
Eating berries, grapes and other fruits daily can convert excess white fat into calorie-burning "beige" fat to prevent weight gain, scientists have found.

In the study, Washington State University scientists fed mice a high fat diet. Those receiving resveratrol in amounts equivalent to 12 ounces of fruit per day for humans - about two or three servings daily - gained 40 per cent less weight than control mice.

Resveratrol is a polyphenol, a type of antioxidant found in most fruits.

Previous studies have suggested that resveratrol can help prevent obesity but how it did that was unclear. Most of the research, including highly publicised studies on wine, also used very large concentrations of resveratrol, much more than a human could consume in a normal diet.

Professor of animal sciences Min Du and visiting scientist Songbo Wang demonstrated that mice fed a diet containing 0.1 per cent resveratrol were able to change their excess white fat into the active, energy-burning beige fat.

"Polyphenols in fruit, including resveratrol, increase gene expression that enhances the oxidation of dietary fats so the body won't be overloaded," said Du.

"They convert white fat into beige fat which burns lipids off as heat - helping to keep the body in balance and prevent obesity and metabolic dysfunction," Du said.

The researchers also showed that an enzyme called AMPK, which regulates the body's energy metabolism, stimulates this transition of white fat into beige fat.

Du said resveratrol is only one of the polyphenolic compounds found in fruit that provides beneficial health effects.

Du said those compounds are high in all fruits but especially rich in blueberries, strawberries, raspberries, grapes and apples.

Wines like merlot or cabernet sauvignon, in contrast, contain only a fraction of resveratrol and other phenolic compounds found in grapes, he said.

"Many of the beneficial polyphenols are insoluble and get filtered out during the wine production process," he said.

The study was published in the International Journal of Obesity.

Jun 20
Potential 'new osteoporosis' therapy identified
Researchers have identified a new therapeutic approach that, while still preliminary, could promote the development of new bone-forming cells in patients suffering from bone loss.

The Scripps Research Institute (TSRI study focused on a protein called PPARy (known as the master regulator of fat) and its impact on the fate of stem cells derived from bone marrow (mesenchymal stem cells).

Since these mesenchymal stem cells can develop into several different cell types-including fat, connective tissues, bone and cartilage, they have a number of potentially important therapeutic applications.

The scientists knew that a partial loss of PPARy in a genetically modified mouse model led to increased bone formation. To see if they could mimic that effect using a drug candidate, the researchers combined a variety of structural biology approaches to rationally design a new compound that could repress the biological activity of PPARy.

The results showed that when human mesenchymal stem cells were treated with the new compound, which they called SR2595 (SR=Scripps Research), there was a statistically significant increase in osteoblast formation, a cell type known to form bone.

Researcher Patrick Griffin added that these findings demonstrate for the first time a new therapeutic application for drugs targeting PPARy, which has been the focus of efforts to develop insulin sensitizers to treat type 2 diabetes.

He added that they have already demonstrated SR2595 has suitable properties for testing in mice; the next step is to perform an in-depth analysis of the drug's efficacy in animal models of bone loss, aging, obesity and diabetes.

The study is published in the journal Nature Communications.

Jun 19
Large parental age gap ups autism risk in kids
Children born to teenage mothers and whose parents have a large gap between their ages are at an increased risk of developing autism spectrum disorder (ASD), says a large study involving 5.7 million children in five countries.

The study also confirmed that older parents are at higher risk of having children with ASD which is characterised by social avoidance, repetitive behaviours and difficulty communicating.

"When we first reported that the older age of fathers increases risk for autism, we suggested that mutations might be the cause. Genetic research later showed that this hypothesis was correct," said study co-author Abraham Reichenberg, neuropsychologist and epidemiologist with the Icahn School of Medicine at Mount Sinai, in New York City.

"In this study, we show for the first time that autism risk is associated with disparately-aged parents.

Future research should look into this to understand the mechanisms," Reichenberg noted.

The study, published in the journal Molecular Psychiatry, looked at autism rates among 5,766,794 children -- including more than 30,000 with autism -- in Denmark, Israel, Norway, Sweden and Western Australia.

The children were born between 1985 and 2004, and the researchers followed up on their development until 2009, checking national health records for autism diagnoses.

Autism rates were 66 percent higher among children born to fathers over 50 years of age than among those born to fathers in their 20s. Autism rates were 28 percent higher when fathers were in their 40s versus 20s.

Autism rates were 15 percent higher in children born to mothers in their 40s, compared to those born to mothers in their 20s.

Autism rates were 18 percent higher among children born to teenage mothers than among those born to mothers in their 20s.

Autism rates rose still higher when both parents were older, in line with what one would expect if each parent's age contributed to risk.

Autism rates also rose with widening gaps between two parents' ages. These rates were highest when fathers were between 35 and 44 and their partners were 10 or more years younger.

"These results suggest that multiple mechanisms are contributing to the association between parental age and ASD risk," the authors concluded.

Jun 18
Drug with potential to reduce weight identified
New York: In what could lead to anti-obesity treatment for the elderly who may not always have the fitness to exercise, researchers have discovered that an existing drug used in transplants may help reduce food consumption and body weight.

Rapamycin, a pharmaceutical used to coat coronary stents and prevent transplant rejection, reduces obesity and preserves lean body mass when given intermittently to older rats, the findings showed.

"We need to be able to intervene with treatments for older adults. They`re going to have health care issues, and not everyone can get up and exercise," said study co-lead author Christy Carter, assistant professor at University of Florida College of Medicine.

"So if you can give them a jump-start or combine rapamycin with other therapies, you could have better health outcomes," Carter said.

Using 25-month-old rats, which are about equivalent to 65-year-old people, the researchers found that body weight dropped by approximately 13 percent after the rats were treated with rapamycin.

The drug targets how the body makes leptin, a hormone produced by fat cells that affects hunger and metabolism.

Rapamycin`s ability to stabilise the rats` leptin level made them lighter, the study said.

It worked so well that the older rats ultimately developed a lean-to-fat ratio similar to that of their younger counterparts, researchers found.

"In this case, we feel like we restored the body composition to that of a young animal," Carter said.

In a second study, researchers found that small, intermittent amounts of rapamycin produced the desired slimming effect in both young and old rats.

"One point that is common is that it seems to work better in animals, old or young, that have more fat," lead authors Philip Scarpace, professor at University of Florida College of Medicine.

The two rapamycin-related studies were published in the Journals of Gerontology as a joint effort of two research teams.

Jun 17
Cinnamon may hold key to beat colorectal cancer
Cinnamon may do more than add flavour to your food, as a new study has claimed the a component found in the spice is a potent inhibitor of colorectal cancer.

Associate Professor Georg Wondrak, Ph.D. and Professor Donna Zhang, Ph.D. at the University of Arizona recently completed a study in which they proved that adding cinnamaldehyde, the compound that gives cinnamon its distinctive flavor and smell, to the diet of mice protected the mice against colorectal cancer. In response to cinnamaldehyde, the animals' cells had acquired the ability to protect themselves against exposure to a carcinogen through detoxification and repair.

Zhang deemed the finding "significant," as colorectal cancer is aggressive and associated with poor prognoses, and there was an urgent need to develop more effective strategies against this disease.

The next step in the research is to test whether cinnamon, as opposed to cinnamaldehyde, prevents cancer using this same cancer model. Because cinnamon is a common food additive already considered safe - it's not a synthetic, novel drug-a study in humans may not be too far off.

The study is published online and will appear in a print issue of Cancer Prevention Research later this spring.

Jun 16
'Nutritious' avocados may help beat deadly leukemia
Adding to the benefits of avocados, scientists have found that the nutritious fruit may hold the key to beating deadly leukemia.

University of Waterloo Professor Paul Spagnuolo has discovered a lipid in avocados that combats acute myeloid leukemia (AML) by targeting the root of the disease - leukemia stem cells. Worldwide, there are few drug treatments available to patients that target leukemia stem cells.

AML is a devastating disease and proves fatal within five years for 90 per cent of seniors over age 65.

Spagnuolo said that the stem cell is largely responsible for the disease developing and it's the reason why so many patients with leukemia relapse. They performed many rounds of testing to determine how the new drug worked at a molecular level and confirmed that it targets stem cells selectively, leaving healthy cells unharmed.

He added that not only does avocatin B eliminate the source of AML, but its targeted, selective effects makes it less toxic to the body, too.

The drug is still years away from becoming approved for use in oncology clinics, but Spagnuolo is already performing experiments to prepare the drug for a Phase I clinical trial.

Spagnuolo is among only a handful of researchers worldwide, applying the pharmaceutical industry's rigorous drug discovery research processes to food-derived compounds, called nutraceuticals.

The research is published in the journal Cancer Research.

Jun 15
You can include pork in recipe to lower BP
If you are following a diet to lower blood pressure, you may expand your protein options to include lean, unprocessed pork, new research suggests.

The Dietary Approaches to Stop Hypertension (DASH) diet is recommended to reduce blood pressure and is focused on the increased consumption of fruits and vegetables, whole-grains, low-fat dairy products, nuts, poultry and fish, while reducing fats, red meats, including pork, and added sugars.

"If people have to rely only on fish and chicken their diet choices can be limited and our results support that lean pork may be a viable option for people who are consuming a DASH diet without compromising the effectiveness of the diet plan," said co-author Drew Sayer, doctoral student in nutrition science at Purdue University in the US.

The study that appeared in American Journal of Clinical Nutrition compared lean, unprocessed pork with chicken and fish as the predominant protein source in a DASH-style diet.

The consumption of these DASH-style diets for six weeks reduced all measures of blood pressure with no differences in responses between DASH with chicken and fish and DASH with pork, the study found.

"This study supports that the DASH diet can include lean and unprocessed red meats in the appropriate serving sizes," Wayne Campbell, professor of nutrition science at Purdue University, said.

Jun 13
Human trial to assess efficacy of autism drug treatment
A clinical trial to investigate the safety and efficacy of a drug therapy for autism has been launched in the US, University of California, San Diego School of Medicine has said in a statement.

The phase 1 clinical trial, which is recruiting 20 participants, will evaluate suramin -- a century-old drug still used for African sleeping sickness -- as a novel treatment for children with a diagnosis of Autism Spectrum Disorder (ASD).

ASD is characterised by social impairments, communication difficulties and restricted, repetitive and stereotyped patterns of behaviour.

"To date, there are no medications that can cure ASD, and very few that can improve its core symptoms," said Robert Naviaux, professor of medicine, pediatrics and pathology at the UC San Diego School of Medicine.

Previous published research by Naviaux and colleagues reported that a single injection of suramin reversed symptoms of ASD in mouse models.

This trial is the first to test suramin in children with ASD.

It is also the first clinical investigation of a novel theory, advanced by Naviaux, that posits autism may be a consequence of abnormal cell communication resulting from abnormal activation of the cell danger response.

Cells threatened or damaged by microbes, such as viruses or bacteria, or by physical forces or by chemicals, such as pollutants, react defensively, a part of the normal immune response, Naviaux said.

Their membranes stiffen. Internal metabolic processes are altered - most notably mitochondria, the cells' critical 'power plants' -- resulting in activation of the cell danger response and reduced communications between cells.

Naviaux said the cell danger response theory does not contradict other research regarding the causes of autism.

Rather, it offers another perspective and, perhaps, a new therapeutic target.

The study will involve 10 to 12 clinical visits over three to four months for each child.

In the trial, suramin will be given as a single dose through an intravenous line. Half of the participating children will receive suramin, half will receive a placebo (saline infusion).

Behavioural and medical tests will be conducted before and after treatment, and include some blood and urine analyses, the statement said.

Jun 12
Weight-loss surgery boosts sex life too
New York: The popular weight-loss surgery not only makes you look fit and healthy but can also bring spark back in your bedroom life, reveals a study.

Bariatric surgery leads to greater intimacy between life partners as going through the period becomes a "joint journey" for the couples.

"In the study, the couples felt their post-operative success was due to a joint effort on the part of both partners," said Mary Lisa Pories from East Carolina University in the US.

The research team interviewed 10 couples about the effects of the weight-loss surgery that one of the partners had undergone.

All the patients and their significant others viewed the surgery and subsequent adjustments that needed to be made as part of a team effort.

Couples highlighted the adjustment that was needed to adapt to their partners` significant weight loss.

The couples also had more energy needed to adjust to new eating habits.

On an emotional level, the couples reported more positive moods and better self-esteem.

"They also reported sharing greater intimacy and affection, and being better able to resolve conflict. Their sexual relationships also improved and, in many cases, became more enjoyable," Pories said.

A better understanding of how bariatric surgery impacts the dynamics of a couple`s relationship could help physicians, nurses and social workers to support patients and their partners more effectively, the authors said.

Bariatric surgery is the most effective way to counter morbid obesity.

It results in substantial weight loss and reduces other health-related conditions.

The findings were published in Springer`s journal Obesity Surgery.

Jun 11
Eat few peanuts every day to slash early death risk from cancer
A new study has suggested that peanuts can protect against early death from cancer and heart disease.

The Maastricht University study found that men and women who eat at least 10g of nuts or peanuts and not peanut butter per day have a lower risk of dying from several major causes of death than people who do not consume them, News.com.au reported.

Researchers in the Netherlands said peanuts and tree nuts both contain various vitamins, fibre, antioxidants and compounds such as monounsaturated and polyunsaturated fatty acids that can possibly contribute to the lower death rates.

They said peanut butter contains salt and trans fatty acids that could inhibit the protective effects of peanuts.

Women who ate nuts were also often leaner, had never smoked and were less likely to report diabetes.

Lead researcher Piet van den Brandt said that a higher intake was not associated with further reduction in mortality risk.

The study is published in the International Journal of Epidemiology.

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